• Journal of Preventive Medicine and Public Health
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• 제56권3호
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• pp.221-230
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• 2023

Objectives: The second wave of coronavirus disease 2019 (COVID-19) cases in Indonesia, during which the Delta variant predominated, took place after a vaccination program had been initiated in the country. This study was conducted to assess the impact of COVID-19 vaccination on unfavorable clinical outcomes including hospitalization, severe COVID-19, intensive care unit (ICU) admission, and death using a real-world model. Methods: This single-center retrospective cohort study involved patients with COVID-19 aged ≥18 years who presented to the COVID-19 emergency room at a secondary referral teaching hospital between June 1, 2021 and August 31, 2021. We used a binary logistic regression model to assess the effect of COVID-19 vaccination on unfavorable clinical outcomes, with age, sex, and comorbidities as confounding variables. Results: A total of 716 patients were included, 32.1% of whom were vaccinated. The elderly participants (≥65 years) had the lowest vaccine coverage among age groups. Vaccination had an effectiveness of 50% (95% confidence interval [CI], 25 to 66) for preventing hospitalization, 97% (95% CI, 77 to 99) for preventing severe COVID-19, 95% (95% CI, 56 to 99) for preventing ICU admission, and 90% (95% CI, 22 to 99) for preventing death. Interestingly, patients with type 2 diabetes had a 2-fold to 4-fold elevated risk of unfavorable outcomes. Conclusions: Among adults, COVID-19 vaccination has a moderate preventive impact on hospitalization but a high preventive impact on severe COVID-19, ICU admission, and death. The authors suggest that relevant parties increase COVID-19 vaccination coverage, especially in the elderly population.

• Journal of Korean Biological Nursing Science
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• 제23권4호
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• pp.330-338
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• 2021

Purpose: This cross-sectional study aimed to identify factors affecting coronavirus disease 2019 (COVID-19) vaccination intention. Methods: For an anonymous online survey, recruitment notices were posted on an anonymous community by each university, and an online survey was conducted through online form from June to July 2021. COVID-19 knowledge and health-protective behavior were measured using a questionnaire based on previous literature and reflecting the Korea Centers for Disease Control and Prevention's COVID-19 Response Guidelines. The psychological antecedents of vaccination were measured by 5C scale. Results: Two-hundred and ninety-four college students (women 67.3%) answered the survey; 179 (60.9%) reported that they would accept a COVID-19 vaccine. The mean scores for COVID-19 knowledge and health-protective behavior were 22.97±5.33 (out of 35) and 9.92±2.22 (out of 12), respectively. For the psychological antecedents of vaccination, the mean scores for confidence, collective responsibility, calculation, complacency, and constraints were 4.45 (± 1.24), 5.61 (± 1.09), 5.09 (± 1.18), 2.42 (± 1.11), and 2.37 (± 1.19) out of 5 points, respectively. The confidence, calculation, and collective responsibility were associated with vaccination intention. Additionally, the top reason for those who were less prone to accept vaccination against COVID-19 was concern about vaccine safety. Conclusion: The higher the confidence in the vaccine and the higher the collective responsibility, the higher the vaccination intention. As it is a factor related to an individual's perception of COVID-19 information, it is necessary to increase confidence in the vaccines through obtaining accurate information on the safety, effectiveness, and side effects of the COVID-19 vaccines and vaccination.

• Journal of Medicine and Life Science
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• 제20권2호
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• pp.73-82
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• 2023

Multiple studies have reported on unilateral axillary adenopathy following coronavirus disease 2019 (COVID-19) vaccination, which is currently recognized as a common finding. Here, we present a series of eight adult patients with reactive axillary lymphadenopathy following COVID-19 vaccination, in whom the follow-up ultrasonography (US) showed resolution of a previously noted unilateral axillary adenopathy. From March 2021 to March 2022, 2,599 consecutive women underwent breast US in Jeju National University Hospital. We identified 10 patients with unilateral axillary lymphadenopathy following COVID-19 vaccination detected on the breast US. The 10 patients were recommended for follow-up US. Two patients were lost to follow-up, whereas the remaining eight patients underwent follow-up US, in whom resolution of the unilateral axillary lymphadenopathy was noted. Radiologists should be aware of evolving guidelines for evaluating and managing axillary lymphadenopathy to avoid false positive biopsies. Recent studies on lymphadenopathy following COVID-19 vaccination show that a prolonged duration until resolution is often observed. Therefore, a follow-up US examination at least 12 weeks after vaccination may be reasonable. Furthermore, management guidelines should include a risk-stratified approach considering both vaccination timing and the patient's overall risk of metastatic disease.

