• 제목/요약/키워드: Conjugated Linoleic

검색결과 359건 처리시간 0.024초

Conjugated Linoleic Acid(CLA)와 Coumarin의 첨가가 꽃사슴 녹용 및 혈액의 생화학적 성분에 미치는 영향 (Effect of Feeding of Conjugated Linoleic Acid(CLA) and Coumarin on the Biochemical Composition of Velvet Antler and Blood Serum in Spotted Deer(Cervus nippon))

  • 전병태;정지훈;이상무;문상호
    • Journal of Animal Science and Technology
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    • 제47권3호
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    • pp.429-438
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    • 2005

  • This experiment was conducted to determine the effects of feeding CLA and coumarin on the changes of biochemical composition of velvet antler and blood serum in spotted deer (Cervus nippon). There were no significant differences between treatments in crude protein, crude fiber, and crude ash contents of velvet antler. The content of fatty acid did not differ between treatments, although there were significant differences (P<0.05) in C16:0 and C20:0. The content of collagen was significantly higher (P<0.05) in control than those in CLA and coumarin treatments. There were no significant differences between treatments in the contents of amino acids. Some constituents of blood showed much differences in comparison of pre and post-experiment for all treatments. Feeding of CLA and coumarin was not influential on the chemical composition of velvet antler and blood serum.

  • https://doi.org/10.5187/JAST.2005.47.3.429 인용 PDF KSCI

Use of Transgenic and Mutant Animal Models in the Study of Heterocyclic Amine-induced Mutagenesis and Carcinogenesis

  • Dashwood, Roderick H.
    • BMB Reports
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    • 제36권1호
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    • pp.35-42
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    • 2003

  • Heterocyclic amines (HCAs) are potent mutagens generated during the cooking of meat and fish, and several of these compounds produce tumors in conventional experimental animals. During the past 5 years or so, HCAs have been tested in a number of novel in vivo murine models, including the following: lacZ, lacI, cII, c-myc/lacZ, rpsL, and $gpt{\Delta}$ transgenics, $XPA^{-/-}$, $XPC^{-/-}$, $Msh2^{+/-}$, $Msh2^{-/-}$ and $p53^{+/-}$ knock-outs, Apc mutant mice ($Apc^{{\Delta}716}$, $Apc^{1638N}$, $Apc^{min}$), and $A33^{{\Delta}N{\beta}-cat}$ knock-in mice. Several of these models have provided insights into the mutation spectra induced in vivo by HCAs in target and non-target organs for tumorigenesis, as well as demonstrating enhanced susceptibility to HCA-induced tumors and preneoplastic lesions. This review describes several of the more recent reports in which novel animal models were used to examine HCA-induced mutagenesis and carcinogenesis in vivo, including a number of studies which assessed the inhibitory activities of chemopreventive agents such as 1,2-dithiole-3-thione, conjugated linoleic acids, tea, curcumin, chlorophyllin-chitosan, and sulindac.

  • https://doi.org/10.5483/BMBRep.2003.36.1.035 인용 PDF