• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2507-2511
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• 2016

Purpose: To study the diagnostic accuracies of serum human epididymis protein 4 (HE-4) levels, virtual organ computer-aided analysis (VOCAL) parameters and endometrial volume in endometrial cancer cases. Materials and Methods: One hundred and seven patients (37 with endometrial cancer and 70 with benign endometrial pathology) were included in this study. VOCAL parameters and serum HE-4 levels were compared between the groups. Results: Area under the curve (AUC) values were 0.702, 0.658, 0.706 for vascularization index (VI), the flow index (FI) and the vascularization flow index (VFI), respectively. A cut off value of 0.568 for VI demonstrated 70% sensitivity, 72% specificity, 56% positive predictive value (PPV) and a81% negative predictive value (NPV). A cut off value of 25.8 for showed a senitivith of 70% and a specificity of 58% with aPPV of 46% and NPV of 78%, and with a cut off value of 0.12 for VFI 70%, 69%, 54% and 81%, respectively. The area under the curve for HE-4 was 0.814. A cut off value of 458 pmol/L was predictive of malignancy with 86% sensitivity and 63% specificity. Conclusions: VOCAL parameters and serum HE-4 levels were statistically significantly higher in the endometrial cancer patients. Serum HE-4 levels provided a greater sensitivity compared to power doppler angiography for predicting malignancy or benign endometrial pathology.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.38 no.8
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• pp.657-663
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• 2014

Since 2007, the defect confirmation test for vehicles using PEMS has been enforced in USA. This test can measure emissions from on-street vehicles using a device mounted on a car. Europe has confirmed its plan for introducing this test from EURO6, 2013. Thus, the Korean government is also under pressure to adopt this method that reflects the real-world driving conditions using PEMS, considering the emission controls for domestic heavy-duty vehicles. To provide various utilizations of the PEM, this emission test has been developed in accordance with the type of driving road, DPF, ISG, and air conditioner. This research aims to provide the fundamental materials for implementing defect confirmation tests for commercial vehicles, which are appropriate for domestic emission control situations, after studying the defect confirmation test methods for heavy-duty vehicles using PEMS.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2291-2295
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• 2016

Small molecule tyrosine kinase inhibitors targeting HER 2 receptors have emerged as an important therapeutic approach in inhibition of downstream proliferation and survival signals for the treatment of breast cancers. Recent drug discovery efforts have demonstrated that naturally occurring polyphenolic compounds like delphinidin have potential to inhibit proliferation and promote apoptosis of breast cancer cells by targeting HER2 receptors. While delphinidin may thus reduce tumour size, it is associated with serious side effects like dysphonia. Owing to the narrow therapeutic window of delphinidin, the present study aimed to identify high affinity compounds targeting HER2 with safer pharmacological profiles than delphinidin through virtual screening approaches. Delphinidin served as the query parent for identification of structurally similar compounds by Tanimoto-based similarity searching with a threshold of 95% against the PubChem database. The compounds retrieved were further subjected to Lipinski and Verber's filters to obtain drug like agents, then further filtered by diversity based screens with a cut off of 0.6. The compound with Pubchem ID: 91596862 was identified to have higher affinity than its parent. In addition it also proved to be non-toxic with a better ADMET profile and higher kinase activity. The compound identified in the study can be put to further in vitro drug testing to complement the present study.

• Journal of the Society of Naval Architects of Korea
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• v.46 no.6
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• pp.587-594
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• 2009

In the paper the effect of a stern-plate attached to a ship was taken into account. The relationship between the trim angle of a ship and the wave-resistance coefficient induced by the a stern-plate was studied using the potential flow analysis method. Numerical algorithm was described using the panel method and the vortex lattice method(VLM) to simulate the flow phenomena around a ship. The non-linearity of the free surface boundary conditions were considered using the iterative method and the IGE-GMRES(Incomplete Gaussian Elimination-The Generalized Minimal RESidual) algorithm was adopted to solve the linear equation at each iterative step. Numerical calculations were carried out to investigate the validity of the adopted algorithm using KCS(KRISO 3600 TEU Container) hull. Possible cases for attachment of the plate were checked. The results showed that the numerical algorithm could be physically appropriate.

• Journal of The Korean Association of Information Education
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• v.20 no.6
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• pp.543-552
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• 2016

Recently, a number of researches focus on social network analysis and it is applied to various fields not only in social science area but also in natural science area. Therefore, the social network analysis and the text analysis were conducted in order to analyze the current trend of the theses in information education field. The result indicated that the most frequently mentioned words were consistent with the development of information technology and the change in information education curriculum. That is, the mentioned words were computer aided instruction (CAI) and courseware for period 1, ICT for period 2, smart and scratch for period 3, and in period 4, computational thinking ability and coding appeared for the first time. Moreover, as the result of social network analysis, it concluded the research topics became more complicated and detailed as the words diversified throughout the period in which the simplified network in period 1 changed its configuration into a structure with more diversified words of higher centrality.

