• Journal of Preventive Medicine and Public Health
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• 제33권3호
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• pp.343-348
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• 2000

Objectives : This study was conducted to integrate the results of studies assessing the association between chronic noise exposure and blood pressure. Methods : Using a MEDLINE search with noise exposure, blood pressure and hypertension as key words, we retrieved articles from the literature that were published from 1980 to December 1999. The criteria for quality evaluation were as follows: 1) the study subjects must have been workers employed at a high noise level area 2) The paper should use average and cumulative noise exposure as method for exposure evaluation. 3) Blood pressure in each article should be reported in a continuous scale Among the 77 retrieved articles, six studies were selected for quantitative meta-analysis. Before the integration of the regression coefficients for the association between blood pressure and noise level, homogeneity tests were conducted. Results : All studies were a cross-sectional design and the study subjects were industrial workers. Five papers used a time-weighted average for noise exposure and only one paper calculated the cumulative noise exposure level. The measurement of blood pressure in the majority of studios were accomplished in a resting stale, and used an average of two or more readings. The homogeneity of studies was rejected in a fixed effect model, so we used the results in a random effect model. The results of the quantitative meta-analysis, the weighted regression coefficient of noise associated with systolic blood pressure and diastolic blood pressure were 0.05 (95% confidence interval [CI]: -0.03, 0.13) and 0.06 (95% CI: -0.01, 0.13), respectively. Conclusions : Our results suggested that chronic exposure to industrial noise does not cause elevated blood pressure.

• 한국학교ㆍ지역보건교육학회지
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• 제8권2호
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• pp.49-59
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• 2007

Objectives: This study was designed to understand the oral health fact of high school students, search for an education method and learning goal appropriate for the subjects, and utilize them as basic data to think of effective solutions for oral health care. Methods: The samples to achieve the purpose of this research are composed of 386 students in J industrial high school, OO city, Kyounggido, the number of male students 286, and female students 100. Data were statistically analyzed by frequency analysis, cross tabulation by using SPSS WIN Ver. 12.0. Results: First, The answers in terms of oral symptoms were in the order of 31.8% for gum hurt and bleeding, 31.4% for pain in teeth by drinking or eating hot and cold drinks or food, 27.1% for broken or cracked teeth, 25.7% for aching and throbbing teeth, 20.6% for unpleasant mouth smell, and 5.7% for pain of tongue and soft oral tissues. Second, In terms of behavior for oral health, 88.4% answered that they consume cariogenic snacks, while 29.2% of them, 2.5% of male and 6.3% of female enjoy consuming them but hardly brush their teeth after consumption. Third, In terms of timing for brushing teeth, the results show that 50.0% do so before breakfast, 47.9% after breakfast, 15.2% after lunch, 36.9% after dinner, 65.5% before going to sleep, and 3.5% after consuming snacks, whereas 64.2% answered that they are not aware of fluorine mouthwash. Fourth, In terms of oral health condition. proportion of children with one or more caries in permanent teeth was 71.0%, while 51.4% have $2{\sim}3$ cariogenic teeth, and 16.8% have more than 4 cariogenic teeth. Considering sex, female students have somewhat higher ratio showing 68.5% for male and 78.0% for female, but the ratio was 53.1% for male and 46.7% for female in case of $2{\sim}3$ cariogenic teeth, and 17.5% for male and 15.8% for female in case of more than 4 cariogenic teeth. 9.3% of students turned out to have decayed teeth. Fifth, In terms of oral hygiene condition, only 7.9% of them had excellent condition, and 38.4% need to improve. More specifically, 41.1% of male students and 30.6% of female students need to improve their oral hygiene condition. Conclusions: The study results suggest that School Dental health programs increase and need to be community-incorporated and comprehensive from elementary to high school.

• 한국강구조학회 논문집
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• 제24권6호
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• pp.671-682
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• 2012

