• Biomolecules & Therapeutics
• /
• v.19 no.3
• /
• pp.308-314
• /
• 2011

It has been shown that circadian genes not only play an important role on circadian rhythms, but also participate in other physiological and pathological activities, such as drug dependence, cancer development and radiation injury. The Per2, an indispensable component of the circadian clock, not only modulates circadian oscillations, but also regulates organic function. In the present study, we applied mPER2-upregulated NIH3T3 cells to reveal the relationship of mPer2 and the cells damaged by ultraviolet C (UVC). NIH3T3 cells at the peak of the expression of mPer2 induced by phorbol 12-myristate 13-acetate (PMA) demonstrated little damage by UVC evaluated by MTT assay, cell growth curves and cell colony-forming assay, compared with that at the nadir of the expression of mPer2. Overexpression of mPER2, accompanied p53 upregulated, also demonstrated protective effect on NIH3T3 cells damaged by UVC. These results suggest that mPer2 plays a protective effect on cells damaged by UVC, whose mechanism may be involved in upregulated p53.

• Biomolecules & Therapeutics
• /
• v.28 no.3
• /
• pp.250-258
• /
• 2020

Emphysema, a major component of chronic obstructive pulmonary disease (COPD), is a leading cause of human death worldwide. The progressive deterioration of lung function that occurs in the disease is caused by chronic inflammation of the airway and destruction of the lung parenchyma. Despite the main impact of inflammation on the pathogenesis of emphysema, current therapeutic regimens mainly offer symptomatic relief and preservation of lung function with little therapeutic impact. In the present study, we aimed to discover novel therapeutics that suppress the pathogenesis of emphysema. Here, we show that LJ-2698, a novel and highly selective antagonist of the adenosine A₃ receptor, a G protein-coupled receptor involved in various inflammatory diseases, significantly reversed the elastase-induced destructive changes in murine lungs. We found that LJ-2698 significantly prevented elastase-induced airspace enlargement, resulting in restoration of pulmonary function without causing any obvious changes in body weight in mice. LJ-2698 was found to inhibit matrix metalloproteinase activity and pulmonary cell apoptosis in the murine lung. LJ-2698 treatment induced increases in anti-inflammatory cytokines in macrophages at doses that displayed no significant cytotoxicity in normal cell lines derived from various organs. Treatment with LJ-2698 significantly increased the number of anti-inflammatory M2 macrophages in the lungs. These results implicate the adenosine A₃ receptor in the pathogenesis of emphysema. Our findings also demonstrate the potential of LJ-2698 as a novel therapeutic/preventive agent in suppressing disease development with limited toxicity.

• Toxicological Research
• /
• v.17
• /
• pp.139-144
• /
• 2001

Chewing betel quid is associated with an increased risk of oral cancer. The betel quid chewed in Taiwan includes the inflorescence of Piper betle, which contains high concentrations of safrole (15 mg/fresh weight). Piper betle leaf is also used in betel quid; however, the concentration of safrole in betel leaf has not been documented. Chewing betel quid may contribute to safrole exposure in man (420 mm in saliva). Using $a^{32}$P-postlabeling method, we have recently demonstrated the presence of stable safrole-like DNA adducts in human oral tissues following betel quid chewing. Safrole is a rodent hepatocar-cinogen, and the real nature of safrole-DNA adducts in human tissues beside oral has not been elucidated. In this paper, we tested the safrole DNA adducts forming potential in human hepatic and oral derived cells by the ${32}^P$-postlabeling technique. The results suggest that oral cancer derived cell OC-2 alone is not able to form safrole-DNA adduct. However, safrole DNA adducts can be detected following I'-hydroxysafrole, a proximate safrole metabolite, treatment. In addition, pretreament of cytochrome P450 inducers also enhanced the formation of previously undetectable safrole DNA adducts. This finding couples with our previous results suggest that oral may serve as a target tissue for safrole, and safrole may be involved in oral carcinogenesis.

