• 제목/요약/키워드: Conformation

검색결과 970건 처리시간 0.024초

이량체액정의 상전이에 의한 Conformation Entropy 변화 (Conformation Entropy Changes of Dimer Liquid Crystals on the Crystal-Nematic and Nematic-Isotropic Transitions)

  • 남수용
    • 한국인쇄학회지
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    • 제14권1호
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    • pp.75-88
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    • 1996
  • Digital image capturing technology has been making great progress recently, and we can now simply capture the color image by digital camera, flat-bed scanner of Photo CD system. A lot of professionals are instrested in the capability of Photo CD and other digital images in the printing and publishing industry. But these images were not processed a suitable image processing to use in the hard copy. In this paper we described a method of the digital enhancement processiing to use in the printing and publishing industry. Experimental result show that the described method was useful and valid for the digital image enhancement to use in the hard copy.

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Conformational Characteristics of p-tert-Butylcalix[6]arene Mono-Alkyl Ester Derivatives

  • Yu, Hyo-Yeon;Seok, Da-Hyun;Chang, Suk-Kyu;Ahn, Sang-Doo;Chung, Kee-Choo
    • 한국자기공명학회논문지
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    • 제14권2호
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    • pp.144-153
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    • 2010
  • Conformational properties of several mono-alkyl ester derivatives of p-tert-butylcalix[6]arene depending on temperatures have been investigated by solution NMR spectroscopy. It is found out that all derivatives can adopt a cone-like conformation around room temperature, while the conformational characteristics at high temperatures seem to be quite different each other.

양자역학 이론에 의한 의약품 N,N-디메틸-m-톨루아미드의 분자구조와 약리효과에 관한 연구 (Molecular Orbital Consideration of the Conformation and Biological Activities of Medical Drug, N,N-Diethyl-m-toluamide)

  • 김의락;서배석;이명재
    • 대한화학회지
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    • 제19권4호
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    • pp.213-217
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    • 1975
  • N,N-디에틸-m-톨루아미드 분자는 malaria 모기에 대한 방충제로서의 효력이 있지만 메틸기가 오르토나 파라 위치에 있는 이성질체들은 그러한 효능이 없다. 반 실험적 양자역학 이론인 확장 Huckel 이론을 사용하여 이들 분자들의 형태를 계산하고 상기의 차이점을 이론적으로 설명하고 실험결과와 비교하였다.

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Synthesis and NMR Studies of (E)-1-Aryl-3-(2-pyrrolyl)-2-propenones and (E)-3-Aryl-1-(2-pyrrolyl)-2-propenones

  • Han Lee, In-Sook;Jeoung, Eun Ji;Lee, Chang Kiu
    • Bulletin of the Korean Chemical Society
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    • 제34권3호
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    • pp.936-942
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    • 2013
  • Series of (E)-1-aryl-3-(2-pyrrolyl)-2-propenones, that were aldol condensation products between pyrrole-2-carbaldehyde and m- and p-substituted acetophenones, were prepared and their $^1H$ and $^{13}C$ NMR spectra were examined to obtain the information on the conformation of the enone system. Similar studies were carried out with (E)-3-aryl-1-(2-pyrrolyl)-2-propenones that were prepared from 2-acetylpyrrole and m- and p-substituted benzaldehydes. The substituent chemical shifts were studied by applying the Hammett relationship.

Structural Damage of DNA by 6-Sulfooxymethyl Benzo(a)pyrene

  • Cho, Young-Sik;Chung, An-Sik
    • BMB Reports
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    • 제28권1호
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    • pp.1-5
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    • 1995
  • The effect of 6-sulfooxymethyl benzo(a)pyrene (SMBP) on conformational changes of calf thymus DNA was investigated. As SMBP is a strong electrophile, the covalent binding of SMBP to DNA should distort three dimensional conformation of DNA at the binding sites. A formaldehyde-unwinding methods were used to determine the rate of DNA denaturation. The increase in absorbance at 251nm was detected by addition of formaldehyde following treatment with SMBP. SMBP changed supercoiled DNA to relaxed and linear DNA as determined by electrophoresis, which was similar to the change in DNA due to in vitro treatment with benzo(a) pyrene diol epoxide. Treatment with SMBP completely denatured DNA under alkaline conditions. However, DNA was nicked or partially denatured under neutral condition. The absorption band of DNA was increased by the treatment with SMBP in V79 cells, which may be explained by the formation of stabilized SMBP-DNA adduct.