• 한방안이비인후피부과학회지
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• 제35권3호
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• pp.95-106
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• 2022

Objectives: The purpose of this study is to report a case of lymphadenopathy and hearing loss in a patient after coronavirus disease 2019(COVID-19) vaccination. Methods: The patient diagnosed as lymphadenopathy and hearing loss(sensorineural hearing loss) after the first and second rounds of the Pfizer COVID-19 vaccination. We applied Korean medical treatment including herbal medicine and acupuncture for lymphadenopathy and SSNHL. We used VAS(Visual Analog Scale), CT-scan and Pure Tone Audiometry to estimate they symptoms. Results: After the treatment, general symptoms of lymphadenopathy and hearing loss including aural fullness showed big improvement. Conclusions: This case report shows effect of Korean medicine on lymphadenopathy and SSNHL and suggests a possibility of Korean medicine to treat adverse events following COVID-19 vaccination.

• 대한한방내과학회지
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• 제43권6호
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• pp.1255-1263
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• 2022

Objective: To report a clinical case of Guillain-Barré syndrome-like neurological symptoms, including limb weakness, phantosmia, and nausea/vomiting after COVID-19 vaccination (AstraZeneca) that was improved by traditional Korean medicine (TKM) treatment. Methods: A 73-year-old male complained of extreme limb weakness, severe phantosmia, and nausea/vomiting after COVID-19 vaccination. No abnormalities had appeared in various radiological and laboratory tests, but the symptoms had continued to worsen for three months before visiting our clinic. Results: The patient was diagnosed with neurological complications suspicious of Guillain-Barré syndrome after COVID-19 vaccination. The patient was treated with acupuncture, moxibustion, herbal drugs (Banhabakchulchunma-tang), and nasal inhalation therapy with Aquilariae Lignum. Three weeks after Korean medicine treatment, his neurological symptoms had improved. Nausea/vomiting and phantosmia continued to show improvement, and muscle strength was gradually recovered in both lower limbs. Conclusion: Traditional Korean medicine could be a choice for the treatment of neurological complications after COVID-19 vaccination.

• Journal of Oral Medicine and Pain
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• 제47권1호
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• pp.62-66
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• 2022

Recent case studies raised the possibility that cutaneous and oral mucosal manifestations may be associated with the coronavirus disease 2019 (COVID-19) vaccination. A healthy 43-year-old male presented an acute aphthous stomatitis following Moderna COVID-19 vaccination. This rare case draws attention to a potential etiologic effect for oral mucosal manifestation from COVID-19 vaccination. Further investigation to shed light on prevalence and pathophysiologic association of this oral lesion and COVID-19 vaccination deserve attention.

• 대한간호학회지
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• 제53권2호
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• pp.208-211
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• 2023

Purpose: This study aimed to investigate COVID-19 vaccination intentions in Korean parents for their children aged 5 to 11 years and the factors influencing them. Methods: A cross-sectional online survey of 363 parents of children aged 5 to 11 years was conducted in Korea in April 2022. Data were analyzed using independent t-test, χ² -test, Fisher's exact test, and hierarchical logistic regression analysis using SPSS/WIN 26.0 and MedCalc software version 20.113. Results: Of 363 Korean parents with children aged 5 to 11, 42.4% intended to vaccinate their children. Significant factors influencing vaccination intention were the second or third birth order of children (OR = 3.45, 95% CI = 1.45~8.21), vaccine hesitancy-confidence (OR = 2.00, 95% CI = 1.51~2.65), vaccine hesitancy-collective responsibility (OR = 1.57, 95% CI: 1.10~2.25), and COVID-19 anxiety-avoidance (OR = 1.55, 95% CI = 1.13~2.11). Conclusion: Findings suggest that COVID-19 vaccine campaigns based on reliable information and evidence from health authorities are needed to increase COVID-19 vaccination. Well-designed health communications for the target population may help to increase parental vaccine acceptance.

