• Genomics & Informatics
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• 제10권3호
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• pp.153-166
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• 2012

A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of pathogens and lead to primary innate immune activation against invaders, and G-protein coupled receptors (GPCRs), whose interaction with their cognate ligands activates heterotrimeric G proteins and regulates specific downstream effectors, including immuno-stimulating molecules. Once TLRs are activated, they lead to the expression of hundreds of genes together and bridge the arm of innate and adaptive immune responses. We characterized the gene expression profile of Toll-like receptor 4 (TLR4) in RAW 264.7 cells when it bound with its ligand, 2-keto-3-deoxyoctonate (KDO), the active part of lipopolysaccharide. In addition, to determine the network communications among the TLR, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), and GPCR, we tested RAW 264.7 cells with KDO, interferon-${\beta}$, or cAMP analog 8-Br. The ligands were also administered as a pair of double and triple combinations.

• 한국통신학회논문지
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• 제8권4호
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• pp.164-171
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• 1983

본 논문에서는 비교적 짧은 계단형 멀티모우드 광섬유를 이용하여 여러 정보의 채널을 전송하는 광멀티플렉싱 기술인 각도분할방식(ADM: Angular Division Multiplexing)에 대해 논하였다. 평면파 입력에 대한 광섬유 내의 모우드 결합과 출력 파워 분포가 계산되었으며 시스템의 혼신도 결정이 제시되었다. 모우드 결합 하에서 광섬유의 길이와 입력조건에 따른 펄스폭이 평면 도파판과 광섬유에 대해 비교, 계산되었다. NA(Numerical Aperture)아래의 입력각에 대한 각도폭은 입력각이 클수록 줄어들었으며 출력은 입력각에 파워가 집중된 환형으로 나타났으며 이는 ADM시스템의 중요한 요인이 되었다.

• 한국통신학회논문지
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• 제23권6호
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• pp.1562-1574
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• 1998

본 논문에서는 ATM(Asynchronous Transfer Mode) 교환기 시스템에 T1, E1 및 부분적으로 E1급 속도의 중 저속 HDSL(High-rate digital subscriber line) 정합 기능을 개발하고, 근단누화(NEXT), 임펄스. 선로 잡음(power line noise) 및 접지 임피던스(longitudinal) 잡음 같은 주요 전송 손실이 존재하는 0.4 mm 및 0.5 mm의 기존 전화가입자 선로(UTP, Unshielded twisted pair)를 사용하는 CSA(Carrier serving areas) 선로 모델을 이용하여 $10^{-7}$의 BER(Bit error rates)의 전송 성능을 만족하기 위한 가입자 서비스 전송 거리 성능을 평가하였다. HDSL은 DSI, ISDN 기본 속도 접속 및 DLC 피더에 사용될 것이며 광 케이블과 인터페이스될 것이다. 또한, HDSL 시잔 전망을 제시한다.

• The Journal of Korean Physical Therapy
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• 제12권1호
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• pp.163-172
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• 2000

The purpose of this study was to provide experimental evidence and theoretical background for the applicability of bilateral transfer paradigm to the rehabilitation programs for children with hemiplegic cerebral palsy. Children with hemiplegia, which means unilateral motor disabilities, display abnormal motor and postural patterns of the affected side due to hemiparesis, spasticity, and sensory disorders, resulting in a decreased motor abilities of the affected side compared to unaffected side. Accordingly, they tend to rely on the unaffected limb for everyday activities, which further deteriorates the functions of the affected side by causing associated reaction, abnormal postural patterns, and hypertonus. Rehabilitation programs developed for children with hemiplegic cerebral palsy include neurodevelopmental treatment, application of cast or splint to unaffected limb, neuromuscular electrical stimulation, and task oriented model. These programs, however, have several drawbacks, such as discontinuity in treatment effect and psychological hatred to the force use of the affected side. In order to solve these problems and enhance the efficiency of the rehabilitation programs, it is required to maximize the use of the affected side without hatred. Characteristics of the control system, such as temporal coupling and spatial assimilation between limbs and neural crosstalk at different levels of central motor pathway, suggest that the bilateral transfer paradigm may enhance the efficiency of the rehabilitation programs for children with hemiplegic cerebral palsy.

• Journal of the Optical Society of Korea
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• 제13권3호
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• pp.354-360
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• 2009

We investigate theoretically the tolerance of 40 Gbps phase-modulated (PM) duobinary signals using a vestigial sideband (VSB) filter on impairments which occurred in dense wavelength-division multiplexing (DWDM) systems, compared to the conventional duobinary signals. Our simulation results show that PM duobinary signals can't have the gain on the spectral efficiency achieved by utilizing the VSB filtering technique. In order to increase the spectral efficiency, they indispensably require to be transmitted at the optimum bandwidth of multiplexer (MUX) and demultiplexer (DEMUX) since they are susceptible to inter-channel crosstalk. It is also shown that the PM duobinary modulation format has a large tolerance on self-phase modulation (SPM) and cross-phase modulation (XPM) under the condition which MUX and DEMUX have been tuned at an optimum bandwidth; it has 1.2 dB power penalty at the fiber launching power (FLP) of 15 dBm and the channel spacing of 50 GHz.

