The influenza A viruses have high mutation rates and cause a serious health problem worldwide. Therefore, this study focused on genome characterization of the viruses isolated from Thai patients based on the next-generation sequencing technology. The nasal swabs were collected from patients with influenza-like illness in Thailand during 2017-2018. Then, the influenza A viruses were detected by reverse transcription-quantitative polymerase chain reaction and isolated by MDCK cells. The viral genomes were amplified and sequenced by Illumina MiSeq platform. Whole genome sequences were used for characterization, phylogenetic construction, mutation analysis and nucleotide diversity of the viruses. The result revealed that 90 samples were positive for the viruses including 44 of A/H1N1 and 46 of A/H3N2. Among these, 43 samples were successfully isolated and then the viral genomes of 25 samples were completely amplified. Finally, 17 whole genomes of the viruses (A/H1N1, n=12 and A/H3N2, n=5) were successfully sequenced with an average of 232,578 mapped reads and 1,720 genome coverage per sample. Phylogenetic analysis demonstrated that the A/H1N1 viruses were distinguishable from the recommended vaccine strains. However, the A/H3N2 viruses from this study were closely related to the recommended vaccine strains. The nonsynonymous mutations were found in all genes of both viruses, especially in hemagglutinin (HA) and neuraminidase (NA) genes. The nucleotide diversity analysis revealed negative selection in the PB1, PA, HA, and NA genes of the A/H1N1 viruses. High-throughput data in this study allow for genetic characterization of circulating influenza viruses which would be crucial for preparation against pandemic and epidemic outbreaks in the future.
Kim, Soo Hyun;Lee, AhReum;Kim, SuJi;Kim, Kyeong Jo;Kwon, Ojun;Choi, Joon Young;Koo, Jin Suk;Roh, Seong-Soo
The Korea Journal of Herbology
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v.32
no.4
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pp.17-24
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2017
Objectives : Advanced glycation end products (AGEs) is bind formation of glucose and protein. Acceleration of AGE formation during hyperglycemia is associated with the pathogenesis of diabetic complications and causes kidney and skin damage. The aim of this study was investigated the AGEs inhibitory activity and antioxidant activity of water extracts from young persimmon (YP) and heated young persimmon (HYP). Methods : Paeoniae Radix Alba (YP) is prepared by heating with 30% ethanol. AGEs formation inhibitory activities of YP and HYP measured using bovine serum albumin. To evaluate the protective effects of YP and HYP in diabetic rats induced with streptozotocin (STZ) and methyl glyoxal (MGO), SD rats were distributed into four groups; normal mice (Nor), AGEs-induced rats (Con), AGEs-induced rats treated with 100 mg/kg YP (YP), AGEs-induced rats treated with 100 mg/kg heated YP (HYP) for 3weeks. Heated young persimmon respectively decrease AGEs construction. Results : YP and HYP administration inhibited the biomarkers of AGEs in serum, kidney and skin tissues. AGE-induced rats revealed that the significant decreased collagen however, heat processing methods of young persimmon up regulated inhibits AGEs-induced collagen decrease. The expressions of AGEs were decreased in YP and HYP treated group compared with the control group in tissues. It specifies that HYP has potential to serve as a positive regulator of via AGEs path way. Conclusion : It has proposed that may have an improvement effect on diabetic complications, heated young persimmon has AGEs inhibitory excellent activities and antioxidant effect.
Journal of the Computational Structural Engineering Institute of Korea
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v.35
no.1
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pp.15-22
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2022
This paper introduces research on the hinge joint of modular structure joints using finite element analysis. The modular structure has a characteristic in that it is difficult to expect the integrity of columns and beams between unit modules because the construction is carried out such that the modules are stacked. However, the current modular design ignores these structural characteristics, considers the moment transmission for the lateral force, and analyzes it in the same manner as the existing steel structure. Moreover, to fasten the moment bonding, bolts are fastened outside and inside the module, resulting in an unreasonable situation in which the finish is added after assembly. To consider the characteristics that are difficult to expect, such as unity, a modular structure system using hinge joints was proposed. This paper proposed and reviewed the basic theory of joints by devising a modified scissors model that is modified from the scissors model used in other research to verify the transmission of load when changing from the existing moment junction to a hinge junction. Based on the basics, the results were verified by comparing them with Midas Gen, a structural analysis program. Additionally, the member strength and usability were reviewed by changing the modular structure designed as a moment joint to a hinge joint.
