• The Journal of the Korea Contents Association
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• v.17 no.7
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• pp.498-504
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• 2017

Oral health behavior such as toothbrushing one's teeth, using dentifrice and such are an important part of improving one's oral health and therefore quality of life. However, it is also necessary to research exposure to harmful chemical substances. Therefore, this study investigated the factors that affect researching fluorine exposure resulting from oral health behavior initiation so that correct oral health guidelines can be provided. As a result of applying the fluorine compound's oral exposure in the ConsExpo 5.0 model, adult males' oral external dose was at 0.000196 mg/kg, oral acute (internal) dose at 0.000196 mg/kg/day and oral chronic (internal) dose at 0.000465 mg/kg/day. In the case of females, the oral dose was at $4.1{\times}10^{-6}mg/kg$, oral acute (internal) dose at $4.1{\times}10^{-6}mg/kg$ and oral chronic (internal) dose at $9.99{\times}10^{-6}mg/kg/day$.

• The Journal of the Korea Contents Association
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• v.22 no.7
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• pp.663-669
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• 2022

The content of fluoride in toothpaste commercially available in Korea has been increased to less than 1500 ppm. The purpose is to provide these results to consumers and to suggest alternatives to the safe use of toothpaste. This study was conducted on 1,300 people for 2 weeks from March 2021. As a research tool, general characteristics and oral health behaviors were surveyed. ConsExpo Web 1.0.2. It was used as an input variable for exposure evaluation. As a result of the study, when a toothpaste containing 1500 ppm of fluoride was used, the external dose on day of exposure was 2.3×10-2 mg/kg/day for males, 2.9×10-2 mg/kg/day for females, and children aged 2-3 years was estimated to be 7.3×10 -2 mg/kg/day. As a result of this study, it is thought that as the fluoride content of toothpaste distributed in the market increases, it will be used as a basic data to present standards for safe use by consumers.

• Journal of Environmental Health Sciences
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• v.50 no.1
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• pp.43-53
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• 2024

Background: Exposure assessment is an important part of risk assessment for consumer products. Exposure models are used when estimating consumer exposures by considering exposure routes, subjects, and circumstances. These models differ based on their tiers, types, and target populations. Consequently, exposure estimates may vary between models. Objectives: This study aimed to compare the results of different exposure models using identical exposure factors. Methods: Chemical exposure from consumer products was calculated using four consumer exposure assessment models: Targeted Risk Assessment 3.1, Consumer Exposure Model 2.1 (CEM), ConsExpo web 1.1.1, and the Korean Exposure Algorithm (primary and detailed) issued by the Ministry of Environment, No. 972 (MOE). The same exposure factors were used in each model to calculate inhalation and dermal exposures to acetaldehyde, d-limonene, and naphthalene in all-purpose cleaners, leather coating sprays, and sealants. Results: In the results, TRA provided the highest estimate. Generally, MOE (detailed), CEM and ConsExpo showed lower exposures. The inhalation exposure for leather coating spray showed the largest differences between models, with differences reaching up to 1.2×10⁷ times. Since identical inputs were used for the calculations, it is likely that the models significantly influenced the estimated results. Conclusions: Despite using the same exposure factors to calculate dermal and inhalation exposures, the results varied substantially based on the model's exposure algorithm. Therefore, selecting an exposure model for assessing consumer products should be done with careful consideration.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.3
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• pp.358-367
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• 2019

Objectives: This study aimed to review model algorithms and input parameters applied to some exposure models and to compare the simulated estimates using an exposure scenario from each model. Methods: A total of five exposure models which can estimate inhalation exposure were selected; the Korea Ministry of Environment(KMOE) exposure model, European Centre for Ecotoxicology and Toxicology of Chemicals Targeted Risk Assessment(ECETOC TRA), SprayExpo, and ConsExpo model. Algorithms and input parameters for exposure estimation were reviewed and the exposure scenario was used for comparing the modeled estimates. Results: Algorithms in each model commonly consist of the function combining physicochemical properties, use characteristics, user exposure factors, and environmental factors. The outputs including air concentration ($mg/m^3$) and inhaled dose(mg/kg/day) are estimated applying input parameters with the common factors to the algorithm. In particular, the input parameters needed to estimate are complicated among the models and models need more individual input parameters in addition to common factors. In case of CEM, it can be obtained more detailed exposure estimates separating user's breathing zone(near-field) and those at influencing zone(far-field) by two-box model. The modeled exposure estimates using the exposure scenario were similar between the models; they were ranged from 0.82 to $1.38mg/m^3$ for concentration and from 0.015 to 0.180 mg/kg/day for inhaled dose, respectively. Conclusions: Modeling technique can be used for a useful tool in the process of exposure assessment if the exposure data are scarce, but it is necessary to consider proper input parameters and exposure scenario which can affect the real exposure conditions.

• Journal of Environmental Health Sciences
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• v.50 no.4
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• pp.237-256
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• 2024

Background: Human health and environment exposure assessments of chemicals are essential part for REACH and BPR as well as K-REACH and K-BPR. Several useful exposure assessment tools have been developed and updated to become extensively used during more than fifteen years of chemical registrations under REACH and their updates are still going on. Objectives: Evolution of regulatory tools for environment, workers and consumers exposure assessments under REACH is investigated focusing on why and how tools have been developed and updated for the future regulatory tools in Korea. Methods: REACH regulatory tools including EUSES, ECETOC TRA and CHESAR as well as built-in models SimpleTreat and SimpleBox were chosen with other frequently used Tier 1 and 2 tools. Available resources such as homepage information, background documents, related scientific reports, relevant journal publications, up-to-date lists of new version publications, release notes and user guides were reviewed extensively and summarized using easy-readable Tables and Figures. Results: SimpleTreat and SimpleBox are built-in models both for EUSES and ECETOC TRA (Environment). ECHA's CHESAR contains ECETOC TRA (Workers) and ECETOC TRA (Consumers) as well as EUSES and ECETOC TRA (Environment) for environment exposure assessment while results of Tier 2 Stoffenmanager and ConsExpoWeb can be imported. Evolution of CHESAR from version 1 (2010) to 3.8 (2023) has focused on the compatibility of frequent updates of IUCLID, importing functionality, editability, updated use maps, harmonised conditions of use as well as updates of the built-in tools evolved according to scientific development, refinements of the tool, increased conservatism and user-friendliness. CHESAR Platform 1.0 will soon be published to serve both for REACH and BPR. Conclusions: Updates of the tools can be successfully continued by transparency of the tools, participation of industry sectors for tool refinements and tool developers'/authorities' encouragements of partners/users to jointly innovate tools through scientific researches, tool validations and user feedback.