• Journal of Microbiology and Biotechnology
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• v.29 no.11
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• pp.1830-1840
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• 2019

Loliolide is one of the most ubiquitous monoterpenoid compounds found in algae, and its potential therapeutic effect on various dermatological conditions via agent-induced biological functions, including anti-oxidative and anti-apoptotic properties, was demonstrated. Here, we investigated the effects of loliolide on hair growth in dermal papilla (DP) cells, the main components regulating hair growth and loss conditions. For this purpose, we used a three-dimensional (3D) DP spheroid model that mimics the in vivo hair follicle system. Biochemical assays showed that low doses of loliolide increased the viability and size of 3D DP spheroids in a dose-dependent manner. This result correlated with increases in expression levels of hair growth-related autocrine factors including VEGF, IGF-1, and KGF. Immunoblotting and luciferase-reporter assays further revealed that loliolide induced AKT phosphorylation, and this effect led to stabilization of β-catenin, which plays a crucial role in the hair-inductive properties of DP cells. Further experiments showed that loliolide increased the expression levels of the DP signature genes, ALP, BMP2, VCAN, and HEY1. Furthermore, conditioned media from loliolide-treated DP spheroids significantly enhanced proliferation and the expression of hair growth regulatory genes in keratinocytes. These results suggested that loliolide could function in the hair growth inductivity of DP cells via the AKT/β-catenin signaling pathway.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.24 no.3
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• pp.134-145
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• 1998

Facial hyperpigmentation in women, which is considered to be a serious cosmetic disability and a cause of mental distress, requires proper management. Melanocyte dendricity is a crucial factor affecting epidermal pigmentation. We found that BQ-788, the endothelin-B (ETB) receptor antagonist, blocks the formation of multi-dendricity which is induced by cocultured keratinocytes. Melanocytes in vivo show numerous dendrites which are in close contact with multiple keratinocytes, forming the epidermal-melanin unit. While melanocytes transfer their melanosomes into the neighboring keratinocytes via dendrites, keratinocytes secrete many growth factors and cytokines that influence viability, morphology, and melanin formation of melanocytes. Endothelin-1 (ET-1), prostaglandin E2(PGE2), and leukotriene-C4 (LT-C4) have been suggested as the candidates for increasing dendricity. Other reports suggested that ET-1 has stimulatory effects on proliferation and melanin formation of melanocytes in vitro. In the present study, using type-specific ET receptor antagonists, we observed how the morphology of melanocytes could be modulated in a coculture system. In addition, the roles of ET-1 for morphology and proliferation on melanocytes were evaluated in different culture media. We suggest that ET-1 increases dendricity and proliferation of melanocytes, and that its dendrite-inducing effect and mitogenic effect are regulated independently.

• Microbiology and Biotechnology Letters
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• v.48 no.4
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• pp.471-479
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• 2020

The aim of this study was to investigate the anti-oxidant and anti-inflammatory activities of the Rhododendron weyrichii flower extract fermented using Shindari, a traditional Jeju barley Nuruk-based fermentation. In this study, we examined the antioxidant potential of R. weyrichii flower extracts (RF) and R. weyrichii flower extracts fermented with Nuruk or Shindari (RFFN or RFFS, respectively) using various in vitro antioxidant assays including DPPH and ABTS radical scavenging assays, total phenol content and FRAP assays. We also evaluated the anti-inflammatory activity of the RF and RFFS on murine RAW 264.7 cells. The anti-inflammatory activity was evaluated by treating the RAW 264.7 cells with various concentrations (6.25, 12.5, 25, and 50 ㎍/ml) of RF or RFFS. As a result, we observed that the ABTS radical scavenging activity and total phenol content of RFFS was higher than that of RF and RFFN. Additionally, lipopolysaccharide-induced nitric oxide (NO) production was significantly lower in RFFS-treated cells when compared to the LPS-treated control. In addition, RFFS-treated cells exhibited decreased expression of inducible NO synthase (iNOS) proteins and high-performance liquid chromatography (HPLC) fingerprinting showed that both the quercetin and quercetin glucoside (quercitrin and isoquercitrin) levels were affected by the fermentation process. In conclusion, our data suggests that traditional fermentation could be an important strategy in improving the biological properties of raw materials including their antioxidant and anti-inflammatory activities. Finally, RFFS may be a candidate for developing topical antioxidant and anti-inflammatory agents.

• Analytical Science and Technology
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• v.35 no.1
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• pp.32-40
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• 2022

The concentrations of radon in the atmosphere were measured at the Gosan site of Jeju Island during 2017-2018, in order to investigate the time-series variation characteristics and the dependency of airflow transport pathways. The mean ²²²Rn concentration was 2,480 mBq m^-3, and its monthly concentration in November was 3,262 mBq m^-3, more than twice as that in July (1,459 mBq m^-3). The diurnal radon concentrations increased throughout the nighttime to the maximum (2,862 mBq m^-3) at around 7 a.m., then gradually decreased throughout the daytime by the minimum (1,997 mBq m^-3) at around 3 p.m. The seasonal and monthly variations of CO, NO₂, O₃ showed a roughly similar pattern to that of radon for the same period, as high in winter and low in summer. The cluster back trajectory analysis described that about 60 % of overall airflow pathways was influenced by the airflow from China. The concentrations of radon and gaseous pollutants were relatively high as the airflow was influenced by China continent, but comparatively much lower as influenced by the northern Pacific Ocean.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.8
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• pp.236-250
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• 2016

