• Journal of ILASS-Korea
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• v.21 no.1
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• pp.1-6
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• 2016

A gasoline injector rig which can measure cumulative injected fuel mass under a vehicle driving condition was developed. The measurement system consists of an engine control unit (ECU), data acquisition (DAQ) and injected fuel collection system using loadcells. By supplying reconstructed sensor signals which simulate the real vehicle's sensor signals to the ECU, the ECU drives injectors as if they were driven in the vehicle. The vehicle's performance was computer simulated by using $GT-Suite^{(R)}$ software based on both engine part load performance and automatic transmission shift map. Throttle valve position, engine and vehicle speed, air mass flow rate et al. were computer simulated. The used vehicle driving pattern for the simulation was FTP-75 mode. For reconstructing the real vehicle sensor signals which are correspondent to the $GT-Suite^{(R)}$ simulated vehicle's performance, the DAQ systems were used. The injected fuel was collected with mess cylinders. The collected fuel mass in the mess cylinder with elapsed time after starting FTP-75 driving mode was measured using loadcells. The developed method shows highly improved performance in fast timing and accuracy of the cumulative injected fuel mass measurement under the vehicle driven condition.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2006.06a
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• pp.233-234
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• 2006

LNG is extremely cold, $-160^{\circ}C$ in its liquid state. When it vaporizes, returning to its natural state (re-vaporization), it cools its surroundings. This is cold energy. The manufacturing of liquid air is the first processes developed as the most effective utilization of LNG cold. In this paper, adopting the LNG cold process for manufacturing liquid air was developed and analysed. The result showed that as the higher air pressure and adapting nitrogen precooling, liquefaction rate and cumulative mass was increased.

• Journal of The Korean Astronomical Society
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• v.38 no.2
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• pp.161-164
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• 2005

We present a theoretical formalism by which the global and the local mass functions of dark matter substructures (dark subhalos) can be analytically estimated. The global subhalo mass function is defined to give the total number density of dark subhalos in the universe as a function of mass, while the local subhalo mass function counts only those sub halos included in one individual host halo. We develop our formalism by modifying the Press-Schechter theory to incorporate the followings: (i) the internal structure of dark halos; (ii) the correlations between the halos and the subhalos; (iii) the subhalo mass-loss effect driven by the tidal forces. We find that the resulting (cumulative) subhalo mass function is close to a power law with the slope of ${\~}$ -1, that the subhalos contribute approximately $10\%$ of the total mass, and that the tidal stripping effect changes the subhalo mass function self-similarly, all consistent with recent numerical detections.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.1
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• pp.45-54
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• 2017

Our study aims to determine the metabolism and excretion of novel pulmonary-targeting docetaxel liposome (DTX-LP) using the in vitro and in vivo animal experimental models. The metabolism and excretion of DTX-LP and intravenous DTX (DTX-IN) in New Zealand rabbits were determined with ultra-performance liquid chromatography tandem mass spectrometry. We found DTX-LP and DTX-IN were similarly degraded in vitro by liver homogenates and microsomes, but not metabolized by lung homogenates. Ultra-performance liquid chromatography tandem mass spectrometry identified two shared DTX metabolites. The unconfirmed metabolite $M_{un}$ differed structurally from all DTX metabolites identified to date. DTX-LP likewise had a similar in vivo metabolism to DTX-IN. Conversely, DTX-LP showed significantly diminished excretion in rabbit feces or urine, approximately halving the cumulative excretion rates compared to DTX-IN. Liposomal delivery of DTX did not alter the in vitro or in vivo drug metabolism. Delayed excretion of pulmonary-targeting DTX-LP may greatly enhance the therapeutic efficacy and reduce the systemic toxicity in the chemotherapy of non-small cell lung cancer. The identification of $M_{un}$ may further suggest an alternative species-specific metabolic pathway.

• Earthquakes and Structures
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• v.27 no.4
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• pp.303-315
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• 2024

This study proposes a comprehensive methodology for estimating accumulative damage of bridge structures under multiple seismic excitations, in the framework of site-specific probabilistic hazard analysis. Specifically, a typical earthquake-prone region in China is chosen to perform probabilistic seismic hazard analysis (PSHA) to find the mean annual rate (MAR) of ground motion intensity at a specific level, based on which, a mass of ground motion observations is selected to construct random earthquake sequences with various number of shocks. Then, nonlinear time history analysis is implemented on the finite element (FE) model of a RC girder bridge at the site of interest, to investigate structural responses under different earthquake sequences, and to develop predictive model for cumulative damage computation, in which, a scalar seismic intensity measure (IM) is adopted and its performance in damage prediction is discussed by an experimental column. Furthermore, a mathematic model is established to calculate occurrence probability of earthquakes with various number of shocks, based on PSHA and homogenous Poisson random process, and a modified cumulative damage indicator is proposed, accounting for probabilistic occurrence of various earthquake scenarios. At end, the applicability of the proposed methodology to main shock and aftershock scenarios is validated, and characteristics of damage accumulation under different multiple earthquake scenarios are discussed.

