• 한국발생생물학회지:발생과생식
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• 제16권4호
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• pp.363-370
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• 2012

The outer dense fiber 2 (ODF2) protein is an important component of sperm tail outer dense fiber and localizes at the centrosome. It has been reported that the RO072 ES cell derived homozygote knock out of ODF2 results in an embryonic lethal phenotype, and XL169 ES cell derived heterozygote knock out causes severe defects in sperm tail development. The ODF2s splicing variant, Cenexin1, possesses a C-terminal extension, and the phosphorylation of serine 796 residue in an extended C-terminal is responsible for Plk1 binding. Cenexin1 assembles ninein and causes ciliogenesis in early stages of the cell cycle in a Plk1-independent manner. Alternatively, in the late stages of the cell cycle, G2/M phase, Cenexin1 binds to Plk1 and results in proper mitotic progression. In this study, to identify the in vivo function of Plk1 binding to phosphorylated Cenexin1 S796 residue, and to understand the in vivo functional differences between ODF2 and Cenexin1, we generated ODF2/Cenexin1 S796A/Cenexin1 WT expressing transgenic mice in a RO072 ES cell derived $ODF2^{+/-}$ knock out background. We observed a severe defect of sperm tail development by ectopic expression of Cenexin1 S796A mutant and no phenotypic differences between the ectopic expression of ODF2/Cenexin1 WT in $ODF2^{+/-}$ background and in normal wild type mice.

• Journal of Nutrition and Health
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• 제36권8호
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• pp.841-850
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• 2003

Soy-based formula has been used for centuries in Korea. Soybeans contain phytochemicals with a biochemically active component, isoflavone. Isoflavone is a kind of phytoestrogens, structurally and functionally similar to estrogen. This study was conducted to investigate the effects of soy-based infant formula on growth, development, and isoflavone concentration in the plasma and urine. Thirty-nine healthy infants who were delivered at K university medical center were recruited. Experimental groups were the breast milk group (n = 15, BM) who were fed breast milk, soy-based formula group (n = 10, SBF) who were fed soy-based infant formula, and the casein-based formula group (n = 14, CBF) who were fed casein-based infant formula for 4 months. HPLC analysis was used to measure the concentration of isoflavones. The measurements of infant weight, length, head circumference and chest circumference were all in the normal growth range and were similar among the experimental groups. No significant differences were found in the scores of total mean of infant development test (Development Quotient, DQ) among the experimental groups. The isoflavone content of soy-based formula was significantly higher than. that of breast milk and casein-based formula. Plasma concentration of daidzein and genistein in the infants fed soy-based formula (daidzein : 264.1 ng/ml, genistein : 392.1 ng/ml) was significantly higher (p<.0001) than that in infants fed breast milk (daidzein : 3.4 ng/ml, genistein : 3.8 ng/ml) and casein-based formula (daidzein: 8.1 ng/ml, genistein: 9.3 ng/ml). Also, urinary daidzein and genistein concentrations in infants fed soy-based formula (daidzein: 19.82 $\mu$g/ml, genistein : 17.89 $\mu$g/ml) were significantly higher (p<.001) than those in infants fed breast milk (daidzein: 0.28 $\mu$g/ml, genistein : 0.22 $\mu$g/ml) and casein-based formula (daidzein : 0.45 $\mu$g/ml, genistein : 0.33 $\mu$g/ml).

• 산업경영시스템학회지
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• 제42권4호
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• pp.31-38
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• 2019

The purpose of this study is to provide the priority of the front-loading factors in the design stage of the automotive parts development process in order to efficiently and effectively respond to the demands of the car maker (customer). Front-loading is defined as a strategy in order to improve development performance by shifting the identification and solving of design problems to earlier phases of a product development process. Two approaches of the front-loading are project-to-project knowledge transfer and rapid problem solving. For the study, a survey was conducted on the R&D department in the automobile parts company and analyzed by AHP (Analytic Hierarchy Process) method. The result of the survey shows the cost savings is the highest weight in terms of front-loading effect and in terms of front-loading factors, it gives priorities as "the problems of past project" first, "Design Review" second, "CAE (Computer Aided Engineering)" third, "FMEA (Failure Mode and Effects Analysis)" fourth, "benchmarking" and SR (Sourcing of Requirements). The results of the study will be helpful to provide practical value for improving product design of component development.

