• Parasites, Hosts and Diseases
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• v.55 no.3
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• pp.267-285
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• 2017

Angiostrongylus cantonensis invades the central nervous system (CNS) of humans to induce eosinophilic meningitis and meningoencephalitis and leads to persistent headache, cognitive dysfunction, and ataxic gait. Infected mice (nonpermissive host), admittedly, suffer more serious pathological injuries than rats (permissive host). However, the pathological basis of these manifestations is incompletely elucidated. In this study, the behavioral test, histological and immunohistochemical techniques, and analysis of apoptotic gene expression, especially caspase-3, were conducted. The movement and motor coordination were investigated at week 2 post infection (PI) and week 3 PI in mice and rats, respectively. The cognitive impairs could be found in mice at week 2 PI but not in rats. The plaque-like lesion, perivascular cuffing of inflammatory cells, and dilated vessels within the cerebral cortex and hippocampus were more serious in mice than in rats at week 3 PI. Transcriptomic analysis showed activated extrinsic apoptotic pathway through increased expression of TNFR1 and caspase-8 in mice CNS. Immunohistochemical and double-labeling for NeuN and caspase-3 indicated the dramatically increased expression of caspase-3 in neuron of the cerebral cortex and hippocampus in mice but not in rats. Furthermore, western-blotting results showed high expression of cleaved caspase-3 proteins in mice but relatively low expression in rats. Thus, extrinsic apoptotic pathway participated in neuronal apoptosis might be the pathological basis of distinct behavioral dysfunctions in rodents with A. cantonensis infection. It provides the evidences of a primary molecular mechanism for the behavioral dysfunction and paves the ways to clinical diagnosis and therapy for A. cantonensis infection.

• Journal of the Korean Society of Costume
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• v.15
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• pp.217-231
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• 1990

The purposes of this study were to research 1) the background of origination, 2) the process of development and 3) the influences to modern clothing culture of American sportswear. The most Influential sportswear designers in America from beginning period to present : such as Claire McCardell, Calvin Klein, Ralph Lauren and Donna Karan were selected to study their life and achievements in the world sportswear market. The Results were as follows : 1) World War I & II have caused the greatest changes to modern history America became the center of world economy, society and culture. Politically, they have influenced democracy world-wide and raised the social status of women. The free American women enjoyed sports, Jazz drinking and car-driving. The advanced technology have accelerated mechanization and mass-production to the fashion industrv. 2) The above historical backgrounds have caused to change women's clothing to casual, practical and simple form. Dorothy Shaver at Lord & Taylor began promoting American designers who created the original American spirit. Claire McCardell created the seperated American sportswear to become world-wide fashion. Calvin Klein and Ralph Lauren, the sportswear designers who have the unique American feeling have come to have riches and fames equal to the top designers in Paris. 3) The American sportswear and fashion industry influenced Paris Mode, the traditional Haute Couture to open Pret-a-porter-a-porter. The concept of seperated coordination in American sportswear have promoted the advanced marketing techniques and merchandising systems to modern ready-to-wear industry. Fashion in 1980s have increased the mutual interdepedence between the American sportswear industry and the creative Paris Mode. And then, the fashion world in 1990s and 21C will be changed and developed on the basis of American sportswear mechanism.

• Information Systems Review
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• v.8 no.2
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• pp.103-117
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• 2006

As the interest in the combinatorial auction has increased, diverse combinatorial auction market types have been proposed. Although there have been several studies on the combinatorial auction design, the studies covered some factors or partial dimensions of combinatorial auction design. Given the potential practical value of combinatorial auctions, it is necessary to approach it with an integrated and systematic design methodology for supporting a comprehensive range of combinatorial auction models. Thus, we present a systematic framework for combinatorial auction design methodology. In particular, we classified the combinatorial auction architecture types, process types, and mechanism types. This framework characterizes the different combinatorial auction models, and lead to a useful taxonomy of the combinatorial auction design factors and taxonomy of the market types by coordination among the design factors. In addition, we illustrate an n-bilateral combinatorial auction market, derived from our design methodology, to show the viability of our study.

