• Molecules and Cells
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• v.42 no.2
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• pp.161-165
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• 2019

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide and has high rates of metastasis. Transforming growth factor beta-inducible protein (TGFBI) is an extracellular matrix component involved in tumour growth and metastasis. However, the exact role of TGFBI in NSCLC remains controversial. Gene silencing via DNA methylation of the promoter region is common in lung tumorigenesis and could thus be used for the development of molecular biomarkers. We analysed the methylation status of the TGFBI promoter in 138 NSCLC specimens via methylation-specific PCR and evaluated the correlation between TGFBI methylation and patient survival. TGFBI promoter methylation was detected in 25 (18.1%) of the tumours and was demonstrated to be associated with gene silencing. We observed no statistical correlation between TGFBI methylation and clinicopathological characteristics. Univariate and multivariate analyses showed that TGFBI methylation is significantly associated with poor survival outcomes in adenocarcinoma cases (adjusted hazard ratio = 2.88, 95% confidence interval = 1.19-6.99, P = 0.019), but not in squamous cell cases. Our findings suggest that methylation in the TGFBI promoter may be associated with pathogenesis of NSCLC and can be used as a predictive marker for lung adenocarcinoma prognosis. Further large-scale studies are needed to confirm these findings.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.76.1-76.1
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• 2019

CTA 102, one of gamma-ray bright active galactic nuclei (AGN) has been observed with Korean very long baseline interferometry (VLBI) network (KVN) during the period of 2012 December-2018 May as part of interferometric Monitoring Of Gamma-ray Bright AGN (iMOGABA). Multi-frequency VLBI observations enable us to compare the milliarcsecond(mas)-scale iMOGABA images of relativistic jets with those from the Monitoring Of Jets in AGN with Very long baseline array (VLBA) Experiments (MOJAVE) and the VLBA-Boston University(BU)-BLAZAR programs which use VLBA with its angular resolutions of 0.2-1.3 mas. In spite of the relative larger beam sizes of KVN (1-10 mas), we are able to identify jet components of CTA 102 using the KVN multi-frequency VLBI observations with those resolved with VLBA. Considering an instrumental beam blending effect on the jet component identification, we were able to obtain a blending shift of the core position based on a convolution analysis using the VLBA data. When we apply the core position shift to the KVN images of CTA 102, we find that the identified jet components of CTA 102 from the KVN observations are well matched with those from the VLBA observations. Based on the results of the analysis, we may be able to study the jet kinematics and its correlation with gamma-ray flare activity.

• Nuclear Engineering and Technology
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• v.53 no.11
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• pp.3580-3596
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• 2021

An integral test facility, PILLAR, was commissioned, aiming to provide valuable experimental results which can be referenced by system and component designers and used for the performance demonstration of liquid-metal-cooled, passive small modular reactors (SMRs) toward their licensing. The setup was conceptualized by a scaling analysis which allows the vertical arrangements to be conserved from its prototypic reactor, scaled uniformly in the radial direction achieving a flow area reduction of 1/200. Its final design includes several heater rods which simulate the reactor core, and a single heat exchanger representing the steam generators in the prototype. The system behaviors were characterized by its data acquisition system implementing various instruments. In this paper, we present not only a detailed description of the facility components, but also selected experimental results of both steady-state and transient cases. The obtained steady-state test results were utilized for the benchmark of a system code, achieving a capability of accurate simulations with ±3% of maximum deviations. It was followed by qualitative comparisons on the transient test results which indicate that the integral system behaviors in passive LBE-cooled systems are able to be predicted by the code.

• Journal of the Architectural Institute of Korea Structure & Construction
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• v.35 no.10
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• pp.143-153
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• 2019

In this study, a full scale 3-axes shake table test for M-bar and T-bar type ceilings commonly used in the country was conducted. Through damage inspection during the test, seismic performance of ceilings according to variables, such as clearance between wall mold and ceiling as well as existence of facilities, was evaluated. A test frame consisted of square hollow section members was used for the shake table test. The experimental method was performed as a fragility test using required response spectrum described in ICC-ES AC156. In the case of architectural nonstructural component that contain ceilings, it mainly is evaluated the performance by post-test visual inspection. For the evaluation of seismic performance of ceilings, this study classified and defined damaged items for targeted ceiling system referring to illustrative damage according to nonstructural performance levels accordance with ASCE 41 and previous studies. And proposed illustrative damage items classification was utilized to compare the degree of the damage according to experimental variables. The experiment results confirmed that differences in boundary conditions due to the clearance at wall mold and the installation of facilities had a significant effect on the seismic performance of the ceiling.

• Journal of Forest and Environmental Science
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• v.37 no.2
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• pp.128-140
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• 2021

Tropical dry forests are one of the most threatened, widely distributed ecosystems in tropics and estimation of forest biomass is a crucial component of global carbon emission estimation. Therefore, the present study was aimed to quantify the biomass and carbon storage in trees on large scale (10, 1 ha plots) in the dry mixed evergreen forest of Javadhu forest of Eastern Ghats. Biomass of adult (≥10 cm DBH) trees was estimated by non-harvest methods. The total biomass of trees in this tropical dry mixed evergreen forest was ranged from 160.02 to 250.8 Mg/ha, with a mean of 202.04±24.64 Mg/ha. Among the 62 tree species enumerated, Memecylon umbellatum accumulated greater biomass and carbon stocks (24.29%) more than the other species in the 10 ha study plots. ANOVA revealed that there existed a significant variation in the total biomass and carbon stock among the three plant types (Evergreen, brevi-deciduous and deciduous (F (2, 17)=15.343, p<0.001). Basal area and density was significant positively correlated with aboveground biomass (R² 0.980; 0.680) while species richness exhibited negative correlation with above ground biomass (R² 0.167). Finding of present study may be interpreted as most of the trees in this forest are yet to be matured and there is a net addition to standing biomass leading to carbon storage.

