• Advances in concrete construction
• /
• v.16 no.4
• /
• pp.177-188
• /
• 2023

In the context of the shortage of river sand, two types of manufactured sand (MS) were used to partially replace river sand (RS) to design manufactured sand concrete (MSC). A total of 81 specimens were designed for uniaxial compression test and beam flexure test. Two parameters were considered in the tests, including the types of MS (i.e. limestone manufactured sand (LMS), pebble manufactured sand (PMS)) and the MS replacement percentage (i.e., 0%, 25%, 50%, 75%, 100%). The stress-strain curves of MSC were obtained. The effects of these parameters on the compressive strength, elastic modulus, peak strain, toughness and flexural strength were discussed. Additionally, the sensitivity of particle size distributions to the performance of MSC was evaluated based on the grey correlation analysis. The results showed that compared with river sand concrete (RSC), the rising slope of the stress-strain curves of limestone manufactured sand concrete (LMSC) and pebble manufactured sand concrete (PMSC) were higher, the descending phrase of LMSC were gentle but that of PMSC showed an opposite trend. The physical and mechanical properties of MSC were affected by the MS replacement percentage except the compressive strength of PMSC. When the replacement percentage of LMS and PMS were 50% and 25% respectively, the corresponding performances of LMSC and PMSC were better. In generally, when the replacement percentage of LMS and PMS were same, the comprehensive performance of LMSC were better than that of PMSC. The constitutive model and the equations for mechanical properties were proposed. The influence of particle ranging from 0.15 mm to 0 mm on the performance of MSC was lower than particle ranging from 4.75 mm to 0.15 mm but this influence should not be ignored.

• Biomolecules & Therapeutics
• /
• v.32 no.3
• /
• pp.301-308
• /
• 2024

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by extracellular amyloid plaques composed of amyloid β-peptide (Aβ). Studies have indicated that Ca²⁺ dysregulation is involved in AD pathology. It is reported that decreased capacitative Ca²⁺ entry (CCE), a refilling mechanism of intracellular Ca²⁺, resulting in increased Aβ production. In contrast, constitutive activation of CCE could decrease Aβ production. Panax ginseng Meyer is known to enhance memory and cognitive functions in healthy human subjects. We have previously reported that some ginsenosides decrease Aβ levels in cultured primary neurons and AD mouse model brains. However, mechanisms involved in the Aβ-lowering effect of ginsenosides remain unclear. In this study, we investigated the relationship between CCE and Aβ production by examining the effects of various ginsenosides on CCE levels. Aβ-lowering ginsenosides such as Rk1, Rg5, and Rg3 potentiated CCE. In contrast, ginsenosides without Aβ-lowering effects (Re and Rb2) failed to potentiate CCE. The potentiating effect of ginsenosides on CCE was inhibited by the presence of 2-aminoethoxydiphenyl borate (2APB), an inhibitor of CCE. 2APB alone increased Aβ42 production. Furthermore, the presence of 2APB prevented the effects of ginsenosides on Aβ42 production. Our results indicate that ginsenosides decrease Aβ production via potentiating CCE levels, confirming a close relationship between CCE levels and Aβ production. Since CCE levels are closely related to Aβ production, modulating CCE could be a novel target for AD therapeutics.

• Proceedings of the Korean Environmental Sciences Society Conference
• /
• 2003.05a
• /
• pp.249-254
• /
• 2003

