• Title/Summary/Keyword: Crude drug

Search Result 377, Processing Time 0.024 seconds

A Comparative Biological Study of the Rhizome and Main Root from Red and White Ginsengs (홍삼 및 백삼의 뇌두, 동체에 대한 생물활성 비교)

  • Park, Jong-Dae;Wee, Jae-Joon;Kim, Young-Sook;Kim, Si-Kwan;Park, Ki-Hyun
    • Journal of Ginseng Research
    • /
    • v.20 no.3
    • /
    • pp.256-261
    • /
    • 1996
  • Comparative biological activities of 70fr methanol extracts from the main roots and rhizomes of both red and white ginsengs were investigated using several in vitro experimental models. The main root of red ginseng and the rhizome of white ginseng strongly inhibited lipld peroxidation of hepatic microsomes induced by the non-enzymatic $Fe^{+}$ / Ascorbate system. The main root and rhizome of red ginseng markedly inhibited the release of G07, GPT and LDH by $CCl_4$-induced cytotoxicity in primary cultured rat hepatocytes as compared with those of white ginseng. And also, the main root of red ginseng showed a slight differentiating activity on HL-60 cancer cell line. The results suggest that the rhizome of ginseng have potential as a source of medicinal crude drug with possible pharmacolobica1 applications .

  • PDF

Inhibitory Effect of Shimotsu-to, a Traditional Chinese Herbal Prescription, on Acute Inflammation in Rats and Guinea Pigs

  • Sakuma, Katsuya;Izumi-Kaji;Masahiko-Ogihara;Katsumi-Yamamoto
    • Archives of Pharmacal Research
    • /
    • v.19 no.2
    • /
    • pp.122-125
    • /
    • 1996
  • We examined the effect of topical application of Shimotsu-to, a traditional Chinese herbal prescription, on carrageenin-induced edema in rats and ultraviolet radiation-induced erythema in guinea pigs. Shimotsu-to (5% in water) markedly suppressed an acute edema of rat hindpaw induced by 1% carrageenin, and was more effective than any other single crude drug componcent of Shimotsu-to, Topical treatment with this prescription also inhibited ultraviolet erythema on the back skin of guinea pigs (a human sunbrun model). These results suggest the therapeutic effect on acute inflammation by topical application of Shimotsu-to.

  • PDF

Effect of Natural Drugs on the Life Support of Starving Rats (기아를 일으킨 흰쥐의 생명연장에 미치는 천연약물의 효과)

  • 박시원;이현아
    • YAKHAK HOEJI
    • /
    • v.39 no.1
    • /
    • pp.14-23
    • /
    • 1995
  • The current study was undertaken to select the crude drug showing life prolonging effect on the starved rats(Sprague-Dawley) and elucidate the reaction mechanism there of. As distilled water extracts prepared from twenty kinds of natural drugs were administered orally to female starved rats, Bupleuri Radix demonstrated the most prominent effect with 34.6% increment in the survival time. To investigate underlying mechanism of life prolonging effect of Bupleuri Radix, the concentrations of adrenocorticosteroids(corticsterone, testosterone and aldosterone) and enzyme activities of superoxide dismutase(SOD), glutamate oxaloacetate transaminase(GOT), glutamate pyrurate transaminase(GPT) were assayed in the serums of rats starved for, 2, 4 and 6 days respectively. The results manifested much elevated values of corticosterone, aldosterone(2 days) and rather decreasing tendency afterwards, specially in the late periods of starvation(6 days). With respect to such a considerable changes according to starvation periods, Bupleur Radix restored these values much near to normal suggesting that Buplerum Radix may play a life prolonging action during starvation probably through reinforcing the homeostatic properties of corticosteroids and some enzyme activities.

