• Gut and Liver
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• 제12권6호
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• pp.682-693
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• 2018

Background/Aims: Intestinal barrier dysfunction is a hallmark of inflammatory bowel diseases (IBDs) such as ulcerative colitis. This dysfunction is caused by increased permeability and the loss of tight junctions in intestinal epithelial cells. The aim of this study was to investigate whether estradiol treatment reduces colonic permeability, tight junction disruption, and inflammation in an azoxymethane (AOM)/dextran sodium sulfate (DSS) colon cancer mouse model. Methods: The effects of $17{\beta}$-estradiol (E2) were evaluated in ICR male mice 4 weeks after AOM/DSS treatment. Histological damage was scored by hematoxylin and eosin staining and the levels of the colonic mucosal cytokine myeloperoxidase (MPO) were assessed by enzyme-linked immunosorbent assay (ELISA). To evaluate the effects of E2 on intestinal permeability, tight junctions, and inflammation, we performed quantitative real-time polymerase chain reaction and Western blot analysis. Furthermore, the expression levels of mucin 2 (MUC2) and mucin 4 (MUC4) were measured as target genes for intestinal permeability, whereas zonula occludens 1 (ZO-1), occludin (OCLN), and claudin 4 (CLDN4) served as target genes for the tight junctions. Results: The colitis-mediated induced damage score and MPO activity were reduced by E2 treatment (p<0.05). In addition, the mRNA expression levels of intestinal barrier-related molecules (i.e., MUC2, ZO-1, OCLN, and CLDN4) were decreased by AOM/DSS-treatment; furthermore, this inhibition was rescued by E2 supplementation. The mRNA and protein expression of inflammation-related genes (i.e., KLF4, NF-${\kappa}B$, iNOS, and COX-2) was increased by AOM/DSS-treatment and ameliorated by E2. Conclusions: E2 acts through the estrogen receptor ${\beta}$ signaling pathway to elicit anti-inflammatory effects on intestinal barrier by inducing the expression of MUC2 and tight junction molecules and inhibiting pro-inflammatory cytokines.

• 비교문화연구
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• 제26권
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• pp.123-144
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• 2012

In the modern society in which globalization and localization proceed simultaneously, diversified and rapid migration of diaspora makes a new from of boundary off the frame of the state and the nation. This new border accompanies cultural change and racial mixture; retains ethnic conflict, the gap between rich and poor, alienation and discrimination, as well as power conflict; and extends its influence. Nowadays, the countries all over the world including Korea face problem of Diaspora in numerous forms. And each country takes an approach to the problem of the diaspora in the aspects of their society, culture and political technology. This implies that most countries, without understanding the new form of border which is alive and dynamic, define and conceptualize the diaspora in the frame of one state and one nation to carry forward the policies accordingly, resulting in inequal, incomplete and awkward homogenization. This study aimed to explore the identity of the diaspora, the core for the problem solving. Of course, studies about the identity of the diaspora have been continued until today and many great outcomes have been achieved. Nevertheless, this study aimed to explore the identity of the diaspora and the national policies which have a close interrelationship with it. It is because the study ultimately aimed to highlight the interrelationship between the destination countries, Russia and China, and the diaspora, through the definition and the classification of Russian diaspora and Chinese diaspora and the analysis of the national policies about that. However, the intention was not to distinguish superiority through the comparison of the polices about the diaspora between two countries, but to focus on the diversity of the identity of the diaspora through defining each different diaspora and paralleling the policies. Second, the reason for looking into the diaspora policies of these two countries is because it is judged the changes in the diaspora policies of each country is one of the active factors for the changes in the identify of the diaspora of each country and it is the basic research for the study on the identity of the diaspora. New migration of diaspora changes the identity of the state, and the state makes the policies and enforce the policies, resulting in the influence on the diaspora. This interaction acts as the growth factor for the new boundary. The causes of Russian diaspora and Chinese diaspora show apparent 'differences'. In parallel with this, the policies about the diaspora in Russia and China arouse 'differences' to the diaspora. The variation of the identity of the diaspora made by these differences will suggest other viewpoints on the diaspora, and these viewpoints will become the foundation for solving the problem of the diaspora in the present times.

