• 제목/요약/키워드: Control group

검색결과 29,419건 처리시간 0.06초

Effects of Castration and Administration of Testosterone Propionate on the Thyroid Gland, Adrenal Gland and Testis in Immature Male Rats (미성숙 수흰쥐에 있어서 생식선척출 및 propionate testosterone 투여가 갑상선, 부신 및 정소조직에 미치는 영향)

  • 김종호;정영채;김창근
    • Korean Journal of Animal Reproduction
    • /
    • 제4권1호
    • /
    • pp.35-45
    • /
    • 1980
  • The purpose of this experiment was to investigate the effects of castration and administration of testosterone propionate(TP) on the development of the thyroid, adrenal glands and the testis in immature male rats, 25 days immatured, weighing 64.1${\pm}$2g, were divided into two groups of control and castrated, each sub-divided into 30 rats again, treated and untreated with TP respectivity. Each rat was given 20$m\ell$ of TP subcutaneously at two weeks interval. Six rats among each group were randomly sacrificed at 7, 21, 35, 49, and 63 days after treatment, of which their thyroid, adrenal glands and testis were collected for cytometric observation. The results obtained were as follows. 1. The size of the follicle of thyroid glands had a tendency to increase proportionally to the treatment period in every group. However, in castration group, the follicular size of the untreated with TP were significantly increased from 49 days (p<0.05) after treatment than that of the treated with TP, while in control group, the treated with TP were not increased during the treatment period. Regarding the height of the follicular epithelial cell in thyroid gland, the treated with TP had a tendency to increase than the untreated with TP in both castration and control group. 2. Regarding the size of the follicle of thyroid gland in relation with the increment period, the untreated with TP in control group were slightly increased from 49 days after treatment, but the treated with TP were not changed significantly. Castration group had a tendency to increase significantly than the control group, especially the untreated with TP in castration group were significantly increased. 3. As for the change of the relative height of thyroidal follicular epithelial cell in relation with the increment of treatment period, the untreated, A and C group, in both castration and control group were increased at 35 days 63 days after treatment while the treated, B and D group had tendency to increase from 21 days after treatment. 4. Regarding the thickness fo adrenal cortex, the castration group had a tendency to increase than the control group until 21 days after treatment. But, at 35 days, the change of the thickness was reversed; Mean while at 49 days and 63 days, especially C group in castration were significantly increased than any other groups although there were no significant differences among the every group during the whole treatment period. Regarding the thickness of adrenal cortex in relation with the increment of treatment period, A, B and C group had a tendency to increase until 21 days after treatment. After that period, there was no significant increment in all groups. Especially, in D group, there were no significant changes from 7 days to 63 days after treatment. 5. As for the tickness of adrenal medulla, there were no significant changes in every group of castration and TP treatment, except that the castration group had a tendency to increase continually than the control throughout the whole treament period. 6. In terms of the number, diameter and thickness of seminiferous tubule in testis of control group, the treated group with TP were distinctly reduced than those of the untreated group from 49 days after treatment respectively.

  • PDF

A Study on Anti-oxidative Effect of Electroacupuncture at Kokchi($LI_{11}$) in Rats (곡지(곡지)에 시술(施術)한 저주파 전침자극(電鍼刺戟)의 항산화(抗酸化) 효과(效果)에 대(對)한 실험적(實驗的) 연구(硏究)량)

  • Park, Choon-Eul;Kim, Young-Il;Yim, Yun-Kyoung
    • Journal of Acupuncture Research
    • /
    • 제24권3호
    • /
    • pp.81-97
    • /
    • 2007
  • Objectives: The purpose of this study is to investigate the anti-oxidative effect of electroacupuncture at Kokchi($LI_{11}$) in rats. Methods: A study administer AAPH to the abdominal cavity of rats and stimulate Kokchi($LI_{11}$) of the rat that lead to oxidative stress by electropuncture. And the study survey serum albumin, total bilirubin, LDL-cholesterol, LDH, Glucose, GOT, GPT and measure SOD activity, GSH concentration, catalase activity, NO concentration, MDA concentration. Results: 1. At the analysis of blood chemistry Albumin and Glucose significantly increase at $LI_{11}$-NR group, $LI_{11}$-EA group than at control group and holder group. LDL cholesterol, GOT, GPT decrease meaningfully. 2. As results of measurement at liver, SOD, Catalase represnet significantly increase at $LI_{11}$-NR group and $LI_{11}$-EA group than at control group and holder group. 3. Glutathione has some increases at the $LI_{11}$-NR group and $LI_{11}$-EA group than at the control group and the holder group. 4. As a result of measurement of NO and MDA's content, the content of NO decrease at the $LI_{11}$-NR group than at the control group. That reduces more meaningfully at the $LI_{11}$-EA group than at the control group. MDA has a significant decrease at the $LI_{11}$-NR group and the $LI_{11}$-EA group. 5. At the histological analysis, the study confirm that the density of intracellular cytoplasm in the liver tissue decreases at the control group as compared with the Normal group and the size of cell increases. Conclusions : These results suppose that electroacupuncture at $LI_{11}$ has an anti-oxidant effect in human.

