• Journal of Life Science
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• v.24 no.1
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• pp.92-97
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• 2014

Cordycepin, an active component originally isolated from the traditional medicine Cordyceps militaris, is a derivative of the nucleoside adenosine, which has been shown to possess a number of pharmacological properties, including antioxidant and anti-inflammatory activities, immunological stimulation, and antitumor effects. This study was conducted on cultured human prostate carcinoma LNCap cells to elucidate the possible mechanisms by which cordycepin exerts its anticancer activity, which, until now, has remained poorly understood. Cordycepin treatment of LNCap cells resulted in dose-dependent inhibition of cell growth and the induction of apoptotic cell death as detected by an MTT assay, cleavage of poly ADP-ribose polymerase, and annexin V-FITC staining. Flow cytometric analysis revealed that cordycepin resulted in G2/M arrest in cell cycle progression and downregulation of cyclin B1 and cyclin A expression in a concentration-dependent manner. Moreover, the incubation of cells with cordycepin caused a striking induction in the expression of the cyclin-dependent kinase (CDK) inhibitor p21Waf1/Cip1 without affecting the expression of the tumor suppressor p53. It also resulted in a significant increase in the binding of CDK2 and CDC2 to p21. These findings suggest that cordycepin-induced G2/M arrest and apoptosis in human prostate carcinoma cells is mediated through p53-independent upregulation of the CDK inhibitor p21.

• Journal of the Korean Magnetics Society
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• v.25 no.6
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• pp.189-197
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• 2015

As enforced the regulation of fuel efficiency, the electrification of automotive components in internal combustion vehicle has been applied instead of hydraulic pressure. A typical example of such parts is the EPS (electric power steering), and it is applied to most automotive at present. In electric power steering system, the core component is motor. The reduction of cogging torque and torque ripple is required to improve steering feeling and reduce NVH (Noise Vibration Harshness) in EPS. Generally the skewed design of stator or rotor is applied in order to reduce cogging torque and torque ripple. This paper propose the design and analysis methodology of Brusheless PMSM (Permanent Magnet Synchronous Motor) which is applied to skewed stator. The proposed methodology is as follows: First Intial Design PMSM with skewed stator for EPS, Second Optimal design using RSM (Response surface method), Third Performance Analysis such as Phase Back EMF, Inductance, Load torque using FEA (Finite Element Method). Finally, the reliability of proposed design methodology will be verified through the experiments of prototype sample.

• Education of Primary School Mathematics
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• v.14 no.3
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• pp.237-259
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• 2011

Mathematics learning disabilities is a specific learning disorder affecting the normal acquisition of arithmetic and spatial skills. Reported prevalence rates range from 5 to 10 percent and show high rates of comorbid disabilities, such as dyslexia and ADHD. In this study, the characteristics and the causes of this disorder has been examined. The core cause of mathematics learning disabilities is not clear yet: it can come from general cognitive problems, or disorder of innate intuitive number module could be the cause. Recently, researchers try to subdivide mathematics learning disabilities as (1) semantic/memory type, (2) procedural/skill type, (3) visuospatial type, and (4) reasoning type. Each subtype is related to specific brain areas subserving mathematical cognition. Based on these findings, the author has performed a basic research to develop grade specific diagnostic tests: number processing test and math word problems for lower grades and comprehensive math knowledge tests for the upper grades. The results should help teachers to find out prior knowledge, specific weaknesses of students, and plan personalized intervention program. The author suggest diagnostic tests are organized into 6 components. They are number sense, conceptual knowledge, arithmetic facts retrieval, procedural skills, mathematical reasoning/word problem solving, and visuospatial perception tests. This grouping will also help the examiner to figure out the processing time for each component.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.1
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• pp.86-92
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• 2014

Cordycepin is the major functional component of Cordyceps species and is widely used in traditional oriental medicine. Cordycepin has been shown to possess many pharmacological properties, such as enhancement of immune function along with anti-inflammatory, antioxidant, anti-aging, and anti-cancer effects. Here, we investigated the inhibitory effects of cordycepin on cell migration and invasion, which are two critical cellular processes that are often deregulated during metastasis, using HCT116 human colorectal carcinoma cells. According to our data, cordycepin at non-cytotoxic concentrations markedly inhibited the motility and invasiveness of HCT116 cells in a time-dependent manner. RT-PCR and Western blotting results indicated that cordycepin reduced the levels of claudin proteins, which are major components of tight junctions (TJs), and induced tightening of TJs. Cordycepin also attenuated the expression and activities of matrix metalloproteinases (MMPs)-2 and -9, whereas levels of tissue inhibitor of metalloproteinases (TIMPs)-1 and -2 were simultaneously elevated. These findings suggest that cordycepin reduces the migration and invasion of HCT116 cells by modulating the activities of TJs and MMPs.

