• Archives of Pharmacal Research
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• 제23권3호
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• pp.230-236
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• 2000

(1'R, 2R)-, (1'R, 2S)-, (1'S, 2R)- and (1'S, 2S)-$\alpha$-hydroxymetoprolol; (2R)- and (2S)-O-des-methylmetoprolol; and (2R)- and (2S)-metoprolol acid are major metabolites of (2R)-and (2S)-metoprolol, $\beta$-adrenergic antagonist. The focus of most chiral separation methods until now has been on determination of the enantiomeric parent drug. However, it is just as important to be able to follow the metabolism of the enantiomers and their possible chiral metabolites. Therefore, for the study of stereoselective metabolism and pharmacokinetics of metoprolol, the chiral separation of the enantiomers of metoprolol and its metabolites has been investigated using four chiral stationary phases, i.e., Chiralcel OD, Chiral-AGP, Cyclobond I and Sumichiral OA-4900 columns. Metoprolol acid was resolved only by Sumichiral OA-4900. Chiralcel OD provided the highest separation factor and resolution value for metoprolol and O-desmethylmetoprolol and partially resolved the four stereoisomers of $\alpha$-hydroxymetoprolol. Diastereomeric $\alpha$-hydroxymetoprolols were resolved using the coupled column chromatographic system of two chiral stationary phases, Sumichiral OA-4900 column and Chiralcel OD column.

• 대한원격탐사학회지
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• 제18권1호
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• pp.53-59
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• 2002

The MSC is a payload on the KOMPSAT-2 satellite to perform the earth remote sensing. The instrument images the earth using a push-broom motion with a swath width of 15 km and a GSD(Ground Sample Distance) of 1 m over the entire FOV(Field Of View) at altitude 685 km. The instrument is designed to haute an on-orbit operation duty cycle of 20% over the mission lifetime of 3 years with the functions of programmable gain/offset and on-board image data compression/storage. The MSC instrument has one channel for panchromatic imaging and four channel for multi-spectral imaging covering the spectral range from 450nm to 900nm using TDI(Time Belayed Integration) CCD(Charge Coupled Device) FPA(Focal Plane Assembly). The MSC hardware consists of three subsystem, EOS(Electro Optic camera Subsystem), PMU(Payload Management Unit) and PDTS(Payload Data Transmission Subsystem) and each subsystems are currently under development and will be integrated and verified through functional and space environment tests. Final verified MSC will be delivered to spacecraft bus for AIT(Assembly, Integration and Test) and then COMSAT-2 satellite will be launched after verification process through IST(Integrated Satellite Test). In this paper, the introduction of MSC, the configuration of MSC electronics including electrical interlace and design of CEU(Camera Electronic Unit) in EOS are described. MSC Operation parameters induced from the operation concept are discussed and analyzed to find the influence of system for on-orbit operation in future.

• Bulletin of the Korean Chemical Society
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• 제19권6호
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• pp.654-660
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• 1998