분석에 이용된 격자망은 동곡, 고로, 미성, 병천, 효령 및 무성지점에 각각 12개, 30개, 45개, 76개, 46개 및 1265개의 조격자를 구성하였으며 하천의 수로방향 및 경사형태를 세분화하기 위하여 각 지점에 대하여 8개, 24개, 24개, 44개, 12개 및 64개의 세격자로 분할하였다. AGNPS를 이용한 첨두유량의 모의발생 결과치가 동곡, 고로, 미성, 병천, 효령 및 무성지점에서 측정값과 비교하여 각 호우사상별로 상대오차가 1.0~25.0%, 4.0~27.0%, 7.0~29.2%, 2.0~23.9%, 3.0~25.0% 및 3.6~21.0%의 차이를 나타내었다. 분석결과에서 AMCII조건에서는 관측치와 분석결과치가 유사하게 나타났으나 AMCI조건에 대해서는 상대적으로 작은 값을 보였으며 AMCIII조건에서는 다소 큰 값으로 분석되었다. SCS방법에서 제안하는 AMC조건별 CN값을 우리 실정에 적합하도록 수정 보완하기 위한 수정 유출곡선지수 $CN_{m}$ /I과 $CN_{m}$/III을 재구성하였으며, 여기에 적용되는 수정 유출 곡선지수식의 계수 a를 추정한 결과, 기왕에 발표된 연구결과와 거의 일치된 경향을 나타내었다. 제안된 수정 CN식을 이용하여 산정한 결과치와 관측치는 거의 유사하게 나타났다. AGNPS모델에 의한 유출량 산정에 있어 수문학적 토양피복형수(CN)의 결정을 위하여 선행강우량과 토양의 공극율 및 지형인자인 각 셀마다의 유역경사를 이용하여 관계식(CN =f($X_1$, $X_2$, $X_3$))을 유도하였으며, 분석 결과에서 CN이 선행강우량과 가장 밀접한 관계가 있음을 알 수 있었으며 유역경사, 토양의 공극율 순으로 나타났다..88mg/$\ell$~의 범위로 나타났다. 무태교 지점에서의 총인의 농도는 0.52mg/$\ell$~0.99mg/$\ell$~의 범위이었다. 신천에 금호강물을 혼합한 이후에도 부유물질, 생화학적산소요구량, 암모니아태 질소, 총인 등의 농도가 개선되지 않았다. 즉 금호강물의 혼합은 신천수질환경사업소에서 배출되는 방류수에 함유되어 있을 2차 오염물질의 희석이라는 이점외의 수질개선효과는 확인되지 않았다.l years and a new type of transfer crane has been developed. Design concepts and control methods of a new crane will be introduced in this paper.and momentum balance was applied to the fluid field of bundle. while the movement of′ individual material was taken into account. The constitutive model relating the surface force and the deformation of bundle was introduced by considering a representative prodedure that stands for the bundle movement. Then a fundamental equations system could be simplified considering a steady state of the process. On the basis of the simplified model, the simulation was performed and the results co

• Proceedings of the Korean Environmental Sciences Society Conference
• /
• 2003.05a
• /
• pp.292-296
• /
• 2003

Autoclaving처리를 하지 않은 키토산과 autoclaving처리한 키토산과의 중금속 흡착실험을 해 본 결과 다음과 같은 결과를 도출 할 수 있었다. 1) 먼저 중금속간의 흡착능을 고찰하기 위하여 Langmuir와 Freundlich 흉착등온식에 적용시켜 본 결과 Freundlich 흡착등온식 보다는 Langmuir 흡착등온식이 보다 적합한 것으로 나타났다. 2) 시간에 따라서 autoclaving 처리한 키토산의 중금속 제거 가능성과 그 효율을 검토하기 위하여 각 중금속간의 Langmuir 흡착등온식을 이용하여 $q_{max}$를 나타냈다. 15 min > 60 min > 0 min 순으로 모든 중금속 제거 실험에서 15 min 동안 autoclaving 처리한 키토산의 중금속 흡착량이 가장 높은 것으로 나왔다. 그러므로 기존의 키토산 보다는 15 min동안 autoclaving 처리한 키토산이 중금속 제거에 더 좋은 흡착제로써 역할을 할 수 있을 것으로 판단된다. 3) 키토산을 이용한 중금속 제거에서는 $Pb^{2+}$ > $Cd^{2+}$ > $Cu^{2+}$ > $Cr^{3+}$순서로 제거가 되었다. 여러 연구자들의 실험 결과를 종합해 볼 때 Pb$^{2+}$가 중금속 중에 제거가 잘 된다는 연구 결과가 많이 발표 되었으며, $Cd^{2+}$, $Cu^{2+}$, $Cr^{3+}$의 경우에는 흡착제의 종류에 따라서 제거되는 순서가 다르다는 연구 결과들이 보고 되고 있다. 그러나 어떠한 이유로 중금속의 제거에 차이가 있는지에 대해서는 명확한 결론이 내려져 있지 않는 실정이다. 이러한 중금속간의 경쟁적인 관계에 대해 더 많은 세밀한 연구가 이루어져야 할 것 같다.는 0.52mg/$\ell$~0.99mg/$\ell$~의 범위이었다. 신천에 금호강물을 혼합한 이후에도 부유물질, 생화학적산소요구량, 암모니아태 질소, 총인 등의 농도가 개선되지 않았다. 즉 금호강물의 혼합은 신천수질환경사업소에서 배출되는 방류수에 함유되어 있을 2차 오염물질의 희석이라는 이점외의 수질개선효과는 확인되지 않았다.l years and a new type of transfer crane has been developed. Design concepts and control methods of a new crane will be introduced in this paper.and momentum balance was applied to the fluid field of bundle. while the movement of′ individual material was taken into account. The constitutive model relating the surface force and the deformation of bundle was introduced by considering a representative prodedure that stands for the bundle movement. Then a fundamental equations system could be simplified considering a steady state of the process. On the basis of the simplified model, the simulation was performed and the results could be confirmed by the experiments under various conditions.뢰, 결속 등 다차원의 개념에 대한 심도 깊은 연구와 최근 제기되고 있는 이론

