• Journal of Ginseng Research
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• v.40 no.4
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• pp.400-408
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• 2016

Background: Ginsenoside Rh2 (GRh2) is the main bioactive component in American ginseng, a commonly used herb, and its antitumor activity had been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in HCT116 colorectal cancer cells. Methods: We examined the effect of GRh2 on HCT116 cells ex vivo. Next, we performed in vitro binding assay and in vitro kinase assay to search for the target of GRh2. Furthermore, we elucidated the underlying molecular mechanisms for the antitumor effect of GRh2 ex vivo and in vivo. Results: The results of our in vitro studies indicated that GRh2 can directly bind with PBK/TOPK and GRh2 also can directly inhibit PBK/TOPK activity. Ex vivo studies showed that GRh2 significantly induced cell death in HCT116 colorectal cancer cells. Further mechanistic study demonstrated that these compounds inhibited the phosphorylation levels of the extracellular regulated protein kinases 1/2 (ERK1/2) and (H3) in HCT116 colorectal cancer cells. In vivo studies showed GRh2 inhibited the growth of xenograft tumors of HCT116 cells and inhibited the phosphorylation levels of the extracellular regulated protein kinases 1/2 and histone H3. Conclusion: The results indicate that GRh2 exerts promising antitumor effect that is specific to human HCT116 colorectal cancer cells through inhibiting the activity of PBK/TOPK.

• Computers and Concrete
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• v.24 no.3
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• pp.207-222
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• 2019

This paper has presented an effective and accurate meso-scale finite element model for simulating the fracture process of concrete under compression-shear loading. In the proposed model, concrete is parted into four important phases: aggregates, cement matrix, interfacial transition zone (ITZ), and the initial defects. Aggregate particles were modelled as randomly distributed polygons with a varying size according to the sieve curve developed by Fuller and Thompson. With regard to initial defects, only voids are considered. Cohesive elements with zero thickness are inserted into the initial mesh of cement matrix and along the interface between aggregate and cement matrix to simulate the cracking process of concrete. The constitutive model provided by ABAQUS is modified based on Wang's experiment and used to describe the failure behaviour of cohesive elements. User defined programs for aggregate delivery, cohesive element insertion and modified facture constitutive model are developed based on Python language, and embedded into the commercial FEM package ABAQUS. The effectiveness and accuracy of the proposed model are firstly identified by comparing the numerical results with the experimental ones, and then it is used to investigate the effect of meso-structure on the macro behavior of concrete. The shear strength of concrete under different pressures is also involved in this study, which could provide a reference for the macroscopic simulation of concrete component under shear force.

• KIPS Transactions on Software and Data Engineering
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• v.10 no.6
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• pp.223-234
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• 2021

Recent advances in the 4th Industrial Revolution have accelerated the change of the shopping behavior from offline to online. Search queries show customers' information needs most intensively in online shopping. However, there are not many search query research in the field of search, and most of the prior research in the field of search query research has been studied on a limited topic and data-based basis based on researchers' qualitative judgment. To this end, this study defines the type of search query with data-based quantitative methodology by applying machine learning to search research query field to define the 15 topics of search query by conducting topic modeling based on search query and clicked document information. Furthermore, we present a new classification system of new search query types representing searching behavior characteristics by extracting key variables through principal component analysis and analyzing. The results of this study are expected to contribute to the establishment of effective search services and the development of search systems.

• Korean Journal of Clinical Pharmacy
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• v.31 no.4
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• pp.324-331
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• 2021

To investigate signals of adverse drug reactions of finasteride by using the Korea Adverse Events Reporting System (KAERS) database. This pharmacovigilance was based on the database of the drug-related adverse reactions reported spontaneously to the KAERS from 2013 to 2017. This study was conducted by disproportionality analysis. Data mining analysis was performed to detect signals of finasteride. The signal was defined by three criteria as proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). The signals of finasteride were compared with those of the other drugs; dutasteride (similar mechanism of action), minoxidil (different mechanism but similar indications for alopecia), silodosin (different mechanism but similar indications for BPH). It was examined whether the detected signals exist in drug labels in Korea. The total number of adverse event-drug pairs was reported 2,665,429 from 2013 to 2017, of which 1,426 were associated with finasteride. The number of investigated signals of finasteride was 42. The signals that did not include in the drug label were 29 signals, including mouth dry, hypotension, dysuria etc. The signal of finasteride was similar to that of dutasteride and silodosin but was different to that of minoxidil. Early detection of signals through pharmacovigilance is important to patient safety. We investigated 29 signals of finasteride that do not exist in drug labels in Korea. Further pharmacoepidemiological studies should be needed to evaluate the signal causality with finasteride.