$[Fe^{II}Fe^{III}BPLMP(OAc)_2](BPh_4)_2$ (1), a new model for the reduced form of the purple acid phosphatases, has been synthesized by using a dinucleating ligand, 2,6-bis[((2-pyridylmethyl)(6-methyl-2-pyridylmethyl)amino) methyl]-4-methylphenol (HBPLMP). Complex I has been characterized by X-ray diffraction method as having (μ-phenoxo)bis(acetato)diiron core. Complex 1 was crystallized in the monoclinic space group C2/c with the following cell parameters: a=41.620(6) Å, b=14.020(3) Å, c=27.007(4) Å, β=90.60(2)°, and Z=8. The iron centers in the complex 1 are ordered as indicated by the difference in the Fe-O bond lengths which match well with typical $Fe^{III}-O\; and\; Fe^{II}-O$ bond lengths. Complex 1 has been studied by electronic spectral, NMR, EPR, SQUID, and electochemical methods. Complex 1 exhibits strong bands at 592 nm, 1380 nm in $CH_3CN$ (ε = 1.0 × 103 , 3.0 × 102). These are assigned to $phenolate-to-Fe^{III}$ and intervalence charge-transfer transitions, respectively. Its NMR spectrum exhibits sharp isotropically shifted resonances, which number half of those expected for a valence-trapped species, indicating that electron transfer between $Fe^{II}\;and\;Fe^{III}$ centers is faster than NMR time scale. This complex undergoes quasireversible one-electron redox processes. The $Fe^{III}_2/Fe^{II}Fe^{III}\;and\;Fe^{II}Fe^{III}/Fe^{II}_2$ redox couples are at 0.655 and -0.085 V vs SCE, respectively. It has $K_{comp}=3.3{\times}10^{12}$ representing that BPLMP/bis(acetate) ligand combination stabilizes a mixed-valence $Fe^{II}Fe^{III}$ complex in the air. Complex 1 exhibits a broad EPR signal centered near g=1.55 which is a characteristic feature of the antiferromagnetically coupled high-spin $Fe^{II}Fe^{III}$ system $(S_{total}=1/2)$. This is consistent with the magnetic susceptibility study showing the weak antiferromagnetic coupling $(J= - 4.6\;cm^{-1},\; H= - 2JS_1{\cdot}S2)$ between $Fe^{II}\; and \;Fe^{III}$center.

• Earthquakes and Structures
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• 제17권4호
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• pp.373-385
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• 2019

In this article, different frequently adopted modeling aspects of linear and nonlinear dynamic soil-structure interaction (SSI) are studied on a pile-supported integral abutment bridge structure using the open-source platform OpenSees (McKenna et al. 2000, Mazzoni et al. 2007, McKenna and Fenves 2008) for a 2D domain. Analyzed approaches are as follows: (i) free field input at the base of fixed base bridge; (ii) SSI input at the base of fixed base bridge; (iii) SSI model with two dimensional quadrilateral soil elements interacting with bridge and incident input motion propagating upwards at model bottom boundary (with and without considering the effect of abutment backfill response); (iv) simplified SSI model by idealizing the interaction between structural and soil elements through nonlinear springs (with and without considering the effect of abutment backfill response). Salient conclusions of this paper include: (i) free-field motions may differ significantly from those computed at the base of the bridge foundations, thus put a significant bias on the inertial component of SSI; (ii) conventional modeling of SSI through series of soil springs and dashpot system seems to stay on the safer side under dynamic conditions when one considers the seismic actions on the structure by considering a fully coupled SSI model; (iii) consideration of abutment-backfill in the SSI model positively affects the general response of the bridge, as a result of large passive resistance that may develop behind the abutments.

• 한국전자통신학회논문지
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• 제14권5호
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• pp.1009-1018
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• 2019

본 연구에서는 표면근전도 측정기 기반의 재활의료기기의 설계 및 구현에 관한 내용을 기술한다. 재활시스템은 BLDC모터와 모터 드라이브를 이용하여 제어된다. BLDC모터 드라이브는 동작제어를 하며, 속도는 외부 서보모터를 통해 드라이브를 제어한다. 또한 모터 외부에 결합된 포텐쇼미터는 모터에 의해 회전하는 부하 위치 정보를 전달한다. 재활 알고리즘은 환자가 일정 각도 범위에서 주기적인 수축 이완 재활운동을 속도단계별로 실행하며 재활운동 시 사용자 설정 단계에 따른 모터를 활용하여 $0{\sim}120[^{\circ}]$의 최대각도로 제한하여 제어한다. 보행 알고리즘은 양쪽 안쪽넓은근에 부착된 표면근전도 측정기로 획득한 신호의 차이 값을 이용하여 근전도 신호가 낮은 다리에 모터제어로 보상해주며 보행운동 시 모터와 표면근전도 측정기를 활용하여 $0{\sim}88[^{\circ}]$의 최대각도로 제한하여 제어한다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2015년도 학술발표회
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• pp.467-467
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• 2015