• ETRI Journal
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• 제24권2호
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• pp.81-96
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• 2002

This paper describes our design of a hybrid amplifier composed of a distributed Raman amplifier and erbium-doped fiber amplifiers for C- and L-bands. We characterize the distributed Raman amplifier by numerical simulation based on the experimentally measured Raman gain coefficient of an ordinary single mode fiber transmission line. In single channel amplification, the crosstalk caused by double Rayleigh scattering was independent of signal input power and simply given as a function of the Raman gain. The double Rayleigh scattering induced power penalty was less than 0.1 dB after 1000 km if the on-off Raman gain was below 21 dB. For multiple channel amplification, using commercially available pump laser diodes and fiber components, we determined and optimized the conditions of three-wavelength Raman pumping for an amplification bandwidth of 32 nm for C-band and 34 nm for L-band. After analyzing the conventional erbium-doped fiber amplifier analysis in C-band, we estimated the performance of the hybrid amplifier for long haul optical transmission. Compared with erbium-doped fiber amplifiers, the optical signal-to-noise ratio was calculated to be higher by more than 3 dB in the optical link using the designed hybrid amplifier.

• 전자공학회논문지A
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• 제31A권6호
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• pp.88-97
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• 1994

We describe the design, fabrication, and performance of the optical fiber-photodiode 1$\times$12 arry module using mesa-type InS10.53T GaS10.47TAS/INP 1$\times$12 PIN photodiode array. We fabricated the PIN PD array for high-speed optical fiber parallel data link optimizing quantum efficiency, operating speed sensitivity from the PIN-FET structure, and electrical AC crosstalk. For each element of the array, the diameter of the photodetective area is 80 $\mu$m, the diameter of the p-metal pad is 90 $\mu$m, and the photodiode seperation is 250 $\mu$m to use Si v-groove. Ground conductor line is placed around diodes and p-metal pads are formed in zigzag to reduce Ac capacitance coupling between array elements. The dark current (IS1dT) is I nA and the capacitance(CS1pDT) is 0.9 pF at -5 V. No signifcant variations of IS1dT and CPD from element to element in the array were observed. We calulated the coupling efficiency for 10/125 SMF and 50/125 GI MMF, and measured the responsivity of the PD array at the wavelength is 1.55 $\mu$ m. Responsivities are 0.93 A/W for SMF and 0.96 A/W for MMF. The optical fiber-PD array module is useful in numerous high speed digital and analog photonic system applications.

• 대한전자공학회논문지SD
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• 제41권10호
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• pp.51-56
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• 2004

광소자의 재료물질로서 특성이 우수하며 열광학계수가 큰 silicon을 기반으로 한 SOI (Silicon-on-insulator)를 사용하여 열광학 1×2 광스위치를 제안, 제작하였다. SOI wafer는 도파로가 형성될 상위 Si 층(n=3.5)과 클래딩 영역이 될 산화막 매립층(n=1.5) 그리고 기판인 Si인 3층으로 이루어진다. BPM(Beam propagation method) 전산모의를 통해 20dB 이상의 누화특성을 갖는 단일모드의 1×2 비대칭 y-분기 광도파로를 형성하고, 열확산 전산모의를 통해 금속열선을 설계 제작하였다. 제작된 광스위치는 약 3.5 watts의 구동 전력에서 20dB 이상의 채널간 누화가 측정되었다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제14권6호
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• pp.824-831
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• 2014

In this study, structural variations and overlay errors caused by multiple patterning lithography techniques to print narrow parallel metal interconnects are investigated. Resistance and capacitance parasitic of the six lines of parallel interconnects printed by double patterning lithography (DPL) and triple patterning lithography (TPL) are extracted from a field solver. Wide parameter variations both in DPL and TPL processes are analyzed to determine the impact on signal propagation. Simulations of 10% parameter variations in metal lines show delay variations up to 20% and 30% in DPL and TPL, respectively. Monte Carlo statistical analysis shows that the TPL process results in 21% larger standard variation in delay than the DPL process. Crosstalk simulations are conducted to analyze the dependency on the conditions of the neighboring wires. As expected, opposite signal transitions in the neighboring wires significantly degrade the speed of signal propagation, and the impact becomes larger in the C-worst metals patterned by the TPL process compared to those patterned by the DPL process. As a result, both DPL and TPL result in large variations in parasitic and delay. Therefore, an accurate understanding of variations in the interconnect parameters by multiple patterning lithography and adding proper margins in the circuit designs is necessary.

• 한국군사과학기술학회지
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• 제10권2호
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• pp.90-99
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• 2007

We demonstrate an 80km-reach 64-channel DWDM-PON based on wavelength-locked F-P LDs by changing the position of the C-band BLS for upstream channels from the CO to the RN. It mitigates the necessity of the high power C-band BLS and its handling problems. It also reduces back scattering induced penalty. We obtained less than $10^{-6}$ PLRs in all 128channels through 80km SMF. We also demonstrate a 240km-reach DWDM-PON based on wavelength-locked F-P LDs by adding a bidirectional erbium-doped fiber amplifier(EDFA). We show packet-loss-free transmission in all 128channels at 125 Mb/s per channel over 240km SMF We report the detuning effect of arrayed waveguide gratings(AWGs) and crosstalk effect in the implemented system. We Propose an architecture of a next generation defense wire communication system with the demonstrated long-reach DWDM-PON.