• 항공우주의학회지
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• 제31권1호
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• pp.13-16
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• 2021

The coronavirus disease-19 (COVID-19) vaccine is expected to play an important role in stopping the pandemic. Studies show that COVID-19 vaccines are effective at keeping you from getting COVID-19. Getting a COVID-19 vaccine will also help keep you from getting seriously ill even if you do get COVID-19. Efforts to find an effective vaccine against severe acute respiratory syndrome coronavirus 2 have progressed unprecedentedly through active support from public research grants and private-public partnership programs. Clinical studies have been actively conducted, and some vaccines are being vaccinated with approval for urgent use. The WHO has approved and supplied the Pfizer-BioNTech COVID-19 vaccine and the Oxford-AstraZeneca COVID-19 vaccine. In Korea, the Oxford-AstraZeneca vaccine was approved for urgent use, and vaccination began on February 26, 2021. In this paper, the efficacy and side effects of each vaccines and the effect on pilots and air traffic controllers related to COVID-19 vaccination were investigated in terms of aviation medicine.

• Pediatric Infection and Vaccine
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• 제29권1호
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• pp.37-45
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• 2022

본 델파이 연구에서는 5-11세 소아청소년의 코로나19 백신 접종과 관련하여 소아청소년 감염 분과 전문의와 코로나19 백신 전문가들을 대상으로 온라인 설문 조사를 시행하였다. 총 20문항에 대해 두 라운드 동안 각각 46명, 38명이 설문에 응답하였다. 패널들은 5-11세 소아청소년들이 코로나19에 쉽게 감염되지만 중증 진행의 위험도는 여전히 낮은 것으로 판단하였고, 만성 질환을 가진 소아는 중증 진행 위험도가 약간 있는 것으로 평가하였다. 코로나19 백신은 5-11세 소아에게 대체로 위험하지 않다고 응답하였고, 백신 접종의 기대 이익과 잠재적인 위해에 대한 비교는 대체적으로 중립적인 견해를 보였다. 또한 현재 소아에게 유일하게 허가된 mRNA 백신 플랫폼은 지속 가능하겠지만 소아에게는 재조합 단백질 플랫폼 백신이 추후 가장 적절할 것으로 평가되었다. 최종적으로 5-11세 소아에게 코로나19 예방 접종 권장에 대해서는 중립적인 입장을 보였다. 이에 모든 소아청소년들에게 일괄적인 접종 보다는 개별화된 선별 접종이 더 바람직할 것으로 보이며, 소아의 코로나19 백신 접종에 대한 과학적 근거 마련을 위한 지속적인 모니터링이 필요할 것으로 보인다.

• 한국간호교육학회지
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• 제28권3호
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• pp.296-304
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• 2022

Purpose: This study aimed to examine the association of COVID-19 vaccine attitudes and cognitions of COVID-19-related stigma with vaccine hesitancy among college students. Methods: This cross-sectional study using a web-based survey was conducted with 242 college students in April 2021 before Korea's national COVID-19 vaccination program had begun. Data were analyzed using multinominal logistic regression analyses. Results: Of the participants who were unsure of their intention to receive the COVID-19 vaccine, 66.0% had less experience with flu vaccinations and were 1.43 times more likely to report a mistrust of vaccine benefits (OR=1.43, CI=1.22, 1.68). Those with no intention of receiving the vaccine were 25.0% less likely to be aware of COVID-19 stigma (OR=0.75, CI=0.65, 0.86), 2.08 times more likely to mistrust vaccine benefits (OR=2.08, CI=1.62, 2.68), and 1.53 times more likely to worry about an unforeseen future negative side effects from vaccination (OR=1.53. CI=1.16, 2.00). Conclusion: Nurses could play an important role in educating college students about vaccination benefits, including reviewing vaccines' side effects with evidence, to reduce vaccine hesitancy. College students who have less empathy for others regarding COVID-19 infection might have higher COVID-19 vaccine hesitancy. Accordingly, explaining to students the necessity of their vaccination in preventing transmission to the surrounding community and vulnerable populations is critical.