• Journal of Periodontal and Implant Science
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• 제51권3호
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• pp.163-178
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• 2021

Purpose: The aim of this study was to evaluate clinical factors affecting the longevity of fixed retainers and the influence of fixed retainers on periodontal health in periodontitis patients. Methods: In total, 52 patients with at least 2 years of follow-up after periodontal and orthodontic treatment were included in this study. After scaling and root planing, orthodontic treatment with fixed appliances or clear aligners was performed. Fixed retainers with twist-flex stainless steel wires were bonded to the palatal or lingual sides of anterior teeth. Changes in clinical parameters, including the plaque index, gingival index, calculus index (CI), probing pocket depth, and radiographic bone levels, were evaluated before bonding of fixed retainers and at a 12-month follow-up. Cumulative survival rates (CSRs) for retainer failure were evaluated according to sex, site, CI, stage of periodontitis, and the severity of the irregularity with the log-rank test and hazard ratios (HRs). Results: Twelve months after bonding of fixed retainers, improvements were observed in all clinical parameters except CI and radiographic bone gain. The overall CSR of the retainers with a CI <1 at the 12-month follow-up after bonding of fixed retainers was significantly higher than that of the retainers with a CI ≥1 at the 12-month follow-up (log-rank test; P<0.001). Patients with stage III (grade B or C) periodontitis had a higher multivariate HR for retainer failure (5.4; 95% confidence interval, 1.22-23.91; P=0.026) than patients with stage I (grade A or B) periodontitis. Conclusions: Although fixed retainers were bonded in periodontitis patients, periodontal health was well maintained if supportive periodontal treatment with repeated oral hygiene education was provided. Nonetheless, fixed retainer failure occurred more frequently in patients who had stage III (grade B or C) periodontitis or a CI ≥1 at 12-month follow-up after bonding of fixed retainers.

• Journal of Chest Surgery
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• 제55권3호
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• pp.189-196
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• 2022

Background: This study investigated the predictive value of the frailty index calculated using laboratory data and vital signs (FI-L) in patients who underwent coronary artery bypass grafting (CABG). Methods: This study included 508 patients (age 67.3±9.7 years, male 78.0%) who underwent CABG between 2018 and 2021. The FI-L, which estimates patients' frailty based on laboratory data and vital signs, was calculated as the ratio of variables outside the normal range for 32 preoperative parameters. The primary endpoints were operative and medium-term all-cause mortality. The secondary endpoints were early postoperative complications and major adverse cardiac and cerebrovascular events (MACCEs). Results: The mean FI-L was 20.9%±10.9%. The early mortality rate was 1.6% (n=8). Postoperative complications were atrial fibrillation (n=148, 29.1%), respiratory complications (n=38, 7.5%), and acute kidney injury (n=15, 3.0%). The 1- and 3-year survival rates were 96.0% and 88.7%, and the 1- and 3-year cumulative incidence rates of MACCEs were 4.87% and 8.98%. In multivariable analyses, the FI-L showed statistically significant associations with medium-term all-cause mortality (hazard ratio [HR], 1.042; 95% confidence interval [CI], 1.010-1.076), MACCEs (subdistribution HR, 1.054; 95% CI, 1.030-1.078), atrial fibrillation (odds ratio [OR], 1.02; 95% CI, 1.002-1.039), acute kidney injury (OR, 1.06; 95% CI, 1.014-1.108), and re-operation for bleeding (OR, 1.09; 95% CI, 1.032-1.152). The minimal p-value approach showed that 32% was the best cutoff for the FI-L as a predictor of all-cause mortality post-CABG. Conclusion: The FI-L was a significant prognostic factor related to all-cause mortality and postoperative complications in patients who underwent CABG.