• Korean Journal of Clinical Pharmacy
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• v.33 no.2
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• pp.86-96
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• 2023

Background: Using KIDS-KAERS database (KIDS-KD) from 2016 to 2020, the aim is to investigate signals of adverse events of alpha-adrenoceptor antagonists and to present adverse events that are not included in the precautions for use when marketing approval. Methods: This study was conducted by disproportionality analysis. Data mining analysis was performed to detect signals of alpha-adrenoceptor antagonists, such as terazosin, doxazosin, alfuzosin, silodosin, and tamsulosin. The signal was defined by three criteria as proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). Detected signals were compared with product labeling and the European Medicines Agency-Important Medical Events list. Results: Out of the total number of 408,077 reports for adverse events, 6,750 cases were reported as adverse events of alpha-adrenoceptor antagonists. Dizziness, mouth dryness, hypotension postural, and oedema peripheral are identified as common adverse events of five alpha-adrenoceptor antagonists and are typically listed on drug labels. However, new signals were detected for pneumonia, chronic obstructive airway disease, eye diseases such as glaucoma and cataracts, fracture, and ileus of tamsulosin that were not previously listed on the drug labels in Korea. Conclusions: This study identified signals related to adverse drug reactions of alpha-adrenoceptor antagonists and presented serious adverse events, suggesting new adverse reactions to be aware of when using alpha-adrenoceptor antagonists.

• Proceedings of the Mineralogical Society of Korea Conference
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• 2002.10a
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• pp.53-67
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• 2002

As in the past, we are concerned today with the magnitudes of mineral resources and the adequacy of these resources to meet future needs. In looking at global resource issues, we should consider the need for the resource, its supply, and the environmental consequences of using it. The need for a resource can become a resource dependency, especially as the global population expands and each of us becomes increasingly dependent upon hundreds of natural materials. Therefore, our great mineral consumption makes the human population a true 'Geologic Force', which will be even more significant in the future when the global population is projected to reach alarming proportions. Although our supplies of mineral resources probably will be sufficient for the 21s1 century, the uneven distribution of minerals in the Earth's crust almost certainly will continue to be a major problem The most likely result will be major shifts in both prices and sources of supply of many mineral resources. As for energy resources, we must avoid an obsessive dependency on one fuel and expand instead to thor energy resources. Finally, because the use of resources affects the environment, we need to focus on resource exploitation and global pollution, particularly in regard to ground water and arable land. We must manage our resources so as to be in balance with our environment. And the accelerated industrialization of South Korean economy over the last three decades has resulted in the mass consumption of nuneral commodities. South Korea has around 50 useful mineral commodities for the mineral industry, among 330 kinds of minerals described. The component ratio of the mining industry sector of the gross national production(GNP) in South Korea dropped from $1.2\%\;in\;1971\;to\;0.34\%$ in 1997 due to the rapid growth of other industries In the countxy. During the period from 1971 to 1997, the average growth rate of mineral consumption in South Korea was $9.13\%$ yearly and that of GNP per capita was $14.97\%$. The mineral consumptions per capita showed a continual Increase during the last 30 years as follows(parenthesis. GNP per capita): 0.99 metric tons in 1971($\$289$), 3.83 metric tons in 1989($\$5,210$), 6.11 metric tons in 1995 ($\$10,037$), and 6.66 metric tons in 1997($9,511). The total amount of mineral consumption in South Korea was 33 million tons of 32 mineral commodities in 1971, and 306 million metric tons of 47 mineral commodities In 1997.

• Ocean and Polar Research
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• v.29 no.2
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• pp.87-99
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• 2007

This study was conducted to understand the source and behavior of organic matter using the fluorescent technique (excitation-emission matrix) as a part of environmental monitoring program in the Korea manganese nodule mining site in the Northeastern Pacific Ocean. Water samples were collected at $0^{\circ},\;6^{\circ}N$, and $10.5^{\circ}N$ along $131.5^{\circ}W$ in August 2005. The concentration of total organic carbon (TOC) ranged from 58.01 to $171.93\;{\mu}M-C$. The vertical distribution of TOC was characterized as higher in the surface layer and decreased with depth. At $6^{\circ}N$, depth-integrated (from surface to 200 m depth) TOC was $337.1\;gC/m^2$, which was 1.4 times higher value than other stations. The exponential decay curve fit of vertical profile of TOC indicated that 59% of organic carbon produced by primary production in the surface layer could be decomposed by bacteria in the water column. Dissolved organic matter is generally classified into two distinctive groups based on their fluorescence characteristics using three-dimensional excitation/emission (Ex/Em) fluorescence mapping technique. One is known as biomacromolecule (BM; protein-like substance; showing max. at Ex 280/Em 330), mainly originated from biological metabolism. The other is geomacromolecule (GM; humic-like substance; showing max. at Ex 330/Em 430), mainly originated from microbial degradation processes. The concentration of BM and GM was from 0.42 to 7.29 TU (tryptophan unit) and from 0.06 to 1.81 QSU (quinine sulfate unit), respectively. The vertical distribution of BM was similar to that of TOC as high in the surface and decreased with depth. However, the vertical distribution of GM showed the reverse pattern of that of BM. From these results, it appeared that BM occupied a major part of TOC and was rapidly consumed by bacteria in the surface layer. GM was mainly transformed from BM by microbial processes and was a dominant component of TOC in the deep-sea layer.

