• Journal of Korean Critical Care Nursing
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• v.12 no.1
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• pp.94-108
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• 2019

Purpose : Heart failure (HF) is considered an important medical burden with rehospitalization and mortality. Anemia is a major risk factor associated with the severity of HF. To improve the understanding of the impact of anemia in the population with HF, we explored the prevalence of anemia, its guidelines, relationship between anemia and mortality or rehospitalization, and limitation of reviewed papers of various populations with HF. Method: We used Whittemore and Knafl's integrative review methodology (2005), and thirty research papers were analyzed. PubMed, CINAHL, Cochrane, PsychInfo, Embase, Web of Science were searched for papers published between January 1960-June 2018. Results: Anemia in individuals with HF was primarily defined using the World Health Organization guideline. The prevalence of anemia in patients with HF varied from 9% to 56.7%. Moreover, such a condition significantly increases the prevalence of mortality or rehospitalization in patients with HF. The analyzed majority were non-prospective cohort study including secondary data analysis. Conclusion: Anemia in individuals with HF is a significant risk factor of mortality and rehospitalization. Prospective cohort studies should be designed to identify the optimal value for screening anemia and the impact of anemia on rehospitalization and mortality among HF patients.

• Geomechanics and Engineering
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• v.34 no.3
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• pp.285-301
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• 2023

During the construction of E75 highway through Grdelica gorge in Serbia, a major failure occurred in the zone of reinforced rock slope. Excavation was performed in highly anisotropic Paleozoic schist rock formation. The reinforcement consisted of the two rows of micropile wall with pre-stressed anchors. Forces in anchors were monitored with load cells while benchmarks were installed for superficial displacement measurements. The aim of the study is to investigate possible causes of instability considering different probability distributions of the strength of discontinuities and anchor bond strength by applying different optimization techniques for finding the critical failure surface. Even though the deterministic safety factor value is close to unity, the probability of failure is governed by variability of shear strength of anisotropic planes and optimization method used for locating the critical sliding surface. The Cuckoo search technique produces higher failure probabilities compared to the others. Depending on the assigned statistical distribution of input parameters, various performance functions of the factor of safety are obtained. The probability of failure is insensitive to the variation of bond strength. Different sampling techniques should yield similar results considering that the sufficient number of safety factor evaluations is chosen to achieve converged solution.

• Structural Engineering and Mechanics
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• v.22 no.6
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• pp.685-700
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• 2006

The effective length factor is a familiar concept for practicing engineers and has long been an approach for column stability evaluations. Neglecting the effects of axial force in the restraining members, in the case of sway prevented frames, is one of the simplifying assumptions which the Alignment Charts, the conventional nomographs for K-Factor determination, are based on. A survey on the problem reveals that the K-Factor of the columns may be significantly affected when the differences in axial forces are taken into account. In this paper a new iterative approach, with high convergence rate, based on the general principles of structural mechanics is developed and the patterns for detection of the critical member are presented and discussed in details. Such facilities are not available in the previously presented methods. A constructive methodology is outlined and the usefulness of the proposed algorithm is illustrated by numerical examples.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.8
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• pp.3578-3585
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• 2012

The purpose of this study was to establish the critical limit at CCP (Critical Control Point) of HACCP (Hazard Analysis Critical Control Point) system for instant noodle and it was conducted at P company in Ichen(Gyeonggi-do), Korea. According to the CCP, Fried process were experimented to removal and decrease of microbiological and chemical hazards by measuring of each temperature and times. As a result, the standard plate count and pathogenic microorganism were not detected by fried processing (Temperature : $145{\pm}10^{\circ}C$, Time : $75{\pm}30$ sec). The acid value of chemical hazards produced by fried processing was able to manage, showed lower (0.2) than the legal limit (0.6). Air-borne bacterial examination results detected(3 CFU/mL, 3 CFU/mL) in the Frying Room and Steam Room. Therefore, the CCP-BC of fried process would be a great alternative to prevent and remove hazard analysis, such as general and pathogenic microorganism (E. coli O157:H7, B. cereus, Listeria monocytogenes, Salmonella spp, Sthaph. aureus etc), chemical hazard analysis. In conclusion, it suggested that HACCP plan was necessary for management standard and systematic approach in establishement of critical limit, solving the problem, method of verification, education and records management by fried processing.

• Journal of Digital Convergence
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• v.10 no.6
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• pp.93-98
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• 2012

This study was to analyze the influences of various factors on the u-health service. Data was surveyed from experienced of u-Health service sectors. We measured legal support, IT-infra, user education, the user education, and the u-Health solution, are the critical success factors for the u-Health service. Also we evaluated u-Health services by survey data from the users. We did also the research to evaluate the validity and reliability of these factors. After that the Analytical Hierarchy Process (AHP) was applied to measure the weights among these factors. Factor analysis resulted in 6 major factors (Eigenvalue > 1.0). The AHP analysis showed the list of Critical Success Factors weighted by its significance priorities. The results of this paper could be the valuable references for the policy making process of the u-Health system in Korea.

• Journal of Digital Convergence
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• v.10 no.3
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• pp.51-58
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• 2012

The goal of this paper is to set up the rank list of the critical success factors according to its weights. To get the empirical data for this research, the Internet-based questionnaires were performed. This research is carried out in two steps. At first step, the critical success factors(CSF) are crystallized through factor analysis methods. To find out the weights and ranks of critical success factors in second step, the analytical hierarchical process(AHP) method were performed. The order list of all CSFs will be determined according to their priorities. This order list shows which factors have the most useful influence on the performance and success of SCM. This result could play the role as milestone for the effective management of Supply Chain Management System in korean manufacturing company.