  • PDF

Studies on Efficacy of Crude Drug by Processing(III): Effect of Paeoniae Radix alba on CNS and Isolated Ileum (생약의 수치(修治)에 따른 약효연구(제3 보) : 백작약(白芍藥)이 중추신경계 및 적출장관에 미치는 영향)

  • Hong, Nam-Doo;Rho, Young-Soo;Cho, Young-Whan;Ju, Soo-Man
    • Journal of Pharmaceutical Investigation
    • /
    • v.16 no.3
    • /
    • pp.124-131
    • /
    • 1986
  • Pharmacological activities of Paeoniae Radix alba were studied with water extract (F-I), parched preparation (F-II) and 25% ethanol-treated preparation (F-III) of it. The results were summerized as follows; 1) Analgesic actions were recognized with F-I, F-II and F-III. 2) Sedative actions were recognized with F-I and F-III. 3) Prolonged effect of sleeping time were recognized significantly with F-I and F-III. 4) Antipyretic actions were recognized with F-1, F-II and F-III in rabbits. 5) F-I, F-II and F-III showed the antagonic action against contraction of isolated-ileum induced by acetylcholine, barium chloride and histamine in mice and guinea-pigs.

  • PDF

Pharmacognostical Studies on the Folk Medicine "EJePiNaMu" (민간약 "에제피나무"의 생약학적 연구)

  • Bae, Ji-Yeong;Ahn, Mi-Jeong;Park, Jong-Hee
    • Korean Journal of Pharmacognosy
    • /
    • v.43 no.1
    • /
    • pp.1-5
    • /
    • 2012
  • Korean folk medicine "EJePiNaMu" has been used orally to cure neuralgia, rheumatism and common cold. To clarify the botanical origin of this crude drug, comparative anatomical studies were made on the branches of Zanthoxylum species growing wild in Korea, i.e. Z. coreanum, Z. piperitum, Z. piperitum var. pubescens, Z. planispinum, Z. schinifolium, Z. schinifolium var. inermis, Z. schinifolium var. microphyllum. As a result, it was clarified that "EJePiNaMu" was the branch of Zanthoxylum planispinum.

Pharmacognostical Studies on the Folk Medicine 'GulGeoRiIp' (민간약 굴거리잎의 생약학적 연구)

  • Lee, Chang-Hoon;Bae, Ji-Yeong;Park, Jong-Hee
    • Korean Journal of Pharmacognosy
    • /
    • v.41 no.3
    • /
    • pp.153-156
    • /
    • 2010
  • Korean folk medicine 'GulGeoRiIp' has been used to gastroentric trouble and indigestion from drinking. The botanical origin of the crude drug has never been studied pharmacognostically. To clarify the botanical origin of GulGeoRiIp, the morphological and anatomical characteristics of Daphniphyllum species growing in Korea, i.e. Daphniphyllum macropodum Miq. and D. glaucescens Blume were studied. As a result, GulGeoRiIp was proved to be the leaf of Daphniphyllum macropodum Miq.(Euphorbiaceae).

Pharmacognostical Studies on the Folk Medicine ‘Bong Seon Wha Dae’ (민간약 봉선화대의 생약학적 연구)

  • Kim, Jeong-Myo;Do, Woen-Im;Park, Jong-Hee
    • Korean Journal of Pharmacognosy
    • /
    • v.34 no.3 s.134
    • /
    • pp.193-196
    • /
    • 2003
  • Korean folk medicine 'Bong Seon Wha Dae' has been used to cure constipation and acute gastritis by meat. The botanical origin of the crude drug has not been studied pharmacogostically. To clarify the botanical origin of 'Bong Seon Wha Dae', the morphological and anatomical characteristics of Impatiens species growing in Korea, I.e. I. Balsamina L., I. Noli-tan-gere L., I. Textori Miq. And I. textori Miq. for. pallenscens Hara were studied. As a result, 'Bong Seon Wha Dae' was proved to be the stem of I. Balsamina L.

Physico-phytochemical Evaluation of Raw Material and CO2 extract of Fruits of Terminalia chebula

