• The Journal of Korean Institute of Communications and Information Sciences
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• v.38C no.10
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• pp.887-895
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• 2013

Metastatic bone cancer, the cancer which occurred in the various organs and progressively spread to bone, is one of the complications in cancer patients. This cancer is divided into the osteoblast and osteolytic metastasis. Although Computer Tomography(CT) could be an useful tool in diagnosis of bone metastasis, lesions are often missed by the visual inspection and it makes clinicians difficult to detect metastasis earlier. Therefore, in this study, we construct a three-dimensional(3D) volume rendering data from tomography images of the chest CT, and apply a 3D based image processing algorithm to them for detection bone metastasis lesions. Then we perform a three-dimensional visualization of the detected lesions.From our test using 10 clinical cases, we confirmed 94.1% of average sensitivity for osteoblast, and 90.0% of average sensitivity, respectively. Consequently, our findings showed a promising possibility and potential usefulness in diagnosis of metastastic bone cancer.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.38 no.5
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• pp.23-32
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• 2001

Electrical impedance tomography (EIT) is a relatively new imaging modality in which the resistivity (conductivity) distribution of the unknown object is estimated based on the known sets of injected currents and measured voltages on the surface of the object. In this paper, we propose a dynamical EIT reconstruction algorithm based on the regularized extended Kalman filter(EKF). The EIT inverse problem is formulated as dynamic equation which consists of the slate equation and the observation equation, and the unknown state(resistivity) is estimated recursively with the aid of the EKF. In doing so, the generalized Tikhonov regularization technique is employed in the cost functional to mitigate the ill-posedness characteristics of the inverse problem. Computer simulations for the 16-channel synthetic data are provided to illustrate the reconstruction performance of the proposed algorithm.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.1
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• pp.36-42
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• 2009

We have developed software for converting the volumetric voxel data obtained from X-ray computed tomography(CT) into computer-aided design(CAD) data. The developed software can used for non-destructive testing and evaluation, reverse engineering, and rapid prototyping, etc. The main algorithms employed in the software are image reconstruction, volume rendering, segmentation, and mesh data generation. The feasibility of the developed software is demonstrated with the CT data of human maxilla and mandible bones.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.4
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• pp.455-461
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• 2012

Obesity is associated with numerous diseases such as type 2 diabetes, hypertension and cancer. Inhibition of adipogenesis is a effectite strategy to anti-obesity. In this study, Galla Chinenisis extract (GCE) inhibited adipocyte differentiation in OP9 cells. There was no cytotoxicity when cells were treated with GCE in designated time intervals, unaffected by concentration. In this cell model, increases in fat storage were inhibited by 2 days treatment with various concentration of GCE, visualized by Oil red-O, BODIPY and DAPI staining. To understand the underlying mechanism at the molecular level, the effects of GCE were examined on the expression of the genes involved in adipogenesis by real-time PCR. In the progress of adipocyte differentiation with GCE-treated, the mRNA level of adipogenic genes such as peroxisome-proliferator-activated receptors gamma ($PPAR{\gamma}$), computer-assisted axial tomography/enhancer binding protein-alpha ($C/EBP{\alpha}$) were decreased. Also, GCE treatment inhibited increase of mRNA expression, which is adipogenic factor such as fatty acid synthase (FAS), hormone-sensitve lipase (HSL), lipoprotein lipase (LPL), and adipocyte-specific lipid binding protein (aP2). Therefore, the result of this study suggest that Galla Chinenisis extract can prevent adipocyte differentiation and GCE may have a great potential as a novel anti-adipogenic agent.

• Korean Journal of Veterinary Research
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• v.44 no.1
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• pp.131-136
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• 2004

Osseointegration involves anchoring dental implants to stable bone rather than to soft-tissue. Clinical osseointegration is currently defined as the process whereby alloplastic material is asymptomatically and rigidly fixed and maintained in bone during functional loading. Full osseointegration is necessary for the success of long-term dental implants. Recent developments in computer assisted measurement of bone formation have improved maxillofacial examination and osseointegration. Computer assisted examination has also proved effective in dental implantology. This investigation was aimed to determine osseointegration in immediate and delayed implantation in the dog mandible using dental computed tomography (CT) and bone scintigraphy. Five adult (mean age of 2 years) mongrel dogs with a mean weight of 9.1 kg were used in this investigation. Titanium alloy implant systems with 4 mm in diameter and 10 mm in length were chosen for insertion. The second and third left mandibular premolars in each dog were extracted for the delayed implant insertion. Twelve weeks later, the second and third right mandibular premolars were extracted for the immediate implant insertion. Before the delayed and immediate implantation procedures and 0, 4, 8, and 12 weeks after the insertions, dental CT and scintigraphy were conducted. The CT and scintigraphic images indicate that reconstruction of bone surrounding of the immediate implant can be as successful as reconstruction of bone surrounding of the delayed implant.

