• The Korean Society of Law and Medicine
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• v.15 no.1
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• pp.211-237
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• 2014

Because of unpredictability and high possibility of abnormal results by clinical trials compared to general medical behaviors, a procedure for ensuring with sufficient explanations by investigators must be secured. Therefore, in a sequence of clinical trials, what kinds of scope, stage, and method of explanations provided by investigators, including doctors or researchers, to trial subjects are closely related to the compensation for damages by violation of liability for explanation. In case of application of clinical trials to patients who have critical illness such as cancer, issues of "Quality of Life" regarding trial subjects, cancer patients, should be discussed. Especially, in case of clinical trials for terminal cancer patients, the right of subjects' self-determination, which is a fundamental principle in medical behaviors, should be discussed. The right of self-determination includes participation in clinical trials for the possibility of life-sustaining even a little bit, or no participation in clinical trials in order to have a time for completing the rest of his life. Like this, if the extent and scope of explanations related to the issues of "Quality of Life" are raised as main issues, the evaluation of "Quality of Life", should be a prerequisite. In many occasions, realistically, despite bad results such as deaths or serious adverse drug reactions after clinical trials, it may not be easy for compensating to trial subjects or their survivors, who requested civil compensation for damage. Futhermore, in abnormal results after concealment of clinical trials or performance of clinical trials without permission, and in the case of trial subjects' failures of proving proximate cause between the clinical trials and abnormal results, problematic results such as no protection to the trial subjects could be occurred. In performing clinical trials, investigators should provide sufficient explanations for trial subjects and secure voluntary informed consents from the trial subjects. Therefore, clinical trials without trial subjects' permissions and the informed consent process violate trial subjects' rights of self-determination, and the investigators shall be liable for compensation for damages. Then, issues might be addressed are what are essential contents of patients' "rights of self-determination" infringed by clinical trials without subjects' permissions. Two perspectives about patients' rights of self-determination might be considered. One perspective regards physical distress of patients (subjects) from therapies without sufficient explanations as the crux of the matter. The other perspective regards infringement of human dignity caused by being subjects without permission as the crux of the matter irrespective of risks' big and small influences. This research follows perspective of the latter. Forming constant fiduciary relation between investigators (doctors) and subjects (patients) pursuant medical contracts, and in accordance with this fiduciary relation, subjects, who are patients, have expectations of explanations and treatments by the best ways. If doctors and patients set this forth as a premise, doctors should assume civil liability when doctors infringe patients' expectations.

• Korean Journal of Weed Science
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• v.18 no.1
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• pp.12-19
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• 1998

The pattern of rice cultivation in Korea is changing from hand transplanting and machine transplanting into direct-seeding for low input and cost-down practices. However, there are still some obstacles to establish the direct-seeding cultural practices because of poor seedling stand, lodging, and weed infestation. In particular, there were much more and wide weed occurrence in direct-seeding rice as compared with the transplanted rice. Weed occurrence in terms of dry weight of weeds was highest in dry direct-seeded rice followed by sowing an puddled soil, sowing on submerged soil in order as compared with transplanting with infant rice seedling. Echinochloa crux-galli was a common dominant weed with 35~44% distribution in any direct-seeding methods. The dominant weed species were E. crux-galli, Cyperus difformis, C. serotinus, and Ludwigia prostrata in dry-seeded rice. The dominant weed species in water-seeded rice were E. crus-galli, Eleocharis kuroguwai, Scirpus juncoides, and Monochoria vaginalis. Yield loss of rice due to weeds at weedy condition was 96% in dry direct-seeded rice. In water-seeded rice, yield loss was 61%, whereas yield loss was 40% in machine transplanting with infant rice seedling.

• Animal cells and systems
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• v.2 no.1
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• pp.139-144
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• 1998

I examined the projection of glutamatergic neurons in the lateral reticular nucleus into ansiform (crus l and ll) and paramedian lobules in the rat cerebellum using immunocytochemical methods with antiserum against glutamate combined with WGA-HRP histochemistry. The projections of glutamatergic neurons from the lateral reticular nucleus to crus l were most extensive in number among the three injection cases and the majority of projections originated at the dorsal to dorsomedial region of the ipsilateral magnocellular nucleus. Glutamate-immunoreactive cells projecting to crus ll were less extensive in number than those projecting to crus l and were mainly localized at the dorsomedial portion of the ipsilateral magnocellular nucleus. Double-labelled neurons projecting to crus l or crux ll were also located at ipsilateral subtrigeminal as well as contralateral magnocellular nuclei. Glutamatergic neurons projecting to paramedian lobules were moderate in number and mainly located at the dorsal area of the ipsilateral magnocellular nucleus. A few double-labelled cells were also found at ipsilateral subtrigeminal or contralateral magnocellular nuclei. The present study suggests that glutamate-immunoreactive neurons at the dorsal to dorsomedial magnocellular division of the lateral reticular nucleus may participate in the excitatory control of target neuronal activities at ipsilateral, posterior hemispheric lobules of the rat cerebellum.

• Journal of the Korean Institute of Intelligent Systems
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• v.6 no.2
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• pp.13-21
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• 1996

The necessity and usefulness of higher-order neural networks have been well-known since early days of neurocomputing. However the explosive number of terms has hampered the design and training of such networks. In this paper we present an evolutionary learning method for efficiently constructing problem-specific higher-order neural models. The crux of the method is the neural tree representation employing both sigma and pi units, in combination with the use of an MDL-based fitness function for learning minimal models. We provide experimental results in classification and prediction problems which demonstrate the effectiveness of the method. I. Introduction topology employs one hidden layer with full connectivity between neighboring layers. This structure has One of the most popular neural network models been very successful for many applications. However, used for supervised learning applications has been the they have some weaknesses. For instance, the fully mutilayer feedforward network. A commonly adopted connected structure is not necessarily a good topology unless the task contains a good predictor for the full *d*dWs %BH%W* input space.