• Journal of Astronomy and Space Sciences
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• v.18 no.3
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• pp.191-208
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• 2001

We have recently compiled a database of the properties of 192 impact craters, which supercedes previous compilations. Using our database, the impact structures found in North America, Europe and Australia have been examined; these cratonic areas have been relatively stable for considerably long geological periods, and thus have been best preserved. It is confirmed that there is a close correlation between the geological epoch boundaries, the epochs of mass extinctions, antral the "timing" of impacts. In addition, the terrestrial cumulative flux of objects >20km is found to be $1.77{\times}10^{-15}km^{-2}yr^{-1}$, over the last 120 Myr, which is much smaller than the published values in McEwen et al. (1997) and Shoemaker (1998) ($5.6{\pm}2.8{\times}10^{-15}km^{-2}yr^{-1}$. For terrestrial impact structures with D> 50 km, the apparent cumulative flux over the last 2450 Myr is ~50 times smaller than the corresponding value for the Moon. If we assume that the Earth and the Moon suffered the same level of bombardment over this time, this would mean that the actual flux of impacting bodies, capable of making craters with D)50 km, was ~ 50 times larger than the apparent flux estimated from the currently known terrestrial records.

• Journal of Korean Medical Science
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• v.33 no.50
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• pp.318.1-318.10
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• 2018

Background: In this prospective cohort study, we investigated the association between fatty acid ethyl esters (FAEEs) in meconium as biomarkers of prenatal ethanol exposure and growth deficits, as birth outcomes, that constitute several of the key cardinal features of fetal alcohol syndrome. Methods: A total of 157 meconium samples were collected from enrolled infants within 24 hours of birth, and nine FAEEs were quantified using liquid chromatography/tandem mass spectrometry. The relationships between cumulative concentrations of nine species of FAEEs in meconium and birth parameters of growth (age-sex-specific centiles of head circumference [HC], weight, and length) and respective and combined birth outcomes of growth deficits (HC ${\leq}10th$ centile, weight ${\leq}10th$ centile, and length ${\leq}10th$ centile) were determined. Results: Multivariate logistic regression analysis demonstrated that higher cumulative concentrations of meconium FAEEs correlated with elevated risks for HC and length, both, 10th percentile or less (adjusted odds ratio [aOR], 2.94; 95% confidence interval [CI], 1.12-7.74; P = 0.029) and HC and weight and length, all of them, 10th percentile or less (aOR, 3.27; 95% CI, 1.12-9.59; P = 0.031). Conclusion: The elevated cumulative FAEEs in meconium were associated with combined growth deficits at birth, specifically HC and length, both, 10th percentile or less, which might be correlated with detrimental alcohol effects on fetal brain and bone development, suggesting a plausible alcohol-specific pattern of intrauterine growth restriction.

• Tunnel and Underground Space
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• v.12 no.3
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• pp.198-209
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• 2002

To assess deep geological environment for the research and development of hish-level radioactive waste disposal, six boreholes of 3" in diameter were installed in two granitic areas. An areal extent of the rock block scale in the study sites was estimated by the lineament analysis from satellite images and shaded relief maps. The characterization of fracture system developed in rock block scale was carried out based on the acoustic televiewer logging in deep boreholes. In the Yuseong site, the granite rock mass was divided into the upper and lower zones at around -160m based on the probabilistic distribution characteristics of the geometric parameters such as orientation, fracture frequency, spacing and aperture size. Since the groundwater flow is dependent on the fracture system in a fractured rock mass, the correlation of the fracture frequency and cumulative aperture size to the hydraulic conductivity was also discussed.

• Earthquakes and Structures
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• v.7 no.4
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• pp.415-448
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• 2014

A method is presented in this paper to analyze the dynamic response behavior of suspended building structures. The effect of semi-rigid connections that link suspended floors with their supporting structure on structural performance is investigated. The connections, like the restrains in non-structural suspended components, are designed as semi-rigid to avoid pounding and as energy dissipation components to reduce structural response. Parametric study is conducted to assess the dynamic characteristics of suspended building structures with varying connection stiffness and suspended mass ratios. Modal analysis is applied to identify the two distinct sets of vibration modes, pendulum and bearing, of a suspended building structure. The cumulative modal mass is discussed to ensure the accuracy in applying the method of response spectrum analysis by SRSS or CQC modal combination. Case studies indicate that a suspended building having semi-rigid connections and proper suspended mass ratios can avoid local pounding failure and reduce seismic response.

• Steel and Composite Structures
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• v.4 no.5
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• pp.355-365
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• 2004

A new reduction method of residual stress in welding joint is proposed where welded metals are shaken during welding. By an experiment using a small shaker, it can be shown that tensile residual stress near the bead is significantly reduced. Since tensile residual stress on the surface degrades fatigue strength for cumulative damage, the proposed method is effective to reduction of residual stress of welded joints. The effectiveness of the proposed method is demonstrated by the response analysis using one mass model with nonlinear springs.