• Bulletin of the Korean Chemical Society
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• 제33권2호
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• pp.519-523
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• 2012

A kinetic study is reported on nucleophilic displacement reactions of benzyl 2-pyridyl carbonate 6 with alkalimetal ethoxides, EtOM (M = Li, Na, and K), in anhydrous ethanol at $25.0{\pm}0.1^{\circ}C$. The plots of pseudo-firstorder rate constant $k_{obsd}$ vs. [EtOM] curve upward, a typical phenomenon reported previously for alkaline ethanolysis of esters in which alkali-metal ions behave as a Lewis-acid catalyst. The kobsd value for the reaction of 6 with a fixed EtOK concentration decreases rapidly upon addition of 18-crown-6-ether (18C6), a complexing agent for $K^+$ ion up to [18C6]/[EtOK] = 1.0 and then remains constant thereafter, indicating that the catalytic effect exerted by K+ ion disappears in the presence of excess 18C6. The reactivity of EtOM towards 6 increases in the order $EtO^-$ < EtOLi < EtONa < EtOK, which is contrasting to the reactivity order reported for the corresponding reactions of 2-pyridyl benzoate 4, i.e., $EtO^-$ < EtOK < EtONa < EtOLi. Besides, 6 is 1.7 and 3.5 times more reactive than 4 towards dissociated $EtO^-$ and ion-paired EtOK, respectively. The reactivity difference and the contrasting metal-ion selectivity are discussed in terms of electronic effects and transition-state structures.

• 지능정보연구
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• 제11권3호
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• pp.129-139
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• 2005

급속한 정보통신의 발달은 인간의 삶에 직접적인 영향을 끼치는 단계에 접어들게 되었다. 기존의 컴퓨팅은 사용자의 요청에 근거하여 동작하지만 유비쿼터스 컴퓨팅은 사용자의 의향과 상황을 인지해 능동적으로 목표를 설정하고 협력을 통하여 업무를 수행하게 된다. 앞으로 다가올 새로운 컴퓨팅 환경에서 주된 역할을 하게 될 개체인 에이전트와 이들이 상호 협력하는 기반구조인 다중 에이전트 시스템에 관하여 활발히 연구가 진행 중이다. 본고에선 다중 에이전트 시스템에서의 의미적 상호 운용성을 보장하고 지적활동의 중심적 자료구조가 될 온톨로지와 온톨로지를 효율적으로 관리하는 저장소에 관한 요구사항과 구조를 제시한다. 또한 분산적으로 관리 되는 온톨로지 저장소와 다중 에이전트 환경에서 일반적인 온톨로지 저장소 사용을 위한 온톨로지 에이전트를 제시한다.

• Fisheries and Aquatic Sciences
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• 제12권3호
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• pp.194-202
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• 2009

Sulfated fucans are known to have both anti-thrombotic and anti-coagulant activities. In this study, the variation in platelet aggregation and anti-coagulant activities was investigated in vitro with regard to administered dose, molecular weight distribution, sulfate content, and sugar composition in two algal fucoidans from Eisenia bicyclis and Undaria pinnatifida sporophylls (Mekabu). The anti-coagulant activity largely correlated with sulfate content and with molecular weight distribution in a dose-dependent manner. However, both fucoidans demonstrated inhibitory responses to ADP-induced platelet aggregation in dose- and structure-dependent manners that contrasted with the anti-coagulant activity. Neither molecular weight distribution nor sulfate content greatly affected platelet-aggregation inhibition (PA-inhibition) by the fucoidan fractions, whereas anti-coagulant activity was sensitive to these structural factors. Interestingly, an E. bicyclis fucoidan fraction exhibited almost complete PA-inhibition at a treatment dose of 500 mg/mL while retaining weak anti-coagulant activity. In conclusion, these observations suggest that fucoidan may be a useful anti-thrombotic or anti-platelet agent in various arterial thrombotic disorders, including post-vascular intervention with controlled bleeding complications, due to its anti-coagulant modulating activity.

• 생명과학회지
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• 제17권7호통권87호
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• pp.910-914
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• 2007

본 연구는 MRI 조영제나 새로운 생리활성 물질을 개발키 위해 paraformaldehyde와 hypophosphorous acid를 아미노산인 glycine 혹은 glutamic acid와 함께 반응시켜 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-diazadiphos-phocme-1,5-diacetic acid 1 와 3,7-dihydrexy-3,7-dioxoperhydre-1,5,3,7-diazadiphos-phocme-1,5-di- (2-glutaric acid)3을 합성하였다. 그러나 aspartic acid에 의한 2-[5-(1,2-dicarboxy-ethyl)-3,7-dihydroxy-3,7-dioxo-315.715-[1,5,3,7]diazadiphosphocan-1-yl]-succinic acid 2는 얻지 못했다. 합성 된 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-dia-zadiphosphocine-1,5-diacetic acid 1을 산 촉매에 의한 에스테르화반응시켜 화합물 3,7-dihydroxy-3,7-dioxoper-hydro-1,5,3,7-diazadiphosphocine-1,5-diacetic acid methyl ester 4, 3,7-dihydroxy-3,7-dioxoperhydro-1,5,3,7-dia-zadiphosphocine-1,5-diacetic acid ethyl ester 5, 그리고 3,7-dihyoxy-3,74dioxoperhyo-1,5,3,7-diazadiphosphocine-1,5-diacetic acid propyl ester 6을 합성하였다. 계속해서 다양한 반응을 통해 새로운 화합물을 합성할 것이며 생리활성검색도 실시할 예정이다.