• 비교문화연구
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• 제34권
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• pp.93-114
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• 2014

Gaston Bachelard had a revolutionary progress in the field of human understanding by proposing his theory of image and imagination. His theory of the new image was so powerful, almost all areas of human science, particularly that of literary criticism, were strongly influenced and this influence continues until today. Today almost everyone accepts his theory of the image without much objection, but not rarely asked where began his transfer from the philosophy of science to the images. We propose a hypothesis that the beginning of the new concept of Bachelard's image was inspired by studies of contemporary science, especially quantum mechanics. The Heisenberg's uncertainty principle was the core of quantum mechanics, and opens new perspectives on the material world. We could summarize the message of the uncertainty principle : the material world is made up of various layers, and the material can not be measured by the location and movement at the same time. So we must have a new point of view of another dimension to know this material world. Bachelard had accepted this view of Heisenberg and developed his own theory of epistemological rupture. What is revolutionary in the theory of Bachelard's image is the fact that he looked at the images with the new perspective. The human psyche is another world compared to the rational world that dominates our daily lives. Bachelard insists that the image can not be explained by the concept. The fantasy world is a totally different world to that of rationality. That is why it can not be explained by the language of rationality as the concept. The imaginary world exists independently of the real world, but it is superimposed on the real world. These two worlds are influencing each other, and it is between these two world where our daily lives continues. The declaration of Bachelard 'image is a specific reality' is never a metaphor or rhetorical expression. This is an ontological expression that must truthfully. The imaginary world is a world built on the image and it works according to its own law. It is not a representation or copy of the real world. But the world of imagination are not alone. It exists in the same time and space with the world of science. It is superimposed with the world of science. Both two world influence each other. Bachelard has made a revolutionary change by studying the images. He gave them their own place. It has changed the views on the images that were treated as mere representations of reality. Thanks to him, the image can have its own value, that of a factor that creates reality. Bachelard shows how we can go deep into the source of being and the universe if we look at the pictures with the eyes of other dimensions.

• 비교문화연구
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• 제31권
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• pp.119-153
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• 2013

There is the commonness between I-Ching of Asian scriptures and Analytic Psychology of C. G. Jung as the conjunction of opposites of yin and yang. I-Ching has the base of the Great Absolute(太極) as yin and yang. Jung's psychology has the basic structure of opposite contents of psyche. The former wants to find the proper answer for the situation as fortune book, the latter realization of personal psyche. At this basis to approach I-Ching through the Analytic Psychology can be connected with the screening its inner system and structure in the frame of depth psychology. Basically I-Ching is the scripture about the good or ill luck, regret and stinginess. All of them are related with the psychology of human beings practically. I-Ching as the main scripture of Asia has the core theme concept of the mean (中). Previously mentioned the good or ill luck, regret and stinginess are included into this as the large view point. The best decision between the given situation and the fortune teller pursues the mean(中) path of both. Jung's psychology also attaches importance to the proper balance among personal conscious, unconscious and his surrounded situations. Goodness is relied on the mean, healthy psyche the harmony with the psychological and real situations of a person. But this balance and mean cannot be achieved without any reason but by the result of the conjunction of opposites. The opposites are the Ch'ien(乾, the Creative, Heaven) and K'un(坤, the Receptive, Earth) as yin and yang in I-Ching and the conscious and unconscious in Jung's psychology. These can be opened to masculine and feminine, psyche and matter, transcendent and existence and casuality and acausal synchronicity. Conjunction of these opposites can develope and create the new conscious and creative situation. Finally yin and yang from the Great Absolute and conscious and unconscious from Self become the opposites and go through necessary step of separation and sublimation for the creation of new level. In the Great Absolute there are yin and yang and yin the latter contains the cyclic process which can make the former renew. Conjunction of opposite in Jung's psychology also go through the similar process as the Great Absolute of yin and yang.

• 한국광학회지
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• 제19권4호
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• pp.255-261
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• 2008

광 백 플레인이나 광 연결용으로 활용될 수 있는 연성 광 PCB의 핵심 요소인 광 배선(도파로)의 전파 특성을 분석하였으며, 광배선 제작 공정에서 발생할 수 있는 구조적 오차로 인한 전파 손실 발생 문제를 다루었다.제작 공차 분석을 통해 전파 손실을 -1 dB/mm 이하로 유지하기 위해서는 광 배선 측벽 각도가 $1^{\circ}$ 이내로 제어되어야 하며, 결합 손실과 구부러짐 손실을 각각 -1 dB 이하로 유지하기 위해서는 광원과 광 배선 간격은 $160\;{\mu}m$ 이내, 횡방향 정렬 오차는 ${\pm}15\;{\mu}m$ 이내, 광원 각도는 $6^{\circ}$ 이하로 정렬되어야 하며, 광 배선의 구부러짐 반경은 5 mm 이상이 되어야 함을 알 수 있었다.

