• Title/Summary/Keyword: Controlling of Properties

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Controlled Release of Drugs from Silicone Rubber Matrices-Effects of Physical Properties of Drugs and Release Controlling Agents on Drug Release Mechanisms- (실리콘 마트릭스로부터의 약물조절 방출-약물 및 방출조절제의 물성이 방출기전에 미치는 영향-)

  • Jeon, So-Young;Lee, Seung-Jin
    • Journal of Pharmaceutical Investigation
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    • v.21 no.4
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    • pp.237-245
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    • 1991
  • Matrix type silicone rubber devices were designed for long-term implantable drug delivery system. Release controlling agents (RCA), i.e., polypropylene glycol, polyethylene glycol, were employed to control drug release from the devices. The release rate of drug from RCA dispersed silicone matrices was mainly dependent on hydrophilicity-hydrophobicity of drug and RCA. In the case of hydrophilic drug, the release from the RCA dispersed matrix was regulated by swelling kinetics. Especially when the relatively hydrophobic polypropylene glycol was used, swelling control mechanism induced zero-order release kinetics. Whereas, the release of hydrophobic drug was resulted from partition mechanism. The effect of RCA was to increase drug diffusivity.

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Combustion Control and Symptom Detection on Self-excited Combustion Oscillation (자려 연소진동에 관한 연소제어와 징후의 검출)

  • Yang Young-Joon
    • Journal of Advanced Marine Engineering and Technology
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    • v.28 no.7
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    • pp.1111-1122
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    • 2004
  • An idea to suppress the self-excited combustion oscillation was applied to the flames. The characteristics of unsteady combustion were examined and the unsteady combustion was driven by forced pulsating mixture supply that can modulate its amplitude and frequency. The self-excited combustion oscillation having weaker flow velocity fluctuation intensity than that of the forced pulsating supply can be suppressed by this method. The effects of the forced pulsation amplitude and frequency on controlling self-excited combustion oscillations were also investigated comparing with the steady mixture supply. The unsteady combustion used in this experiment plays an important role in controlling self-excited combustion oscillation. Symptoms of self-excited combustion oscillation were also studied in order to predict the onset of combustion oscillation before it proceeded to a catastrophic failure For the purpose, the unique measures to observe the onset of self-excited combustion oscillations based on the careful statistics of fluctuating properties in flames, such as pressure or emission of OH radicals, have been proposed.

Synthesis of Dopamine by Plasma (플라즈마를 이용한 도파민 합성)

  • Kim, Seong-In;Lee, Deok-Yeon;Lee, Hae-Sin
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.121.2-121.2
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    • 2014
  • Synthesis of catecholamine from aniline is achieved by plasma enhanced CVD process. Catecholamine has a variety of functions in body such as brain and bloodstream controls. Catecholamine also has an interesting property of a material independent ability of functionalizing surface, which is found at mussels' adhesive nature. Synthesis of catecholamine has only been available from DOPA by chemical reduction and oxidation. This study presents the direct synthesis of catecholamine from further elemental source, aniline, which has not been achieved by a conventional chemical method. The process also indicates that a variety of catecholamine can be formed by controlling reactant gases. In additional to PECVD's very useful properties such as conformal, ultrathin and uniform coatings, a direct synthesis from aniline and a capability of controlling formation of a variety catecholamine is believed to open up a numerous applications.

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Investigation of Oxygen Functional Group Movement in Graphene Oxide Devices (그래핀 산화물 소자에서의 산소 작용기 이동 연구)

  • Eun Hee Kee;Mohd Musaib Haidari;Ji Hoon Jeon;Jin Sik Choi;Bae Ho Park
    • Journal of Sensor Science and Technology
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    • v.32 no.2
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    • pp.100-104
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    • 2023
  • In this study, a device was fabricated to check the possibility of a memory device by controlling the oxygen functional groups in graphene oxide formed with a 45-second exposure time. We discovered that graphene oxide can be formed using the ultraviolet (UV) light treatment method with different exposure times. Moreover, Raman spectroscopy measurement revealed that the oxygen functional groups can be moved by controlling the voltage. We further studied the change in the local graphene oxide region, which was found to be related to the modulation of the electrical properties of the device. Therefore, the fabricated graphene oxide device can be used as a wettability switching membrane and graphene-based ion transport device.

