• Interaction and multiscale mechanics
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• 제4권2호
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• pp.165-171
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• 2011

In this study, we proposed a three-dimensional dynamic model under the diffuse interface description for the single crawling cell. From the developed model, we described the clear evolution processes for crawling neutrophil and assessed the reliable quantitative chemotactic property, which confirmed the high possibility of adequate predictions. To establish the system considering of multiple mechanisms such as, diffusion, chemotaxis, and interaction with surface, a diffuse interface model is employed.

• 대한기계학회논문집A
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• 제35권11호
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• pp.1355-1360
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• 2011

흡착형 세포의 이동에 있어 세포와 바닥면간의 상호작용은 매우 중요한 역할을 한다. 본 논문은 주화성에 의한 흡착형 세포의 이동에 있어 세포와 바닥면과의 상호작용에 따른 영향을 보이기 위해 확산계면모델을 바탕으로 한 3 차원의 입체 모델을 제안한다. 세포와 바닥면간의 영향을 표현하기 위해 세포 주위 물질과의 관계를 고려한 경계에너지를 고려하였다. 본 연구에서 적용한 확산계면모델은 경계에너지, 주화성, 확산성을 모두 고려한 다중 메커니즘 모델로서 흡착형 세포이동의 역학적 특성을 정확히 예측하는데 있어 높은 신뢰성을 보일 것이라 기대된다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1638-1642
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• 2008

Cell migration is one of the essential mechanisms responsible for complex biological processes. Intensive researches have begun to elucidate the mechanisms and search intriguing conditions for efficient control of cell migration. One general mechanism which is widely applicable for cells including neutrophil, Escherichia coli and endothelial cell is chemotaxis. Especially, understanding the chemotactic mechanics of cell crawling has important implications for various medical and biological applications. The single cell study for chemotaxis has an advantage over studies with the population of cells in providing a clearer observation of cell migration, which leads to more accurate assessments of chemotaxis. In this paper, we propose a three-dimensional model considering a single crawling cell to study its chemotaxis. The semi-implicit Fourier spectral method is applied for high efficiency and numerical stability. The simulation results reveal rich dynamics of cell.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.4997-4999
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• 2015

Advanced oral squamous cell carcinoma (SCC) is a possible risk factor for myiasis, a parasitic infestation of vital tissue of humans or other mammals by dipterous larvae (maggots). Oral myiasis is a rare entity, and is mostly associated with various medical and anatomical conditions, such as neglected mandibular fracture, lip incompetence, cerebral palsy, poor oral hygiene, suppurative lesions, and cancerous wounds. Larvae cause itching and irritation due to their crawling movements and can destroy vital tissues, inducing serious or even life-threating hemorrhage. The aim of the present article was to highlight the occurrence of oral myiasis in association with squamous cell carcinoma and also to highlight the treatment and preventive approaches for such cases. A literature search was performed using MEDLINE for articles published in English relating to the occurrence of oral myiasis in oral SCC. Our search revealed 6 reports on myiasis associated with oral SCC. The surgical debridement of infected tissue with the removal of maggots is the treatment of choice in most cases of oral myiasis.