• 한국의사학회지
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• 제29권2호
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• pp.49-59
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• 2016

Ginseng, a Korean native herb, has been a symbol of mystic cure-all which provides longevity benefits throughout Korean history. According to Chinese historical records, a major source of wild ginseng has been described as Korean peninsula, which is the most suitable ginseng production area, and the Manchu region near Mt. Baekdu and the Maritime Province. Since Tang dynasty period (618-917 CE), Chinese has also called ginseng as "Goryeo Ginseng", which is named after "Goguryeo" (37 BCE-668 CE), an ancient kingdom of Korea, from which they mainly imported the herb as the region was famous for its high quality of ginseng. To date, it refers to Korean ginseng. This study compares the medicinal properties of ginseng as stated in the ancient Korean medical books with the major Korean historical records regarding the usage of ginseng and its symbolism of longevity in everyday life. By contrasting these findings, we tried to figure out how the actual medicinal properties of ginseng and the anticipation of longevity are related. It was confirmed that the expectations about longevity were widely applied to everyday life. In addition, the study investigates the various usage of ginseng as a motive for decorative patterns and as an ingredient for daily products including snacks, health drinks, various types of food, clothing patterns, and so on. Finally, the usage of ginseng ingredients in the cosmetic products fulfilled the desire of Korean people to purchase, showing the aesthetic recognition and medicinal understandings about the herb. These findings suggest that ginseng is an important medicinal agent that not only symbolizes longevity and good health but also has a great influence on the lives of Koreans.

• Journal of Ginseng Research
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• 제41권2호
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• pp.180-187
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• 2017

Background: The incidence of halitosis has a prevalence of 22-50% throughout the world and is generally caused by anaerobic oral microorganisms, such as Fusobacterium nucleatum, Clostridium perfringens, and Porphyromonas gingivalis. Previous investigations on the structure-activity relationships of ginsenosides have led to contrasting results. Particularly, the antibacterial activity of less polar ginsenosides against halitosis-related bacteria has not been reported. Methods: Crude saponins extracted from the Panax quinquefolius leaf-stem (AGS) were treated at $130^{\circ}C$ for 3 h to obtain heat-transformed saponins (HTS). Five ginsenoside-enriched fractions (HTS-1, HTS-2, HTS-3, HTS-4, and HTS-5) and less polar ginsenosides were separated by HP-20 resin absorption and HPLC, and the antimicrobial activity and mechanism were investigated. Results: HPLC with diode-array detection analysis revealed that heat treatment induced an extensive conversion of polar ginsenosides (-Rg1/Re, -Rc, -Rb2, and -Rd) to less polar compounds (-Rg2, -Rg3, -Rg6, -F4, -Rg5, and -Rk1). The antimicrobial assays showed that HTS, HTS-3, and HTS-4 were effective at inhibiting the growth of F. nucleatum, C. perfringens, and P. gingivalis. Ginsenosides-Rg5 showed the best antimicrobial activity against the three bacteria, with the lowest values of minimum inhibitory concentration and minimum bactericidal concentration. One major reason for this result is that less polar ginsenosides can more easily damage membrane integrity. Conclusion: The results indicated that the less polar ginsenoside-enriched fraction from heat transformation can be used as an antibacterial agent to control halitosis.

• 인지과학
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• 제27권3호
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• pp.407-420
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• 2016

본 연구는 최후통첩 게임 패러다임을 활용하여 의사결정자의 역할 주체 (개인 vs. 대표자)와 상대그룹과의 사회적 관계 (중립적 vs. 경쟁적)에 따른 행동적 불연속성을 검증하였다. 참가자들은 모두 최후통첩 게임에서 제안자가 아닌 응답자의 역할을 하였으며, 그룹의 대표자로 의사결정할 때 더 많은 제안을 수락함으로써 개인으로서 의사결정할 때보다 더 경제적으로 합리적인 행동패턴을 보였다. 하지만 이러한 개인-대표자 행동 불연속성은 중립적 관계에서만 유지되었다. 상대방 그룹이 참가자 그룹과 경쟁적인 관계에 있는 조건에서는 역할 주체가 그룹의 대표자일 때 오히려 더 많은 제안을 거부함으로써 경제적으로 더 비합리적인 행동패턴을 보였다. 특히, 경쟁적 관계와의 최후통첩 게임에서는 상대방 그룹에 대한 마음 귀인의 정도에 따라 다른 수준의 의사결정 편향을 관찰할 수 있었다. 구체적으로, 경쟁적 관계에 있는 그룹에 대해서 더 많은 마음을 귀인하는 참가자일수록 더 높은 수준의 거부 비율을 보임을 알 수 있었다. 본 연구는 그룹 맥락에서의 개인 의사결정 패턴 - 때로는 전체 그룹의 금전적 이익을 포기하고 궁극적으로는 사회적 잉여의 준최적화를 초래할 수 있는 - 에 대한 이해를 제공한다는 데 그 중요성이 있다.