• Proceedings of the Korean Society For Composite Materials Conference
• /
• 2003.04a
• /
• pp.180-183
• /
• 2003

In this work. a potential inexpensive epoxy resin. epoxidized soybean oil (ESO) was synthesized and applied as a toughening agent for 4.4'-tetradiglycidyl diaminodiphenyl methane (TGDDM). The chemical structure of ESO was characterized by FT-IR, $^1H NMR, and ^{13}C NMR$ spectroscopy. The curing behaviors. thermal stabilities. fracture toughness. and flexural strength of TGDDM/ESO blend systems were investigated by using the dynamic DSC. thermogravimetric analysis (TGA). and flexural tests. The thermal stabilities of TGDDM/ESO blend systems were decreased with increasing ESO contents. whereas the critical stress intensity factor ($K_{IC}$) and flexural strength ($\sigma_f$) were increased with ESO contents up to 10 wt% ESO.

• Knowledge Management Research
• /
• v.4 no.2
• /
• pp.95-105
• /
• 2003

The purpose of the current study is to explore what are critical success factors(CSFs) from Posco Engineering and Construction Company's knowledge management practice. From a deep case study of the company, five CSFs are delineated. The first factor is to clarify knowledge management vision and strategy so that people in the company clearly understand directions of where the company goes to implement knowledge management. The second one is to grip the whole picture of knowledge management realms. Narrow eyes for the knowledge management leads to failure. The third factor depends on how to acquire people's cooperation. The fourth one has something to do with a way of approach. Unilateral or delegated approach is fragile for the successful implementation of knowledge management. Shared approach raises the probability of success. The fifth one is to monitor implementation acts and processes.

• The Korean Journal of Applied Statistics
• /
• v.3 no.1
• /
• pp.89-103
• /
• 1990

An analysis of mean procedure is presented for testing the significance of two factor interactions for unbalanced case. When at least one factor if at only two levels, the technique is the same as that of Ott(1967) and Nelson(1988) except that we have used the critical value by using the Sidak's multiplicative inequality. The technique can be extended to the case in which both factors more than two levels. Tables of critical values g($\alpha ; (p, q) ; v$) are given for $\alpha$=0.05 and 0.01 ; (p, q) combinations satisfying $3 \leq p \leq q \leq 5$ ; and various degrees of freedom v. We present and prove the formula of the variance of the interactions for the n-way model.

• Journal of Korea Water Resources Association
• /
• v.32 no.4
• /
• pp.469-478
• /
• 1999

Explicit equations of minimum velocity, energy slope and pipe diameter are developed to ensure the cleaning of sewerage pipes. The equations of power form are employed for the estimation of critical shear stress of sediment particles and the friction factor of commercial pipes. They are all based on the existing laboratory data. Several cases are tested to check the values suggested in the manual, using the equations developed in the present study.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2011.05a
• /
• pp.181-184
• /
• 2011

The earlier studies which are related to conflict management for urban regeneration project were based on limited case-studies on a specific phase. In addition, those studies did not considered a multidisciplinary approach for critical factor of conflict occurrence. In this reason, to establish a practical management or a policy is limited. In this paper, 'Good communication and information sharing' and 'Cooperativeness of stakeholders on project' are defined by critical factors for minimization of conflict between stakeholders. Furthermore we analysis the influence of those factors to minimization of conflict using path-analysis. This paper contributes to increase the efficiency of conflict management through understanding influence of each factors.

• IMMUNE NETWORK
• /
• v.11 no.6
• /
• pp.336-341
• /
• 2011

T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus, quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to positive and negative selection. Recently, it has been suggested that self-reactive T cells, escape from negative selection, should be suppressed in the periphery by regulatory T cells (Tregs) expressing Foxp3 transcription factor. Foxp3 is a master factor that is critical for not only development and survival but also suppressive activity of Treg. However, signals that determine Treg fate are not completely understood. The availability of mutant mice which harbor mutations in TCR signaling mediators will certainly allow to delineate signaling events that control intrathymic (natural) Treg (nTreg) development. Thus, we summarize the recent progress on the role of TCR signaling cascade components in nTreg development from the studies with murine model.

