• 지질공학
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• 제19권3호
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• pp.295-306
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• 2009

본 연구는 지하수, 토양, 대기의 노출경로에 따라서 부산광역시 사상공단의 지하수와 토양이 인체와 환경에 미치는 영향을 평가하였다. 토양과 대기의 노출경로에 따른 발암 위해는 나타나지 않았으나, 지하수에서는 TCE와 PCE의 발암 위해성이 각각의 기준 한계값인 1.0E-6과 1.0E-5에 대해서 각각 6.7E-6과 1.0E-5로 나타나 발암 위해가 있는 것으로 판단되었다. 대기에서는 비발암성 위해가 나타나지 않았다. 토양의 위해계수와 위해지수는 각각 3.4E-5와 5E-5로서 기준 한계값(1.0) 보다 낮게 나타났으나, 지하수의 위해계수와 위해지수는 각각 0.7 (위해성이 없음)과 1.4(위해성이 있음)로 나타났다. TCE의 최소성분감소비(CRF)는 2.5로서 TCE의 정화작업이 요구된다. 18개의 노출인자에 대한 민감도 분석 결과, 8개의 노출 인자(비 발암 물질에 대한 평균 수명, 발암 물질에 대한 평균 수명, 체중, 노출기간, 노출빈도, 피부노출빈도, 토양 섭취율, 물 섭취율)의 변화에 따라서 위해도가 변화하는 것으로 나타났다.

• Tuberculosis and Respiratory Diseases
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• 제81권1호
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• pp.6-12
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• 2018

The role of the treatment for latent tuberculosis infection (LTBI) has been underscored in the intermediate tuberculosis (TB) burden countries like South Korea. LTBI treatment is recommended only for patients at risk for progression to active TB-those with frequent exposure to active TB cases, and those with clinical risk factors (e.g., immunocompromised patients). Recently revised National Institute for Health and Care Excellence (NICE) guideline recommended that close contacts of individuals with active pulmonary or laryngeal TB, aged between 18 and 65 years, should undergo LTBI treatment. Various regimens for LTBI treatment were recommended in NICE, World Health Organization (WHO), and Centers for Disease Control and Prevention guidelines, and superiority of one recommended regimen over another was not yet established. Traditional 6 to 9 months of isoniazid (6H or 9H) regimen has an advantage of the most abundant evidence for clinical efficacy-60%-90% of estimated protective effect. However, 6H or 9H regimen is related with hepatotoxicity and low compliance. Four months of rifampin regimen is characterized by less hepatotoxicity and better compliance than 9H, but has few evidence of clinical efficacy. Three months of isoniazid plus rifampin was proved equivalence with 6H or 9H regimen in terms of efficacy and safety, which was recommended in NICE and WHO guidelines. The clinical efficacy of isoniazid plus rifapentine once-weekly regimen for 3 months was demonstrated recently, which is not yet introduced into South Korea.

• 대한안전경영과학회지
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• 제17권1호
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• pp.93-101
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• 2015

The demand from customers on better products and systems seems to be ever increasing. To meet the demand, the systems are becoming more and more complicated in terms of both scale and functionality, thereby requiring enormous effort in the development. One bright spot of this trend is that such effort has been the driving forces of the remarkable advancement in modern systems development. On the other hand, safety issues appear to be critical in many large-scale systems such as transportation and weapon systems including high-speed trains, airplanes, ships, missiles/rockets launchers, and so on. Such systems turn out to be prone to a variety of faults and thus the resultant failure can cause disastrous accidents. For the reason, they can be referred to as safety-critical systems. The systems failure can be attributed to either random or systemic factors (or sometimes both). The objective of this paper is on how to reduce potential systemic failure in safety critical systems. To do so, a proper system design is pursued to minimize the risk of systemic failure. A focus is placed on the fact that complex systems have a lot of complicated interfaces among the system elements. To effectively handle the sources of hazards at the complicated interfaces and resultant failure, a method is developed by utilizing a design structure matrix. As a case study, the developed method is applied in the design of train control systems.

• 항공우주시스템공학회지
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• 제6권3호
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• pp.7-12
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• 2012

The contents of aircraft system safety assessment vary depending on factors such as the complexity of the system, how critical the system is to flight safety, what volume of experience is available on the type of system and the novelty and complexity of the technologies being used. If the system safety assessment is to substantiate that the developed products are 'safe enough' to be taken into use, then the system safety assessment should be planned and managed to provide the necessary assurance that all relevant hazards and failure conditions have been identified and that all significant combinations of hazards and failures which could cause those conditions have been considered. The assessment must assist the designer and management in making decisions. It must make clear what the critical features of each system are and upon which special manufacturing techniques, inspection, testing, crew drills and maintenance practice they are critically dependent. This paper has prepared to study on promoting the efficiency of aircraft system safety assessment and to present how to compile system safety assessment strategy.

• 중환자간호학회지
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• 제12권1호
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• pp.22-35
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• 2019

Purpose : This study was to determine the levels of environmental stressor, posttraumatic stress disorder, and quality of life in intensive care units (ICU) survivors after intensive care, and to explore the factors affecting posttraumatic stress disorder and quality of life. Methods: With a longitudinal survey design, data were collected from 116 patients who were discharged from the ICU of a university hospital. The environmental stressor, posttraumatic stress disorder, and quality of life were measured immediately following and 1 month after the ICU discharge. Results: Of all the subjects, 16.4% experienced posttraumatic stress disorder after discharge. Multiple regression analysis revealed that ICU environmental stressors, experience of ICU readmission, using psychotropic drugs and narcotic analgesics, and ICU admission after surgery or cardiac intervention accounted for 22.2% of posttraumatic stress disorder. Posttraumatic stress disorder and sedation status when entering ICU accounted for 28.3% of the quality of life 1 month after ICU discharge. Conclusion: Nursing interventions focused on ICU environmental stressors would not only reduce environmental stress but also contribute to the reduction of posttraumatic stress disorder and later improvement of quality of life.