As a case study, this paper aims to analyze the outcome of culture projects that are, like the building project of culture city, comprehensively funded by integrating individual projects with various purposes. Considering that there is no assessment indicators on the performance of culture city building project, it tries to propose and analyze indicators for evaluating the outcome, influence, and effect of the project, by taking into account social, cultural, and economical effect. The analysis result demonstrates the building project of specialized region in culture has bigger income effect than the construction project of cultural facilities or cultural voucher program. Because income growth leads to consumption growth, a project type with bigger income effect has more influence on industrial growth. In other words, the study shows that comprehensive funding projects, by integrating programs related to cultural citizens, cultural programs, and cultural space, is more effective for sustainable cultural development of a region. And it means the way of government assistance for cultural projects does need to change from individual project-based to comprehensive funding project-based.
Journal of the Korean Institute of Electrical and Electronic Material Engineers
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v.35
no.6
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pp.631-638
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2022
Microgrid, which enables the production and consumption of electricity to be done independently on a small scale, has been studied on one of the solutions of reinforcement for flexibility of electronic system. This study examined the application effect of new microgrid by applying hybrid battery in electric power storage device. We designed the system to highlight the advantage of each battery and complement the disadvantage by using hybrid system with Lithium-ion battery and interval Redox flow battery. It runs with lithium-ion battery during the initial startup while the Redox flow battery operates for a long time at the end of excessive period, and it enables a discharge of Lithium-ion and Redox flow battery at the same time when the load has a large output. We chose Maldives as a subject of this study for organizing and optimizing independent microgrid. Maldives is the country to accomplish 100% domestic electricity in South Asia, but the whole electric power is supplied through diesel generation imported fossil fuel. We organized and optimized microgrid for energy independence on Malahini island to solve Maldives energy cost problem and global energy environment matters. We analyzed the daily power supply and accumulated the power supply from September 18, 2018~February 11, 2019. The accumulated power supply was about 120.4 MWh and the daily power supply was about 800~1000 kWh. Based on the collected information, we divided the cases into three models which are only diesel generator, solar generator as well as diesel generator, and solar+ESS+diesel generator. We analyzed the amount of oil consumption compared to the cost of construction and power output. The result showed that solar+ESS+diesel generator was most economically feasible. As well, we obtained that our considering hybrid battery system reduced the fuel consumption for diesel power generation about 10~15%.
Kim, Do-Eun;Kim, Sung-hwan;Choi, Seong-woo;Son, Yong-Hoon;Zoh, Kyung-jin
Journal of the Korean Society of Environmental Restoration Technology
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v.25
no.4
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pp.49-65
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2022
Since trees in the city are green assets that create a healthy environment for the city, systematic management of trees improves urban ecosystem services. The sporadic urban tree information centered on the site is vast, and it is difficult to manage the data, so efforts to increase efficiency are needed. This paper summarizes tree data inventory based on data constructed by Seoul Green Trust activists and constructs and discloses online database maps using Tableau Software. In order to verify the utilization of the map, we divided into consumer and supplier aspects to collect various opinions and reflect feedback to implement tree database maps for each area and species of Seoul Forest. As a result, the utilization value of tree database in urban parks was presented. The technical significance of this study is to systematically record the process of constructing and implementing a dashboard directly using the Mapbox platform and Tableau Software in the field of landscaping for the first time in Korea. In addition, the implications and supplements of landscape information were derived by collecting user opinions on the results. This can be used as an exploratory basis in the process of developing online-based services such as web and apps by utilizing landscaping tree information in the future. Although the visualization database currently constructed has limitations that ordinary users cannot interact in both directions because it utilizes business intelligence tools in terms of service provision it has affirmed both the database construction and its usability in web public format. In the future it is essential to investigate the assets of the trees in the city park and to build a database as a public asset of the city. The survey participants positively recognized that information is intuitively presented based on the map and responded that it is necessary to provide information on the overall urban assets such as small parks and roadside trees by using open source maps in the future.