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.14 no.3
• /
• pp.403-414
• /
• 1994

Nonlinear analysis of RC containment structure under thermal load and pressure is presented to trace the behaviour after an assumed LOCA. The temperature distribution varying with time through the wall thickness is determined by transient finite element analysis with the two time level scheme in time domain. The layered shell finite elements are used to represent the containment structures in nuclear power plants. Both geometric and material nonlinearities are taken into account in the finite element formulation. The constitutive relation of concrete is modeled according to Drucker-Prager yield criteria in compression. Tension stiffening model is used to represent the tensile behaviour of concrete including bond effect. The reinforcing bars are modeled by smeared layer at the location of reinforcements accounting elasto-plastic axial behaviors. The steel liner model under Von Mises yield criteria is adopted to represent elastic-perfect plastic behaviour. Geometric nonlinearity is formulated to consider the large displacement effect. Thermal stress components are determined by the initial strain concept during each time step. The temperature differential between any two consecutive time steps is considered as a load incremental. The numerical results from this study reveal that nonlinear temperature gradient based on transient thermal analysis will produces excessive large displacement. Nonlinear behavior of containment structures up to ultimate stage can be traced reallistically. The present study allows more realistic analysis of concrete containment structures in nuclear power plants.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.39 no.4
• /
• pp.106-113
• /
• 1997

Dynamic loading of structures often causes excursions of stresses well into the inelastic range, and the influence of the geometric changes on the dynamic response is also significant in many cases. Therefore, both material and geometric nonlinearity effects should be considered in case that a dynamic load acts on the structure. A structure in a nuclear power plant is a structure of importance which puts emphasis on safety. A nuclear container is a pressure vessel subject to internal pressure and this structure is constructed by a reinforced concrete or a pre-stressed concrete. In this study, the material nonlinearity effect on the dynamic response is formulated by the elasto-viscoplastic model highly corresponding to the real behavior of the material. Also, the geometrically nonlinear behavior is taken into account using a total Lagrangian coordinate system, and the equilibrium equation of motion is numerically solved by a central difference scheme. The constitutive relation of concrete is modeled according to a Drucker-Prager yield criterion in compression. The reinforcing bars are modeled by a smeared layer at the location of reinforcements, and the steel layer model under Von Mises yield criteria is adopted to represent an elastic-plastic behavior. To investigate the dynamic response of a nuclear reinforced concrete containment structure, the steel-ratios of 0, 3, 5 and 10 percent, are considered. The results obtained from the analysis of an example were summarized as follows 1. As the steel-ratio increases, the amplitude and the period of the vertical displacements in apex of dome decreased. The Dynamic Magnification Factor(DMF) was some larger than that of the structure without steel. However, the regular trend was not found in the values of DMF. 2. The dynamic response of the vertical displacement and the radial displacement in the dome-wall junction were shown that the period of displacement in initial step decreased with the steel-ratio increases. Especially, the effect of the steel on the dynamic response of radial displacement disapeared almost. The values of DMF were 1.94, 2.5, 2.62 and 2.66, and the values increased with the steel-ratio. 3. The characteristics of the dynamic response of radial displacement in the mid-wall were similar to that of dome-wall junction. The values of DMF were 1.91, 2.11, 2.13 and 2.18, and the values increased with the steel-ratio. 4. The amplitude and the period of the hoop-stresses in the dome, the dome-wall junction, and the mid-wall were shown the decreased trend with the steel-ratio. The values of DMF were some larger than those of the structure without steel. However, the regular trend was not found in the values of DMF.