• KIPS Transactions on Computer and Communication Systems
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• v.4 no.1
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• pp.5-10
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• 2015

D2D (Device-to-Device) communication underlaying LTE-advanced networks is a promising technology to improve the system capacity and spectral efficiency. By sharing the same radio resources with cellular user equipments, D2D communications can significantly enhance the overall spectral efficiency. However, it may cause interference between D2D link and cellular link. Careful resource allocation and interference coordination between cellular and D2D communications are very important and need to be properly handled. This paper proposes a radio resource allocation scheme based on FFFR (Flexible Fractional Frequency Reuse) for D2D communication underlaying cellular networks. The base station selects randomly resource blocks assigned to cellular users, and reuses them for a D2D pair. Through simulations, we have confirmed that the proposed scheme improves the system throughput, reduces the computational complexity, and mitigates the interference of D2D link and cellular link.

• Journal of the Korean Society for Railway
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• v.15 no.5
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• pp.524-530
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• 2012

Recently, open access policy to railway operation has been widely discussed. Compared to the case of Korea, European countries have dealt with this topic over a few decades. The competition on railway slots incurs an important technological problem about how to optimally allocate railway slots requested from RUs to them. In other words, the authority should be able to coordinate the timetables requested from RUs in the non-discriminatory manner. Related with the coordination, compared to the other European countries, which have done many studies and experiments especially on auction mechanisms, Korean railway has paid less attention to this topic and there have not been any related studies. Our study analyses the state-of-the-arts about the railway slot allocation especially focusing on the auction mechanisms and the associated optimization problems. And we suggest a new railway slot allocation mechanism and related optimization model reflecting the adjustment within the tolerance and the operational policies between railway undertakings.

• Journal of Intelligence and Information Systems
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• v.12 no.2
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• pp.99-123
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• 2006

In an effect to composite an optimal supply chain, this study has introduced an agent-based negotiation as a method to assign a lot of orders to a large number of participants. As a resources allocation mechanism to form a strategic cooperation based on information sharing between supply chain members(buyers, manufacturers, suppliers), this agent negotiation provides coordination functions allowing all participants to make a profit and accomplishing Pareto optimum solution from the viewpoint of a whole supply chain. A SET model-based scheduling takes into consideration both earliness production cost and tardiness production cost, along with a competitive relationship between multiple participants. This study has tried to prove that the result of an agent-based negotiation is a Pareto optimal solution under the dynamic supply chain environment, establishing the mathematical formulation for a performance test, and making a comparison with the heuristic Branch & Bound method.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.6
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• pp.744-749
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• 2013

The protection switching technology is widely adopted in the fiber-optical transmission equipments based on TDM(Time Division Multiplexing), such as PDH, SDH/SONET. A variety of protection switching algorithms for Ethernet networks and the progress of standardization are summarized in the document. There are several kinds of protection switching algorithms for Ethernet networks, such as STP, RSTP, MSTP and etc. However, since Ethernet signal move through detour route, it causes much time to recover. Accordingly, it is difficult to secure a usability of Ethernet networks and QOS(Quality of Service). Also, if the protection switching protocol standardized by IEEE and ITU-T is used, it remains a inherent network switching time for protection. Therefore, a specific protection switching algorithm for Ethernet are needed for seamless and stable operation of Ethernet networks service for Distribution Automation System(DAS). A reliable protection algorithm with no switching delay time is very important to implement Self-healing service for DAS. This study of FPGA based protection switching algorithm for Ethernet networks shows that in case of faults occurrence on distribution power network, immediate fault isolation and restoration are conducted through interaction with distribution equipments using P2P(Peer to Peer) communication for protection coordination. It is concluded that FPGA based protection switching algorithm for Ethernet networks available 0ms switching time is crucial technology to secure reliability of DAS.