  • PDF

A Study on the Effects of Structure of Intellect(SOI) Program on the Intelligence and Thinking Abilities (SOI 프로그램이 아동의 지능 및 사고력 개발에 미치는 영향)

  • 이기우
    • Journal of Gifted/Talented Education
    • /
    • 제7권1호
    • /
    • pp.51-76
    • /
    • 1997
  • The purpose of this study was to investigate the effects of Structure of Intellect( SOI) program for children. To achieve this purpose, 81 second grade children were sampled in a elementary school located In Seoul-city and randomly assigned to the experimental group and control group The SO1 training program were treated to the experimental group for 10 weeks, and the 'Thinking Abilities Test developed by Korea Creativity Research Institute were administered to them for pre-test and post-test. The collected data were analyzed by t-test for comparing the group means of experimental group and control group 'I'he results of this study were as follows : Firstly ere were statistically significant differences between experimental group and control group on the post-test scores of arithmetic[t(79)=2.73p,< .01] and visual memory[t(79)-3.68,p <.001]. The mean scores of experimental group(M=8.63) u ere higher than that of control group(Mz7.34) on arithmetic, and the mean scores to experimental group(M=16.68) were higher than that of control group(M=15 32) on visual memory Secondly there were no statistically significant differences between experimental group and control group on the post-test scores of logistic thinking abilities[t(79)=0.22, p>.05] and abstract thinking abilities[t(79)-0.22, p>.051. Thirdly, the post-test scores of visual memory and logical thinking abilities were more increased in the low intelligence group than the high intelligence group. This result showed that the SO1 program were more effective for the low intelligence group. Fourthly, the post-test scores of visual memory and logical thinking abilities were more increased in the low achievement group than the high achievement group. This result showed that the SO1 program were more effective for the low achievement group.

  • PDF

Effect of exercise during acute stage of stroke on affected and unaffected hindlimb muscle mass of cerebral ischemic rat (뇌졸증 후 급성기 운동이 뇌허혈 유발쥐의 뒷다리근 질량에 미치는 영향)

  • Im, Ji-Hye;Choe, Myoung-Ae
    • Journal of Korean Biological Nursing Science
    • /
    • 제4권1호
    • /
    • pp.51-69
    • /
    • 2002
  • The purpose of this study was to identify the effect of cerebral ischemia on affected(Lt) and unaffected(Rt) side of soleus, plantaris and gastrocnemius muscle mass and determine the effect of exercise on affected and unaffected side on soleus, plantaris and gastrocnemius muscle mass during acute stage of stroke. Sixteen male Sprague-Dawley rate with 200-270g body weight were randomly divided into three groups: control, stroke, and exercise after stroke(St+Ex) group. The control group received sham operation and the stroke group and St+Ex group received transient right MCA(middle cerebral artery) occlusion operation. The St+Ex groups ran on a treadmill for 20min/day at 10m/min and $10^{\circ}$ grade for 6days. During the experimental period body weight and diet intake was measured every morning. On the 7th day after operation, muscles were dissected from both affected and unaffected side of hindlimb. Cerebral infarction of stroke and St+Ex groups were identified by staining with TCC for 30 minutes. The data were analyzed by Kruskal-Wallis test and Mann-Whitney U test using the SPSSWIN 9.0 program. Significance was accepted at the level of p<0.05. The results were summarized follows : 1) There were no significant difference of the body weight on the first day of experiment among 3 groups. Whereas on the 7th day, the body weight of both stroke group and St+Ex group were significantly smaller than that of control group. Body weight of St+Ex group on the 7th day tended to be larger than that of stroke group. 2) Total diet intake of both stroke group and St+Ex group were also significantly smaller than that of control group. While total amount of diet intake in St+Ex group tended to be larger than that of stroke group. 3) The weight of gastrocnemius muscle of affected side in stroke group significantly decreased compared to that of control group and the weight of soleus and plantaris muscle of affected side in stroke group tended to decrease compared to that of control group. 4) The weight of plantaris muscle of unaffected side in stroke group significantly decreased compared to that of control group and the weight of soleus and gastrocnemius muscle of unaffected side in stroke group tended to decrease compared to those of control group. 5) The weight of gastrocnemius muscle of affected side in stroke group significantly decreased compared to that of unaffected side and there was no significant difference of the weight of soleus and plantaris muscle in stroke group between affected side and unaffected side. 6) The weight of soleus, plantaris and gastrocnemius muscle of both affected side and unaffected side in St+Ex group had a tendency of increase compared to those of stroke group. The relative weight of soleus and gastrocnemius muscle of affected side and soleus muscle of unaffected side in St+Ex group had a tendency to increase compared to those of stroke group. Based on these results, exercise during acute stage of stroke might attenuate muscle atrophy of both affected and unaffected side of hindlimb muscles.