• Korea-Australia Rheology Journal
• /
• v.21 no.1
• /
• pp.59-69
• /
• 2009

The prediction of pressure drop for a droplet flow in a confined micro channel is presented using FE-FTM (Finite Element - Front Tracking Method). A single droplet is passing through 5:1:5 contraction - straight narrow channel - expansion flow domain. The pressure drop is investigated especially when the droplet flows in the straight narrow channel. We explore the effects of droplet size, capillary number (Ca), viscosity ratio ($\chi$) between droplet and medium, and fluid elasticity represented by the Oldroyd-B constitutive model on the excess pressure drop (${\Delta}p^+$) against single phase flow. The tightly fitted droplets in the narrow channel are mainly considered in the range of $0.001{\leq}Ca{\leq}1$ and $0.01{\leq}{\chi}{\leq}100$. In Newtonian droplet/Newtonian medium, two characteristic features are observed. First, an approximate relation ${\Delta}p^+{\sim}{\chi}$ observed for ${\chi}{\geq}1$. The excess pressure drop necessary for droplet flow is roughly proportional to $\chi$. Second, ${\Delta}p^+$ seems inversely proportional to Ca, which is represented as ${\Delta}p^+{\sim}Ca^m$ with negative m irrespective of $\chi$. In addition, we observe that the film thickness (${\delta}_f$) between droplet interface and channel wall decreases with decreasing Ca, showing ${\delta}_f{\sim}Ca^n$ Can with positive n independent of $\chi$. Consequently, the excess pressure drop (${\Delta}p^+$) is strongly dependent on the film thickness (${\delta}_f$). The droplets larger than the channel width show enhancement of ${\Delta}p^+$, whereas the smaller droplets show no significant change in ${\Delta}p^+$. Also, the droplet deformation in the narrow channel is affected by the flow history of the contraction flow at the entrance region, but rather surprisingly ${\Delta}p^+$ is not affected by this flow history. Instead, ${\Delta}p^+$ is more dependent on ${\delta}_f$ irrespective of the droplet shape. As for the effect of fluid elasticity, an increase in ${\delta}_f$ induced by the normal stress difference in viscoelastic medium results in a drastic reduction of ${\Delta}p^+$.

• Journal of the Korea Concrete Institute
• /
• v.18 no.5 s.95
• /
• pp.677-685
• /
• 2006

Control of the temperature difference across a section is an effective strategy to minimize the hydration-heat-induced cracks for the structures where internal restraint is dominant. The domestic code, however, overestimates probability of the crack occurrence judging from the foreign codes and construction experiences of real structures. Therefore, the background of the equation presented in the domestic code was investigated step by step to examine validity of the equation, and, as a result, it was found that the equation is established on a basis of simple elastic model where the change of elastic modulus in an early age is not considered. An advanced assessment strategy was proposed taking into account the hypoelastic model which corresponds to an incremental constitutive equation. The presented procedure resulted in an increased crack index, i.e. decreased crack risk, the value of which depends on various conditions of the mix and structures. Also, a prediction equation of the temperature difference was proposed which can readily consider the effect of the curing condition and ambient temperature in a hand calculation. For further study, the assessment equation may be more classified to strictly consider the characteristics of the mix and structures if the analytical and experimental data are accumulated.

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
• /
• 2003.04a
• /
• pp.472-477
• /
• 2003

멸종위기종의 서식지를 효율적으로 관리하기 위해서는 해당 종의 서식 가능한 지역의 분포를 알아야 한다. 본 연구의 목적은 GIS와 퍼지집합을 이용하여 산양(Nemorhaedus caudatus)의 서식지적합성모형을 개발하여 멸종 위기종의 서식지를 관리하기 위한 정보를 제공하는 것이다. 산양의 서식지적합성모형 개발을 위한 본 연구의 주요내용은 다음과 같다. 첫째, 산양 서식지 이용에 관한 기존 연구를 바탕으로 산양의 잠재적 서식지 환경변수를 분류하였으며, 분석 대상지의 산양 흔적 조사를 통해 서식지 환경변수의 재분류 및 x²검정(Chi-square test)을 통한 변수들의 유용성을 파악하고, 쌍체비교를 통한 환경변수별 가중치를 계산하였다. 둘째, 기존 부울논리(boolean logic)의 단점을 보완하기 위해 현장 조사의 결과를 바탕으로 퍼지논리(fuzzy logic)에 의한 산양 서식지의 각 환경변수별 주제도를 작성하고, 주제도들의 상관관계를 분석하여 상호 관련성이 높은 변수들의 중복을 피하였다. 셋째, 환경변수별 주제도와 변수별 가중치를 바탕으로 다기준평가기법(MCE, Multi-Criteria Evaluation)을 이용하여 분석대상지의 산양 서식지적합성모형을 개발하였다. 마지막으로, 개발된 서식지적합성모형의 타당성을 검증하기 위해 분석대상지 외부 지역을 대상으로 검증을 실시하였다. 분석 결과 분석대상지의 분류정확도는 서식가능성 0.5를 기준으로 93.94%의 매우 높은 분류정확도를 나타내었으며, 검증대상지에서는 95.74%의 분류정확도를 나타내어 본 모형의 분류정확도는 일관성이 높은 것으로 판단되었다. 또한 전체 공원구역에서 서식가능성 0.5이상의 면적은 59%를 차지하였다.퇴적이 우세한 것으로 관측되었다.보체계의 구축사업의 시각이 행정정보화, 생활정보화, 산업정보화 등 다양한 분야와 결합하여 보다 큰 시너지 효과와 사용자 중심의 서비스 개선을 창출할 수 있는 기반을 제공할 것을 기대해 본다.. 이상의 결과를 종합해볼 때, ${\beta}$-glucan은 고용량일 때 직접적으로 또는 $IFN-{\gamma}$ 존재시에는 저용량에서도 복강 큰 포식세로를 활성화시킬 뿐 아니라, 탐식효율도 높임으로써 면역기능을 증진 시키는 것으로 나타났고, 그 효과는 crude ${\beta}$-glucan의 추출조건에 따라 달라지는 것을 알 수 있었다.eveloped. Design concepts and control methods of a new crane will be introduced in this paper.and momentum balance was applied to the fluid field of bundle. while the movement of′ individual material was taken into account. The constitutive model relating the surface force and the deformation of bundle was introduced by considering a representative prodedure that stands for the bundle movement. Then a fundamental equations system could be simplified considering a steady state of the process. O