• Korean Journal of Agricultural Science
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• v.14 no.1
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• pp.81-97
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• 1987

Two nozzles with different size (Figure 2) were particularly designed to supply air through the swirl core into the central part of the liquid stream in the same parallel direction to produce a well-mixed air and water in the whirl chamber as spray liquid in bubble formation. Atomization was attempted to improve by using both the preliminary break-up process with less viscosity and less surface tension in the whirl chamber and the effects of increased frequency of the band of drops with the raised ambient air density in front of the nozzle orifice. The volumetric ratio between spray liquid and air on four levels was used to investigate the effects of air as a component of the mixture on atomization. The results of the experiment were summarized as follows; Droplet size became progressively finer as the operating pressure was increased in the range of $0.70kg/cm^2$ to $6.33kg/cm^2$, which was similar to the previous works. The new atomizing mechanism so-called 'air-center nozzle' gave a narrower range in droplet size distribution with smaller volumetric median diameter (VMD) than that of the existing spray system at a given pressure, which showed the possibility of improvement of atomization in a certain limit. The volumetric median diameter produced by the new atomizing mechanism was decreased from the central region toward the exterior edges across the spray pattern.

• Proceedings of the International Union of Geodesy And Geophysics Korea Journal of Geophysical Research Conference
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• 2003.05a
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• pp.20-20
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• 2003

In the summers of 1997 and 1998 and in February of 2000 we made 570 measurements of the ambient geomagnetic field 120 cm above the pavement surface of State Route 130, south of Pahoa, the island of Hawaii using a three-component fluxgate magnetometer. We measured at every 15.2 m (50 feet) interval covering a distance of 6, 310 m (20, 704 ft) where both historic and pre-historic highly magnetic basalt flows underlie. We also collected 197 core samples from eight road cuts, 489 specimens of which were subject to AF demagnetizations at 5 - 10 mT level up to a maximum field of 60 mT. We observed significant inclination anomalies ranging from a minimum of $31^{\circ}$ to a maximum $40^{\circ}$ where a uniform inclination value of $36.7^{\circ}$ (International Geomagnetic Reference Field, IGRF) was expected. Since the mean of the observed inclinations is approximately $35^{\circ}$ we assume that the study area is slightly affected by the magnetic terrain effect to a systematically shallower inclinations for being located in the regionally sloping surface of the southern side of the island (Baag, et al., 1995). We observed inclination anomalies showing wider (spacial) wavelength (160 - 600 m) and higher amplitudes in the historic lava flows area than in the northern pre-historic flows. Our observations imply that preexisting inclination anomalies such as those that we observed would have been interpreted as paleosecular variation (PSV). These inclination anomalies can best be attributed to concealed underground highly magnetic dikes, channel type lava flows, on-and-off hydrothermal activities through fissure-like openings, etc. Both the within- and between-site dispersions of natural remanent magnetization (NRM) are largest (up to ${\pm}7^{\circ}$) above the flows of 1955, while the area of pre-historic flows in the northern part of the study area exhibit the smallest dispersion. Nevertheless, mean inclinations of each historic flow of 1955 and 1790 are almost identical to that of the corresponding present field, whereas mean of NRM (after AF demagnetization) inclinations for each of the four pre-historic lava flow units is twelve to thirteen degrees lower than the present field inclination. We observed three cases of very large inclination variations from within a single flow, the best fitting curves of which are linear, second and third order polynomials each from within a single flow, whereas no present field variations are observed. This phenomena can be attributed to the notion that local magnetic anomalies on the surface of an active volcano are not permanent, but are transient. Therefore we believe that local magnetic anomalies of an active volcano may be constantly modified due to on going subsurface injections and circulations of hot material and also due to wide spacial and temporal distribution of highly magnetic basaltic flows that will constantly modify the topography which will in turn modify the local ambient geomagnetic field (Baag, et al., 1995). Our observations bring into question the general reliability of PSV data inferred from volcanic rocks, because on-going various geologic and geophysical activities associated with active volcano would continuously deflect and modify the ambient geomagnetic field.