• Journal of Chest Surgery
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• 제56권5호
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• pp.304-310
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• 2023

Background: The late progression of tricuspid regurgitation (TR) after mitral valve surgery is well known. However, few reports have described the progression of TR after aortic valve surgery. We investigated the incidence of and risk factors for the development of significant TR after isolated aortic valve replacement (AVR). Methods: This study analyzed patients with less than moderate TR who underwent isolated AVR at Seoul National University Hospital from January 1990 to December 2018. Significant TR was defined as moderate or higher. Echocardiographic follow-up was performed in all patients. The Fine-Gray model was used to identify clinical risk factors for the development of significant TR. Results: In total, 583 patients (61.7±14.2 years old) were included. Operative mortality occurred in 9 patients (1.5%), and the overall survival rates at 10, 20, and 25 years were 91.1%, 83.2%, and 78.9%, respectively. Sixteen patients (2.7%) developed significant TR during the follow-up period (13 moderate; 3 severe). The cumulative incidence of significant TR at 10, 20, and 25 years was 0.77%, 3.83%, and 6.42%, respectively. No patients underwent reoperation or reintervention of the tricuspid valve. Hemodialysis or peritoneal dialysis for chronic kidney disease (hazard ratio [HR], 5.188; 95% confidence interval [CI], 1.154-23.322) and preoperative mild TR (HR, 5.919; 95% CI, 2.059-17.017) were associated with the development of significant TR in the multivariable analysis. Conclusion: TR progression after isolated AVR in patients with less than moderate TR is rare. Preoperative mild TR and hemodialysis or peritoneal dialysis for chronic kidney disease were significant risk factors for the development of TR.

• 대한이식학회지
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• 제31권4호
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• pp.200-206
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• 2017

Background: Risk factors for bone avascular necrosis (AVN), a common late complication after kidney transplantation (KT), are not well known. Methods: Patients that underwent living-donor KT at Asan Medical Center between January 2009 and July 2016 were included in this retrospective study to determine the incidence and risk factors for AVN after KT. Results: Among 1,570 patients that underwent living-donor KT, 33 (2.1%) developed AVN during a mean follow-up of 49.8±25.0 months. Additionally, AVN was diagnosed at a mean of 13.9±6.6 months after KT. The mean cumulative corticosteroid dose during the last follow-up in patients without AVN (9,108±3,400 mg) was higher than that that in patients with AVN (4,483±1,114 mg) until AVN development (P<0.01). More patients among those with AVN (n=4, 12.1%) underwent steroid pulse treatment because of biopsy-proven rejections during the first 6 months after KT than patients without AVN (n=68, 4.4%; P=0.04). Female (hazard ratio [HR], 2.29; P=0.04) and steroid pulse treatment during the first 6 months (HR, 2.31; P=0.02) were significant AVN risk factors as revealed by the Cox proportional multivariate analysis. However, no significant differences in rejection-free graft survival rates were observed between the two groups (P=0.67). Conclusions: Steroid pulse treatment within 6 months of KT and being female were independent risk factors for AVN development.

• 대한안전경영과학회지
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• 제25권1호
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• pp.7-14
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• 2023

We attempted to provide an overview of the laws and current state of the 3D printing industry in South Korea and around the world, using the annual industry surveys and the Wohler report. Additionally, we reviewed articles relating to the potential exposure to hazards associated with 3D printing using metal materials. In South Korea, there were 406 3D printing-related businesses, employing 2,365 workers, and the market size was estimated at 455.9 billion won in 2021. Globally, the average growth rate of the 3D printing industry market over the past 10 years was 27.4%, and the market size was estimated at $11.8 billion in 2019. The United States had the highest cumulative installation ratio of industrial 3D printers, followed by China, Japan, Germany, and South Korea. A total of 6,168 patents related to 3D printing were registered in the US between 2010 and 2019. Harmful factors during metal 3D printing was mainly evaluated in the powder bed fusion and direct energy deposition printing types, and there is a case of material extrusion type with metal additive filaments. The number, mass, size distribution, and chemical composition of particles were mainly evaluated. Particle concentration increases during the opening of the chamber or post-processing. However, operating the 3D printer in a ventilated chamber can reduce particle concentration to the background level. In order to have a safe and healthy environment for 3D printing, it is necessary to accumulate and apply knowledge through various studies.