• 디지털융복합연구
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• 제19권9호
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• pp.169-180
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• 2021

본 연구는 R을 활용한 사회네트워크 분석(SNA)을 실시하여 국내 스마트물류에 관한 연구 동향을 분석하고 스마트물류 현황 및 정책 검토 등과 함께 스마트물류 분야에 대한 이해를 높이고 시사점을 도출하는 데 목적이 있다. 분석 기간과 대상은 지난 10년간(2011~2020년) 스마트물류 주제의 학술지 논문 128편이며, 결과는 4차 산업혁명이 공식 언급된 2016년 1월 세계경제포럼(WEF)을 기준으로 전기(2011~2015년)와 후기(2016~2020년)로 구분하고 빈도분석, 네트워크 중심성 분석, 시각화 등을 진행했다. 주요 연구결과는 연구의 양적 증가와 분야의 다양화 그리고 중복 키워드 비중의 확대로 핵심 분야에서 연구 집중도가 높아지는 것을 확인했으며, Logistics, Authentication, Smart, Service, RFID, Technology, Revolution 등 매개중심성과 연결중심성이 높은 키워드를 제시했다. 또한, 연구대상 논문의 핵심 키워드로 네트워크를 시각화한 이후 매개중심성을 중심으로 구조를 검토했으며 분석의 대상이 된 초기 연구가 물류 분야에 집중되었다면, 2016년 이후 4차 산업혁명 및 주요 기술 등으로 연구의 중심이 다양화 및 확대되고 있음을 확인했다. 분석결과와 함께 스마트 물류 동향과 국내 정책 등을 검토했으며 연구의 한계점 및 향후 연구과제를 제시했다.

• 한방재활의학과학회지
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• 제31권4호
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• pp.129-143
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• 2021

Objectives This study was aimed to evaluate clinical practice guidelines (CPGs) of traffic injuries, which has already been developed at domestic or outside of country, and to explore the Korean medical treatments included in the CPGs. Methods Twelve electronic databases (PubMed, Cochrane library, China National Knowledge Infrastructure [CNKI {Chinese Academic Journals, CAJ}], Research Information Sharing Service [RISS], Oriental Medicine Advanced Searching Integrated System [OASIS], KoreaMed, Korean Medical Guideline Information [KoMGI), National Guideline Clearinghouse [AHRQ], Core Outcome Measures in Effectiveness Trials Initiative Website [COMET], Turning Research into Practice [TRIP], The National Institute for Health and Care Excellence [NICE], and Medical Research Information Center [MedRIC]) up to July 2021 were searched. Only systematically developed CPGs for traffic injuries were selected and appraised. The appraisal was conducted by using Appraisal of Guidelines for Research & Evaluation (AGREE) II tool. Results Six CPGs were included and evaluated. All CPGs were appraised as highly recommended because they exceeded 60% in more than 4 among 6 domains of AGREE II, including domain of 'rigor of development', and 30% in the rest. Recommendations related to Korean medicine treatments such as on manual therapy related to Chuna were given in 6 CPGs, 4 for acupuncture, 1 for Qigong and 1 for Taping. Conclusions The 6 CPGs were developed up to now through a systematic development methodology and there were many recommendations for Korean medical treatments related to manual (Chuna) treatment, acupuncture and Qigong. However, the evidence for the side effects and risk factors of Korean medical treatments was scantly reflected in CPGs. Therefore, it is considered that balanced CPG with benefits and risks should be developed, covering Korean medical diagnosis, treatment and prognosis.

