• Journal of Pharmaceutical Investigation
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• 제22권1호
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• pp.33-40
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• 1992

This study was aimed to control the release characteristics of ketoprofen by microencapsulating $ketoprofen-{\beta}-cyclodextrin\;(KF-{\beta}-CyD)$ solid dispersion with Eudragit RS by the phase separation method using a nonaqueous vehicle. KF alone was also microencapsulated with Eudragit RS by the evaporation process in water phase. The results obtained showed that it was not possible to microencapsulate KF alone by phase separation in a chloroform-cyclohexane system while it was easy to microencapsulate $(KF-{\beta}-CyD)$ solid dispersion system. For the microcapsules, the release test was performed in the first fluid (pH 1.2) and the second fluid (pH 6.8) of K.P.V disintegration medium at $37^{\circ}C$. The release of KF from $(KF-{\beta}-CyD)$ solid dispersion microcapsules (1:1 core wall ratio) was more sustained than that from KF microcapsules, and followed zero-order kinetics. Especially, solid dispersion microcapsules showed pH-independent release patterns with higher wall to core ratio (1:1 w/w).

• 한국항공우주학회지
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• 제31권10호
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• pp.66-72
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• 2003

우주발사체의 2단용 엔진으로 10톤급 케로신 액체로켓엔진에 대한 냉각 기구로서, 재생냉각과 막냉각을 고려한 냉각특성에 대한 해석전 연구를 수행하였다. 연소기 내에서 연소 가스의 유동이 축방향으로 층류화되어 있다는 개념하에, 엔진 단면을 서로 독립적인 중심부와 외곽부로 나누며, 외곽부에는 여분의 연료를 분무시킴으로써 연소가스 온도를 낮추어 냉각채널로 전달되는 열유속량과 벽면 온도를 감소시킬 수 있었으며, 엔진의 열적 안정성을 향상시킬 수 있었다.

• 설비공학논문집
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• 제7권4호
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• pp.577-588
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• 1995

A numerical study is made on the melting process of an unconstrained ice inside an isothermal ice-ball capsule. The unmelted ice core is continuously ascending on account of buoyancy forces. Such a buoyancy-assisted melting is commonly characterized by the existence of a thin liquid film above the ice core. The present study is motivated to present a full-equation-based analysis of the influences of the initial subcooling and the natural convection on the fluid flow associated with the buoyancy-assisted melting. In the light of the solution strategy, the present study is substantially distinguished from the existing works in that the complete set of governing equations in both the melted and unmelted regions are resolved in one domain. Numerical results are obtained by varying the wall temperature and initial temperature. The present results reported the transition of the flow pattern in a spherical capsule, as the wall temperature was increased over the density inversion point. In addition, time wise variation of the shapes for the liquid film and the lower ice surface, the time rate of change in the melt volume fraction and the melting distance at symmetric line is analyzed and is presented.

• Archives of Pharmacal Research
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• 제14권4호
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• pp.298-304
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• 1991

Isoprinosine, an antiviral agent with a bitter taste, has been clinically used up to a maximum of 4 g daily in 4-8 doses. In this investigation, isoprinosine was microencapsulated with ethylcellulose 22 cps, 50 cps and 100 cps by means of polymer deposition from cyclohexane through temperature change. Complete removal of cyclohexane from the microcapsules was necessary, since ethylcellulose-coated microcapsules obtained from cyclohexane medium were heavily solvated with cyclohexane and formed lumps even after drying. The displacement of cyclohexane by n-hexane during isolation of microcapsules (Method III) or the freezing of the anal-washed microcapsules before drying (Mothod II) provided the dried products which were more discrete microcapsules than those which were simply dried in the air overnight (Method I). Method III was especially the most effective procedure in preparing finer and more discrete microcapsules. The drug-release from microcapsules was influenced by the ratio of core to wall, the viscosity grade of ethylcellulose and the overall microcapsule size. The release rate was adequately fitted to both the first-order and the diffusion-controlled processes. It is therefore possible to design the release-controlled microcapsules with ethylcellulose of different viscosity along with various core to wall ratio.

• Nuclear Engineering and Technology
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• 제45권4호
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• pp.469-476
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• 2013

In a postulated severe core damage accident in a PHWR, multiple failures of core cooling systems may lead to the collapse of pressure tubes and calandria tubes, which may ultimately relocate inside the calandria vessel forming a terminal debris bed. The debris bed, which may reach high temperatures due to the decay heat, is cooled by the moderator in the calandria. With time, the moderator is evaporated and after some time, a hot dry debris bed is formed. The debris bed transfers heat to the calandria vault water which acts as the ultimate heat sink. However, the questions remain: how long would the vault water be an ultimate heat sink, and what would be the failure mode of the calandria vessel if the heat sink capability of the reactor vault water is lost? In the present study, a numerical analysis is performed to evaluate the thermal loads and the stresses in the calandria vessel following the above accident scenario. The heat transfer from the molten corium pool to the surrounding is assumed to be by a combination of radiation, conduction, and convection from the calandria vessel wall to the vault water. From the temperature distribution in the vessel wall, the transient thermal loads have been evaluated. The strain rate and the vessel failure have been evaluated for the above scenario.