Sustainable water resource management requires the assessment of hydrological variability in response to climate fluctuations and anthropogenic activities. Determining quantitative estimates of water balance and total basin discharge are of utmost importance to understand the variations within a basin. Hard-to-reach areas with few infrastructures, coupled with lengthy administrative procedures makes in-situ data collection and water management processes very difficult and unreliable. In this study, the hydrological behavior of Lake Chad whose extent, extreme climatic and environmental conditions make it difficult to collect field observations was examined. During a 10 year period [January 2003 to December 2013], dataset from space-borne and global hydrological models observations were analyzed. Terrestial water storage (TWS) data retrieved from Gravity Recovery and Climate Experiment (GRACE), lake level variations from Satellite altimetry, water fluxes and soil moisture from Global Land Data Assimilation System (GLDAS) were used for this study. Furthermore, we combined altimetry lake volume with TWS over the lake drainage basin to estimate groundwater and soil moisture variations. This will be validated with groundwater estimates from WaterGAP Global Hydrology Model (WGHM) outputs. TWS showed similar variation patterns Lake water level as expected. The TWS in the basin area is governed by the lake's surface water. As expected, rainfall from GLDAS precedes GRACE TWS with a phase lag of about 1 month. Estimates of groundwater and soil moisture content volume changes derived by combining altimetric Lake Volume with TWS over the drainage basin are ongoing. Results obtained shall be compared with WaterGap Hydrology Model (WGHM) groundwater estimate outputs.

• Advances in aircraft and spacecraft science
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• 제3권3호
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• pp.351-366
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• 2016

Macroperforations improve the sound absorption performance of porous materials in acoustic cavities and in waveguides. In an acoustic cavity, enhanced noise reduction is achieved using porous materials having macroperforations. Double porosity materials are obtained by filling these macroperforations with different poroelastic materials having distinct physical properties. The locations of macroperforations in porous layers can be chosen based on cavity mode shapes. In this paper, the effect of variation of macroporosity and double porosity in porous materials on noise reduction in an acoustic cavity is presented. This analysis is done keeping each perforation size constant. Macroporosity of a porous material is the fraction of area covered by macro holes over the entire porous layer. The number of macroperforations decides macroporosity value. The system under investigation is an acoustic cavity having a layer of poroelastic material rigidly attached on one side and excited by an internal point source. The overall sound pressure level (SPL) inside the cavity coupled with porous layer is calculated using mixed displacement-pressure finite element formulation based on Biot-Allard theory. A 32 node, cubic polynomial brick element is used for discretization of both the cavity and the porous layer. The overall SPL in the cavity lined with porous layer is calculated for various macroporosities ranging from 0.05 to 0.4. The results show that variation in macroporosity of the porous layer affects the overall SPL inside the cavity. This variation in macroporosity is based on the cavity mode shapes. The optimum range of macroporosities in poroelastic layer is determined from this analysis. Next, SPL is calculated considering periodic and nodal line based optimum macroporosity. The corresponding results show that locations of macroperforations based on mode shapes of the acoustic cavity yield better noise reduction compared to those based on nodal lines or periodic macroperforations in poroelastic material layer. Finally, the effectiveness of double porosity materials in terms of overall sound pressure level, compared to equivolume double layer poroelastic materials is investigated; for this the double porosity material is obtained by filling the macroperforations based on mode shapes of the acoustic cavity.

• Coupled systems mechanics
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• 제4권4호
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• pp.297-316
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• 2015