박스형 거더나 박공형 철골조 프레임에서 주름웨브보의 사용은 최근 많이 늘어가고 있다. 그 이유는 얇은 주름웨브보를 사용함으로서 압연형강이나 용접을 이용한 조립보에 비해 중량을 크게 줄일 수 있으며, 박판의 좌굴은 주름이 막아줄 수 있기 때문이다. 자동생산기술의 향상으로 인해 주름웨브를 가진 단위 부재를 양산할 수 있게 되어 적용분야가 확장되고 있으며, 주름웨브보의 부재 제원을 고려한 최적설계의 구현이 필요하게 된다. 이를 위해 본 논문에서는 주름웨브보의 생산부재 데이터를 고려한 이산화 최적구조설계 프로그램을 개발하여 집중하중과 등분포하중을 받는 주름웨브 단순보에 대해 적용하였다. 최소중량을 목적함수로, 세장비, 응력 및 처짐을 제약조건으로 채택하고, 전역최소값을 탐색하기 위해서 유전자 알고리즘을 채택하였으며, 생산부재의 번호를 불연속설계변수로 이용하였다. 최종적으로 해석설계의 검증을 위해서 이산화 최적설계 결과를 연속일 때의 결과와 비교하였으며, 최적단면 특성에 대해 분석하였다.

• 농약과학회지
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• 제6권2호
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• pp.72-79
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• 2002

일련의 3-phenyl-2,5-dihydroisoxazol-5-one(A)과 3-phenylisoxazole(B)유도체 중, 치환-phenyl기가 변화함에 따라 metalaxyl 살균제에 대하여 감수성(SPC:95C C7105)이나 저항성(RPC: 95CC7303)을 나타내는 고추역병균(Phytophthora capsici)의 살균활성 에 관한 비교 분자장 분석(CoMFA) 결과를 검토하였다. 살균활성은 (A)가 (B)보다 큰 경향이었으며 활성을 나타내는 가장 안정한 기질 분자의 형태는 평면성에 가까운 구조이었다. 두 균주를 대상으로 살균 활성에 미치는 CoMFA 장을 계산한 바, 상대적인 기여도는 공히, 정전기장이 가장 우세하였고 소수성장 및 입체장은 비슷한 정도로 기여하였다. 또한, CoMFA 모델은 좋은 상관성과 높은 예측성($q^2>0.570$ 및 $r^2>0.968$)을 나타내었다. 등고도 분석으로부터 RPC에 대한 살균활성의 선택성 요소는 benzoyl-기의 ortho, meta(C14 및 C15) 위치에는 부피가 큰 치환체를 그리고 meta, para(C15 및 C16) 위치부근에는 음하전을 생성하는 전자끌게가 도입되어야 할 것으로 판단된다.

• Asian-Australasian Journal of Animal Sciences
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• 제33권2호
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• pp.187-196
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• 2020

Objective: Porcine respiratory disease is one of the most important health problems causing significant economic losses. To understand the genetic basis for susceptibility to swine enzootic pneumonia (EP) in pigs, we detected 102,809 single nucleotide polymorphisms in a total of 249 individuals based on genome-wide sequencing data. Methods: Genome comparison of susceptibility to swine EP in three pig breeds (Jinhua, Erhualian, and Meishan) with two western lines that are considered more resistant (Duroc and Landrace) using cross-population extended haplotype homozygosity and F-statistic (F_ST) statistical approaches identified 691 positively selected genes. Based on quantitative trait loci, gene ontology terms and literature search, we selected 14 candidate genes that have convincible biological functions associated with swine EP or human asthma. Results: Most of these genes were tested by several methods including transcription analysis and candidate genes association study. Among these genes: cytochrome P450 1A1 and catenin beta 1 (CTNNB1) are involved in fertility; transforming growth factor beta receptor 3 plays a role in meat quality traits; Wnt family member 2, CTNNB1 and transcription factor 7 take part in adipogenesis and fat deposition simultaneously; plasminogen activator, urokinase receptor (completely linked to AXL receptor tyrosine kinase, r² = 1) plays an essential role in the successful ovulation of matured oocytes in pigs; colipase like 2 (strongly linked to SAM pointed domain containing ETS transcription factor, r² = 0.848) is involved in male fertility. Conclusion: These adverse genes susceptible to swine EP may be selected while selecting for economic traits (especially reproduction traits) due to pleiotropic and hitchhiking effect of linked genes. Our study provided a completely new point of view to understand the genetic basis for susceptibility or resistance to swine EP in pigs thereby, provides insight for designing sustainable breed selection programs. Finally, the candidate genes are crucial due to their potential roles in respiratory diseases in a large number of species, including human.

