• 한국조리학회지
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• 제22권7호
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• pp.173-186
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• 2016

본 연구는 기능성 성분들이 함유하고 있는 꾸지뽕잎 분말 첨가에 따른 식빵의 품질 특성을 알아보고자 진행하였다. Mixograph, pH, TPA, 부피, 비용적, 수분, 영상분석, 색도, 기호도 검사, 보존성 검사를 통하여 꾸지뽕잎 분말을 첨가한 식빵을 분석하였다. Mixograph를 측정 결과, 꾸지뽕잎 분말을 첨가한 반죽은 제빵 적성에 적합하였다. 꾸지뽕잎 pH의 경우 분말의 첨가량이 많아질수록 pH는 높아졌으며, 1차 발효 후와 식빵의 pH는 첨가량이 많을수록 낮아졌다. TPA 분석결과, 꾸지뽕잎 분말 첨가량이 높아질수록 경도, 씹힘성, 검성은 높아졌으며, 탄력성, 응집성, 탄성은 유의적인 차이가 없었고, 꾸지뽕잎 식빵의 부피와 비용적은 감소하였다. 영상분석 결과 기공의 조밀도, 껍질의 두께, 크기는 첨가량이 많아질수록 유의적인 차이를 보여주었으며, 색도는 꾸지뽕잎 분말의 첨가량에 따라 L값은 어두워졌다. 기호도 검사 결과, 외관과 조직감은 CLP3가 대조구보다 좋았으며, 맛과 전체적인 기호도는 CLP2가 대조구보다 더 좋게 평가되었다. 보존성 측정 결과, 경도는 24, 48, 72시간 동안 모두 꾸지뽕잎 분말 1~2% 첨가한 시료가 대조구와 유의적인 차이를 보이며 경도가 낮았으며, 적은 양의 꾸지뽕잎 첨가가 식빵 속질의 부드러움을 유지하는데 좋은 것으로 사료되며, 수분함량이 낮아지긴 하였으나, 대조구와 유의적인 차이가 없었다.

• 한국식품영양과학회지
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• 제28권6호
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• pp.1310-1315
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• 1999

Polyphenolic compounds widely occurring in the traditional medicine plants have been reported to possess strong antioxidant activity. The antioxidative substances of water soluble extract from leaves, stem bark, root bark and fruit powder of Cudrania tricuspidata were tested in three different in vitro experimental models. In oxidation models using DPPH( , ' diphenyl picrylhydrazyl) method, Fe2+ induced linoleic acid peroxidation, and autooxidation of hepatic microsomal membranes, the antioxidative activities of water soluble extract from stem bark were strong than that from leaves and root bark. Fruits of Cudrania tricuspidata contained the highest amounts of polyphenolic compounds among the parts of this plant. The changes in polyphenolic compound contents of fruit powder caused by heat treatment (20oC, 40oC, and 60oC) were also monitored. After water blanching, contents of phenolic compounds was increased slightly in the following order; 20oC(1454mg), 40oC(1487mg), and 60oC(1511mg). These results supports that water soluble extracts from Cudrania tricuspidata contain antioxidative compounds.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 춘계학술발표회
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• pp.81-81
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• 2018

The present study was investigated on in vitro anti-obesity effect of 4-hydroxybenzyl alcohol from Cudrania tricuspidata. We isolated various compounds from Cudrania tricuspidata. Among these compounds, anti-obesity effects of 4-hydroxybenzyl alcohol was examined by lipase activity assay, cyclic adenosine monophosphate (cAMP)-specific phosphodiesterase type IV (PDE4) activity assay, and citrate synthase activity assay. 4-hydroxybenzyl alcohol and Cudrania tricuspidata extracts inhibited the enzymatic activities of lipase, PDE4, and citrate synthase. Lipase is known to mediate the hydrolysis of triacylglycerol in adipose tissue and cholesterol esters in other tissue or cells. Also, PDE4 hydrolyses cAMP, a crucial secondary messenger for in metabolic pathways including glucose and lipid metabolism, lipolysis, and thermogenic function. 4-hydroxybenzyl alcohol and Cudrania tricuspidata extracts induced the inhibitory effect against each enzymatic activity on several specific substrates as observed by detection at 405 or 412 nm. These findings might be attributable to the inhibition of adipogenesis, and partial prevention of obesity. In conclusion, these results show that 4-hydroxybenzyl alcohol and Cudrania tricuspidata may be a critical candidate as a natural anti-obesity source.

