• KSII Transactions on Internet and Information Systems (TIIS)
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• 제18권4호
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• pp.1075-1089
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• 2024

In this paper, the optimizations of multi-hop cooperative molecular communication (CMC) system in cylindrical anomalous-diffusive channel in three-dimensional enviroment are investigated. First, we derive the performance of bit error probability (BEP) of CMC system under decode-and-forward relay strategy. Then for achieving minimum average BEP, the optimization variables are detection thresholds at cooperative nodes and destination node, and the corresponding optimization problem is formulated. Furthermore, we use conjugate gradient (CG) algorithm to solve this optimization problem to search optimal detection thresholds. The numerical results show the optimal detection thresholds can be obtained by CG algorithm, which has good convergence behaviors with fewer iterations to achieve minimized average BEP compared with gradient decent algorithm and Bisection method which are used in molecular communication.

• Advances in Traditional Medicine
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• 제1권1호
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• pp.71-81
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• 2000

High molecular weight water-insoluble chitosan alone has been previously shown to exhibit in vitro stimulatory effect on macrophages nitric oxide (NO) production. However, high molecular weight water-soluble chitosan (WSC) had no effect on NO production by itself. When WSC was used in combination with recombinant $interferon-{\gamma}\;(Rifn-{\gamma})$, there was a marked cooperative induction of NO synthesis in a dose-dependent manner. The optimal effect of WSC on NO synthesis was shown at 24 h after treatment with $rIFN-{\gamma}$. The increased production of NO from $rIFN-{\gamma}$ plus WSC-stimulated RAW 264.7 macrophages was decreased by the treatment with $N^G$ $monomethyl-_L-arginine$. The increase in NO synthesis was reflected, as an increased amounts of inducible NO synthase (iNOS) protein. Synergy between $rIFN-{\gamma}$ and WSC was mainly dependent on WSC-induced nuclear $factor-_KB$ activation. The present results indicate that WSC may provide various activities such as anti-microbial, anti-tumoral, and anti-viral. In addition, since NO has emerged as an important intracellular and intercellular regulatory molecule having functions as diverse as vasodilation, neural communication, cell growth regulation and host defense, it is tempting to hypothesize that this WSC is involved in the local control of the various fundamental processes such as cardiagra, cardiac infarction, impotence etc.