• Proceedings of the PSK Conference
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• 2003.04a
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• pp.228.2-229
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• 2003

Estrogen Receptor is a ligand-activated transcription factor. The concentration of the receptor is a major component that regulates expression of estrogen-responsive genes. We have studied mechanism of estrogen receptor alpha (ER${\alpha}$) downregulation by HIF-1 using HIF-1${\alpha}$/VP16 constructs. ER${\alpha}$ is known to be downregulated under hypoxic condition. Transcriptional response under hypoxia is mediated through Hypoxia-inducible factor-1 (HIF-1), a transcription factor that is usullaly degraded but stabilized under hypoxia. (omitted)

• Journal of the Korea Computer Industry Society
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• v.9 no.4
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• pp.143-148
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• 2008

The major influence factor on carbonation of concrete structures is carbon dioxide concentration. In this study, carbonation analyses with carbon dioxide concentration were carried out by the developed program. Also, the service life of concrete strucures was predicted. The carbonation depth was 50mm in case that carbon dioxide concentration wad 0.1%. It was shown that the service life of concrete structures with 40mm cover depth was 67 years even though they had been exposed at carbon dioxide concentration 0.1% during 100 years.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1434-1437
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• 2003

Sometimes open holes are required for the function and the weight reduction of structure and machinery. However, the serious stress concentration occurs because of the geometric discontinuity caused by the holes and cutting section. In this study, it is attempted to obtain the stress concentration coefficients of the inner surface of the hole boundary by changing the position and the shape of holes on the homogeneous isotropic plate. And the effects on the plate are investigated. The results show that the stress level becomes low and the distribution area widens the position of stress concentration changes as the ratio a/b increases and change to a circle. And as the ratio a/l decreases, the stress concentration reduces. As the plate with three holes. the stress $\sigma$$\_$x/ and $\tau$$\_$xy/ of hole 1,3 becomes high, especially $\sigma$$\_$x/ dominant and high.

• Journal of the Korea Computer Industry Society
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• v.9 no.3
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• pp.137-142
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• 2008

The major influence factor on chloride penetration into concrete structures is chloride ion concentration. In this study, chloride penetration analyses with chloride ion concentration were carried out by the developed program. Also, the service life of concrete structures was predicted. The penetration depth was 32mm in case that chloride ion concentration wad 600ppm. It was shown that the service life of concrete structures with 40mm cover depth was 167 years even though they had been exposed at chloride ion concentration 600ppm during 100 years.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.833-836
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• 2002

Sometimes open holes are required for the function and the weight reduction of structure and machinery. However, the serious stress concentration occurs because of the geometric discontinuity caused by the holes and cutting section. In this study, it is attempted to obtain the stress concentration coefficients of the inner surface of the hole boundary by changing the position and the shape of holes on the homogeneous isotropic plate. And the effects on the plate are investigated. The results show that the stress level becomes low and the distribution area widens the position of stress concentration changes as the ratio ah increases and change to a circle. And as the ratio a/l decreases, the stress concentration reduces.

• Bulletin of the Korean Chemical Society
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• v.31 no.7
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• pp.2025-2030
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• 2010

When $Cu^{2+}$ was used as an electron acceptor, removal of $Cu^{2+}$ was achieved from the synthesized wastewater (SW) in the cathode compartment of a microbial fuel cell (MFC). By addition of $KNO_3$, the different initial pH of the SW showed no effect on the removal efficiency of $Cu^{2+}$. For $Cu^{2+}$ concentration of 50 mg/L the removal efficiencies were found to be 99.82%, 99.95%, 99.58%, and 99.97% for the $KNO_3$ concentrations of 0, 50, 100 and 200 mM, and to be 99.4%, 99.9%, 99.7%, and 99.7% for pH values of 2, 3, 4, and 5, respectively. More than 99% $Cu^{2+}$ was removed for the $Cu^{2+}$ concentrations of 10, 50, and 100 mg/L, while only 60.1% of $Cu^{2+}$ was removed for the initial concentration of 200 mg/L (pH 3). The maximum power density was affected by both $KNO_3$ concentration and initial concentration of $Cu^{2+}$. It was increased by a factor of 1.5 (from 96.2 to 143.6 mW/$m^2$) when the $KNO_3$ concentration was increased from 0 to 200 mM (50 mg/L $Cu^{2+}$), and by a factor of 2.7 (from 118 to 319 mW/$m^2$) when $Cu^{2+}$ concentration was increased from 10 to 200 mg/L (pH 3).

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.278-278
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• 1996

Judging from hydrocortisone concentration in dosing area, the extent of absorption was reduced in the liposome-gel formulation. However, higher and sustained skin concentrations of hydrocortisone were achieved for the liposome-gel as compared to the ointment. Drug concentration in both viable and deep skin reached its maximum within 0.5 h after application of both formulations to both skin types. Drug concentrations in both skins from the ointment declined with time, while those from the liposome-gel were greatly sustained. The sustainment by the liposome-gel was more remarkable in the viable skin than in the deep skin. Drug concentration in the viable skin could be maintained at a nearly constant level for over 8 h by applying the liposome-gel. As a result, a 5-fold higher viable skin drug concentration was obtained from the liposome-gel than from the ointment at 8 h after the application to the SC-removed skin. However, the plasma concentration of hydrocortisone at 4 h from the liposome-gel was only one-fourth (p<0.01) the value from the ointment when the drug was applied to the SC-removed skin, consistent with. the lower urinary (one-third, p<0.05) and fecal (one-half, p＜0.05) excretion. Conclusions : Retarded diffusion of the drug from the skin to the systemic blood stream appears to be a potential factor in the sustained skin concentration of hydrocortisone from the liposome-gel, Interaction of hydrocortisone in the skin with phosphatidylcholine, a component of the liposomes and skin, may well be a factor in retarding the diffusion of the drug in the skin.