• 대한지리학회지
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• 제43권1호
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• pp.117-133
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• 2008

개발밀도는 현대 도시 관리의 주요 관심사임에도 불구하고 이론 실증적으로 분석할 수 있는 지원 체계가 미비하다. 본 연구에서는 셀룰러 오토마타 기반의 도시 모델링 방법론을 확장하여 개발밀도를 고려한 도시 토지이용 변화 모델을 개발하고 그 타당성을 평가하고자 한다. 제안된 모델은 구조적인 측면에서 개발밀도를 명시적으로 고려할 분만 아니라 국지적인 밀도 변화를 직접적으로 추정한다. 개발된 모델을 1980년대 초$\sim$2000년대 초의 서울 도심부 토지이용 변화에 적용하였으며, 그 결과를 다양한 방법을 통해 검토하였다. 검토 결과 제안된 모델은 토지의 용도 변화 뿐만 아니라 밀도 변화에도 유의미하게 적용될 수 있는 것으로 평가되었다. 하지만 제안된 모델은 데이터 구득의 한계로 인해 공간적, 시간적 제약을 가지게 되었다. 더불어 모델의 보정 및 타당성 검토 방법론은 본 연구에서 충분히 검토되지 못하였으며, 향후 지속적으로 연구될 필요가 있다.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제6권2호
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• pp.150-160
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• 2000

클라이언트/서버 응용은 크게 데이타베이스 서버와 응용 및 프리젠테이션 로직을 포함한 클라이언트로 구성된다. 이러한 클라이언트/서버 응용은 최근의 웹의 성장과 함께 자바 언어를 많이 이용하는데 특히 클라이언트 쪽의 GUI 구현과 JDBC를 이용한 클라이언트/서버 응용에 많이 쓰인다. JDBC를 이용하여 클라이언트/서버 응용을 개발할 경우 먼저 응용의 바탕이 되는 데이타베이스의 설계, JDBC 접속을 위한 코딩, 데이타베이스로부터 선택된 데이타들을 보여주기 위한 리포트 양식 등의 설계가 필요하다. 본 논문에서는 이러한 JDBC를 이용한 클라이언트/서버 응용 개발에 필요한 컴포넌트들을 자바빈즈로설계 및 구현하고 이를 이용한 개발 환경을 제시한다. 구현된 환경을 이용하면 클라이언트/서버 응용의 개발에 있어서 소스 코드 편집을 최소화하고 자바빈즈 컴포넌트들의 선택 및 이들의 속성 편집만으로 쉽게 구현할 수 있다.

• 한국산림과학회지
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• 제94권5호통권162호
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• pp.330-333
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• 2005

The relationship between the contents of methyl trans-cinnamate and the ratio of DP/DS (diameter of pileus / diameter of stalk) in the fruit-body of Tricholoma matsutake during its development was investigated. The stages of development were divided as follows: stage A is less than 1, stage B is from 1 to less than 2, stage C is from 2 to less than 3, and stage D is more than 3 of the values of DP/DS. The contents of methyl trans-cinnamate in pileus and stalk of pine mushroom ranged from $77{\mu}g/g$ to $824{\mu}g/g$ and from $7.6{\mu}g/g$ to $22.4{\mu}g/g$, respectively during its development. In the part of pileus, there is no relevance of the methyl trans-cinnamate content of pine mushroom between the stage A and B, but there was significantly different among the stage of B, C and D. In the case of stalk, the relevance of the methyl trans-cinnamate content of pine mushroom between stage D and other stages showed a low difference. In addition, as pileus of pine mushroom developed the level of the aroma compound increased as well and showed higher correlation relationship ($r^2=0.877$) between the contents of methyl trans-cinnamate in the pileus and the ratio of DP/DS. From the results of this study, we can conclude that the aromatic component of pine mushroom can be deduced from the value of DP/DS, which indicates the stage of the development appearance.

• 한국동물위생학회지
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• 제38권1호
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• pp.25-30
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• 2015

Bee venom has been used as to prevent and treat bovine mastitis as natural antimicrobial compounds in some dairy cattle farms in Korea. It is needed to determine the residual of bee venom in milks of dairy cattle treated with bee venom. Since bee venom is not approved as a raw material for animal drugs, the preprocessing method to detect bee venom residual in milk and the tolerance limit for its residue has not been established yet in Korea. Therefore, the purpose of this study was to develop pre-processing method not affecting major component of bee venom for detection of its residue in milks using ultra-high performance liauid chromatography (UHPLC). In addition, bee venom residue was also analyzed in milk samples of dairy cattle treated for mastitis with bee venom using UHPLC with the developed pre-processing method in this study. As a result, melittin, histamin and phospolipase A2, the major components of bee venom, were all detected by UHPLC with the pre-processing method developed in this study. The results of this study suggest that the pre-processing method developed in this study can be useful to detect bee venom residue in dairy cattle milk. We also found that no bee venom residues were detected in milk samples collected from dairy cattle treated with bee venom after 1 and 3 days, respectively.