• The Journal of the Korean dental association
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• v.55 no.12
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• pp.842-849
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• 2017

The term, 'crossed occlusion' implies clinical situation in which the residual teeth in one arch have no contact with those in the antagonistic arch, resulting in the collapse of occlusal vertical dimension. The treatment goal of this pathologic condition is restoration of the collapsed vertical dimension and stabilization of abnormal mandibular position. Previously, konus removable prostheses or tooth supported overdentures were suggested to solve crossed occlusion. Nowadays, dental implants have been used for definitive support to solve this problem. In this case report, a 65 years old female patient had a crossed occlusion, in which the maxillary posterior residual teeth and mandibular anterior residual teeth cross. Interim removable and fixed dental prostheses were used to confirm the proper vertical and horizontal jaw relation. After that, the mandibular posterior edentulous region was restored with implant-supported fixed dental prostheses. Computer tomography guided implant surgery was performed according to the concept of the restoration-driven implant placement. The maxillary anterior edentulous region was restored with Kennedy class IV removable prosthesis, considering the patient's economic status. The patient's jaw position and prostheses have been well maintained at the follow-up after 6 months of definitive restoration. The antero-posterior crossed occlusion problems appeared to be effectively solved with the combination of removable in one arch and implant-supported fixed prostheses in the other.

• Korean Journal of Biological Psychiatry
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• v.17 no.3
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• pp.127-135
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• 2010

Objectives : This study was conducted to compare between hallucination group and delusion group in patient with schizophrenia, using Brain $^{99m}Tc$-ECD PECT. Methods : Among 16 patients with less than 3 schizophrenic episodes, 8 patients whose initial symptom was hallucination were assigned to the hallucination group, and other 8 patients with initial sumptom of delusion were assinged to the hallucination group. All of the patients clinically evaluated using the PANSS and BPRS. Both groups of patients and 8 healthy subjects underwent $^{99m}Tc$-ECD PECT. Results : Score of thinking disturbance subscale of BPRS were significantly lower in the hallucination group than the delusion group. In SPECT analysis, the hallucination group showed significantly increased perfusion in some areas of the right temporal lobe, bilateral limbic lobes and left parietal lobe compared to delusion group. Both group had a reduced rCBF in some areas of the frontal lobe. Conclusion : The hallucniation group, compared with the delusion group, showed significantly increased regional cerebral blood flow in some regions. Therefore, this data suggests that different neural substrates may affect the process of auditory hallucination and delusion.

• Journal of Korea Multimedia Society
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• v.8 no.5
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• pp.641-650
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• 2005

In this parer, curve stopping function based on the CT number of lung parenchyma from CT lung images is proposed to detect lung region in replacement of conventional edge indication function in geodesic active contour model. We showed that the proposed method was able to detect lung region more effectively than conventional method by applying three kinds of measurement numerically. And, we verified the effectiveness of proposed method visually by observing the detection Procedure on actual CT images. Because lung parenchyma region could be precisely detected from actual EBCT (electron beam computer tomography) lung images, we were sure that the Proposed method could aid to early diagnosis of lung disease and local abnormality of function.

• Korean Journal of Soil Science and Fertilizer
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• v.44 no.3
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• pp.517-526
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• 2011

Soil structure plays an important role in ecological system, since it controls transport and storage of air, gas, nutrients and solutions. The study of soil structure requires an understanding of the interrelations and interactions between the diverse soil components at various levels of organization. Investigations of the spatial distribution of pore/particle arrangements and the geometry of soil pore space can provide important information regarding ecological or crop system. Because of conveniences in image analyses and accuracy, these investigations have been thrived for a long time. Image analyses from soil sections through impregnated blocks of undisturbed soil (2 dimensional image analyses) or from 3 dimensional scanned soils by computer tomography allow quantitative assessment of the pore space. Image analysis techniques can be used to classify pore types and quantify pore structure without inaccurate or hard labor in laboratory. In this paper, the last 50 years of the soil image analyses have been presented and measurements on various soil scales were introduced, as well. In addition to history of image analyses, a couple of examples for soil image analyses were displayed. The discussion was made on the applications of image analyses and techniques to quantify pore/soil structure.

• Progress in Medical Physics
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• v.33 no.4
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• pp.172-179
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• 2022

Recently, tetrahedral phantoms have been newly adopted as international standard mesh-type reference computational phantoms (MRCPs) by the International Commission on Radiological Protection, and a program has been developed to convert them to computational tomography images and DICOM-RT structure files for application of radiotherapy. Through this program, the use of the tetrahedral standard phantom has become available in clinical practice, but utilization has been difficult due to various library dependencies requiring a lot of time and effort for installation. To overcome this limitation, in this study a newly developed TET2DICOM-GUI, a TET2DICOM program based on a graphical user interface (GUI), was programmed using only the MATLAB language so that it can be used without additional library installation and configuration. The program runs in the same order as TET2DICOM and has been optimized to run on a personal computer in a GUI environment. A tetrahedron-based male international standard human phantom, MRCP-AM, was used to evaluate TET2DICOM-GUI. Conversion into a DICOM-RT dataset applicable in clinical practice in about one hour with a personal computer as a basis was confirmed. Also, the generated DICOM-RT dataset was confirmed to be effectively implemented in the radiotherapy planning system. The program developed in this study is expected to replace actual patient data in future studies.