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
• /
• 2003.04a
• /
• pp.3-8
• /
• 2003

모든 SAR 영상에는 전자기파 간의 간섭으로 인한 스페클 잡영(speckle)이 존재하며, 이를 제거하는 것은 양질의 SAR 영상을 얻기 위한 필수적인 전처리 과정 중 하나라고 할 수 있다. 그러나 이러한 스페클 잡영을 제거하기 위하여 기존에 제안되었던 알고리즘은 잡영은 효과적으로 감소시키는 반면 경계선과 같은 영상의 고유 정보까지 함께 감소시키는 한계가 있었다. 따라서 본 연구에서는 SAR 영상의 경계선은 보존시키면서 영상으로부터 불필요한 잡영을 제거할 수 있는 알고리즘을 구현하고, 기존의 알고리즘과 비교하여 그 효율성을 평가하고자 한다. 영상의 통계적 특성에 근거하는 기존의 알고리즘과는 달리 웨이블렛 변환(Wavelet transform)으로 경계선 및 특징 정보의 여부를 판별한 후 평균 필터(mean filter)를 적용하는 경계선 보존(edge sharpening) 알고리즘은 경계 정보의 신뢰성을 향상시킬 수 있으며, 1차원 필터를 수평, 수직, 대각선, 역대각선 방향으로 적용함으로써 하나의 영상소를 중심으로 모든 방향에 대한 경계선 여부를 확인할 수 있는 장점이 있다. 본 연구에서는 512 × 512로 절취한 1-look SAR 영상에 대하여 창 크기 5 × 5의 경계선 보존 필터를 적용하고 동일영상에 대하여 기존의 Lee, Kuan, Frost 필터 등의 실험결과를 비교함으로써 그 적합성을 판단하고자 하였다. 실험결과에 대한 수치적인 평가는 ①정규화 평균을 이용하여 평균값의 보존 여부, ②편차 계수를 이용한 스페클 잡영의 제거 여부, ③경계선 보존지수(EPI)를 이용한 경계선의 보존 정도를 통해 이루어졌다. 본 연구의 실험결과를 통해 경계선 보존 필터는 평균값의 보존 여부 및 스페클 잡영 제거 정도에 있어 다른 필터들과 큰 차이가 없지만 경계선보존지수는 다른 필터들에 비하여 가장 우수함을 확인할 수 있었다.rbon 탐식효율을 조사한 결과 B, D 및 E 분획에서 유의적인 효과를 나타내었다. 이상의 결과를 종합해볼 때, ${\beta}$-glucan은 고용량일 때 직접적으로 또는 $IFN-{\gamma}$ 존재시에는 저용량에서도 복강 큰 포식세로를 활성화시킬 뿐 아니라, 탐식효율도 높임으로써 면역기능을 증진 시키는 것으로 나타났고, 그 효과는 crude ${\beta}$-glucan의 추출조건에 따라 달라지는 것을 알 수 있었다.eveloped. Design concepts and control methods of a new crane will be introduced in this paper.and momentum balance was applied to the fluid field of bundle. while the movement of′ individual material was taken into account. The constitutive model relating the surface force and the deformation of bundle was introduced by considering a representative prodedure that stands for the bundle movement. Then a fundamental equations system could be simplified considering a steady state of the process. On the basis of the simplified model, the simulation was performed and the results could be confirmed by the experiments under various conditions.뢰, 결속 등 다차원