• Korean Journal of Community Nutrition
• /
• v.6 no.1
• /
• pp.97-107
• /
• 2001

The clustering of insulin resistance with hypertension, glucose intolerance, hyperinsulinemia, increased triglyceride and decreased HDL cholesterol levels, and central and overall obesity has been called syndrome X, or the insulin resistance syndrome(IRS). To develop a nutrition service for IRS, this study was performed to evaluate the prevalence of each component of the metabolic abnormalities of IRS and analyze the clustering pattern of IRS among subjects living in the Taegu community. Participants in this study were 9234(mean age ; M/F 48/40yrs);63.5% were men, 24.4% were obese, 13.3% had hypertension. 3.7% had hyperglycemia, and 32.4% had hyperlipidemia. The IRS was defined as the coexistence of two or more components among metabolic abnormalities; obesity, hypertension. hyperglucemia and hyperlipidemia. The prevalence of IRS in Taegu was 19.2%(M/F:20.8%/16.4%), the clustering of these fisk variables was higher in advanced age group. Among the subjects of IRS having two of more diseases, 75.6% were obese, the pattern were similar in men and women. The younger, the higher the prevalence of obesity associated clustering patterns. The prevalence of obesity associated patterns among the hyperglycemia associated clustering patterns was 44.5%. The samples of the representative clustering patterns were obesity and hyperlipidemia (8.0%), hypertension and hyperlipidemia(3.2%), hypertension, obesity and hyperlipiemia(3.1%), hypertension and obesity(2.3%), and hyperglycemia and hyperlipidemia(0.8%). The clustering of obesity and hyperlipidemia until 50 year old groups, and the clustering of hypertension and hyperlipidemia in the 60 and 70 age groups were the most prevalent. We concluded that insulin resistance syndrome was a relatively common disorder in the Taegu community, and prevalence and the characteristics of the intervention strategies for IRS are desired, an effective improvement will be achieved.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.22 no.2
• /
• pp.203-214
• /
• 1998

The purpose of this study is to classify the upper body of women into several kinds of somatotypes, using the method of Surgical Tape and making their shells. The subjects are 53 females 30 to 39 years-old. Fifty-three anthropometric data are measured per shell of bodysurface; six somatotype factors are obtained through principal component analysis and orthogonal rotation by the method of Varimax, Somatotype of women's upper body is achieved by cluster analysis, using the standardized factor score as an independent variable and the FASTCLUS of SAS by Kmeans. The results are as follows: 1. The number of the factors which explain the somatotype is six and those factors comprise 76.12 percent of total variance. Factor 1: related to the size of shape in the front of upper body Factor S: related to the size of shape in the back of upper body Factor 3: related to the type of the upper chest over the chest circumference line Factor 4: related to the length of·the upper body Factor 5: related to the part of the neck Factor 6: related to the type of the lower chest under the chest circumference line 2. Cluster analysis results in classification of upper body into five clusters. Cluster L: the length is the largest and the circumference is small. The part of waist is the largest and widest among surface areas. Cluster 2: Slender body line from chest to waist is characteristic. The length is longer. The part of upper and lower chest is larger among surface areas. Cluster S: the circumference is the smallest and armhole is small. The length and surface area are small. Cluster 4: the circumference and armhole is the largest. The length is the smallest. Cluster 5: the circumference is average and the length is a little long. The body line(silhouette) from chest to waist is curved slightly.

• Journal of Biomedical Engineering Research
• /
• v.38 no.4
• /
• pp.168-174
• /
• 2017

To improve and downsize the KIOM-Pulse Analysis System(KIOM-PAS), which has been traditionally used in clinical trials, a miniaturized PAS(M-PAS) with a pneumatic pump has been developed. M-PAS is composed of a measurement module and an arm-mounting module, on which an arm can be placed. The measurement module is equipped with a pressing component and sensor, which is a wearable wristband. The arm-mounting module includes a pneumatic motor, data acquisition board and valves. In addition, the measurement module is divided into a fixing module of band type for attachment to a pulsation site and a sensing module, which includes a sensor and a tube. The fixing module and sensing module are constructed independently, and the detachable fastening method improves the posture convenience of the subject during measurement. M-PAS has been reduced to 1/6 the size of KIOM-PAS, and the measurement time is shortened by 22%. Using a simulator, the difference between the waveforms measured by the two devices exhibited a high degree of similarity of within 3.65%. M-PAS represents improvements in size and convenience compared with KIOM-PAS, and it is expected to be widely used in clinics in the future because it improves the attachment method of the fixing module.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.23 no.10
• /
• pp.107-114
• /
• 2009