• Asia-Pacific Journal of Atmospheric Sciences
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• v.54 no.4
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• pp.611-622
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• 2018

Observed climate data are processed under the assumption that their time series are stationary, as in multi-step temperature and precipitation prediction, which usually leads to low prediction accuracy. If a climate system model is based on a single prediction model, the prediction results contain significant uncertainty. In order to overcome this drawback, this study uses a method that integrates ensemble prediction and a stepwise regression model based on a mean-valued generation function. In addition, it utilizes empirical mode decomposition (EMD), which is a new method of handling time series. First, a non-stationary time series is decomposed into a series of intrinsic mode functions (IMFs), which are stationary and multi-scale. Then, a different prediction model is constructed for each component of the IMF using numerical ensemble prediction combined with stepwise regression analysis. Finally, the results are fit to a linear regression model, and a short-term climate prediction system is established using the Visual Studio development platform. The model is validated using temperature data from February 1957 to 2005 from 88 weather stations in Guangxi, China. The results show that compared to single-model prediction methods, the EMD and ensemble prediction model is more effective for forecasting climate change and abrupt climate shifts when using historical data for multi-step prediction.

• Coupled systems mechanics
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• v.10 no.1
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• pp.39-60
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• 2021

The present paper is concerned with the study of nonlinear ultrasonic waves in a magneto thermo (MT) elastic armchair single-walled carbon nanotube (ASWCNT) resting on polymer matrix. The analytical formulation is developed based on Eringen's nonlocal elasticity theory to account small scale effect. After developing the formal solution of the mathematical model consisting of partial differential equations, the frequency equations have been analyzed numerically by using the nonlinear foundations supported by Winkler-Pasternak model. The solution is obtained by ultrasonic wave dispersion relations. Parametric work is carried out to scrutinize the influence of the non local scaling, magneto-mechanical loadings, foundation parameters, various boundary condition and length on the dimensionless frequency of nanotube. It is noticed that the boundary conditions, nonlocal parameter, and tube geometrical parameters have significant effects on dimensionless frequency of nano tubes. The results presented in this study can provide mechanism for the study and design of the nano devices like component of nano oscillators, micro wave absorbing, nano-electron technology and nano-electro- magneto-mechanical systems (NEMMS) that make use of the wave propagation properties of armchair single-walled carbon nanotubes embedded on polymer matrix.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.6
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• pp.377-384
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• 2022

In the design of composite aircraft structures, it is very important to set material allowables and design values, which take into account certification. And when determining the material allowable and design value of composite structures, the static strength, damage tolerance requirements, and environmental effects should be considered. The building block approach has been applied to the civil and military aviation industry for a long time and provides the principal certification methodology. This current certification methodology is based on extensive testing including coupon, element, sub-component, and full scale test. In this paper, some examples of composite allowable tests have been presented and the fundamental background and application methods of the building block approach have been presented.

• BMB Reports
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• v.55 no.9
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• pp.417-428
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• 2022

Herbal medicine, a multi-component treatment, has been extensively practiced for treating various symptoms and diseases. However, its molecular mechanism of action on the human body is unknown, which impedes the development and application of herbal medicine. To address this, recent studies are increasingly adopting systems pharmacology, which interprets pharmacological effects of drugs from consequences of the interaction networks that drugs might have. Most conventional network-based approaches collect associations of herb-compound, compound-target, and target-disease from individual databases, respectively, and construct an integrated network of herb-compound-target-disease to study the complex mechanisms underlying herbal treatment. More recently, rapid advances in high-throughput omics technology have led numerous studies to exploring gene expression profiles induced by herbal treatments to elicit information on direct associations between herbs and genes at the genome-wide scale. In this review, we summarize key databases and computational methods utilized in systems pharmacology for studying herbal medicine. We also highlight recent studies that identify modes of action or novel indications of herbal medicine by harnessing drug-induced transcriptome data.

• Ocean Systems Engineering
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• v.11 no.4
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• pp.373-392
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• 2021

The present paper purposes a numerical evaluation of the Thai Long-Tail Boat propeller (TLTBP) performance by without and with propeller boss cap fins (PBCF) in full-scale operating straight shaft condition in the first. Next, those are applied to inclined shaft conditions. The actual TLTBP has defined an inclined shaft propeller including the high rotational speed, therefore vortex from the propeller boss and boss cap (hub vortex) have been generated very much. The PBCF designs are considered to weaken of vortex behind the propeller boss which makes the saving energy for the propulsion systems. The blade sections of PBCF developed from the original TLTBP blade shape. The integrative for the TLTBP and the PBCF is analyzed to increase the performance using computational fluid dynamics (CFD). The computational results of propeller performance are thoroughly compared between without and with PBCF. Moreover, the effects of each PBCF component are computed to influence the TLTBP performance. The fluid flows around the propeller blades, propeller boss, boss cap, and vortex have been investigated in terms of pressure distribution and wake-fields to verify the increasing efficiency of propulsion systems.