• 한국조경학회지
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• 제43권6호
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• pp.138-149
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• 2015

본 연구는 전통 재현을 위한 합리적 계획 방향을 모색하고자 '의정부 민락 2지구 도시기반시설 조경설계공모(2008)'와 '화성 동탄 2지구 택지개발사업 1단계 조경기본 및 실시설계공모(2012)' 당선안의 설계 도판과 조성 현장을 비교 분석하였다. 먼저 설계 도판에 제시된 텍스트와 평면도, 입단면도, 다이어그램, 사례이미지, 투시도를 분석하여 재현 대상과 재현 경관, 재현 공간의 구성과 배치, 재현 시설물의 디자인과 식재 양상을 파악한 후 조성 현장을 고찰하였다. 연구의 결과는 다음과 같다. 첫째, 재현 대상과 재현 경관의 유형은 대상지의 향토 경관으로써 농업 경관, 전통마을의 생활공간, 전통 수(水) 공간, 전통문화로 구분된다. 둘째, 재현 공간의 구성 및 배치와 관련하여 주변 토지이용과 지역문화유산이 고려된 전통 테마 공간들을 구성하였으나 조성 시 일부는 근린공원에 요구되는 운동공간이나 편의시설공간으로 변경되었다. 셋째, 재현 시설물의 경우 방지원도(方池圓島), 정자, 화계는 현장에 도입되었으나 창의적으로 디자인된 시설물은 설치되지 않았다. 넷째, 전통 식재 기법은 마을숲, 방지 내 원도, 화계에 수목을 도입하는 것에 집중되었다. 다섯째, 전문 자료를 토대로 한 주제 선정과 실험적 시설물 디자인 제시 등 전통 재현 작업이 진일보한 측면을 파악할 수 있었다. 여섯째, 조성 시 실현 가능한 주제 선정, 정보 해석을 위한 전문성, 전통 시설물의 창의적 디자인 등 앞으로 이루어질 전통 재현 작업에 요구되는 과제들을 짚어보았다.

• 자원리싸이클링
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• 제27권1호
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• pp.84-91
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• 2018

본 연구에서는 레이저유도 플라즈마 분광법(Laser induced breakdown spectroscopy, LIBS) 기반의 금속 종류별 스펙트럼 데이터를 이용하여 연성정보(soft information)를 추정하고 최빈 클래스로 분류하는(most probable classification) 금속 분류 방법을 제안한다. 폐금속 자원과 같이 사전 정보가 없는 금속을 분류하는 경우 몇 가지 핵심 구성성분에 대한 정량 분석을 통해서 클래스를 추정하는 방법이 효율적이다. 이에 따라 부분 집합 기반의 부분최소제곱회귀법(Partial Least Square Regression, PLSR)을 이용하여 LIBS 검출 스펙트럼으로부터 각 성분의 농도를 독립적으로 신뢰성 있게 추정하고, 인증 표준물질(CRM) 등 알려진 모집합의 농도정보에 기반하여 최고 확률을 갖도록 분류하는 기술을 제안한다. 샘플 스펙트럼들의 다변량 분석을 통해서 여러 성분의 추정 농도를 다변량 정규 분포를 갖는 것으로 가정하고 통합(Joint) 추정 연성정보를 구할 수 있으며, 이를 활용한 최빈 확률 검출이나 추가적인 사전 정보의 결합 등을 통해서 분류 성능을 향상시킬 수 있다. 제안된 기술의 평가를 위해서 9가지 종류의 CRM 금속시료의 LIBS 스펙트럼 데이터를 사용하며, 부분 집합 기반의 PLSR 농도 추정 기술을 기반으로 단변량 혹은 다변량 정규 분포 연성 정보추정을 통해 미지 금속의 검출과 연성 정보의 검출 등을 테스트 하였다. 또한 방사형 차트(Radar chart)를 이용하여 추정된 농도와 획득한 연성정보를 효과적으로 시각화함으로써 기존 라이브러리에 포함된 부분 집합의 금속과 비교하여 해당 금속과의 유사성을 그래프를 통해 추정할 수 있다.

• 대한치과의사협회지
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• 제48권2호
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• pp.119-126
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• 2010