• Journal of Life Science
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• v.22 no.9
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• pp.1173-1179
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• 2012

The importance of genetic stability and bio-safety in the environment has recently been recognized for many (genetically modified) GM plants. This study evaluated the GM safety of transgenic rice and its environmental variance. Data on agronomic characters and principal component were collected for vitamin A-enriched GM rice and four check cultivars in a large GM field trial during 2009-2011. The cultivation environment was a large GM field and a greenhouse. In this experiment, there was no significant difference between the agronomic characters of the GM rice and those of a donor plant, 'Nagdong'. In terms of grain characteristics, the appearance and physicochemical characteristics of the GM rice and those of the donor plant were similar. However, the grain of the GM rice developed a white core and a white belly when planted in the greenhouse. The type and distribution of dominant weed species were not different in the GM rice and the 'Nagdong'. In addition, gene flow was not detected in the dominant weed species based on PCR analysis.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.11
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• pp.1031-1040
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• 2010

Hash join is one of the core algorithms in databases management systems. If a hash join cannot complete in one-pass because the available memory is insufficient (i.e., hash table overflow), however, it may incur a few sequential writes and excessive random reads. With harddisk as the tempoary storage for hash joins, the I/O time would be dominated by slow random reads in its probing phase. Meanwhile, flash memory based SSDs (flash SSDs) are becoming popular, and we will witness in the foreseeable future that flash SSDs replace harddisks in enterprise databases. In contrast to harddisk, flash SSD without any mechanical component has fast latency in random reads, and thus it can boost hash join performance. In this paper, we investigate several important and practical issues when flash SSD is used as tempoary storage for hash join. First, we reveal the va patterns of hash join in detail and explain why flash SSD can outperform harddisk by more than an order of magnitude. Second, we present and analyze the impact of cluster size (i.e., va unit in hash join) on performance. Finally, we emperically demonstrate that, while a commerical query optimizer is error-prone in predicting the execution time with harddisk as temporary storage, it can precisely estimate the execution time with flash SSD. In summary, we show that, when used as temporary storage for hash join, flash SSD will provide more reliable cost estimation as well as fast performance.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.34 no.4
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• pp.98-109
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• 2016

The purpose of this study is to identify characteristics of spatial structure of Jiangnan water town in China which has been developed along the water channel. Spatial structural characteristics of the water town, Wuzhen and Nanxun in Zhejiang Province are as follows. First, location of town, spatial framework, lot division, and architectural style get determined by the water channel. The water channel is constructed in cross shape, T-shape, or in combination. Secondly, public space of water town is established along main water channel. Visually and functionally alternating private buildings are established on the water channel side and they are creating unique landscape of Jiangnan water town in overall harmony. Thirdly, residential area is established on the east-west water channel side with southward sunny-faced arrangement and waterside residence is in introvert spatial structure with courtyard but the exterior space is connected with water channel intimately. Fourthly, various spatial components along the water channel enrich the sense of place in water town. The components are corridor with roof, tea house, waterside steps, waterside theater and watergate etc. Uniqueness of place is becoming the core competence in modern townscape. In this aspect, Jiangnan water town with historical and cultural accumulation is suggesting a significant implication. Major implications are as follows. First, promotion of proximity to the water is the basic value that the spatial plan of waterfront needs to pursue. Secondly, mixed use is essential for effective land use and revitalization of waterfront. Thirdly, waterfront plan based on the local uniqueness as the place asset is being required.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.22 no.5
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• pp.29-35
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• 2022

This paper proposes a fuel cell education framework installed on a Metaverse environment, which is to reduce the burden of education costs and improve the effect of education or learning. This Meta-Fuel cell platform utilizes the Unity 3D Web and enables not only theoretical education but also hands-on training. The platform was designed and developed to accommodate a variety of unit education contents, such as ppt documents, videos, etc. The platform, therdore, integrates ppt and video demonstrations for theoretical education, as well as software content "STACK-Up" for hands-on training. Theoretical education section provides specialized liberal arts knowledge on hydrogen, including renewable energy, hydrogen economy, and fuel cells. The software "STACK-Up" provides a hands-on practice on assembling the stack parts. Stack is the very core component of fuel cells. The Meta-Fuelcell platform improves the limitations of face-to-face education. It provides educators with the opportunities of non-face-to-face education without restrictions such as educational place, time, and occupancy. On the other hand, learners can choose educational themes, order, etc. It provides educators and learners with interesting experiences to be active in the metaverse space. This platform is being applied experimentally to a education project which is to develop advanced manpower in the fuel cell industry. Its improvement is in progress.