• Advances in robotics research
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• v.1 no.2
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• pp.155-169
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• 2014

Study results in the last decades show that amount and quality of physical exercises, then the active participation, and now the cognitive involvement of patient in rehabilitation training are known of crux to enhance recovery outcome of motor dysfunction patients after stroke. Rehabilitation robots mainly have been developing along this direction to satisfy requirements of recovery therapy, or focusing on one or more of the above three points. Therefore, neuro-machine interaction based active rehabilitation robot has been proposed for assisting paralyzed limb performing designed tasks, which utilizes motor related EEG, UCSDI (Ultrasound Current Source Density Imaging), EMG for rehabilitation robot control and feeds back the multi-sensory interaction information such as visual, auditory, force, haptic sensation to the patient simultaneously. This neuro-controlled and perceptual rehabilitation robot will bring great benefits to post-stroke patients. In order to develop such kind of robot, some key technologies such as noninvasive precise detection of neural signal and realistic sensation feedback need to be solved. There are still some grand challenges in solving the fundamental questions to develop and optimize such kind of neuro-machine interaction based active rehabilitation robot.

• Journal of the Korean housing association
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• v.20 no.5
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• pp.1-8
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• 2009

Ever-developing information and communications technology has changed the ways of life from that of industrial society to the information-oriented community, and is widely used in a variety of social and economic contexts. Besides, urban problems in today's society are intricately involved so that the possibility of any reliable breakthrough may not to be likely. To work out these complicated problems as well as to understand the crux of the matter more comprehensively, ubiquitous urban planning has been laid out, and as a result attempts to reflect this system are cautiously made in metropolitan areas. However, most u-City planning, integrating uibiquitous technology, has focused on creating urban infrastructure and its services, therefore neglecting the importance of housing in urban space. Consequently, thorough u-City planning has yet to be defined in relation with urban space, and housing planning, established on the basis of the user-oriented housing environment, needs to be urgently made. Centering on the importance of housing in the construction of an improved future urban environment, this study aims to discuss the role of urban environment planning where metropolutan residents can enjoy a comfortable and convenient life. As well, this research paper seeks to focus attention on the consideration for users that is often disregarded but requires reflecting in the u-City planning.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2008.11a
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• pp.96-101
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• 2008

Ever-developing information and communications technology has changed the ways of life from that of industrial society to the information-oriented community, and is widely used in a variety of social and economic contexts. Besides, urban problems in today's society are intricately involved so that the possibility of any reliable breakthrough may not to be likely. To work out these complicated problems as well as to understand the crux of the matter more comprehensively, ubiquitous urban planning has been laid out, and as a result attempts to reflect this system are cautiously made in metropolitan areas. However, most u-City planning, integrating uibiquitous technology, has focused on creating urban infrastructure and its services, therefore neglecting the importance of housing in urban space. Consequently, thorough u-City planning has yet to be defined in relation with urban space, and housing planning, established on the basis of the user-oriented housing environment, needs to be urgently made. Centering on the importance of housing in the construction of an improved future urban environment, this study aims to discuss the role of urban environment planning where metropolutan residents can enjoy a comfortable and convenient life. As well, this research paper seeks to focus attention on the consideration for users that is often disregarded but requires reflecting in the u-City planning.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2004.11a
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• pp.216-219
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• 2004

Construction clients are the key player in that they initiate construction projects and are in a position to influence the efficiency and productivity of the projects. Construction projects by nature require team-working so clients's leadership is the crux of project success. The objective of this paper is to suggest characteristics of construction clients' leadership in terms of best practice based on the analysis of project success cases. Four key elements of construction clients' leadership are identified and best practice from the case studies were related to the elements.

• Korean Journal of Construction Engineering and Management
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• v.12 no.6
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• pp.93-100
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• 2011

As the construction management(CM) market has grown, so has the CM competition in the market place. Consequently, competent construction managers become a core part of CM firms' competitiveness. The objective of the study is to identify and discuss core competencies of construction mangers based on literature survey, Delphi Method and AHP. Among various competencies required for construction managers, skills for problem solving, trust and negotiation skills were identified as the crux of construction managers' competencies. A better understanding of construction managers' core competencies is very critical in terms of CM firms' training of construction managers and continuos self-improvement for construction managers.

• 한국지구물리탐사학회:학술대회논문집
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• 2003.11a
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• pp.328-334
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• 2003

Evaluating stability of dam foundations is one of the prime areas of any rock engineering investigations. Despite best engineering efforts in the design and construction of dam foundations, the foundation regime of a constructed dam suffers deterioration due to continuous erosion from backwater current of dam discharge and dynamic effects of loading and unloading process. Even during construction, development of frequent cracks due to sudden thermal cooling of concrete blocks is not uncommon. This paper presents two case studies from India and Bhutan. In the first case, the back current of water discharge from the Srisailam dam in India had continuously eroded the apron and has eaten into the dam foundation. In the second case with dam construction at Tala Hydroelectric Project in Bhutan, sudden overflow of river during the construction stage of dam had led to development of three major cracks across the dam blocks. This was ascribed to adiabatic cooling effect of concrete blocks overlain by chilled water flow. Non-destructive evaluation of rock mass condition in the defect regime by the borehole GPR survey helped in arriving at the crux so as to formulate appropriate restoration plan.