• Molecules and Cells
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• 제44권8호
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• pp.549-556
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• 2021

Decoding the molecular mechanisms underlying axon guidance is key to precise understanding of how complex neural circuits form during neural development. Although substantial progress has been made over the last three decades in identifying numerous axon guidance molecules and their functional roles, little is known about how these guidance molecules collaborate to steer growth cones to their correct targets. Recent studies in Drosophila point to the importance of the combinatorial action of guidance molecules, and further show that selective fasciculation and defasciculation at specific choice points serve as a fundamental strategy for motor axon guidance. Here, I discuss how attractive and repulsive guidance cues cooperate to ensure the recognition of specific choice points that are inextricably linked to selective fasciculation and defasciculation, and correct pathfinding decision-making.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2016년도 추계학술대회 논문집
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• pp.122.2-122.2
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• 2016

Surface topographical cues has been highlighted to control the fate of neural stem cells (NSCs). Herein we developed a hierarchically patterned substrate (HPS) platform for regulating NSC differentiation. The HPS induced cytoskeleton alignment and highly activated focal adhesion in hNSCs as indicated by enhanced expression of focal adhesion proteins such as focal adhesion kinase (FAK) and vinculin. hNSCs cultured on HPS exhibited enhanced neuronal differentiation compared to flat group. We also developed a graphene oxide (GO)-based hierarchically patterned substrates (GPS) that promote focal adhesion formation and neuronal differentiation of hNSCs. Enhanced focal adhesion and differentiation of hNSCs on the HPS was reversed by blocking the ${\beta}1$ integrin binding and mechanotransduction-associated signals including Rho-associated protein kinase (ROCK) and extracellular-regulated kinase (ERK) pathway, which may suggest a potential mechanism of beneficial effects of HPS. In addition, hNSCs on the HPS differentiated into functional neurons exhibiting sodium currents and action potentials as confirmed by whole cell patch-clamping analysis. The hierarchical topography can direct differentiation of NSCs towards functional neurons, and therefore would be an important element for the design of functional biomaterials for neural tissue regeneration applications.

• 대한지역사회영양학회지
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• 제17권5호
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• pp.623-636
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• 2012

Health Belief Model is a socio-psychological theory of decision making to individual health-related behaviors. This study was aimed to develop an effective education program for hypertension based on health belief model. The main factors of health belief model were investigated by focus group interview (FGI) with 23 hypertensive or prehypertensive subjects aged over fifty years. 'Perceived susceptibility' to hypertension was family history, neglect of health care, preference for salty food, broth of soup and stew. Lifelong medication, complications, and medical costs were reported as 'perceived severity' of hypertension. 'Perceived benefits' of hypertension management were decrease of medicinal dose, reduction of medical costs, and healthy eating habits of the family, while 'perceived barriers' were lack of palatability of low salt diet, convenience-oriented dietary habits, and limited choice of foods when eating out. Subjects mentioned TV health programs, public health center programs, and advice from doctors and family as 'cues to action' of hypertension management. These qualitative information provided basis for developing a nutrition education program for hypertension which could be implemented in the public health center. Eight week program was composed of understanding hypertension, risk factor management (eating habits, weight), low salt diet (principles, cooking), advanced management for healthy diet in 2 sessions, and summary. Each session was designed to alert the susceptibility and severity, to emphasize the benefits, and to reduce the barriers by providing dietary monitoring, practical advice, and action tips.

• 복식문화연구
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• 제7권5호
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• pp.1-18
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• 1999

This study concerns the role of costume in Shakespeare\`s history plays from the viewpoint of the role theory. The term “role” has been used to represent the behavior expected of the occupant of a given position or status. A specific role can not be successfully performed without the aid of the costumes. Costumes are adopted in relation with a specific role. The term ‘role’ had been borrowed from the drama. The similarity between the role on the stage and the role of the social man had been recognized. The similarity between the role on the stage and the role of the social man had been recognized. The typical examples in which the costume help to make access to a specific role and can be effectively exploited for the performance of the role are manifested in the history plays of Shakespeare. Thus, our goal in this study is to analyze the role of costume which appears in Shakespeare\`s history plays from the viewpoint of the role theory. The role of social status and position reflects sex, age, occupation, class, economic position of the characters. In his works, the crown and the mace represented not only the throne but also a previllege and supreme position. The situation role of costume could be widely used for visualizing the psychological situation and external environments of the characters on the stage. The disguise role hided one\`s status, thereby makes possible acting other\`s position. The costume also could symbolize the social status, position, rank, occupation, and the situation, and functioned as a media fo delivering messages to others. The costume performed the role of the physical and psychic protection, and provided its wearer with consolation and peaceful mind. The costume reflected the custom of a society through its wearing configuration. The costume (or a uniform) adopted by a group notified the characteristics and the expectation of action of the group to others. The results obtained from this study can provide useful cues for understanding the role action in the social structure. This kind of understanding reveals the costume phenomena in real life, allows one to perform roles properly and efficiently, and opens our insight on the overall aspects of the costume culture.

• 지역사회간호학회지
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• 제33권2호
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• pp.259-268
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• 2022

Purpose: In Cambodia, noncommunicable diseases (NCDs) account for 64% of all deaths. A lack of risk perception of NCDs leads to poor measures of their prevention and management. This study aimed to investigate Cambodians' risk perceptions of NCDs based on the health belief model. Methods: A cross-sectional design was used, and using convenience sampling, participants included 200 Cambodians aged 40 years or older. A face-to-face administered structured questionnaire was used to assess demographic characteristics, health behaviors, and risk perceptions of NCDs. Results: Of the constructs of NCD risk perception, perceived severity (88.2%) and benefits (86.3%) were high, but relative to these, perceived cues to action (64.1%), barriers (63.5%), and self-efficacy (58.1%) were low. Conclusion: It is important to improve perceived self-efficacy in government health promotion, outreach, and improvement programs and to reduce perceived barriers through medical tests either by facility-based delivery or via outreach health services in Cambodia.

