• Journal of Welding and Joining
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• v.19 no.3
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• pp.285-291
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• 2001

Large steel water pipes are joined prevalently by the bell end method, and are welded both at inside and outside of lapped parts. In practice, welded joints of water pipes are very critical, because in most cases failure of pipes causing leakage occurs at the welded joint. Therefore some methods have been developed to ensure the soundness of welded joints of water pipes, like leakage tests and nondestructive tests (NDTs). But one of the major characteristics that affects the soundness of welded Joints is the stress distribution caused by welding and external forces. Some studies have been carried out on the residual stress of steel water popes, but complex stress distributions by welding and external forces are rarely studied. In this study, temperature and stress distributions in steel water pipes produced by welding are predicted by a three-dimensional finite element method(FEM). Also, stress values are measured from real steel water pipes by the hole-drilling methods, and compared with predicted ones. The influence of some typical post weld treatments on residual stress distribution was also investigated by residual stress measurements.

• Steel and Composite Structures
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• v.50 no.2
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• pp.237-247
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• 2024

Research on interfacial crack formation in orthotropic bi-materials has experienced a notable increase in recent years, driven by growing concerns about structural integrity and reliability. The existence of a crack at the interface of bi-materials has a substantial impact on mechanical strength and can ultimately lead to fracture. The primary objective of this article is to introduce a comprehensive analytical model and establish stress relationships for investigating interfacial crack between two non-identical orthotropic materials with desired crack-fiber angles. In this paper, we present the application of the Interfacial Maximum Tangential Stress (IMTS) criterion, in combination with the Reinforcement Isotropic Solid (RIS) model, to investigate the behavior of interfacial cracks in orthotropic bi-materials under mixed-mode I/II loading conditions. We analytically characterize the stress state at the interfacial crack tip using both Stress Intensity Factors (SIFs) and the T-stress term. Orthotropic materials, due to their anisotropic nature, can exhibit complex crack tip stress fields, making it challenging to predict crack initiation behavior. The secondary objective of this study is to employ the IMTS criterion to predict the crack initiation angle and explore the notable impact of the T-stress term on fracture behavior. Furthermore, we validate the effectiveness of our approach in evaluating Fracture Limit Curves (FLCs) for interfacial cracks in orthotropic bi-materials by comparing our FLCs with relevant experimental data from existing literature.

• Korea-Australia Rheology Journal
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• v.11 no.4
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• pp.321-328
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• 1999

This paper discusses the rheology of complex interfaces comprised of amphiphilic materials that are susceptible to flow-induced orientation and deformation. The consequence of the coupling of the film micro-structure to flow leads to nonlinear rheology and surface fluid dynamics. Experimental methods designed to determine the mechanical rheological material functions of fluid-fluid interfaces as well as local, molecular and morphological responses are presented. These include a newly developed interfacial stress rheometer, flow ultraviolet dichroism, and Brewster-angle microscopy. These techniques are applied to a number of complex interfaces ranging from low molecular weight amphiphiles to polymer monolayers. Nonlinear flow phenomena ranging from two-dimensional nematic responses to highly elastic surface flows that manifest surface normal stress differences and elongational viscosities are described.

• Journal of Integrative Natural Science
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• v.11 no.2
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• pp.101-106
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• 2018

Corticotropin - releasing hormone receptor 1 (CRHR1) forms an integral part of the pathophysiology of disorders like post-traumatic stress disorder, stress, anxiety, addiction, and depression. Hence it is essential to look for new, potent and structure-specific inhibitors of CRHR1. We have analysed the protein-protein interaction complexes of the CRHR1 receptor with its native ligand CRF and full agonist Sauvagine. The structure of Sauvagine was predicted using homology modelling. We have identified that the residues TYR253, ASP254, GLU256, GLY265, ARG1014 and LY1060 are important in the formation of protein-protein complex formation. Future studies on these residues could throw light on the crucial structural features required for the formation of CRHR1-inhibitor complex and in studies that try to solve the structural complexities of CRHR1.

• Computers and Concrete
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• v.15 no.2
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• pp.183-198
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• 2015

Chloride ingress implies a complex interaction between physical and chemical process, in which heat, moisture and chloride ions transport through concrete cover. Meanwhile, reinforced concrete structure itself undergoes evolution due to variation in temperature, relative humidity and creep effects, which can potentially change the deformation and trigger some micro-cracks in concrete. In addition, all of these process show time-dependent performance with complex interaction between structures and environments. In the present work, a time-dependent behavior of chloride transport in reinforced concrete beam subjected to flexural load is proposed based on the well-known section fiber model. The strain state varies because of stress redistribution caused by the interaction between environment and structure, mainly dominated by thermal stresses and shrinkage stress and creep. Finally, in order to clear the influence of strain state on the chloride diffusivity, experiment test were carried out and a power function used to describe this influence is proposed.