This study was conducted to provide baseline data regarding functional cosmetics so that Inula. based cosmetics can increase its competitiveness in the market as well as to understand current trends to enable anticipation of demands for future product development. For this research, general consumers over the age of 20 residing in Seoul and the Gyeonggi district were surveyed. The results show consumers preferred serum-type products among various types of cosmetics, and that they purchased these once every 1-3 months. Consumers also preferred these products in less than 10-30ml capacity, and at costs of less than 30,000-50,000 KRW. For whitening, functional cosmetics consumers also preferred the serum type, in less than 30-50ml capacity and priced less than 30,000-50,000 KRW. Consumers preferred to purchase functional cosmetics in single units. The major purchasing location, with a high preference rate, was cosmetic stores, and the major sources of information, also with high preference rates, were 'experienced reviews from family, friends and acquaintances' and 'TV advertisements'. Respondents selected 'over 50,000 KRW' the most for all items when responding to 'Purchase Intent for Functional Cosmetics containing Inula', and responded that they were willing to pay 10%-30% more for functional cosmetics containing Inula compared to standard functional cosmetics. These results show that businesses in the cosmetics industry need to take consumer demand into account when developing new functional cosmetic products, as well as establish plans to create specialized spaces that provide better quality service and increase word of mouth effect through better utilization of various types of offline media, social media, and blogs. The study also shows a need for businesses to develop products fully utilizing the Inula flower, which has been shown to be effective as a natural skin whitener, wrinkle reducer and skin moisturizer, to appeal to the increasing number of customers interested in health and beauty.

• International Commerce and Information Review
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• v.17 no.3
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• pp.73-91
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• 2015

This study investigated how Korean image and cosmetics products image effect by the Korean Wave(Hanllyu) on the Vietnam Customer focus on the cosmetics. Especially, Korean Wave of this study consisted in the movie/drama, K-pop and Korean stars. Korean image and cosmetics brand image was effected by factors related to the Korean Wave which had been deducted, based on preceeding research. A study was conduct in Vietnam where the spread of the Korean Wave content customer bases has been over along time. A total of 295 samples were used for th final analysis. Data analysis consisted of descriptive statistics, Cronbach's alpha, a confirmatory factor analysis, and multi-regression. It is also found that Korean image and cosmetics brand image has affect by Korean Wave. and Cosmetics purchasing intention has affect Korean image and cosmetics brand image.

• Journal of the Korean Society of Clothing and Textiles
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• v.32 no.7
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• pp.1034-1045
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• 2008

The objectives of this study were to group female consumer types according to cosmetics benefits sought at online and off-line cosmetic shopping malls, and to investigate the differences in consumer values, cosmetic purchase behaviors, and demographic variables according to the consumer types. Subjects were 451 females residing in Seoul, of whom 212 were online shoppers and 239 were off-line shoppers. Five dimensions of cosmetics benefits sought were derived by factor analysis. These were functionality, economy, brand, fashion, and practicality. The female consumers were classified into four benefits sought types by cluster analysis of the five dimensions: T.1 'practicality sought type', T.2 'economy sought type', T.3 'brand function sought type', and T.4 'economic function sought type'. Economy sought consumers purchased cosmetics much more from online shopping malls than from off-line. The cosmetics expenses of practicality sought online consumers were low and many of them were in their 20's and middle-class. Economy sought online consumers preferred domestic brand, their cosmetics expenses were low, and many of them were career women. Practicality sought off-line consumers were high in independent value. Economy sought off-line consumers were low in independent value and social approval value, preferred domestic brand, and distributed more in college students than in career women. Brand function sought off-line consumers purchased cosmetics at department store and regarded social approval value as important. Economic function sought off-line consumers were distributed in middle-class and in diverse age range.

• Journal of the Korean Data and Information Science Society
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• v.25 no.6
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• pp.1273-1281
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• 2014

As a variety of industrial technology advances with various materials developed, cosmetics industry in general is witnessing many kinds of new cosmetic products. At the same time, Cosmetics Act becomes effective, and cosmetics ingredient labeling is implemented. Concerns with life pattern such as life management, biorhythm, right posture, and stress symptoms are on the increase in order to seek high-quality life as well. These life patterns are closely connected not only with life quality and health but with skin management, and thus this paper conducts a survey on the connection between functional cosmetics awareness and life pattern. Results show that out of 16 questions concerning cosmetics awareness, responses to question number 3, 5, 6 and 11 have relevant differences among colleges. Furthermore, the results of cross analysis with life pattern show that there are relevant differences between the year of responses and stress symptoms and between the year of responses and right posture. Lastly, it is shown that answers to questions regarding gender and biorhythm, gender and right posture, and gender and stress symptoms are relevantly different. Further research is needed to reveal the differences between college students and ordinary people at large.

• Journal of the Korean Applied Science and Technology
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• v.41 no.2
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• pp.208-218
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• 2024

Domestic cosmetics companies are striving to protect the environment and solve environmental problems through ESG management. This study analyzed the relationship and influence between the perceived consumption value and purchasing behavior of upcycling cosmetics according to environmental values for MZ generation women in Seoul and Gyeonggi Province. In addition, based on the research results, it was intended to provide basic data for product development and marketing strategies related to upcycling cosmetics. First, all variables were found to be positive (+) correlation. Second, it was found that the higher the environmental value, the higher the perceived consumption value of upcycling cosmetics. Third, it was found that the higher the environmental values, the higher the purchasing behavior. Therefore, it is hoped that it will induce a positive consumption value for upcycling cosmetics, and that the cosmetics industry will be helpful as basic data for the development of related products and the establishment of differentiated marketing strategies.

• Biomolecules & Therapeutics
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• v.21 no.5
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• pp.343-348
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• 2013

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.