• The Korean Journal of Physiology and Pharmacology
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• v.20 no.4
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• pp.367-378
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• 2016

Recently, it was reported that the role of mitochondria-reactive oxygen species (ROS) generating pathway in cisplatin-induced apoptosis is remarkable. Since a variety of molecules are involved in the pathway, a comprehensive approach to delineate the biological interactions of the molecules is required. However, quantitative modeling of the mitochondria-ROS generating pathway based on experiment and systemic analysis using the model have not been attempted so far. Thus, we conducted experiments to measure the concentration changes of critical molecules associated with mitochondrial apoptosis in both human mesothelioma H2052 and their ${\rho}^0$ cells lacking mitochondrial DNA (mtDNA). Based on the experiments, a novel mathematical model that can represent the essential dynamics of the mitochondrial apoptotic pathway induced by cisplatin was developed. The kinetic parameter values of the mathematical model were estimated from the experimental data. Then, we have investigated the dynamical properties of this model and predicted the apoptosis levels for various concentrations of cisplatin beyond the range of experiments. From parametric perturbation analysis, we further found that apoptosis will reach its saturation level beyond a certain critical cisplatin concentration.

• Journal of Korean Critical Care Nursing
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• v.10 no.2
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• pp.1-13
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• 2017

Purpose: This study investigated the effects that the use of a booklet for intensive care unit nurses had on radiation safety management education (knowledge about and behaviors in radiation safety management, and awareness of anxiety caused by radiation hazards). Methods: A randomized control group pretest-posttest design was used. A booklet about radiation safety management developed by the authors was used as educational material. Participants (N=42) were intensive care unit nurses of P hospital in B city. Training was provided to the experimental group (N=21). Knowledge about and behaviors in radiation safety management and awareness of anxiety caused by radiation hazards were measured by questionnaires before and after the intervention. Data was analyzed by an $X^2$-test, non-paired t-test, and paired t-test. Results: There was a significant difference between groups in knowledge of (t=-14.932, p<.001) and behaviors in (t=-8.297, p<.001) radiation safety management and awareness of anxiety caused by radiation hazards (t=9.378, p<.001). Conclusion: The levels of knowledge about and behaviors in radiation safety management and awareness of anxiety generated by radiation hazards of intensive care unit nurses increased after receiving one session of radiation safety management education using the booklet. Therefore, providing radiation safety management training is suggested as an effective strategy for improving radiation safety management.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2003.05a
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• pp.214-225
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• 2003

Now a day, the company must strengthen the contact-point of the customer who the company has and has to block the secession of the customer by providing services or goods on time. Under this market situation, the corporation extends the CRM for the customer management and strategic management, and set the CRM-strategies up for managing the customer relationship. For this, the present enterprise's level and the business-ability for the management of the customer relationship should be considered. Therefore, in this study, we will analyze the critical factors to set the CRM up as a strategy by studying the literature review. In the critical factors, the factors of enterprise level as well as the technical factor will be included. Secondly, as you know, the BSC is used to evaluate the corporation as a index. In this study the BSC model is changed and rearranged for the applied BSC model to measure the C3M level of companies. Thirdly, based on the model developed, the factors in the first step are classified by levels and weighted values are calculated by using AHP method. As a result, we will show the diagnostic model for check the operational performance of management, marketing and sales etc.

• Journal of Korean Critical Care Nursing
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• v.14 no.3
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• pp.128-140
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• 2021

Purpose : This study aimed to identify the incidence of peripheral cyanosis and the characteristics and clinical results of patients with therapeutic hypothermia after a cardiac arrest. Methods : Data were collected from April to June 2021 via the electrical medical records of 95 patients with therapeutic hypothermia for 72 hours after a cardiac arrest admitted to an acute care unit at a tertiary hospital between January 1, 2016, and December 31, 2019. The data were analyzed using descriptive statistics and a t-test, Mann-Whitney U test, Chi-squared test, Fisher's exact test, and logistic regression using SPSS/WIN. Results : The incidence of peripheral cyanosis was 20%. In the peripheral cyanosis group, peripheral vascular disease, fibrinogen, vasopressor, infection, disseminated intravascular coagulation, acute physiology, chronic health evaluation II score on the second hospital day, nursing intervention, and mortality on the seventh hospital day were higher. The level of fibrinogen and use of vasopressors affected the occurrence of peripheral cyanosis. Conclusion : Considering the influencing variables, careful observation is necessary for patients with high fibrinogen levels and vasopressor use. These results provide basic data to recognize the need for nursing intervention for peripheral cyanosis and encourage nurses to deliver them during therapeutic hypothermia.

• Journal of Korean Critical Care Nursing
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• v.14 no.3
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• pp.62-72
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• 2021

Purpose : This study aimed to identify factors influencing clinical nurses' intention to report medication administration errors. Methods : This cross-sectional study collected data from 121 nurses in charge of administering medication at a university hospital in Korea using structured questionnaires. Data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, Pearson's correlation coefficient, and multiple linear regression. Results : Participants' mean age was 26.90±3.99 years, and 89.3% were women. Their mean clinical career duration was 3.88±4.26 years. The average levels of patient safety culture, attitude toward reporting medication administration errors, and intention to report medication administration errors were 7.51 out of 10, 3.36 out of 5, and 4.85 out of 6, respectively. The multiple regression analysis results indicated that the statistically significant influencing factors were patient safety culture (𝛽=.21, p =.018) and attitude toward reporting medication administration errors (𝛽=.22, p =.015). Conclusion : To improve the intention to report medication administration errors among clinical nurses, a patient safety culture must be established, along with an education provision for improving their attitudes toward reporting such administration errors.