• Economic and Environmental Geology
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• v.21 no.2
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• pp.149-164
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• 1988

Electrum-sulfide mineralization of the Samgwang and Sobo mines of the Cheongyang Au-Ag area was deposited in two stages of quartz and calcite veins that fill fault zones in granite gneiss. Radiometric dating indicates that mineralization is Early Cretaceous age (127 Ma). Fluid inclusion and sulfur isotope data show that ore mineralization was deposited at temperatures between $340^{\circ}$ and $180^{\circ}C$ from fluids with salinities of 1 to 8 wt. % equiv. NaCl and a ${\delta}^{34}S_{{\sum}S}$ value of 2 to 5 per mil. Evidence of fluid boiling (and $CO_2$ effervescence) indicates a range of pressures from < 200 to $\approx$ 700 bars, corresponding to depths of ${\approx}1.5{\pm}0.3\;km$ in a hydrothermal system which alternated from lithostatic toward hydrostatic conditions. Au-Ag deposition was likely a result of boiling coupled with cooling. Meaured and calculated hydrogen and oxygen isotope values of ore-forming fluids indicate a significant meteoric water component, approaching unexchanged paleometeoric water values. Comparison of these values with those of other Korean Au-Ag deposits reveals a relationship among depth, Au/Ag ratio and degree of water-rock interaction. All investigated Korean Jurassic and Cretaceous gold-silver-bearing deposits have fluids which are dominantly evolved meteoric waters, but only deeper systems (${\geq}1.5\;km$) are exclusively gold-rich.

• Journal of Intelligence and Information Systems
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• v.16 no.2
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• pp.33-54
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• 2010

The World Wide Web is transitioning from being a mere collection of documents that contain useful information toward providing a collection of services that perform useful tasks. The emerging Web service technology has been envisioned as the next technological wave and is expected to play an important role in this recent transformation of the Web. By providing interoperable interface standards for application-to-application communication, Web services can be combined with component based software development to promote application interaction both within and across enterprises. To make Web services for service-oriented computing operational, it is important that Web service repositories not only be well-structured but also provide efficient tools for developers to find reusable Web service components that meet their needs. As the potential of Web services for service-oriented computing is being widely recognized, the demand for effective Web service discovery mechanisms is concomitantly growing. A number of public Web service repositories have been proposed, but the Web service taxonomy generation has not been satisfactorily addressed. Unfortunately, most existing Web service taxonomies are either too rudimentary to be useful or too hard to be maintained. In this paper, we propose a Web service taxonomy generation framework that combines an artificial neural network based clustering techniques with descriptive label generating and leverages the semantics of the XML-based service specification in WSDL documents. We believe that this is one of the first attempts at applying data mining techniques in the Web service discovery domain. We have developed a prototype system based on the proposed framework using an unsupervised artificial neural network and empirically evaluated the proposed approach and tool using real Web service descriptions drawn from operational Web service repositories. We report on some preliminary results demonstrating the efficacy of the proposed approach.

• Proceedings of the KSEEG Conference
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• 2002.10a
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• pp.53-67
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• 2002

As in the past, we are concerned today with the magnitudes of mineral resources and the adequacy of these resources to meet future needs. In looking at global resource issues, we should consider the need for the resource, its supply, and the environmental consequences of using it. The need for a resource can become a resource dependency, specially as the global population expands and each of us becomes Increasingly dependent upon hundreds of natural materials. Therefore, our great mineral consumption makes the human population a true “Geologic Force”, which will be even more significant in the future when the global population is projected to reach alarming proportions. Although our supplies of mineral resources probably will be sufficient for the 21st century, the uneven distribution of minerals in the Earth's crust almost certainly will continue to be a major problem. The most likely result will be major shifts in both prices and sources of supply of many mineral resources. As for energy resources, we must avoid an obsessive dependency on one fuel and expand instead to other energy resources. Finally, because the use of resources affects the environment, we need to focus on resource exploitation and global pollution, particularly in regard to ground water and arable land. We must manage our resources so as to be in balance with our environment. And the accelerated industrialization of South Korean economy over the last three decades has resulted in the mass consumption of mineral commodities. South Korea has around 50 useful mineral commodities for the mineral industry, among 330 kinds of minerals described. The component ratio of the mining industry sector of the gross national production(GNP) in South Korea dropped from 1.2% in 1971 to 0.34% in 1997 due to the rapid growth of other industries in the country. During the period from 1971 to 1997, the average growth rate of mineral consumption in South Korea was 9.13% yearly and that of GMP per capita was 14.97%. The mineral consumptions per capita showed a continual increase during the last 30 years as follows(parenthesis: GW per capita); 0.99 metric tons in 1997($289), 3.83 metric tons in 1989($5, 210), 6.11 metric tons in 1995 ($10, 037), and 6.66 metric tons in 1997($9, 511). The total amount of mineral consumption in South Korea was 33 million tons of 32 mineral commodities in 1971, and 306 million metric tons of 47 mineral commodities in 1997.