• 국제학술발표논문집
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• The 3th International Conference on Construction Engineering and Project Management
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• pp.83-90
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• 2009

Natural disasters, such as the recent floods in the Midwest, Hurricane Ike in the Gulf coast region (U.S.), and the earthquake in Sichuan (China), cause severe damage to the infrastructure as well as the associated industries and communities that rely on the infrastructure. The estimated damages due to Hurricane Ike in 2008 were a staggering $27 billion, the third worst in U.S. history. In addition, the worst earthquake in three decades in Sichuan resulted in about 90,000 people dead or missing and $20 billion of the estimated loss. A common observation in the analyses of these natural disaster events is the inadequacy of critical infrastructure to withstand the forces of natural calamities and the lack of mitigation strategies when they occur on the part of emergency-related organizations, industries, and communities. If the emergency-related agencies could identify and fortify the vulnerable critical infrastructure in the preparedness stage, the damage and impacts can be significantly reduced. Therefore, it is important to develop a decision support system (DSS) for identifying region-specific mitigation strategies based on the inter-relationships between the infrastructure and associated industries and communities in the affected region. To establish effective mitigation strategies, relevant data were collected from the affected areas with respect to the technical, social, and economic impact levels. The data analysis facilitated identifying the major factors, such as vulnerability, criticality, and severity, for developing a DSS. Customized mitigation strategies that will help agencies prepare, respond, and recover according to the disaster response were suggested.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.450-457
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• 2022

The construction industry is demanding, dynamic, and complex making it difficult for workers to recognize hazards. The nature of construction tasks exposes workers to several critical risk factors, such as a high rate of exertion and fatigue. Recent studies suggest that fatigue may impact hazard recognition in the construction industry. However, most studies rely on subjective measures when assessing the relationship between physical fatigue and hazard recognition, limiting such studies' efficacy. Thus, this study examined the relationship between physical fatigue and hazard recognition using a controlled experiment. Worker fatigue levels were captured using physiological data and a subjective exertion scale. The findings confirmed that physical exertion plays a significant role in hazard recognition skills (p < 0.05). This research contributes to theory and practice by providing a process for objectively assessing the influence of physical fatigue on worker safety and providing construction professionals with some critical insight needed to improve workplace safety.

• Structural Engineering and Mechanics
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• 제73권3호
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• pp.339-351
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• 2020

Earthquakes are natural disasters that cause serious social disruptions and economic losses. In particular, they have a significant impact on critical lifeline infrastructure such as urban water transmission networks. Therefore, it is important to predict network performance and provide an alternative that minimizes the damage by considering the factors affecting lifeline structures. This paper proposes a probabilistic reliability approach for post-hazard flow analysis of a water transmission network according to earthquake magnitude, pipeline deterioration, and interdependency between pumping plants and 154 kV substations. The model is composed of the following three phases: (1) generation of input ground motion considering spatial correlation, (2) updating the revised nodal demands, and (3) calculation of available nodal demands. Accordingly, a computer code was developed to perform the hydraulic analysis and numerical modelling of water facilities. For numerical simulation, an actual water transmission network was considered and the epicenter was determined from historical earthquake data. To evaluate the network performance, flow-based performance indicators such as system serviceability, nodal serviceability, and mean normal status rate were introduced. The results from the proposed approach quantitatively show that the water network is significantly affected by not only the magnitude of the earthquake but the interdependency and pipeline deterioration.

• 시스템엔지니어링학술지
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• 제7권1호
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• pp.1-7
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• 2011

This work describes a study on the Analysis of Alternatives (AoA) based defense decision making. Future battle-space is transformed into a System of Systems (SoS) concept which is accomplished missions and their functions through network based battle management systems under forming their grids of various sensors and shooters in a single theater. The acquisition process is, therefore, changing over from single system requirements to capabilities based acquisition of SoS. AoA help to justify the need for starting, stopping, or continuing an acquisition program. AoA identify potentially viable solutions and provide comparative cost, effectiveness, and risk assessments of each solution to a baseline. The decision making must consider not only cost-effectiveness, risk, and military worth, but also domestic policy, foreign policy, technological maturity of the solution, the environment, the budget, treaties, and a host of additional factors. In this point of view, this paper analyzes AoA template which are critical elements of the defense decision making. From results of this analysis of AoA template for Korean acquisition environment are presented.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7393-7400
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• 2015

Matrix metalloproteinase (MMP) 9, a key member of multifunctional family of zinc dependent endopeptidases has been found to be upregulated during inflammation and in some cancers. MMPs cleave extracellular matrix (ECM) proteins and play critical roles in cellular apoptosis, angiogenesis, tumor growth and metastasis. Several genetic polymorphisms have been identified that show allele specific effects on MMP9 regulation and are associated with gastric cancer, the fourth most common malignancy in the world. Besides Helicobacter pylori infection, genetic predisposition is another documented risk factor for gastric carcinoma. The single nucleotide polymorphism (SNP) at position -1562C/T of MMP9 results in the modulation for binding of transcription factors to the MMP9 gene promoter and thereby causes differences in protein expression and enzymatic activity. MMP9 transcriptional regulation during gastric cancer development remains poorly known although several studies have demonstrated associations between MMP9 -1562 C/T polymorphism with different diseases. Knowledge on mechanisms of MMP9 upregulation during gastric cancer may provide new paradigm in diagnostics and therapeutics.