• Structural Engineering and Mechanics
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• 제88권2호
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• pp.117-128
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• 2023

On February 6, 2023, Türkiye woke up with a strong ground motion felt in a wide geography. As a result of the Kahramanmaraş, Pazarcık and Elbistan earthquakes, which took place 9 hours apart, there was great destruction and loss of life. The 2023 Kahramanmaraş earthquakes occurred on active faults known to pose a high seismic hazard, but their effects were devastating. Seismic code spectra were investigated in Hatay, Adıyaman and Kahramanmaraş where destruction is high. The study mainly focuses on the investigation of ground motion parameters of 6 February Kahramanmaraş earthquakes and the correlation between ground motion parameters. In addition, earthquakes greater than Mw 5.0 that occurred in Türkiye were compared with certain seismic parameters. As in the strong ground motion studies, seismic energy parameters such as Arias intensity, characteristic intensity, cumulative absolute velocity and specific energy density were determined, especially considering the duration content of the earthquake. Based on the study, it was concluded that the structures were overloaded far beyond their normal design levels. This, coupled with significant vertical seismic components, is a contributing factor to the collapse of many buildings in the area. In the evaluation made on Arias intensity, much more energy (approximately ten times) emerged in Kahramanmaraş earthquakes compared to other Türkiye earthquakes. No good correlation was found between moment magnitude and peak ground accelerations, peak ground velocities, Arias intensities and ground motion durations in Türkiye earthquakes. Both high seismic components and long ground motion durations caused intense energy to be transferred to the structures. No strong correlation was found between ground motion durations and other seismic parameters. There is a strong positive correlation between PGA and seismic energy parameter AI. Kahramanmaraş earthquakes revealed that changes should be made in the Turkish seismic code to predict higher spectral acceleration values, especially in earthquake-prone regions in Türkiye.

• 한국산학기술학회논문지
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• 제19권8호
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• pp.433-440
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• 2018

정부 연구개발사업은 미래지향적 성장동력창출, 예산확대 등 중요성이 높아짐에 따라 R&D의 효율성 투자방향 전략 등 패러다임 전환을 통해 구체적으로 미래 비전을 제시하고 있다. 반면에 제재조치에 대한 연구와 관심은 저조함으로 본 논고를 통해 법적근거, 법령 비교분석, 국외사례 등을 검토해 국내에 적용하는 시사점을 도출하고 연구자들의 이해를 도와 실무에 활용하는데 본 연구의 목적이 있다. 또한 제도시행을 알지 못하거나, 소홀함으로 겪는 피해를 사전에 방지하는 효과 및 연구비 집행의 투명성 제고에 기여하고자 한다. 본 연구는 정부R&D의 특성과 제재조치에 대한 기준을 중소기업관련 R&D 투자 상위 3개 부처의 제재조치를 비교 분석하는 방식으로 수행되었다. 우리나라는 2001년 제재조치 도입을 시작으로 누적위반 중과제, 참여제한 기간의 확대, 삼진아웃제도의 도입 등을 통해 연구개발의 도덕적 해이를 방지하고, 재정 건전화를 위한 방향으로 강력히 추진하고 있다. 그럼에도 불구하고 사업비 부정사용은 지속적으로 적발되고 있다. 따라서 강력한 제도보다는 연구자율을 최대한 보장하고, 책임이 강화될 수 있도록 연구수행 주체자 들의 투명한 사업비 집행 의지, 공공재원에 대한 도덕적 접근, 기술개발에 대한 사명감 등 인식전환의 선행이 중요하다.

• 한국가스학회:학술대회논문집
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• 한국가스학회 2005년도 추계학술발표회 논문집
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• pp.37-43
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• 2005

도시가스를 사용하고 있는 사용가구에 대한 설문조사 결과 10가구 당 7가구 꼴로 도시가스가 안전한 것으로 인식하고 있지만 이 중 $30\%$는 향후 가스 안전사고가 자신의 집에서 발생할 가능성이 있다고 인식하고 있어 도시가스이용이 상대적으로 안전하기는 하지만 여전히 사고의 위험성이 상존하고 있다는 것을 도시가스를 사용하는 가구 구성원들이 인식하고 있는 것으로 나타났다. 이러한 도시가스 소비자의 가스안전에 대한 인식은 연령, 성별, 소득수준 등과는 무관한 것으로 분석된 반면, 고학력자이며, 직, 간접적인 가스안전사고 경험이 있고, 가스안전점검요령을 미숙지하고 있는 사람일수록 도시가스사용의 안전성에 대한 인식이 상대적으로 낮게 나타났다. 한편, 대다수의 도시가스사용가구가 최소한의 가스안전점검방법을 알고 있는 반면, 단지 $60\%$만이 자율점검을 실시하고 있는 것으로 나타나 소비자가 자율적인 안전점검에 대해 매우 소홀히 하고 있음을 알 수 있다. 특히 자율점검을 실시하지 않는 이유로 대다수의 응답자가 "외부로부터 안전점검을 받기 때문에 자율점검의 필요성을 못느끼고 있다"라고 응답한 점을 감안할 때 소비자들의 외부에 대한 안전점검의 의존성향을 변화시키기 위해서는 도시가스사 직원의 정기 안전검사시 안전점검 외에도 자율점검의 필요성 및 방법 등에 대한 올바른 교육 및 적극적인 홍보활동이 필요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7097-7103
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• 2014