• International Journal of Internet, Broadcasting and Communication
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• v.7 no.1
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• pp.75-92
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• 2015

This paper presents the application of the bond valence method to estimate the valence charge distribution in several perovskite systems: $La_{{\tilde{1}}x}Pb_xMnO_3$ (x=0.1-0.5), $La_{0.6}Sr_{0.{\tilde{4}}x}Ti_xMnO_3$ (x=0.0-0.25) and $La_{{\tilde{1}}x}Sr_xCoO_3$ (x=0.1-0.5); the reviewing of their crystal structures is also incorporated. The results showed the failure of the elastic bonding mechanism in all studied systems and revealed the general deficit of the valence charge in their unit cells. This valence deficit was not associated with the structural defects and was not equally localized in all coordination spheres. As the content of substitution increased, the charge deficit declined systematically from balanced level, signifying the transfer of valence charge from the ${\tilde{B}}O_6$ to ${\tilde{A}}O_{12}$ spheres. This transfer depended on the valence deviation of spheres and the average reached near 2 electron per unit cell. The possible impact of the limitted accuracy of the available structural data on the bond valence results has also been considered.

• Molecules and Cells
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• v.21 no.2
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• pp.251-260
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• 2006

During mitosis, genomic integrity is maintained by the proper coordination of anaphase entry and mitotic exit via mitotic checkpoints. In budding yeast, mitotic exit is controlled by a regulatory cascade called the mitotic exit network (MEN). The MEN is regulated by a small GTPase, Tem1p, which in turn is controlled by a two-component GAP, Bfa1p-Bub2p. Recent results suggested that phosphorylation of Bfa1p by the polorelated kinase Cdc5p is also required for triggering mitotic exit, since it decreases the GAP activity of Bfa1p-Bub2p. However, the dispensability of GEF Lte1p for mitotic exit has raised questions about regulation of the MEN by the GTPase activity of Tem1p. We isolated a Bfa1p mutant, $Bfa1p^{E438K}$, whose overexpression only partially induced anaphase arrest. The molecular and biochemical functions of $Bfa1p^{E438K}$ are similar to those of wild type Bfa1p, except for decreased GAP activity. Interestingly, in $BFA1^{E438K}$ cells, the MEN could be regulated with nearly wild type kinetics at physiological temperature, as well as in response to various checkpoint-activating signals, but the cells were more sensitive to spindle damage than wild type. These results suggest that the GAP activity of Bfa1p-Bub2p is responsible for the mitotic arrest caused by spindle damage and Bfa1p overproduction. In addition, the viability of cdc5-2 ${\Delta}bfa1 $ cells was not reduced by $BFA1^{E438K}$, suggesting that Cdc5p also regulates Bfa1p to activate mitotic exit by other mechanism(s), besides phosphorylation.

• Journal of Electrical Engineering and Technology
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• v.13 no.5
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• pp.1778-1790
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• 2018

Based on the requirements and characteristics of multi-zone autonomous decision-making in modern power system, fully distributed computing methods are needed to optimize the economic dispatch (ED) problem coordination of multi-regional power system on the basis of constructing decomposition and interaction mechanism. In this paper, four fully distributed methods based on alternating direction method of multipliers (ADMM) are used for solving the ED problem in distributed manner. By duplicating variables, the 2-block classical ADMM can be directly used to solve ED problem fully distributed. The second method is employing ADMM to solve the dual problem of ED in fully distributed manner. N-block methods based on ADMM including Alternating Direction Method with Gaussian back substitution (ADM_G) and Exchange ADMM (E_ADMM) are employed also. These two methods all can solve ED problem in distributed manner. However, the former one cannot be carried out in parallel. In this paper, four fully distributed methods solve the ED problem in distributed collaborative manner. And we also discussed the difference of four algorithms from the aspects of algorithm convergence, calculation speed and parameter change. Some simulation results are reported to test the performance of these distributed algorithms in serial and parallel.