• The Journal of Advanced Prosthodontics
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• v.8 no.3
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• pp.207-213
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• 2016

PURPOSE. A recently introduced direct drill-guiding implant surgery system features minimal tolerance of surgical instruments in the metal sleeve by using shank-modified drills and a sleeve-incorporated stereolithographic guide template. The purpose of this study was to evaluate the accuracy of this new guided surgery system in partially edentulous patients using geometric analyses. MATERIALS AND METHODS. For the study, 21 implants were placed in 11 consecutive patients using the direct drill-guiding implant surgery system. The stereolithographic surgical guide was fabricated using cone-beam computed tomography, digital scanning, computer-aided design and computer-assisted manufacturing, and additive manufacturing processes. After surgery, the positional and angular deviations between planned and placed implants were measured at the abutment level using implant-planning software. The Kruskal-Wallis test and Mann-Whitney U test were used to compare the deviations (${\alpha}=.05$). RESULTS. The mean horizontal deviations were 0.593 mm (SD 0.238) mesiodistally and 0.691 mm (SD 0.344) buccolingually. The mean vertical deviation was 0.925 mm (SD 0.376) occlusogingivally. The vertical deviation was significantly larger than the horizontal deviation (P=.018). The mean angular deviation was 2.024 degrees (SD 0.942) mesiodistally and 2.390 degrees (SD 1.142) buccolingually. CONCLUSION. The direct drill-guiding implant surgery system demonstrates high accuracy in placing implants. Use of the drill shank as the guiding component is an effective way for reducing tolerance.

• Current Industrial and Technological Trends in Aerospace
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• v.7 no.2
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• pp.59-67
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• 2009

Computer Aided Engineering(CAE) technology as well as Design(CAD) and Manufacturing(CAM) have been widely adopted in the aerospace industry in order to develop the structure of airplanes, satellites and launch vehicles. Among them, CAE softwares based on finite element methods such as NASTRAN, ABAQUS and ANSYS have gained many engineers' interest in various industries such as automobiles, civils, aircraft and spacecraft. The softwares usually consist of several modules: Static, Dynamic, Vibration, Impact etc. that make analysis specific to meet the design goals of the structure systems. Recent enhancement in the computer hardwares and numerical algorithms enables us to perform complex analysis like multi-physics, optimum design. Also, they make it possible to deal with a large scale problem easily. This paper reviews structural analysis softwares in aerospace industry and gives a summary on its recent development.

• Journal of the Korean Society for Precision Engineering
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• v.16 no.12
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• pp.230-238
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• 1999

This paper describes a research work of developing computer-aided design of lead frame, semiconductor, with blanking operation which is very precise for progressive working. Approach to the system is based on the knowledge-based rules. Knowledge for the system is formulated from plasticity theories, experimental results and the empirical knowledge of field experts. This system has been written in AutoLISP on the AutoCAD using a personal computer and in I-DEAS Drafting Programming Language on the I-DEAS Master Series Drafting with Workstation, HP9000/715(64) and tool kit on the ESPRIT. Transference of data among AutoCAD, I-DEAS Master Series Drafting, and ESPRIT is accomplished by DXF(drawing exchange format) and IGES(initial graphics exchange specification) methods. This system is composed of six modules, which are input and shape treatment, production feasibility check, strip-layout, die-layout, modelling, and post-processor modules. The system can design process planning and Die design considering several factors and generate NC data automatically according to drawings of die-layout module. As forming process of high precision product and die design system using 2-D geometry recognition are integrated with technology of process planning, die design, and CAE analysis, standardization of die part in die design and process planning of high pression product for semiconductor lead frame is possible to set. Results carried out in each module will provide efficiencies to the designer and the manufacturer of lead frame, semiconductor.

• Journal of KIISE
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• v.41 no.10
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• pp.838-846
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• 2014

Three-dimensional (3D) object retrieval from user-drawn sketch queries is one of the important research issues in the areas of pattern recognition and computer graphics for simulation, visualization, and Computer Aided Design. The performance of content-based 3D object retrieval system depends on the availability of effective descriptors and similarity measures for this kind of data. In this paper, we present a sketch-based 3D object retrieval system by extracting a hybrid edge descriptor which is robust against rotation and translation. The experimental results which are based on HTML5 and WebGL show that proposed sketch-based 3D object retrieval method is very efficient to search and order the 3D objects according to user's intention.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.11a
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• pp.591-594
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• 2000

This paper describes a research work of developing a computer-aided design of product with bending and piercing for progressive working. An approach to the system for progressive working is based on the knowledge-based rules. Knowledge for the system is formulated from plasticity theories, experimental results and the empirical knowledge of field experts. The system has been written in AutoLISP on the AutoCAD with a personal computer and is composed of four main modules, which are input and shape treatment, flat pattern layout, strip layout and die layout module. Based on knowledge-based rules, the system is designed by considering several factors such as radius and angle of bend, material and thickness of product, complexities of blank geometry and punch profile, bending sequence, and availability of press. Strip layout drawing generated by the piercing processes with punch profiles divided into for external area is simulated in 3-D graphic forms, including bending sequences for the product with piercing and bending. Results obtained using the modules enable the manufacturer for progressive working of electronic products to be more efficient in this field.