Controlling Electrical Properties in Zinc Oxide Thin Films by Organic Concentration

  • Yun, Gwan-Hyeok;Han, Gyu-Seok;Jeong, Jin-Won;Seong, Myeong-Mo
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.209.2-209.2
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    • 2013
  • We proposed and fabricated zinc oxide thin-film transistors (TFTs) employing 4-mercaptophenol (4MP) doped ZnO by atomic layer deposition (ALD) that results in highly stable and high performance. The 4MP concentration in ZnO films were varied from 1.7% to 5.6% by controlling Zn:4MP pulses. The n-type carrier concentrations in ZnO thin films were controlled from $1.017{\times}10^{20}/cm^3$ to $2.903{\times}10^{17}/cm^3$ with appropriate amount of 4MP doping. The 4.8% 4MP doped ZnO TFT revealed good device mobility performance of 8.4 $cm^2/Vs$ and the on/off current ratio of 106. Such 4MP doped ZnO TFTs exhibited relatively good stability (${\Delta}V_{th}$: 2.4 V) under positive bias-temperature stress while the TFTs with only ZnO showed a 4.3 ${\Delta}V_{th}$ shift, respectively.

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Synthesis of CNT Arrays with Controlling Morphology for High Spinnablility (방적성 향상을 위한 탄소나노튜브 어레이의 형상제어 및 특성평가)

  • Jeong, Seung Pil;Ryu, Seongwoo;Moon, Sook Young
    • Composites Research
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    • v.32 no.5
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    • pp.265-269
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    • 2019
  • The direct spinning of carbon nanotube (CNT) fibers is a promising method in the high performance composite materials. However, most of the reported CNT arrays do not have spinning properties because of their limited synthesis conditions. In this study, we investigate the properties of spinnable CNT arrays, which is closely related to the morphology of CNT array. The array morphology controlled by controlling the conditions of catalyst, carbon source, etc. By additional carbon source of ethylene and changing the composition of the catalyst, the waviness of the CNT array can be remarkably reduced, which leads to improve of the spinning properties. The synthesized CNT arrays were well aligned along c-axis and the synthesis conditions of the spinning array could be derived.

Hydrogen Embrittlement Properties of SA-723 steel via controlling Gaseous Hydrogen Pre-charging Condition (가스 수소 장입 조건 제어를 통한 SA-723 강의 수소 취화 특성 평가)

  • Kangjin Lee;Jeonghwan Kim;Hwayoung Lee;Dohoon Kim;Soonjik Hong;Gian Song
    • Journal of the Korean Society for Heat Treatment
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    • v.36 no.6
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    • pp.382-388
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    • 2023
  • In this study, hydrogen embrittlement (HE) behavior of a SA-723 steel via controlling gaseous hydrogen pre-charging condition has been analyzed. The gaseous hydrogen charging of the SA-723 steel was performed under a constant pressure of 20 MPa of gaseous H2 at 150℃ and 300℃ for 2 and 6h, and TDS, SSRT and Charpy tests were conducted to analyze the hydrogen embrittlement (HE) behavior of the SA-723 steel. Furthermore, prior to commencing the test, these specimens were coated with Zn to prevent hydrogen from diffusing out of a specimen during the tests. The TDS results showed that the 300℃-6h and 150℃-6h charged steels contain larger amounts of hydrogen than 300℃-2h and 150℃-2h charged steel. The SSRT and Charpy test results also showed the similar trends that the mechanical properties of the steels deteriorate as the amount of hydrogen charged in the steel increases. Therefore, this study suggests that, for SA-723 steel, the charging time parameter is more effective to charge more amount of hydrogen into SA-723 steel, rather than the charging temperature.