• 한국버섯학회지
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• 제10권3호
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• pp.129-135
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• 2012

기능성 느타리버섯 재배를 위하여 국내에서 자생하는 구지뽕나무 톱밥의 적정 첨가량을 구명하기 위하여 실험을 실시하였다. 구지뽕나무 톱밥의 수분함량은 6.4%였고, pH는 7.0이였다. 총질소함량은 0.27%였고, 총탄소함량은 40.9%였으며, C/N율은 152%였다. 혼합배지의 pH는 4.9~5.0이였으며, 총질소함량은 수확후배지에서 증가하였지만 C/N율은 오히려 감소하였다. 무기성분인 $P_2O_5$, CaO, MgO, $Na_2O$, $K_2O$함량은 구지뽕나무 톱밥의 첨가비율에 따라 뚜렷한 차이를 보이지 않았다. 느타리버섯 균사생장은 구지뽕나무 톱밥 10% 첨가에서 가장 빨랐지만, 다른 처리구는 대조구보다 균사 생장이 느렸다. 자실체 수량은 구지뽕나무 톱밥 20% 첨가시 $162g/850m{\ell}$로 가장 높았다. 갓의 크기와 두께는 구지뽕나무 톱밥의 첨가비율에 따라 뚜렷한 차이를 보이지 않았고, 대의 굵기와 길이는 구지뽕나무 톱밥 20% 첨가에서 가장 높았다. 대의 경도는 처리간에 뚜렷한 차이를 보이지 않았지만, 갓의 경도는 구지뽕나무 톱밥의 첨가량이 증가할수록 높은 경향을 보였다. 수확기 갓과 대의 색도는 구지뽕나무 톱밥 20% 첨가에서 L값이 가장 높았지만, a, b값은 처리간에 뚜렷한 차이가 없었다. 자실체의 무기성분과 미량원소의 함량은 구지뽕나무 톱밥 30% 첨가에서 약간 높았다.

• 생약학회지
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• 제32권3호통권126호
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• pp.248-252
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• 2001

The present study was undertaken to elucidate the hypoglycemic effect and inhibitory effect of Cudrania tricuspidata root bark on aldose reductase activity. C. tricuspidata MeOH ext. 1,000 mg/kg showed a significant blood glucose lowering effect on alloxan-induced hyperglycemic rats and increasing body weight. C. tricuspidata MeOH ext. showed a potent inhibitory effect on bovine lens aldose reductase.

• 한국응용과학기술학회지
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• 제27권3호
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• pp.337-343
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• 2010

1-Deoxynojirimycin(1-DNJ) was hardly detected by general UV detector. Therefore, in this study, we analyzed 1-DNJ, a effective functional material in which was contained the leaves of Cudrania tricuspidata and its tea by gas-chromatography. Synthesized a TMS derivative by attaching trimethylsilyl group to 1-DNJ, analyzed this by GC, and could detect a good peak. The leaves of Cudrania tricuspidata contains $1154.83{\pm}56.67$ ug/g.d.w of 1-DNJ and tea of Cudrania tricuspidata leaves does $8.01{\pm}0.61$ ug/g.d.w. This means the contents of 1-DNJ was nearly identical to each other. The larger size of the leaves had the more contents of 1-DNJ and the middle region of collection was the highest than any other collective regions of leaves.