The use of fragility curves in the design of bridges is becoming common these days. In this study, experimental data have been used to develop fragility curves for the potential of girder unseating of a three-segment bridge and a bridge-abutment system including the influence of spatially varying ground motions, pounding, and abutment movement. The ground excitations were simulated based on the design spectra for different soil conditions. The Newmarket Viaduct replacement bridge in Auckland was used as the prototype bridge. These fragility curves were also applied to the 2010 Darfield and 2011 Christchurch earthquakes. The study showed that for bridges with similar characteristics as the chosen prototype and with similar fundamental frequencies, pounding could increase the probability of girder unseating by up to 35% and 30% based on the AASHTO and NZTA seating length requirements, respectively. The assumption of uniform ground excitations in many design practices, such as the NZTA requirements, could potentially be disastrous as girders might have a very good chance of unseating (as much as 53% higher chances when considering spatial variation of ground motions) even when they are designed not to. In the case of superstructures with dissimilar frequencies, the assumption of fixed abutments could significantly overestimate the girder unseating potential when pounding was ignored and underestimate the chances when pounding was considered. Bridges subjected to spatially varying ground excitations simulated based on the New Zealand design spectra for soft soil conditions with weak correlation shows the highest chances of girders falling off, of up to 65% greater than for shallow soil excitations.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2002년도 학술대회지
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• pp.238-252
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• 2002

In order to screen out indicators for the discrimination of ginseng habitat, some physical and chemical characteristics of Korean red ginsengs (94 kinds) and Chinese red ginsengs (50 kinds) were analyzed by using a rheometer, an electronic nose system, a combined technique of solid phase micro-extraction (SPME) and gas chromatograph equipped with an electron capture detector (GC/ECD), an X-ray fluorescence spectrometer (XRF), an inductively coupled plasma mass spectrometer (ICP/MS), a near infrared spectrometer (NIRs) and high performance liquid chromatography equipped with evaporative light scattering detector (HPLC/ELSD). The results are summarized as follows: (i) The rhizome strengths of Korean red ginsengs were significantly higher than those of Chinese red ginsengs. (ii) The electronic nose patterns of Korean red ginsengs were significantly different from those of Chinese red ginsengs. (iii) Some unidentified peaks were detected not in the headspace of Korean red ginsengs but in the headspace of Chinese red ginsengs when the headspace volatiles prepared by the SPME technique were analyzed by GC/ECD. (iv) Either the content ratios of K to Ca or Mn to Fe were significantly different between Korean red ginsengs and Chinese red ginsengs. (v) The reflectance ratios of NIRs wavenumbers such as $904\;cm^{-1}\;to\;1088\;cm^{-1}$ for Korean red ginsengs were significantly different from those for Chinese red ginsengs. (vi) The content ratios of ginsenoside-Rg to ginsenoside-Re of Korean red ginsengs were significantly higher than those of Chinese red ginsengs. These results indicate that the rhizome strength, the electronic nose pattern, the occurrence of ECD-sensitive headspace volatile components, the content ratios of K to Ca and Mn to Fe, the NIRs pattern and the content ratio of ginsenoside-Rg to -Re may be indicators for the discrimination of ginseng habitat.

• Macromolecular Research
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• 제16권3호
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• pp.204-211
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• 2008

A platinum-catalyzed polyelectrolyte porous membrane was prepared by solid-state compression of electrospun polystyrene (PS) fibers and in-situ metallization of counter-balanced ionic metal sources on the polymer surface. Using this ion-exchange metal-polymer composite system, fiber entangled pores were formed in the interstitial space of the fibers, which were surrounded by sulfonic acid sites ($SO_3^-$) to give a cation-selective polyelectrolyte porous bed with an ion exchange capacity ($I_{EC}$) of 3.0 meq/g and an ionic conductivity of 0.09 S/cm. The Pt loading was estimated to be 16.32 wt% from the $SO_3^-$ ions on the surface of the sulfonated PS fibers, which interact with the cationic platinum complex, $Pt(NH_3)_4^{2+}$, at a ratio of 3:1 based on steric hindrance and the arrangement of interacting ions. This is in good agreement with the Pt loading of 15.82 wt% measured by inductively coupled plasma-optical emission spectroscopy (ICP-OES). The Pt-loaded sulfonated PS media showed an ionic conductivity of 0.32 S/cm. The in-situ metallized platinum provided a nano-sized and strongly-bound catalyst in robust porous media, which highlights its potential use in various electrochemical and catalytic systems.