• 지식경영연구
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• 제22권3호
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• pp.235-252
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• 2021

정보통신기술의 발달과 코로나19는 호텔산업에 이례적인 변화를 불러일으켰고, 호텔 고객들의 서비스 로봇과 같은 비대면 서비스에 대한 수요가 급증하였다. 이에 본 연구는 혼합분석기법을 적용하여 호텔 고객의 비대면 서비스에 대한 인식을 조사하고자 한다. 구체적으로 본 연구는 구조방정식모형을 통해 변수들간의 상관관계를 파악하였으며, 나아가 퍼지셋 질적 비교 분석 기법을 적용하여 비대면 서비스를 제공하는 호텔 이용의도를 형성하는 변수들의 패턴을 도출하였다. 분석결과, 서비스 경험 공동창출, 즐거움, 개인화 그리고 신뢰가 비대면 서비스 이용욕구를 거쳐 이용의도에 유의한 영향을 미치는 것으로 나타난 반면에, 퍼지셋 질적 비교 분석 방법에서는 도출된 모든 패턴에서 즐거움이 핵심 요인으로 도출되었다. 이러한 분석결과를 토대로 본 연구는 호텔 고객의 비대면 서비스에 대한 심도 있는 이해를 위한 학술적 근거를 제시하였으며, 호텔 매니저들에게 위드 코로나 시대에 비대면 서비스 전략에 대한 구체적인 가이드라인을 제시하였다.

• 비교문화연구
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• 제50권
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• pp.197-224
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• 2018

2013년 한국의 김장문화와 일본의 와쇼쿠가 함께 유네스코 인류무형문화유산으로 선정되었다. 유네스코에서 김장과 와쇼쿠를 인류무형문화유산으로 지정할 때 '오랜 기간 전해 내려오는 전통', '국가를 대표하는 음식문화'라는 점과 함께, 그 음식을 통해 생성되는 사회적인 관계 속에서의 '결속력', 오랜 기간 동안 전해 내려온 풍습에서 드러나는 각국의 '정체성'에 그 가치를 크게 인정하고 있다. 한국에서 김장은 인류무형문화유산으로 지정된 이후, 문화재청의 무형문화재과에서 종합적으로 관리하고 있고, 일본에서는 농림수산성 중에서도 식료산업국내에 '와쇼쿠실'이라는 부서에서 담당하고 있다. 각국을 대표하는 식문화인 만큼 김장과 와쇼쿠의 활용은 실로 다양하겠지만, 김장의 경우 특히 전국민의 공감대를 형성할 수 있고 겨울을 맞이하기 전에는 누구나 꼭 해야 한다는 점에서 축제로 활용되는 것이 가장 대표적이다. 또한 공연이나 외국인을 대상으로 한 콘텐츠의 활용 사례도 보인다. 와쇼쿠의 경우 지칭하는 범위가 김장보다 넓기 때문에 각 지역의 특산품을 중심으로 헤아릴 수 없이 많은 와쇼쿠 관련 축제가 존재하며, 이외에도 농림수산성에서 실시하고 있는 '와쇼쿠와 지역식문화 계승추진사업'과 연계한 콘텐츠의 활용이 다양하게 이루어지고 있다. 또한 와쇼쿠가 인류무형문화유산이라는 공식적인 타이틀을 가지게 되자, '쿨 재팬 전략'의 핵심 키워드로서도 활용되고 있다.

• 비교문화연구
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• 제52권
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• pp.1-29
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• 2018

'선물'은 서양 문화의 이해에서 핵심적인 코드 중 하나이다. 이 글에서는 선물에 대한 연구에서 혁혁한 업적을 남긴 모스, 데리다, 리쾨르의 선물론을 비교, 분석함으로써, 선물 자체에 대한 이해와 이 개념과 밀접하게 관련이 있는 '용서' 개념의 이해를 위한 초석을 놓고자 한다. 모스에 따르면 선물은 없다. 선물은 주는 것, 받는 것, 갚는 것이라는 세 가지 의무의 지배를 받는 경제적 교환으로 이해된다. 다만 모스는 주는 것이 의무라는 점에 주목하면서 도덕 정립의 가능성을 제시한다. 데리다는 이론적으로 선물 이해의 폭을 최대한 확장시키고 있다. '시간'이라는 요소에 주목하면서 선물은 찰나적으로만 존재하고, 시간이 지나면 결국 경제적 교환이 되고 만다는 점, 곧 선물의 아포리아를 지적한다. 리쾨르는 선물 개념에 적용되는 등가성의 논리와 이를 바탕으로 이루어지는 '정의'를 벗어나 넘침의 논리에 입각한 '사랑'과 '초윤리' 정립의 가능성을 제시한다. 리쾨르는 또한 이런 선물 개념을 토대로 '용서' 개념을 제시함으로써 다수의 인간들이 살아가고 있는 이 세상에서 윤리가 힘을 얻고, 도덕과 인간성이 회복되는 사회를 지향하는 기획에의 동참을 촉구하고 있다.