• 생약학회지
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• 제51권2호
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• pp.100-106
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• 2020

The extract of Cudrania tricuspidata is used in ethnomedicine throughout Eastern Asia in China, Korea and Japan. In Korean traditional medicine, Cudrania tricuspidata has been used to treat eczema, mumps, tuberculosis, contusions, insomnia and acute arthritis. In addition, it has been reported that root extract of Cudrania tricuspidata has anti-platelet effects. Therefore, we investigated which compound in Cudrania tricuspidata has inhibitory effect on platelet aggregation. In this study, we tried to explain the inhibitory mechanism of steppogenin from Cudrania tricuspidata on human platelet aggregation. Collagen-induced human platelet aggregation and [Ca²⁺]_i mobilization were dose-dependently inhibited by steppogenin and we determined the inhibition by steppogenin is due to the down regulation of extracellular-signal-regulated kinase(ERK) and inositol-1,4,5-triphosphate receptor type I(IP₃RI) phosphorylation. In addition, steppogenin inhibited collagen-induced fibronectin adhesion to αIIb/β3 and thromboxane A₂ generation. Thus, in the present study, steppogenin showed an inhibitory effect on human platelet aggregation, suggesting its potential use for preventing platelet-induced cardiovascular disease.

• 생명과학회지
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• 제11권4호
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• pp.328-334
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• 2001

Male Sprageu-Dawely rats fed a cholesterol diet (Control group) or cholesterol diet supplemented with the water-soluble extract of stem bark from Cudrania tricuspidata(CTSB group) at the level of 0.5% for 2 weeks. Concentration of triglyceride in serum of CTSB group was significantly lower than that of control group. However, the other lipids concentrations of liver and serum, body weight gain, and food intake did not show significant difference between CTSB group and control group. Antioxidative activities of water-soluble extract from stem bark of Cudrania tricuspidata on the lipid peroxidation in rat were also studied in vivo by measuring the formation of thiobarbituric acid reactive substance(TBARS). Concentration of TBATS in the liver homogenates of CTSB group was significantly higher than that in control group. Nonheme iron concentration was significantly increased in the liver of CTSB group compared to control group. suggested that enhanced nonheme irom was associated with enhanced peroxidation of liver in CTSB group. These results suggested that water soluble extract from stem bark of Cudrania tricuspidata exert the hypotriglycerolemic effect and might amplify the lipid peroxidation of tissues in cholesterol fed rats.

• 한국식품조리과학회지
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• 제28권6호
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• pp.821-828
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• 2012

In an attempt to identify the neuroprotective effect of Cudrania tricuspidata (CT) leaves against ROS (reactive oxygen species)-induced oxidative stress in neuronal cells, the extracts from CT leaves were investigated using PC12 cells and N18-RE-105 cells. The methanolic and ethanolic extracts from CT were denoted as CTM (Cudrania tricuspidata Leaves methanolic extracts) and CTE (Cudrania tricuspidata Leaves ethanolic extracts), respectively. The neuroprotective effects of the extracts were measured by DCF-DA assay, MTT reduction assay, and LDH release assay. The PC12 cells exposed to $H_2O_2$-induced oxidative stress and the N18-RE-105 cells exposed to glutamate-induced oxidative stress were treated with various concentrations of CTM and CTE. The results, CTM treatments resulted in the induction of a dose-dependent protective effect in PC12 cells and N18-RE-105 cells. Interestingly, CTE also showed neuroprotective effect in PC12 cells and N18-RE-105 cells. Therefore, these results suggest that CTM and CTE could be a new potential candidate as neuroprotective agents against ROS-induced oxidative stress in neuronal cells.

• Archives of Pharmacal Research
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• 제12권1호
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• pp.39-41
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• 1989

From the stem of Cudrania tricuspidata, ${\beta}$-sitosterol, ${\beta}$-sitosterol glucoside, arthocarpesin, norarthocarpetin, and 5-O-methyl genistein were isolated and characterized by spectral data.