  • PDF

A clinical study for the effect of ointment contained Takrisodok-Eum on recovering the damaged skin barrier by Atopic dermatitis (탁리소독음(托裏消毒飮) 함유 외용제의 아토피 피부염에 대한 임상적 연구)

  • O, Min-Ji;Yoo, Young-Beup;Lim, Sin-Heuk;Kim, Hee-Taek
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
    • /
    • 제24권3호
    • /
    • pp.84-107
    • /
    • 2011
  • Purposes : The purpose of present study is to detect the effects of ointment contained Takrisodok-Eum on the skin barrier's recovery of the Atopic dermatitis. Methods : A total of 44 patients who visited Semyung Oriental Medical Center from April 27th, 2011 to September 20th, 2011 were included in the study. In this study, the patients were treated with Takrisodok-Eum (experimental group) and positive control group. For 8 weeks of gross examination, hematological examination and instrumental asessment were made before and after the study to examine how well the products for experimental group with those for control group in recovering the damaged skin barriers by Atopic dermatitis. Results : 1. In the primary endpoint, SCORAD Index showed a statistically significant decline in experimental group. 2. In the secondary endpoint index of skin hydration, both the experimental group and the control group showed statistical significance. 3. In the secondary endpoint index of TEWL, the experimental group showed greater statistical significance than the control group. 4. In the secondary endpoint index of skin pH, skin pH showed a statistically significant decline in both the control group and the experimental group within the normal range. 5. In the secondary endpoint index of Total IgE, Eosinophil count, IL-10, IL-13, both the experimental group and the control group showed no statistical significance. 6. To evaluate the safety of the products for the human body, hematological examination and hematological biochemical examination, vital sign check were conducted; both control group and experimental group showed no abnormal level. And There were no severe adverse events during this study. Therefore, it is suggested that the safety of the products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that Takrisodok-Eum should be effective for the Atopic dermatitis.

Effect of acupuncture at TE4, SP3 and TE4+SP3 in hyperglycemia rats induced by streptozotocin (태백 ${\cdot}$ 양지 자침이 streptozocin에 의해 유발된 고혈당 백서에 미치는 영향)

  • Na, Chang-Su;Youn, Dae-Hwan;Cho, Myung-Rae;Lee, Kang-Ouk
    • Korean Journal of Acupuncture
    • /
    • 제24권1호
    • /
    • pp.95-111
    • /
    • 2007
  • Objectives : This research ws performed to investigate the effect of manual acupuncture at TE4, SP3 and TE4+SP3 on body weight, blood glucose, BUN, creatinine, lipid metabolism, liver function and morphological change of hepatic tissue in hyperglycemia rats. Methods : Experimenal groups were divided into hyperglycemia group(Control group), hyperglycemia and acupuncture therapy group at SP3, hyperglycemia and acupuncture therapy group at TE4, hyperglycemia and acupuncture therapy group at TE4+SP3 , once per 2 days during 5 weeks. Results : Body weight was decreased significantly in TE4 group of fifth week compared with Control group. Blood glucose was decreased significantly in SP3 group compared with control group. Creatinine was decreased significantly in TE4 and TE4+SP3 group compared with control group. Total cholesterol was decreased significantly in TE4+SP3 group compared with control group. Triglyceride was decreased significantly in TE4 gorup compared with control group. In the morphological change of hepatic cell, TE4 and SP3 group were showed he rough endoplasmic reticulum forms aggregates of parallel, flattened cisternae scattered randomly throughout the cytoplasm compared with control gruop. Conclusions : Acupuncture at TE4 can manage hyperglycemia by controlling body weight, and lipid metabolism in hyperglycemia rats induced by streptozotocin.