• 한국항공우주학회지
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• 제41권12호
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• pp.994-1001
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• 2013

헬기의 개발 과정은 설계, 제작 및 시험평가로 구분될 수 있으며, 시험평가는 구성품 시험, Rig 시험, 체계 지상시험 및 비행시험의 순서로 단계적으로 수행된다. 지상시험이 종료되고 최초 비행에 앞서, 비행 안전성을 담보하기 위해 미군사규격은 50시간 비행전 수락시험을 요구하고 있다. 비행전 수락시험은 헬기를 지상결박하여 가혹한 하중을 부과하는 시험으로서, 이의 수행을 위해서는 헬기 시제기와 유사한 별도의 지상 시험 시제기가 필요하며, 많은 비용과 기간이 소요되는 시험이다. KUH의 경우 국내 개발 환경을 고려하여 미군사규격의 요구도를 변형 후 수행하였으며, 본 논문은 KUH 비행전 수락시험의 절차 및 결과를 통하여 헬기 개발 환경에 따른 적절한 비행전 수락시험 수행 방안을 제시하고자 한다.

• 한국환경과학회지
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• 제15권10호
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• pp.919-928
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• 2006

The present study applied an atmospheric flow field model in Gwangyang-Bay which can predict local sea/land breezes formed in a complex terrain lot the development of a model that can predict short term concentration of air pollution. Estimated values from the conduct of the atmospheric flow field were used to evaluate and compare with observation data of the meteorological stations in Yeosu and the Yeosu airport, and the effect of micrometeorology of surround region by the coastal area reclamation was predicted by using the estimated values, Simulation results, a nighttime is appeared plainly land breezes of the Gwangyang-bay direction according to a mountain wind that formed in the Mt. of Baekwooun, Mt. of Youngchui. Land winds is formed clockwise circulation in the north, clockwise reverse direction in the south with Gangyang-bay as the center. Compared with model and observation value, Temperature is tend to appeared some highly simulation value in the night, observation value in the daytime in two sites all, but it is veil accorded generally, the pattern of one period can know very the similarity. And also, wind speed and wind direction is some appeared the error of observation value and calculation results in crossing time of the land wind and sea land, it can see that reproducibility is generally good, is very appeared the change land wind in the nighttime, the change of sea wind in the daytime. And also, according to change of the utilization coefficient of soil before and after development with Gwangyang-Bay area as the center. Temperature after development was high $0.55\sim0.67^{\circ}C$ in the 14 hoots, also was tend to appear lowly $0.10\sim0.22^{\circ}C$ in the 02 hours, the change of u, v component is comparatively tend to reduced sea wind and land wind, it is affected ascending air current and frictional power of the earth surface according to inequality heating of the generation of earth surface.

• 한국컴퓨터그래픽스학회논문지
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• 제25권4호
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• pp.17-24
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• 2019

게임 산업에서 전통적인 게임 개발은 자체 엔진을 사전에 개발하여 게임 콘텐츠를 완성하는 방식이었다. 이로 인해 게임을 개발할 때마다 자체 게임엔진을 개발하는 비용부담이 크다는 단점을 가지고 있다. 또한, 게임 콘텐츠와 게임엔진이 독립적인 형태로 개발이 되어야 하지만 게임엔진이 사전에 마련되지 않으면 게임 콘텐츠가 개발되지 않는 문제점을 갖는다. 이러한 문제점을 해결하기 위해 최근 게임 산업에서는 게임엔진 구현에 집중하기보다는 게임 콘텐츠 생산성을 높이는 방법인 상용 엔진의 라이선스를 구매하여 개발하는 방식을 선택하고 있다. 본 논문에서는 컴포넌트 기반 시스템(Component-Based System)이고 시장 점유율이 가장 높은 게임엔진인 유니티와 언리얼 엔진을 대상으로 두 엔진의 구조, 에디터 인터페이스, 그리고 지원하는 개발 언어를 비교하여 각 게임엔진이 가진 특징들을 분석한다. 특히, FPS(First-Person Shooter) 게임의 구현을 통해 두 엔진에서의 플레이어 구성과 이벤트 처리 방식의 차이를 비교 설명하였다.