• Tuberculosis and Respiratory Diseases
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• v.67 no.6
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• pp.569-573
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• 2009

Idiopathic pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by surfactant component accumulation in the alveolar space. Idiopathic PAP has recently been recognized as a autoimmune disease of impaired alveolar macrophage function caused by autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). While whole lung lavage has been the standard treatment, not every patient shows a complete response. Subcutaneous injection or inhalation of GM-CSF is another promising treatment option for PAP. A 45-year-old patient visited our hospital for dyspnea, he was diagnosed as PAP and underwent whole lung lavage. Eighteen months later, the patient had not achieved complete remission in despite of initial response. After then he was administered with GM-CSF (5 ${mu}g/kg/day$, subcutaneous injection) for fivetimes a week during 2 months. Nine months later, the abnormal shadows in high-resolution computed tomography (HRCT) decreased and the patient fully recovered in forced vital capacity. After 60 months, the HRCT scan showed complete remission of PAP.

• Journal of Korean Neurosurgical Society
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• v.58 no.3
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• pp.205-210
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• 2015

Objective : This study was aimed at optimizing the treatment of non-small-cell lung cancer (NSCLC) patients who are candidates for stereotactic radiosurgery (SRS) for brain metastases and harbor activating epithelial growth factor receptor (EGFR) mutations. Methods : We retrospectively reviewed the medical records from 2005 to 2010 of NSCLC patients with brain metastases harboring an activating EGFR mutation. Patients who received a combination therapy of SRS and EGFR-tyrosine kinase inhibitor (TKI) for brain metastases and those who received SRS without EGFR-TKI were compared. The primary endpoint was progression-free survival (PFS) of the brain metastases. Results : Thirty-one patients were eligible for enrolment in this study (SRS with TKI, 18; SRS without TKI, 13). Twenty-two patients (71.0%) were women and the median overall age was 56.0 years. PFS of brain lesions was not significantly prolonged in SRS with TKI treatment group than in SRS without TKI group (17.0 months vs. 9.0 months, p=0.45). Local tumor control rate was 83.3% in the combination therapy group, and 61.5% in the SRS monotherapy group (p=0.23). There were no severe adverse events related with treatment in both groups. Conclusions : Therapeutic outcome of concurrent SRS and TKI treatment was not superior to SRS monotherapy, however, there was no additive adverse events related with combined treatment.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.12
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• pp.1681-1691
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• 2002

The heat transfer and pressure drop characteristics of heat exchangers with louver fins were experimentally investigated. The samples had small fin pitches (1.0 mm to 1.4 mm), and experiments were conducted up to a very low frontal air velocity (as low as 0.3 m/s). At a certain Reynolds number (critical Reynolds number), the flattening of the heat transfer coefficient curve was observed. The critical Reynolds number was insensitive to the louver angle, and decreased as the louver pitch to fin pitch ratio (L$_{p}$F$_{p}$) decreased. Existing correlations on the critical Reynolds number did not adequately predict the data. It is suggested that, for proper assessment of the heat transfer behavior, the louver pattern in addition to the flow characterization need to be considered. The heat transfer coefficient increased as the fin pitch decreased. At low Reynolds numbers, however, the trend was reversed. Possible explanation is provided considering the louver pattern between neighboring fins. Different from the heat transfer coefficient, the friction factor did not show the flattening characteristic. The reason may be attributed to the form drag by louvers, which offsets the decreased skin friction at a low Reynolds number. The friction factor increased as the fin pitch decreased and the louver angle increased. A new correlation predicted 92% of the heat transfer coefficient and 90% of the friction factor within $\pm$10%.10%.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2003.05a
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• pp.139-142
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• 2003

Traditionally, the thickness of fire protection materials of structural elements such as beam and column have been decided by fire test using the predominant steel section of $H-300{\times}300{\times}10{\times}15$ for column and $H-400{\times}200{\times}8{\times}13$ for beam in Korea. But this way of determination of fire protection thickness yields very unduly results. Because the temperature-increment rate of structural steel elements depends mainly on magnitude of their cross-areas. In general, the thicker size of cross-areas for structural elements, the lower temperature shows up. It had already proved that the fire protection thickness only depends on the size of cross-areas and the fire protection method for three-fide or four-side exposed conditions in European countries, the United State of America and so on. To demonstrate there would be differences among various cross-areas for structural elements, we conducted several fire tests with full-scale specimens of beams and columns. For the determination of critical temperature for steel section when the fire resistant performance is needed to be decided, we conducted with a loaded fire test for beam and column, respectively. The small column in 1.0 meter length and beam in 1.5 meter length were used in order to deprive the rational fire protection thickness of structural elements such as beam and column, respectively. After test, we could obtain there were significant temperature lass between higher cross-areas and lower cross-areas. The critical temperature of steel as a criterion is used 538$^{\circ}C$ for column and 593$^{\circ}C$ for beam which is from ASTM E 119 because we don't make provisions as critical temperature by elements. We could consider that the best way of determination of fire protection thickness is using the following multi-regression equation which was deprived from several fire tests using the concept of section factor, FR(column) = 0.17 +5191.49t A/Hp + 40.77t, FR(beam) = 0.25 +6899.31t A/Hp + 32.60t(where, FR means fire resistant time, t means thickness, A means cross-area and Hp means heated parameter).