  • Chandil, Shachi;Bamoriya, Harikishan
    • CELLMED
    • /
    • v.12 no.1
    • /
    • pp.4.1-4.13
    • /
    • 2022
  • The present communication attempts to evaluate the physicochemical and preliminary phytochemical studies on the fruit of Terminalia chebula Retz. Combretaceae family. Haritaki is one of the most celebrated herbs in the Indian traditional medicine system, Ayurveda. Terminalia chebula is known to exhibit different properties like anticancer, anti-inflammatory, anti-protozoal, antimicrobial, antioxidant, hepato and renal protective activities, and in the management of metabolic syndrome. As there is no detailed standardisation work reported on fruit, the physicochemical parameters, preliminary phytochemical constants, heavy metals, analysis are carried out. The phytochemical screening indicated the presence Tannin, Alkaloid, Phenol, Carbohydrate, Steroids, Protein and Resin compounds in CO2 extract of Haritaki. The present investigation will helpful in assessing the quality and purity of a crude drug. Thus, the study provides facts that CO2 extract of Haritaki contains medicinally important bioactive phytochemical compounds which justifies the use of plant species as conventional medicine for treatment of many diseases.

Quality of Bastard Halibut Surimi Gel as Affected by Harvested Time of Unmarketable Cultured Bastard Halibut Paralichthys olivaceus (생산시기가 비규격 넙치 (Paralichthys olivaceus) 연제품의 품질에 미치는 영향)

  • Shin, Jun-Ho;Park, Kwon-Hyun;Lee, Ji-Sun;Kim, Hyung-Jun;Heu, Min-Soo;Jeon, You-Jin;Kim, Jin-Soo
    • Korean Journal of Fisheries and Aquatic Sciences
    • /
    • v.44 no.3
    • /
    • pp.191-196
    • /
    • 2011
  • In this study, we investigated the chemical and enzymatic properties of unmarketable cultured bastard halibut (UCBH) Paralichthys olivaceus harvested at different times (March, May, July, September, November, and January), and we examined the physical properties of surimi gel from UCBH as a potential source of surimi and surimi gel. The moisture and crude protein contents of UCBH harvested in July and January were >78% and <19%, respectively, which is greater than the moisture content in UCBH harvested in May, March, and September, but lower than the crude protein content. Regardless of the month of harvest, the UCBH had a higher crude protein content than Alaska pollock, which is the largest fishery biomass used for surimi and surimi gel, but a lower moisture content. Regardless of the month of harvest, the enzymatic activity in crude extracts of UCBH muscle ranged from 0.31-0.59 U/mg for casein (pH 6.0 and 9.0) and 11.7-12.7 U/mg for LeuPNA. These findings suggest that autolytic enzymes were unaffected by gel formation. Gel strength was highest in the surimi gel prepared from UCBH harvested in September, November, and January; second highest in that prepared from UCBH harvested in March and May; and lowest in that prepared from UCBH harvested in July. Compared to the gel strength of surimi gel from grade SA commercial Alaska pollock surimi, the strength of the surimi gels prepared from UCBH harvested in March, May, September, November, and January were superior, whereas that of the surimi gel prepared from UCBH harvested in July was similar.

Proximate Compositions of Green Garlic Powder and Microbiological Properties of Bread with Green Garlic (풋마늘 분말의 일반성분 및 풋마늘 첨가 식빵의 미생물학적 특성)

  • Lee Mi Kyung;Park Jung Suk;Na Hwan Sik
    • Food Science and Preservation
    • /
    • v.12 no.1
    • /
    • pp.95-100
    • /
    • 2005
  • To enhance the utilization of green garlic as food materials, the nutritional and microbiological properties of green garlic powder and bread were investigated. Proximate compositions of green garlic powder were as follows; moisture $6.99\%$, crude protein $7.62\%$, crude lipid $1.84\%$, crude ash $6.60\%$, crude fiber $9.88\%$ and carbohydrate $76.95\%$. Free sugars were composed of glucose, glucose and sucrose. The major minerals of green garlic powder were k(1,140 mg/100 g), Ca(679.05 mg/100 g), P(342.09 mg/100 g) and Na(130.42 mg/100 g). In the total and free amino acid analysis, the major amino acids were methionine, cystine, proline and glutamic acid. When various amount of freeze dried green garlic powder were added in bread, bread with $0.5\%$ green garlic powder had lower level of total bacterial count compared with the control group at ambient temperature$(30{\pm}1^{\circ}C)$. Result of sensory evaluation showed that the preference scores decreased as the green garlic powder content increased. Through the result of these experiment we can conclude that the highest quality of green garlic powder content is no more than $0.5\%$ in making bread added with green garlic powder.