• Journal of Environmental Science International
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• v.16 no.12
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• pp.1451-1462
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• 2007

Heavy metal concentrations in the soil were investigated for the abandoned Samkwang metal mine, Cheongyang-Gun, Chungnam Province, Korea. The concentrations of heavy metal(As, Cd, Cu, Ni, Pb, Zn) were determined in mine soils collected at the abandoned mine sites to obtain a general classification and specification of the pollution in this highly polluted region. The results estimated with the normal test and basis statistic on the central tendency and variation showed that the distribution of heavy metal concentration had significantly different at the range of all locations. The range of spatial distribution on the relationship of heavy metal concentration and pH was $4.8{\sim}8.8$ and heavy metal concentration on the type of land use was highest in forest land, and also Ni and Zn in farm and rice field showed the high concentration. The distribution of heavy metal concentration on the depth of a soil showed that the metal concentrations in subsoil were higher than of those in surface soil, while the concentration of Cu and Ni had no significant difference on the depth of soil. Results from the correlation analysis using the data except the extreme and unusual data revel that Zn-Cd(r=0.867), Zn-As(r=0.797), Zn-Pb(r=0.764), Cu-Cd(r=0.673), Cu-As(r=0.614) and Zn-Ni(r=0.605) were the most important parameters in assessing variations of heavy metal in soil. To discriminate pattern differences and similarities among samples, principal factor analysis(PFA) and cluster analysis(CF) were performed using a correlation matrix. This study suggests that PFA and CF techniques are useful tools for identification of important heavy metal and parameters. This study presents the necessity and usefulness of multivariate statistical assessment of complex databases in order to get better information about the quality of soil and gives the basis information to clean up the abandoned mine sites.

• Journal of Environmental Science International
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• v.11 no.7
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• pp.687-696
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• 2002

Air quality monitoring data and meteorology data which had collected from 1995. 1. to 1999. 2. in six areas of Daegu, Manchondong, Bokhyundong, Deamyungdong, Samdukdong, Leehyundong and Nowondong, were investigated to determine the distribution and characteristic of ozone. A equation of multiple regression was suggested after time series analysis of contribution factor and meteorology factor were investigated during the day which had high concentration of ozone. The results show the following; First, 63.6% of high ozone concentration days, more than 60 ppb of ozone concentration, were in May, June and September. The percentage of each area showed that; Manchondong 14.4%, Bokhyundong 15.4%, Deamyungdong 15.6%, Samdukdong 15.6%, Leehyundong 17.3% and Nowondong 21.6%. Second, correlation coefficients of ozone, $SO_2$, TSP, $NO_2$ and CO showed negative relationship; the results were respectively -0.229, -0.074, -0.387, -0.190(p<0.01), and humidity were -0.677. but temperature, amount of radiation and wind speed had positive relationship; the results were respectively 0.515, 0.509, 0.400(p<0.01). Third, $R^2$ of equation of multiple regression at each area showed that; Nowondong 45.4%, Lee hyundong 77.9%, Samdukdong 69.9%, Daemyungdong 78.8%, Manchondong 88.6%, Bokhyundong 77.6%. Including 1 hour prior ozone concentration, $R^2$ of each area was significantly increased; Nowondong 75.2%, Leehyundong 89.3%, Samdukdong 86.4%, Daemyungdong 88.6%, Manchondong 88.6%, Bokhyundong 88.0%. Using equation of multiple regression, There were some different $R^2$ between predicted value and observed value; Nowondong 48%, Leehyundong 77.5%, Samdukdong 58%, Daemyungdong 73.4%, Manchondong 77.7%, Bokhyundong 75.1%. $R^2$ of model including 1 hour prior ozone concentration was higher than equation of current day; Nowondong 82.5%, Leehyundong 88.3%, Samdukdong 80.7%, Daemyungdong 82.4%, Manchondong 87.6%, Bokhyundong 88.5%.

• Korean Journal of Environmental Agriculture
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• v.41 no.1
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• pp.9-15
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• 2022

BACKGROUND: Heavy metals discharged from various sources contaminate the soil and water and the residuals can persistently be accumulated. In this study, the concentration of soil heavy metals was assessed over the whole regions of Korea based on the contamination factor and the geoaccumulation index. METHODS AND RESULTS: The data of averaged concentrations of heavy metals and fluorine were collected from the Korean Statistical Information Service (KOSIS) and the research papers published. In order to classify the levels of heavy metal concentration, the contamination index, including the contamination factor and the geoaccumulation index, based on the relative ratio of the actual concentration of heavy metals in the soil to the background concentration was calculated. In addition, the distribution of heavy metals in soils was visualized by using the geographic information system (GIS). As a result, the Cd contamination in the soils was the most concerned. CONCLUSION(S): This study very roughly indicated the outline of heavy metal concentration over the whole regions of Korea. The change in heavy metals' concentration over the time should further be monitored and the larger data of heavy metal contamination are needed for better understanding in the future.