• Journal of Korean Critical Care Nursing
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• v.14 no.3
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• pp.73-86
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• 2021

Purpose : This study aimed to investigate the effects of oropharyngeal sensory stimulation using low-temperature capsaicin on dysphagia, dietary level, aspiration pneumonia, and nutritional status in acute stroke patients with dysphagia admitted to a stroke intensive care unit. Methods : This study used a randomized controlled trial design and 43 participants were randomly assigned to the experimental group (n=21) or control group (n=22). An oropharyngeal sensory stimulation intervention program was constructed based on previous studies. The intervention was provided before meals twice a day for seven days and started with the first meal after hospitalization. In the control group, a solution was made using only bottled water without adding capsaicin solution, and the intervention was provided at the same time, method, and number of times as the experimental group. Results : As a result of the study, dysphagia and dietary level improved in the experimental group that received oropharyngeal sensory stimulation using capsaicin. There were no effects on the nutritional status or aspiration pneumonia. Conclusion : This study provides basic data for the development of an intervention program for patients with dysphagia by presenting a theoretical basis that oropharyngeal sensory stimulation intervention using capsaicin improves dysphagia and dietary levels.

• Journal of Korean Critical Care Nursing
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• v.12 no.1
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• pp.22-35
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• 2019

Purpose : This study was to determine the levels of environmental stressor, posttraumatic stress disorder, and quality of life in intensive care units (ICU) survivors after intensive care, and to explore the factors affecting posttraumatic stress disorder and quality of life. Methods: With a longitudinal survey design, data were collected from 116 patients who were discharged from the ICU of a university hospital. The environmental stressor, posttraumatic stress disorder, and quality of life were measured immediately following and 1 month after the ICU discharge. Results: Of all the subjects, 16.4% experienced posttraumatic stress disorder after discharge. Multiple regression analysis revealed that ICU environmental stressors, experience of ICU readmission, using psychotropic drugs and narcotic analgesics, and ICU admission after surgery or cardiac intervention accounted for 22.2% of posttraumatic stress disorder. Posttraumatic stress disorder and sedation status when entering ICU accounted for 28.3% of the quality of life 1 month after ICU discharge. Conclusion: Nursing interventions focused on ICU environmental stressors would not only reduce environmental stress but also contribute to the reduction of posttraumatic stress disorder and later improvement of quality of life.

• Advances in concrete construction
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• v.7 no.1
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• pp.39-50
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• 2019

This study presents a comprehensive experimental investigation on mostly encountered types of Reinforced Concrete Haunched Beams (RCHBs) where three modes of RCHBs investigated; the diversity of studied beams makes it a pioneer in this topic. The experimental study consists of twenty RCHBs and four prismatic beams. Effects of important parameters including beam type, the inclination angle, flexure and compressive reinforcement, shear reinforcement on mechanical behavior and failure mode of each mode of RCHBs were examined in detail. Furthermore crack propagation at certain load levels were inspected and visualized for each RCHB mode. The results confirm that RCHBs have different behavior in shear as compared to the prismatic beams. At the same time, different mechanical behavior was observed between the modes of RCHBs. Therefore, RCHBs were classified into three modes according to the inclination shape and mode of failure (Modes A, B and C). However, it was observed that there is no significant difference between RCHBs and prismatic beams regarding flexural behavior. Moreover, a new and unified formula was proposed to predict the critical effective depth of all modes of RCHBs that is very useful to predict the critical section for failure.

• International conference on construction engineering and project management
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• 2007.03a
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• pp.206-217
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• 2007

Generally, there is confusion as to what constitutes TQM, though it can be regarded as a set of concepts and tools for getting all employees focused on continuous improvement, various schools of thought have defined or classified the critical success factors as constructs, concepts and principles. Therefore the main aim of this paper is to provide a practical approach for understanding the quality management terminology. Using the existing quality management measurement instruments available in literature, the terminology used is classified into constructs, practices and finally tools or techniques. Quality Management may then be viewed as a combination of the three sets of terminology. Drawing on the quantitative study which investigated the implementation of TQM within the SME, the critical factors of TQM as used in that study as used to demonstrate the practical approach or methodology for the understanding of the terms thus used. For the benefit of practitioners within the Construction Management field, a bit of clarity is required as regards the terminology used. This study contributes to clarifying the conflicting results being reported in the quality management literature which inevitably leads to having different levels of analysis of Quality Management. Accordingly, the strength of quality management compared with other business philosophies should then focus on the practical methodology, namely the practices and techniques.

• International conference on construction engineering and project management
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• 2009.05a
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• pp.83-90
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• 2009

Natural disasters, such as the recent floods in the Midwest, Hurricane Ike in the Gulf coast region (U.S.), and the earthquake in Sichuan (China), cause severe damage to the infrastructure as well as the associated industries and communities that rely on the infrastructure. The estimated damages due to Hurricane Ike in 2008 were a staggering $27 billion, the third worst in U.S. history. In addition, the worst earthquake in three decades in Sichuan resulted in about 90,000 people dead or missing and $20 billion of the estimated loss. A common observation in the analyses of these natural disaster events is the inadequacy of critical infrastructure to withstand the forces of natural calamities and the lack of mitigation strategies when they occur on the part of emergency-related organizations, industries, and communities. If the emergency-related agencies could identify and fortify the vulnerable critical infrastructure in the preparedness stage, the damage and impacts can be significantly reduced. Therefore, it is important to develop a decision support system (DSS) for identifying region-specific mitigation strategies based on the inter-relationships between the infrastructure and associated industries and communities in the affected region. To establish effective mitigation strategies, relevant data were collected from the affected areas with respect to the technical, social, and economic impact levels. The data analysis facilitated identifying the major factors, such as vulnerability, criticality, and severity, for developing a DSS. Customized mitigation strategies that will help agencies prepare, respond, and recover according to the disaster response were suggested.