Journal of the Korean Society for Library and Information Science
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v.57
no.3
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pp.97-117
/
2023
The purpose of this study is to suggest a mid- to long-term expansion plan to resolve the blind spot and alleviate the imbalance of public library services in Daegu City. The research methods for this purpose included literature review, related laws and statistical data analysis, case study, and opinion survey. As a result, the first service area was set as a total of 14 areas based on administrative districts(Jung-gu, Seo-gu, Nam-gu, and Dalseong-gun each have one, Dong-gu and Buk-gu each have two, and Suseong-gu and Dalseo-gu have three each). Second, the expansion scenario for public libraries in Daegu City was proposed to add 26 libraries by the final target year (2032) based on the trend of national library growth over the past 13 years (2008-2020) and the forecast for the next 10 years (2023-2032). Third, the construction scenarios for each basic local government, excluding the Daegu representative library, are as follows: One library each in Jung-gu, Seo-gu, and Nam-gu; two libraries in Suseong-gu; three libraries in Dalseong-gun; four libraries in Dong-gu; and seven libraries each in Buk-gu and Dalseo-gu. In terms of floor area, it is proposed to add a total of 17 branch libraries with a minimum legal standard of 330-2,499㎡, four central libraries with 2,500-4,999㎡ each, and four central libraries with 5,000-9,999㎡ each. On the premise of these conditions, Daegu City and public libraries should focus on creating an inclusive and open community space, creating a digital platform, strengthening the library operation and cooperation system centered on Daegu representative library, developing collections and specializing services for local hub libraries, enhancing various knowledge information and program services, managing key library indicators and improving social contribution.
KIPS Transactions on Software and Data Engineering
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v.12
no.9
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pp.381-386
/
2023
Many existing test case generation researchers extract test cases from models. However, research on generating test cases from natural language requirements is required in practice. For this purpose, the combination of natural language analysis and requirements engineering is very necessary. However, Requirements analysis written in Korean is difficult due to the diverse meaning of sentence expressions. We research test case generation through natural language requirement definition analysis, C3Tree model, cause-effect graph, and decision table steps as one of the test case generation methods from Korean natural requirements. As an intermediate step, this paper generates test cases from C3Tree model-based decision tables using meta-modeling. This method has the advantage of being able to easily maintain the model-to-model and model-to-text transformation processes by modifying only the transformation rules. If an existing model is modified or a new model is added, only the model transformation rules can be maintained without changing the program algorithm. As a result of the evaluation, all combinations for the decision table were automatically generated as test cases.
Journal of Korea Entertainment Industry Association
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v.13
no.1
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pp.81-88
/
2019
This article aims to identify the characters and theme shown in dance costume and utilize them from an educational perspective by constructing digital museum archiving, which can be systematically collected, classified and stored from dance costume. It deals with definition of digital museum archiving as theoretical background and examples of how to create digital museum archiving as research content. The role that archiving plays in digital museum and effectiveness have been demonstrated. Archive is a term used to indicate extensive material and its storage and referred to as an integrative model of display in the computer-generated space. When it comes to producing dance costume as a form of digital museum, the museum is to be made in the computer-generated area of dance costume. The museum shows each division of major, medium and minor classification. The major classification divides genre of dance performance into Korean dance, modern dance and ballet. The middle involves choreographers, costume designers. The minor categorization includes newspaper, interviews, performance pictures, and programs. Digital museum has the value of space utilization, creation, culture, utilization of multiple educational programs, offering of digital museum content, two-way communication, and program development of the new display form.
Though the stability analysis of soil slopes widely employs the limit equilibrium method, the study on the jointed rock slopes must consider the direction of joint and the characteristics of Joint at the same time. This study analyzes the result of the change in the factors which show the characteristics of discontinuity and the shape factor of rock slopes, and so on, in an attempt to validate the propriety as to the interpretation of jointed rock slope stability which uses the general finite element program. First, the difference depending on the flow rules was compared, and the factor effect study was conducted. The selected independent variables included the direction of joint which displays the mechanical characteristics of discontinuity, adhesive cohesion, friction angle, the inclination and height of rock slope which reveal the shape of slope and surcharge load. And the horizontal displacement was numerically interpreted at the 1/3 point below the slope, a dependent variable, to compare the relative degree of factor effects. The findings of study on factor effects led to the validation that the result of horizontal displacement for each factor satisfied various engineering characteristics, making it possible to be applied to stability interpretation of jointed rock slope. A modelling is possible, which considers the application of the result of real geotechnical surveys & laboratory studies and the non-linear characteristics when designing the rock slope. In addition, the stress change which may result from the natural disaster, such as precipitation, and the construction, can be expressed. Furthermore, as the complicated rock condition and the ground supporting effect can be considered through FEM, it is considered to be very useful in making an engineering decision on the cut-slope, reinforcement and so on.
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