• Wind and Structures
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• 제29권3호
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• pp.209-223
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• 2019

The assessment of wind-induced vibration for tall reinforced concrete (RC) buildings requires the accurate estimation of their dynamic properties, e.g., the fundamental vibration periods and damping ratios. In this study, RC frame-shear wall systems designed under gravity and wind loadings have been evaluated by utilising 3D FE modelling incorporating eigen-analysis to obtain the elastic periods of vibration. The conducted parameters consist of the number of storeys, the plan aspect ratio (AR) of buildings, the core dimensions, the space efficiency (SE), and the leasing depth (LD) between the internal central core and outer frames. This analysis provides a reliable basis for further investigating the effects of these parameters and establishing new formulas for predicting the fundamental vibration periods by using regression analyses on the obtained results. The proposed constrained numerically based formula for vibration periods of tall RC frame-shear wall office buildings in terms of the height of buildings reasonably agrees with some cited formulas for vibration period from design codes and standards. However, the same proposed formula has a high discrepancy with other cited formulas from the rest of design codes and standards. Also, the proposed formula agrees well with some cited experimentally based formulas.

• 한국지진공학회논문집
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• 제28권4호
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• pp.171-181
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• 2024

For low-rise piloti-type buildings that suffered significant damage in the Pohang earthquake, the seismic performance of those designed by codes issued before and after the earthquake has been recently revised. This study started with the expectation that many of the requirements presented in the current codes may be excessive, and among them, the spacing of column stirrup could be relaxed. In particular, the recently revised design code of concrete structures for buildings, KDS 41 20 00, suggests that the column stirrup spacing is 1/2 of the minimum cross-sectional size or 200 mm, which is strengthened compared to KBC 2016, but relaxed than the current KDS, 41 17 00, which is 1/4 of the minimum size or 150 mm. As a result of the study, it was found that the target performance level was sufficiently satisfied by following the current standards and that it could be satisfied even if the relaxed spacing was followed. Therefore, the strict column stirrup spacing of KDS 41 17 00 could be relaxed if a wall other than core walls is recommended in the current guideline for the structural design of piloti-type buildings.

• Structural Engineering and Mechanics
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• 제32권3호
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• pp.399-406
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• 2009

A three-dimensional panel system, which was offered as a new method for construction in Jordan using relatively high strength modular panels for walls and ceilings, is investigated in this paper. The panel consists of two steel meshes on both sides of an expanded polystyrene core and connected together with a truss wire to provide a 3D system. The top face of the ceiling panel was pored with regular concrete mix, while the bottom face and both faces of the wall panels were cast by shotcreting (dry process). To investigate the structural performance of this system, an extensive experimental testing program for ceiling and wall panels subjected to static and dynamic loadings was conducted. The load-deflection curves were obtained for beam and shear wall elements and wall elements under transverse and axial loads, respectively. Static and dynamic analyses were conducted, and the performance of the proposed structural system was evaluated and compared with a typical three dimensional reinforced concrete frame system for buildings of the same floor areas and number of floors. Compressive strength capacity of a ceiling panel is determined for gravity loads, while flexural capacity is determined under the effect of wind and seismic loading. It was found that, the strength and serviceability requirements could be easily satisfied for buildings constructed using the three-dimensional panel system. The 3D panel system is superior to that of conventional frame system in its dynamic performance, due to its high stiffness to mass ratio.

• 콘크리트학회논문집
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• 제18권1호
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• pp.135-145
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• 2006

In high multistory reinforced concrete buildings, coupled shear walls can provide an efficient structural system to resist horizontal force due to wind and seismic effects. Coupled shear walls are usually built over the whole height of the building and re laid out either as a series of walls coupled by beams and/or slabs or a central core structure with openings to accommodate doors, elevators walls, windows and corridors. A number of recent studies have focused on examining the seismic response of concrete, steel, and composite coupling beams. However, since no specific equations are available for computing the bearing strength of steel coupling beam-wall connections, it is necessary to develop such strength equations. There were carried out analytical and experimental studies to develop the strength equations of steel coupling beam-connections. Experiments were conducted to determine the factors influencing the bearing strength of the steel coupling beam-wall connection. The results of the proposed equations were in good agreement with both test results and other test data from the literature. Finally, this paper provides background for design guidelines that include a design model to calculate the bearing strength of steel coupling beam-wall connections.

• Investigative Magnetic Resonance Imaging
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• 제19권3호
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• pp.191-195
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• 2015

We present a 53-year-old woman with a large chest wall mass in the interpectoral space, which was eventually confirmed as a lipogranuloma resulting from hydrogel implant rupture. Ultrasonography (US) showed reduced implant volume with surrounding peri-implant fluid collection, suggesting the possibility of implant rupture. A heterogeneously hypoechoic mass was found between the pectoralis major and minor muscles adjacent to the ruptured implant. On magnetic resonance imaging (MRI), there was a large mass in the left interpectoral space of the upper inner chest wall. The mass showed slightly high signal intensity (SI) on pre-contrast T1-weighted image (WI) with mixed iso and high SI on T2-WI. The signal of the mass was suppressed using the water suppression technique but not with the fat suppression technique on T2-WI. The mass showed diffuse enhancement upon contrast enhancement. The enhancing kinetics showed persistent enhancement pattern. US-guided core needle biopsy revealed a lipogranuloma and removal confirmed a ruptured PIP hydrogel implant.