• Journal of Electrical Engineering and Technology
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• 제8권3호
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• pp.478-489
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• 2013

The controllability and stability of power systems can be increased by Flexible AC Transmission Devices (FACTs). One of the FACTs devices is Interline Power-Flow Controller (IPFC) by which the voltage stability, dynamic stability and transient stability of power systems can be improved. In the present paper, the convenient operation and control of IPFC for transient stability improvement are considered. Considering that the system's Lyapunov energy function is a relevant tool to study the stability affair. IPFC energy function optimization has been used in order to access the maximum of transient stability margin. In order to control IPFC, a Brain Emotional Learning Based Intelligent Controller (BELBIC) and PI controller have been used. The utilization of the new controller is based on the emotion-processing mechanism in the brain and is essentially an action selection, which is based on sensory inputs and emotional cues. This intelligent control is based on the limbic system of the mammalian brain. Simulation confirms the ability of BELBIC controller compared with conventional PI controller. The designing results have been studied by the simulation of a single-machine system with infinite bus (SMIB) and another standard 9-buses system (Anderson and Fouad, 1977).

• 대한의생명과학회지
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• 제12권1호
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• pp.53-56
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• 2006

The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is the circadian pacemaker entrained to the 24-hr day by environmental time cues. Major circadian genes such as mPeriod ($mPer1{\sim}3$) and mCryptochrome ($mCry1{\sim}2$) are actively transcribed by the action of CLOCK/BMAL heterodimers, and in turn, these are being suppressed by the mPER/mCRY complex. In the study, the locomotor activity rhythms of mPer1 Knockout (KO) mice are measured, and the expression profiles of Heat Shock Protein 105kDa (HSP 105) genes in the SCN were measured by in situ hybridization. In agreement with previous reports, the locomotor activity rhythm of mPer1 KO mice was much shorter than that of wildtype. In addition, the total bout of activity of mPer1 KO was less in comparison to control mice. The expression of HSP 105 in the SCN of mPer1 KO mice was ranged from CT6 to CT22, with a peak level at CT14, implying that the gene are under the control of circadian clock. However, the expression of HSP 105 in the SCN of wildtype could not be detected in our study. Further analysis will reveal the direct or indirect regulation by mPer1 on the expression in the SCN and the role of the gene in the circadian clock.

• 동서간호학연구지
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• 제25권2호
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• pp.138-146
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• 2019

Purpose: The purpose of this study was to identify the factors influencing dementia preventive behavior intention of the elderly people based on the Health Belief Model. Methods: The participants included 113 elderly people who met the eligibility criteria. Demographic variables, variables of the Health Belief Model (perceived susceptibility, perceived severity, perceived benefit, perceived barrier, cues to action, general health motivation, and self efficacy), dementia fear and behavioral intention of dementia prevention were examined using structured self-report questionnaires. Statistical analysis was performed by stepwise multiple regression using SPSS for Windows version 21. Results: Self efficacy, alcohol drinking, perceived barrier and education level were significant factors, which explained 32% of the variance in dementia preventive behavior intention. Multiple regression analysis demonstrated that a powerful predictor of dementia preventive behavior intention of the elderly was self efficacy. Conclusion: Developing nursing intervention to enhance self efficacy toward improvement of dementia preventive behavior among elderly people would be recommended.

• 품질경영학회지
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• 제42권2호
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• pp.153-163
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• 2014

Purpose: This research aims to find out clinical information protection behavior within a medical institution in mandatory circumstance based on health psychology theories Methods: This research has developed the survey based on the variables from ealth psychology theories; and conducted the survey during the whole month in April 2013. In the end, 256 samples have been used for this research's analysis. Results: First of all, Empirical results has proved that perceived benefits, self-efficacy, and cues to action have an positive influence on clinical information protection behavior. Perceived barriers has an negative influence. Finally, it has proven from the research that perceived severity and perceived susceptibility do not have an impact on clinical inf ormation protection behavior Conclusion: These findings provide an enriched understanding about medical institution workers information protection behavior on patient's clinical information.

• 한국의류학회지
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• 제17권3호
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• pp.436-447
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• 1993

This study concerns the role of costume in Shakespearean tragedy from the viewpoint of the role theory. The term "role" has been used to represent the behavior expected of the occupant of a given position or status. A specific role can not be successfully performed without the aid of the Costumes. Costumes are adopted in relation with a specific role. The role of social status and position reflects sex, age, occupation, class, economic position of the characters. In his works, the crown and the mace represented not only the throne but also a previllege and supreme position. The sitution role of costume could be widely used for visualizing the psychological situation and external environments of the characters on the stage. The disguise role hided one's status, thereby makes possible acting others position. And the disguise role can bring about the change of status, age, sex, occupation, and atmosphere. The costume could be used as a voucher of love. The costume performed the role of the physical and psychic protection, and provided its wearer with consolation and peaceful mind. The costume reflected the custom of a society through its wearing condition and wearing configuration. The results obtained from this study can provide useful cues for understanding the role action in the social structure. This kind of understanding reveals the costume phenomena in real life, allows one to perform roles properly and efficiently, and opens our insight on the overall aspects of the costume culture.