  • PDF

A Design for Elevator Group Controller of Building using Adaptive Dual Fuzzy Algorithm (Adaptive Dual Fuzzy 알고리즘을 이용한 빌딩의 엘리베이터 군 제어기 설계)

  • 최승민;김훈모
    • Proceedings of the Korean Society of Precision Engineering Conference
    • /
    • 한국정밀공학회 2001년도 춘계학술대회 논문집
    • /
    • pp.578-581
    • /
    • 2001
  • In this paper, the development of a new group controller for high-speed elevator is carried out utilizing approach of an adaptive dual fuzzy logic. A goals of control are the minimization of waiting time, mean-waiting time and long-waiting time in a building. when a new hall call is generated, adaptive dual fuzzy controller evaluate traffic pattern and change appropriately the membership function of fuzzy rule base. Control for co-operation among elevators in group control algorithm are essential, and the most critical control function in group controller is a effective and proper hall call assignment of elevators. Thy group elevator system utilizing adaptive dual fuzzy control reveals a great deal of improvement on its performance.

  • PDF

A Simulation of Elevator Group Controller using Adaptive Dual Fuzzy Algorithm (Adaptive Dual Fuzzy 알고리즘을 이용한 엘리베이터 군 제어 시뮬레이션)

  • 최승민;김훈모
    • Proceedings of the Korean Society of Precision Engineering Conference
    • /
    • 한국정밀공학회 2000년도 추계학술대회 논문집
    • /
    • pp.157-160
    • /
    • 2000
  • In this paper, the development of a new group controller for high-speed elevator is carried out utilizing approach of an adaptive dual fuzzy logic. A goals of control are the minimization of waiting time, mean-waiting time and long-waiting time in a high building, when a new hall call is generated, adaptive dual fuzzy controller evaluate traffic pattern and change appropriately the membership function of fuzzy rule, base. Control for co-operation among elevators in group control algorithm are essential , and the most critical control function in group controller is a effective and proper hall call assignment of elevators. The group elevator system utilizing adaptive dual fuzzy control reveals a great deal of improvement on its performance.

  • PDF

A Study on nutrition Knowledge, Nutritional Attitudes, Dietary Behavior and Dietary Intake by Weight Control Attempt among Middle School Female Students (대전 지역 여중생들의 체중조절 여부에 따른 영양지식, 식태도, 식행동 및 영양소 섭취 실태에 관한 연구)

  • 김경원;신은미
    • Korean Journal of Community Nutrition
    • /
    • 제7권1호
    • /
    • pp.23-31
    • /
    • 2002
  • The purpose of this study was to investigate weight control attempts and related factors among 209 middle school female students in Daejeon. Variables examined were body satisfaction, beliefs regarding weight control, body image, nutrition knowledge, nutritional attitudes, dietary behavior and dietary intake. A cross-sectional survey was employed, and data was analyzed using t-test and chi-square teat (at $\alpha$=0.05). The average height, weight, and body fat (%) of subjects were 160.2cm, 52.4kg, and 25.9%, respectively. Those who attempted weight control were 61.7% of the samples, suggesting that weight control was quite popular among adolescents. Students in the weight control attempt group were more satisfied with their body size (p<0.001), and showed more distorted body image than those in the no weight control attempt group (p<0.001). Most of beliefs regarding weight control were also different in the two groups. The attempt group believed more strongly in the advantages of weight control, and believed less strongly in the harmful effects or difficulties associated with weight control. Although there were no differences in nutrition knowledge in the two groups, nutritional attitudes were slightly more favorable in the attempt group (p<0.01). In contrast, eating behaviors, such as those related to caloric intake (p<0.001), body image (p<0.001), and specific situations (p<0.01) were more desirable in the no-attempt group than in the attempt group. In addition, dietary intake of the attempt group was less adequate than that of the no-attempt group for nutrients such as iron (p<0.01), vitamin A, thiamin, riboflavin, and vitamin C(p<0.05). This study suggests that adolescents who attempt control weight have a more distorted body image and inadequate diet and showed more undesirable eating behaviors. Students should be taught and practice desirable methods of weight control. Educational programs should also include strategies for changing beliefs regarding weight control, as well as modifying diets and eating behaviors.