Because of the increase of power demand and expansion of downtown, it is necessary to install the power transformers at the substation in the residential area. But the public complaints have increased due to the noise of the power transformers in the substation. A soundproof wall has been employed to the power transformers in the outdoor substations and a soundproof door, a soundproof shutter and soundproof equipment for wind-path has been employed to power transformers in the indoor substations in order to isolate sound propagation from the noise of the power transformers. But the noise reduction results of these methods are not satisfied. In this study, a soundproof enclosure is developed to effectively isolate sound propagation from the noise of the power transformers. The performance of the sound attenuation of the developed soundproof enclosure is verified in a 154[kV] transformer. As a result, 15[dB] sound attenuation in 120[Hz] component is achieved by applying the developed soundproof enclosure to a 154[kV] transformer.

• Horticultural Science & Technology
• /
• v.29 no.6
• /
• pp.568-574
• /
• 2011

Measuring tray as a component in irrigation control system using drainage electrodes was designed and applied for tomato perlite bed culture, and the effectiveness of the irrigation control system was investigated in terms of cultural development and cultivation costs. Five different types of measuring trays equipped with drainage electrodes were tested and the traditional tray was used as the control equipped with time clock. After the first experiment, "Tube-2" was removed because of instability of water content in the substrate. After second experiment, "Tube-1" was removed because of instability of water content in the substrate and low plant yields. In third experiment, "Up-Board" exhibited the best stability in water contents and yields as well as efficiencies in water and fertilizer utilization. The "Up-Board" was the most economical and the easiest system among the tested trays. Therefore, the "Up-Board" system was concluded as the excellent design to apply for the control method using drainage electrodes for tomato perlite bed culture.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.6 no.11
• /
• pp.2827-2848
• /
• 2012

Previously, we described a social media cloud computing service environment (SMCCSE). This SMCCSE supports the development of social networking services (SNSs) that include audio, image, and video formats. A social media cloud computing PaaS platform, a core component in a SMCCSE, processes large amounts of social media in a parallel and distributed manner for supporting a reliable SNS. Here, we propose a Hadoop-based multimedia system for image and video transcoding processing, necessary functions of our PaaS platform. Our system consists of two modules, including an image transcoding module and a video transcoding module. We also design and implement the system by using a MapReduce framework running on a Hadoop Distributed File System (HDFS) and the media processing libraries Xuggler and JAI. In this way, our system exponentially reduces the encoding time for transcoding large amounts of image and video files into specific formats depending on user-requested options (such as resolution, bit rate, and frame rate). In order to evaluate system performance, we measure the total image and video transcoding time for image and video data sets, respectively, under various experimental conditions. In addition, we compare the video transcoding performance of our cloud-based approach with that of the traditional frame-level parallel processing-based approach. Based on experiments performed on a 28-node cluster, the proposed Hadoop-based multimedia transcoding system delivers excellent speed and quality.

• The Journal of the Korea Contents Association
• /
• v.12 no.3
• /
• pp.421-433
• /
• 2012

AMGA service, which is one of the EMI gLite middleware components, is widely used for analysis of distributed large scale experiments data as metadata repository by scientific and technological researchers and the use of AMGA is extended farther to include general industries needing metadata Catalogue as well. However AMGA, based unix and Grid UI, has the weakness of being absence of general-purpose user interfaces in comparison to other commercial database systems and that's why it's difficult to use and diffuse it although it has the superiority of the functionality. In this paper, we developed AMGA GUI toolkit to provide work convenience using object-oriented modeling language(UML). Currently, AMGA has been used as the main component among many user communities such as Belle II, WISDOM, MDM, and so on, but we expect that this development can not only lower the barrier to entry for AMGA beginners to use it, but lead to expand the use of AMGA service over more communities.