Introduction. In this study, we applied the immediate loading to implant using temporary prosthesis, and compared the treatment results by each placement site, amongst pre-loading period. The study was intended to search for occurrence of complications and the amount of marginal bone resorption. Materials and Methods. We retrospectively reviewed the medical records of 99 cases of implants from 29 patients who were treated at Seoul National University Bundang Hospital from September 2003 to September 2008. We grouped all the cases by placement arches and pre-loading periods, and subdivided each group by placement site(anterior/posterior), type of prosthesis(full-mouth cross splinting/Partial multiple splinting, Single). Results. In the cases of anterior maxilla, the average amounts of marginal bone resorption showed $1.71{\pm}0.71mm$ in group 1, and $1.44{\pm}0.69mm$ in group 2, which means they revealed no statistically significant difference between group 1 and group 2(p=0.646). In the cases of posterior maxilla, the average amounts of marginal bone resorption showed $1.25{\pm}0.72mm$ in group 1, and $1.14{\pm}1.15mm$ in group 2, which means they were not statistically significant. In the cases of anterior mandible, there was no cases classified as group 4, but the average amounts of marginal bone resorption in group 3 showed $1.38{\pm}0.79mm$. In the cases of posterior mandible, Group 3 showed $1.39{\pm}0.64mm$, and group 4 showed $1.84{\pm}1.19mm$ as amounts of marginal bone resorption, which means they revealed no statistically significant difference between group 3 and group 4(P=0.210). The survival rate of group1 was 97.14%, 92.1% of group3, and 100% of group 2 and group4. According to each type of prosthesis, each average amount of marginal bone resorption revealed no statistically significant difference in maxi11a(p=0.575) in mandible(p=0.206). Conclusion. It is concluded that the marginal bone resorption and the rate of complications might not be affected by placement sites and pre-loading periods. The marginal bone resorption and the rate of complications might vary as different bone quality of placement site and implant system, diameter, length, etc. It is suggested that the proper placement of immediate loading implants decreases the whole treatment period and any inconvenience occurred to patients.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4243-4247
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• 2013

The relationship between the X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism and gliomas remains inclusive or controversial. For better understanding of the effect of XRCC3 Thr241Met polymorphism on glioma risk, a meta-analysis was performed. All eligible studies were identified through a search of PubMed, Elsevier Science Direct, Excerpta Medica Database (Embase) and Chinese Biomedical Literature Database (CBM) before May 2013. The association between the XRCC3 Thr241Met polymorphism and gliomas risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of nine case-control studies including 3,533 cases and 4,696 controls were eventually collected. Overall, we found that XRCC3 Thr241Met polymorphism was significantly associated with the risk of gliomas (T vs. C: OR=1.10, 95%CI=1.01-1.20, P=0.034; TT vs. CC: OR=1.30, 95%CI=1.03-1.65, P=0.027; TT vs. TC/CC: OR=1.29, 95%CI=1.01-1.64, P=0.039). In the subgroup analysis based on ethnicity, the significant association was found in Asian under four models (T vs. C: OR=1.17, 95%CI=1.07-1.28, P=0.00; TT vs. CC: OR=1.79, 95%CI=1.36-2.36, P=0.00; TT vs. TC/CC: OR=1.75, 95%CI=1.32-2.32, P=0.00; TT/TC vs. CC: OR=1.11,95% CI=1.02-1.20). This meta-analysis suggested that the XRCC3 Thr241Met polymorphism is a risk factor for gliomas, especially for Asians. Considering the limited sample size and ethnicities included in the meta-analysis, further large scale and well-designed studies are needed to confirm our results.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.135-135
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• 2017

The Gramene database (http://www.gramene.org) is a powerful online resource for agricultural researchers, plant breeders and educators that provides easy access to reference data, visualizations and analytical tools for conducting cross-species comparisons. Learn the benefits of using Gramene to enrich your lectures, accelerate your research goals, and respond to your organismal community needs. Gramene's genomes portal hosts browsers for 44 complete reference genomes, including crops and model organisms, each displaying functional annotations, gene-trees with orthologous and paralogous gene classification, and whole-genome alignments. SNP and structural diversity data, available for 11 species, are displayed in the context of gene annotation, protein domains and functional consequences on transcript structure (e.g., missense variant). Browsers from multiple species can be viewed simultaneously with links to community-driven organismal databases. Thus, while hosting the underlying data for comparative studies, the portal also provides unified access to diverse plant community resources, and the ability for communities to upload and display private data sets in multiple standard formats. Our BioMart data mining interface enable complex queries and bulk download of sequence, annotation, homology and variation data. Gramene's pathway portal, the Plant Reactome, hosts over 240 pathways curated in rice and inferred in 66 additional plant species by orthology projection. Users may compare pathways across species, query and visualize curated expression data from EMBL-EBI's Expression Atlas in the context of pathways, analyze genome-scale expression data, and conduct pathway enrichment analysis. Our integrated search database and modern user interface leverage these diverse annotations to facilitate finding genes through selecting auto-suggested filters with interactive views of the results.