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Characterization of the molten globule conformation of V26A ubiquitin by far-UV circular dichroic spectroscopy and amide hydrogen/deuterium exchange

  • Park, Soon-Ho
    • BMB Reports
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    • 제41권1호
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    • pp.35-40
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    • 2008
  • The molten globular conformation of V26A ubiquitin (valine to alanine mutation at residue 26) was studied by nuclear magnetic resonance spectroscopy in conjunction with amide hydrogen/deuterium exchange. Most of the amide protons that are involved in the native secondary structures were observed to be protected in the molten globule state with the protection factors from 1.2 to 6.7. These protection factors are about 2 to 6 orders of magnitude smaller than those of the native state. These observations indicate that V26A molten globule has native-like backbone structure with marginal stability. The comparison of amide protection factors of V26A ubiquitin molten globule state with those of initial collapsed state of the wild type ubiquitin suggests that V26A ubiquitin molten globule state is located close to unfolded state in the folding reaction coordinate. It is considered that V26A ubiquitin molten globule is useful model to study early events in protein folding reaction.

Mammalian Mediator 19 Mediates H1299 Lung Adenocarcinoma Cell Clone Conformation, Growth, and Metastasis

  • Xu, Lu-Lu;Guo, Shu-Liang;Ma, Su-Ren;Luo, Yong-Ai
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권8호
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    • pp.3695-3700
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    • 2012
  • Mammalian mediator (MED) is a multi-protein coactivator that has been identified by several research goups. The involvement of the MED complex subunit 19 (MED 19) in the metastasis of lung adenocarcinoma cell line (H1299), which expresses the MED 19 subunit, was here investigated. When MED 19 expression was decreased by RNA interference H1299 cells demonstrated reduced clone formation, arrest in the S phase of the cell cycle, and lowered metastatic capacity. Thus, MED 19 appears to play important roles in the biological behavior of non-small cell lung carcinoma cells. These findings may be important for the development of novel lung carcinoma treatments.

Studies on the Nuclear Magnetic Resonance Spectra of (E)-1-Aryl-3-(2- and 3-thienyl)-2-propenones and Unique Observation of 4J and 5J Coupling in Their 1H-1H COSY

  • HanLee, In-Sook;Jeon, Hyun-Ju;Lee, Chang-Kiu
    • Bulletin of the Korean Chemical Society
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    • 제32권2호
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    • pp.687-692
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    • 2011
  • $^1H$ and $^{13}C$ NMR spectra of series of (E)-1-aryl-(2- and 3-thienyl)-2-propenones, that are aldol condensation products between 2- and 3-thiophenecarbaldehydes and m- and p-substituted acetophenones, were examined to make complete assignments of the chemical shifts. Long range couplings, $^4J$ and $^5J$, are observed in the $^1H-^1H$ COSY of both 2- and 3-thienyl compounds, which makes the elucidation of the conformation in solution possible. In contrast, the 2-furyl analogue shows the long range coupling phenomena, but the 3-furyl and phenyl analogues do not show similar phenomena.

LTV를 이용한 eCRM을 연계한 ATP 모델구현에 관한 연구 (A Design of ATP Model Related eCRM Using LTV)

  • 박재현;양광모;강경식
    • 산업경영시스템학회지
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    • 제25권4호
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    • pp.54-60
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    • 2002
  • In the Supply chain, The ATP(Available to Promise) function doesn't only give customers to conformation of delivery. It can be used by the core function with ATP rule that can reconcile supplies and demands on the supply chain. Therefore We can be acquire the conformation about on the due date of supplier by using the ATP function of management about real and concurrent access on the supply chain, also decide the affect about product availability due to forecasting or customer's orders through the ATP. In this paper, It consolidates the necessity on a ATP and analyzes data which is concerned of ATP. tinder the these environments, defines the ATP nile that can improve the customer value and data flow related the eCRM and builds on a algorithm.

A new type of helix in protein structure.

  • Son, Hyeon-S.
    • 한국생물정보학회:학술대회논문집
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    • 한국생물정보시스템생물학회 2000년도 International Symposium on Bioinformatics
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    • pp.86-87
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    • 2000
  • Protein folding is a fundamental problem in structural bioinformatics and so numerous studies have been devoted to the subject. As the most common regular secondary conformation in proteins, helix has been an important ingredient of the protein folding problem. In particular, alanine based polypeptides are widely studied to identify the helix folding process in that the aianine amino acid is known to have one of the highest helix propensities. In principle, intrinsic helix propensities can be obtained from gas-phase measurements where solvent effect is absent. Hudgins et al. studied alanine-based peptides in vacuo using high-resolution ion mobility measurement technique. It was reported that introduction of a single Iysine at the C terminus resulted in the formation of very stable, monomeric polyalanine helices. We also have investigated helix formation in vacuo with different terminal charge conditions; we have found a new type of helix motif, To the best of our knowledge, this type of helix conformation has not been characterized before and we name it as I-helix.

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