• Archives of Pharmacal Research
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• v.17 no.2
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• pp.80-86
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• 1994

The bioavailability of digoxin generic tablets manufactures in Korea (formulations A & B) wwere compared to a standard (formulation C; Lanoxin brand digoxin, Burroughs Wellcome, USA) in 12 healthy Korean male volunteers (mean age 31.4 years) in a single dose, randomized, complete block crossover study. Using a latin square design, each of the subjects was randomized to the order number and allocated to each of the three treatments of 0.5mg oral digoxin. Digoxin conc4ntrations in serum and urine samples collected for 48 hours after dosing were measured by fluoprescence polarization immunoassy and radioimmunoassy, respectively. Treatments were compared by using nonlinear least squares regession analysis to evaluate the following pharmacokinetic parameters : maximum serum concentation $(C_{max})$; time of maximum serum concentation $(T_{max})$; area under the serum concentration-time curve $AUC_{0-12}$, $C_{max}$\;and\;(AUC_{0-12})$; and cummulative urinary excretion for 0-48 hours $(CLE_{0-48}.\;Mean\;AUC_{0-12},\;C_{max},\;and\;CUE_{0-48}$ values for formulations B and C were significantly different from formulation A (P<0.001), but not significantly diffeerent form each other. Basede on $AUL_{0-12}\;and\;CUE_{0-48}$ respectively, the relative availability of formulation B was 87.5% and 89.6% and the relative availability of formultation A was 43% and 35% when compared to formulation C(the standard).

• Korean journal of applied entomology
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• v.45 no.3 s.144
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• pp.363-369
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• 2006

Effects of three packing materials and exposure time on the mortality of Plodia interpunctella and Tribolium castaneum were studied using $CO_{2}-modified$ atmosphere control. Materials used were triple layered craft paper (KKK), triple layered craft paper with one laminate coating layer (KLK), and triple layered craft paper with one HD film coating layer (KHK). In the test balls (${\phi}1.2\;m$) containing 85% $CO_{2}-modified$ atmosphere, concentration of $CO_{2}$ in small packing envelopes ($9.8{\times}9.8cm$) made of the materials after one day was higher in KKK ($26.67{\pm}0.58%$) than KLK ($23.33{\pm}0.58%$) or KHK ($20.67{\pm}0.58%$). Both P. interpunctella and T. castaneum showed higher mortality in KKK than in either KLK or KHK Similar results were obtained by larger space ($9{\times}4{\times}3m$) and packing volume (20 kg) studies. The effect of the packing materials was clearer on T. castaneum more tolerant to $CO_{2}$ than P. interpunctella. Regression of the insect mortality on cumulative concentration time (${\int}_{0}^{t}c{\times}tdc{\approx}{\sum}concentration{\times}time$) was highly significant. Control of P. interpunctella and T. castaneum by $CO_{2}-modified$ atmosphere were discussed in relation to packing materials, cumulative concentration time of $CO_{2}$ and food products.