• Development and Reproduction
• /
• v.21 no.4
• /
• pp.449-456
• /
• 2017

The germline stem cells of the Drosophila ovary continuously produce eggs throughout the life-span. Intricate regulation of stemness and differentiation is critical to this continuous production. The translational regulator Nos is an intrinsic factor that is required for maintenance of stemness in germline stem cells. Nos expression is reduced in differentiating cells at the post-transcriptional level by diverse translational regulators. However, molecular mechanisms underlying Nos repression are not completely understood. Through three distinct protein-protein interaction experiments, we identified specific molecular interactions between translational regulators involved in Nos repression. Our findings suggest a model in which protein complexes assemble on the 3' untranslated region of Nos mRNA in order to regulate Nos expression at the post-transcriptional level.

• Journal of the Korean Society for Precision Engineering
• /
• v.18 no.1
• /
• pp.111-116
• /
• 2001

A practical scheme to reduce failure of the PCB(Printed Circuit Board) of a monitor is introduced using deformed mode shape under mechanical shock. When the monitor is given critical shock loads, cracks are commonly initiated at the tip of a hole on the PCB. Accordingly, a deformed mode shape of the PCB is obtained using a FEM code to define a weak point on the PCB under mechanical shock, and then the position and direction of the hole is determined to prevent the failure at the critical mode shape. Also, the stress intensity factor around the weak point on the PCB is calculated to check the possibility of fracture by normal tensile stress. In conclusion, present research is useful to assist the practical design of components-layout on the PCB.

• Structural Engineering and Mechanics
• /
• v.3 no.3
• /
• pp.229-244
• /
• 1995

The parametric instability behaviour of a plate subjected to localized in-plane compressive or tensile periodic edge loading is studied, considering the effects of damping into the system. Different edge loading cases have been considered. Damping has been introduced in the form of proportional damping. Dynamic instability behaviour under compressive or tensile periodic edge loading shows that the instability regions are influenced by the load band width and its location on the edge. The effects of damping on the instability regions show that there is a critical value of dynamic load factor beyond which the plate becomes dynamically unstable. The critical dynamic load factor increases as damping increases. Damping generally reduces the widths of the instability regions.

• Tuberculosis and Respiratory Diseases
• /
• v.82 no.1
• /
• pp.42-52
• /
• 2019

Background: Transforming growth factor ${\beta}$ (TGF-${\beta}$), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis. We investigated the effect of RA and the role of these signaling molecules on the phosphorylation of Smad2/3 (p-Smad2/3) induced by TGF-${\beta}1$. Methods: A549 epithelial cells and CCD-11Lu fibroblasts were incubated and stimulated with or without all-trans RA (ATRA) and TGF-${\beta}1$ and with MAPK or MEK inhibitors. The levels of p-Smad2/3 were analyzed by western blotting. For animal models, we studied three experimental mouse groups: control, bleomycin, and bleomycin+ATRA group. Changes in histopathology, lung injury score, and levels of TGF-${\beta}1$ and Smad3 were evaluated at 1 and 3 weeks. Results: When A549 cells were pre-stimulated with TGF-${\beta}1$ prior to RA treatment, RA completely inhibited the p-Smad2/3. However, when A549 cells were pre-treated with RA prior to TGF-${\beta}1$ stimulation, RA did not completely suppress the p-Smad2/3. When A549 cells were pre-treated with MAPK inhibitor, TGF-${\beta}1$ failed to phosphorylate Smad2/3. In fibroblasts, p38 MAPK inhibitor suppressed TGF-${\beta}1$-induced p-Smad2. In a bleomycin-induced lung injury mouse model, RA decreased the expression of TGF-${\beta}1$ and Smad3 at 1 and 3 weeks. Conclusion: RA had inhibitory effects on the phosphorylation of Smad induced by TGF-${\beta}1$ in vitro, and RA also decreased the expression of TGF-${\beta}1$ at 1 and 3 weeks in vivo. Furthermore, pre-treatment with a MAPK inhibitor showed a preventative effect on TGF-${\beta}1$/Smad phosphorylation in epithelial cells. As a result, a combination of RA and MAPK inhibitors may suppress the TGF-${\beta}1$-induced lung injury and fibrosis.