Over-expression of de novo lipogenesis (DNL) genes is associated with the prognosis of various types of cancers. However, the effects of single nucleotide polymorphisms (SNPs) in these genes on recurrence and survival of non-small cell lung cancer (NSCLC) patients after surgery are still unknown. In this study, a total of 500 NSCLC patients who underwent surgery treatment were included. Eight SNPs in 3 genes (ACACA, FASN and ACLY) of the DNL pathway were examined using the Sequenom iPLEX genotyping system. Multivariate Cox proportional hazards regression and Kaplan-Meier curves were used to analyze the association of SNPs with patient survival and tumour recurrence. We found that two SNPs in the FASN gene were significantly associated with the recurrence of NSCLC. SNP rs4246444 had a significant association with lung cancer recurrence under additive model (hazard ratio [HR], 0.82; 95% confidence interval [95%CI], 0.67-1.00; p=0.05). Under the dominant model, rs4485435 exhibited a significant association with recurrence (HR, 0.75; 95%CI, 0.56-1.01; p=0.05). Additionally, SNP rs9912300 in ACLY gene was significantly associated with overall survival in lung cancer patients (HR, 1.41; 95%CI, 1.02-1.94, p=0.04) under the dominant model. Further cumulative effect analysis showed moderate dose-dependent effects of unfavorable SNPs on both survival and recurrence. Our data suggest that the SNPs in DNL genes may serve as independent prognostic markers for NSCLC patients after surgery.

• 한국지진공학회논문집
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• 제12권3호
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• pp.1-10
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• 2008

내진설계기준이 반영되지 않은 기존 구조물의 경우 내진보강에 의하여 구조물의 내진성능을 향상시킬 수 있다. 내진보강의 수준을 합리적으로 결정하기 위해서는 구조물의 사용기간 동안에 예상되는 지진피해 관련 손실이 최소화되도록 하여야 하는데, 이를 위해서는 구조물이 위치한 지역에 대한 지진의 강도별 발생빈도, 지진에 의한 구조물의 기능상실 및 직접/간접 피해를 복합적으로 고려하여 구조물의 예상 손실비용을 산정하여야 하며 이는 구조물 손상에 대한 지진위험도 해석을 통해서 그 해석을 수행할 수 있다. 본 연구에서는 확률적 지진요구모델을 이용한 위험도 평가를 통하여 구조물의 지진에 대한 피해 손실을 정량적으로 산정하고 이를 바탕으로 초기비용과 예상손실비용을 포함한 총 손실비용을 최소화시킬 수 있도록 내진보강 수준을 최적화하는 절차를 제시하였다. 구조물과 관련된 지진피해 산정에 있어서 지진하중의 강도별 발생확률 및 구조물의 손상확률을 동시에 고려하여 구조물 생애주기에 대한 구조물의 지진손상 확률밀도함수 및 누적분포함수를 수식화하였으며 수식의 유효성을 유지하기 위한 확률변수의 유효범위를 정의하였다. 또한 여기에 사회적, 경제적 손실을 정량화하기 위한 손실함수를 결부시켜 구조물과 관련된 지진 피해 손실의 기댓값을 정량적으로 산정할 수 있도록 하였다. 제시된 해석기법은 기존의 시뮬레이션에 의한 손실산정법과 비교하여 해석의 정확도는 잃지 않으면서 구조해석의 반복횟수를 대폭 줄일 수 있다는 장점이 있으며 빌딩과 교량을 비롯한 구조물의 내진성능 평가 및 개선을 위한 의사결정 시에 효율적으로 적용될 수 있을 것으로 판단된다.