• International Journal of Reliability and Applications
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• v.13 no.2
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• pp.71-80
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• 2012

This paper introduces a new approach for evaluating reliability of a complex system in terms of distributional parameters where analytical determination of reliability is intractable. The concept of discrete approximation, reported in the literature so far, fails to meet the latter requirement in terms of distributional parameters. The current work aims at offering a bound based approach where reliability planners not only get a clear idea about the extent of error but also can manipulate in terms of distributional parameters. This reliability approximation has been under taken under the Weibull frame work which is the most widely used model for reliability analysis. Numerical study has been carried out to examine the strength of our proposed reliability approximation via closeness between the two reliability bounds. This approach will be very useful during the early stages of product design as the distributional parameters can be adjusted.

• BMB Reports
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• v.48 no.3
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• pp.184-189
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• 2015

Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2) is known to protect neurons from neurodegeneration during ischemia/reperfusion injury. We recently reported that ROS-mediated oxidative stress promotes phosphorylation of endogenous SHP-2 in astrocytes and complex formation between caveolin-1 and SHP-2 in response to oxidative stress. To examine the region of SHP-2 participating in complex formation with caveolin-1, we generated three deletion mutant constructs and six point mutation constructs of SHP-2. Compared with wild-type SHP-2, binding of the N-SH2 domain deletion mutant of SHP-2 to p-caveolin-1 was reduced greatly, using flow cytometric competitive binding assays and surface plasmon resonance (SPR). Moreover, deletion of the N-SH2 domain of SHP-2 affected $H_2O_2$-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes.

• Molecules and Cells
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• v.40 no.9
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• pp.607-612
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• 2017

When mammalian cells and animals face a variety of internal or external stresses, they need to make homeostatic changes so as to cope with various stresses. To this end, mammalian cells are equipped with two critical stress responses, autophagy and cellular senescence. Autophagy and cellular senescence share a number of stimuli including telomere shortening, DNA damage, oncogenic stress and oxidative stress, suggesting their intimate relationship. Autophagy is originally thought to suppress cellular senescence by removing damaged macromolecules or organelles, yet recent studies also indicated that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins. These seemingly opposite roles of autophagy may reflect a complex picture of autophagic regulation on cellular senescence, including different types of autophagy or a unique spatiotemporal activation of autophagy. Thus, a better understanding of autophagy process will lead us to not only elucidate the conundrum how autophagy plays dual roles in the regulation of cellular senescence but also helps the development of new therapeutic strategies for many human diseases associated with cellular senescence. We address the pro-senescence and anti-senescence roles of autophagy while focusing on the potential mechanistic aspects of this complex relationship between autophagy and cellular senescence.

• The Korean Journal of Health Service Management
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• v.6 no.2
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• pp.1-13
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• 2012

The purpose of this study was to investigate the factors that affect the performance of health insurance review department workers of Korean tertiary hospitals, general hospitals and hospitals. A survey was conducted through structured questionnaire for chiefs and members of health insurance review departments of hospitals, and data from 1,064 respondents were utilized in the final analysis. Survey items included general characteristics of the hospitals and health insurance review departments, job satisfaction and organizational commitment as organizational effectiveness. As multiple linear regression results, in the case of chiefs, the most significantly related factor to job satisfaction was a monthly salary. The other related factor was job stress. In the case of members, the most significantly related factor was job stress. The other related factors were more monthly salary, religious believer, and less complex workplace, in order. As organizational commitment, in the case of chiefs, the most significantly related factor was a monthly salary. The other related factor was more clinical experience. In the case of members, the most significantly related factor was job stress. The other related factors were more monthly salary, tertiary hospitals, more age, and less complex workplace, in order.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.10
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• pp.1500-1508
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• 2004

Stress and displacement fields for a crack propagating along interface between isotropic material and functionally gradient one with linear property gradation along X direction are developed. The stress and displacement fields are obtained from the complex function of steady plane motion for isotropic and functionally gradient material (FGM). The stresses and displacement in isotropic material of bimaterial are not influenced by nonhomogeneity, however, the fields in FCM are influenced by nonhomogeneity in the terms of higher order, n$\geq$3. When the nonhomogeneous parameter in FGM is zero, or in area close to crack tip, the fields are identical to those of isotropic-isotropic bimaterial. Using these stress components, the effects of nonhomogeneity on stresses are discussed.