Effects of metal contacts and doping for high-performance field-effect transistor based on tungsten diselenide (WSe2)

  • Jo, Seo-Hyeon;Park, Jin-Hong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.294.1-294.1
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    • 2016
  • Transition metal dichalcogenides (TMDs) with two-dimensional layered structure, such as molybdenum disulfide (MoS2) and tungsten diselenide (WSe2), are considered attractive materials for future semiconductor devices due to its relatively superior electrical, optical, and mechanical properties. Their excellent scalability down to a monolayer based on the van der Waals layered structure without surface dangling bonds makes semiconductor devices based on TMD free from short channel effect. In comparison to the widely studied transistor based on MoS2, researchs focusing on WSe2 transistor are still limited. WSe2 is more resistant to oxidation in humid ambient condition and relatively air-stable than sulphides such as MoS2. These properties of WSe2 provide potential to fabricate high-performance filed-effect transistor if outstanding electronic characteristics can be achieved by suitable metal contacts and doping phenomenon. Here, we demonstrate the effect of two different metal contacts (titanium and platinum) in field-effect transistor based on WSe2, which regulate electronic characteristics of device by controlling the effective barreier height of the metal-semiconductor junction. Electronic properties of WSe2 transistor were systematically investigated through monitoring of threshold voltage shift, carrier concentration difference, on-current ratio, and field-effect mobility ratio with two different metal contacts. Additionally, performance of transistor based on WSe2 is further enhanced through reliable and controllable n-type doping method of WSe2 by triphenylphosphine (PPh3), which activates the doping phenomenon by thermal annealing process and adjust the doping level by controlling the doping concentration of PPh3. The doping level is controlled in the non-degenerate regime, where performance parameters of PPh3 doped WSe2 transistor can be optimized.

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Fabrication of Luminescent Hydroxyapatite Microspheres for Drug Loading and Release

  • Park, So Yeon;Kwon, Seung Lee;Baek, Mi Yeon;Yoo, Jin Sun;Kim, Min-Cheol;Jung, Hyun Suk
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.360.1-360.1
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    • 2016
  • Hydroxyapatite (Ca10(PO4)6(OH)2, HAP) particles have attracted a great deal of attention in biomedical fields due to their good biocompatibility, bioactivity and fairly broad applications as drug delivery, dental implant, bone cement, and etc. Thus, many researchers have made an effort to add new functionalities such as luminescence, drug delivery, and bone regeneration properties up to HAP powders by controlling their nanostructure as well as composition. In this research, the mesoporous strontium substituted HAP (Sr-HAP) microspheres were synthesized using a hydrothermal method. In this synthesis, aspartic acid monomers were utilized to form microsphere by controlling surface energy of HAP particles and Sr ions were substituted into Ca ion sites, which induced luminescence property in HAP powders. Moreover, the change in the amount of Sr substitution was found to influence the particle size, morphology, and concurrently surface area, which led to changing drug loading as well as drug release property. The amount of Sr influences the morphology, luminescent properties, particle size, surface area cell viability and drug loading property, which are investigated by SEM, TEM, XRD, FTIR, BET, XPS and in vitro test such as MTT assay and drug release test. In particular, the multifunctional Sr-HAP with molar ratios of 0.25 (Sr/(Ca+Sr)) possessed the strongest luminescent property as well as the superior drug loading and sustained release properties that were correspondent with large surface area and pore size. Our study indicates that the fabricated multifunctional Sr-HAP microspheres are quite useful for bone regeneration and drug delivery.

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Correlation Analysis Between Physical Properties of Linerboard and Score Crack (괘선터짐과 라이너지 물성간의 상관성 분석)

  • Chin, Seong-Min;Youn, Hye-Jung;Lee, Hak-Lae
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.41 no.1
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    • pp.30-36
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    • 2009
  • Cracking of scored or creased lines on boards is a serious problem in converting process of corrugated fiberboard. It is important to reduce the possibility of score crack in advance by controlling the related quality factors of linerboard. To find out the key properties affecting score crack, we carried out the correlation analysis between score crack and physical properties of linerboards. Score crack was evaluated by visual rating on surface crack after folding a linerboard using laboratory folding resistance tester. Thickness of linerboard was the most important factor to score crack. The critical limits of thickness and strain can be determined by correlation analysis for reducing the possibility of score crack.