• Food Science of Animal Resources
• /
• v.37 no.6
• /
• pp.931-939
• /
• 2017

Alcoholic liver disease (ALD) is a complex multifaceted disease that involves oxidative stress and inflammation as the key mediators. Despite decades of intensive research, there are no FDA-approved therapies, and/or no effective cure is yet available. Probiotics have received increasing attention in the past few years due to their well-documented gastrointestinal health-promoting effects. Interestingly, emerging studies have suggested that certain probiotics may offer benefits beyond the gut. Lactobacillus fermentum LA12 has been previously demonstrated to play a role in inflammatory-related disease. However, the possible protective effect of L. fermentum LA12 on ALD still remain to be explored. Thus, the aim of this study was to evaluate the possible protective effect of L. fermentum LA12 on alcohol-induced gut barrier dysfunction and liver damage in a rat model of alcoholic steatohepatitis (ASH). Daily oral administration of L. fermentum LA12 in rat model of ASH for four weeks was shown to significantly reduced intestinal nitric oxide production and hyperpermeability. Moreover, small intestinal histological- and qRT-PCR analysis further revealed that L. fermentum LA12 treatment was capable of up-regulating the mRNA expression levels of tight junction proteins, thereby stimulating the restitution of barrier structure and function. Serum and hepatic analyses also revealed that the restoration of epithelial barrier function may prevent the leakage of endotoxin into the blood, subsequently improve liver function and hepatic steatosis in the L. fermentum LA12-treated rats. Altogether, results in this study suggest that L. fermentum LA12 may be used as a dietary adjunct for the prevention and treatment of ASH.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.15 no.4
• /
• pp.99-106
• /
• 2011

This study performed research for improvement on basic concept of PBD applying suitable design method before and after LB-DECK composition. According to study, in this case, before composition, it can reduce minuteness cracks by increasing bending tensile strength utilizing polymer concrete, can expect sensuous effect, improve durability as to low permeability, and was evaluated that can reduce covering depth according as it. Also, because LB-DECK baseplate that apply the empirical design method composite is superior load resistance ability than general baseplate, safety is increased, it is expected to secure constructibility and economic performance at the same time because reinforcement arrangement method and reinforcement amount are fixed even if span effective span is increased at ultimate strength design method application.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.14 no.8
• /
• pp.884-890
• /
• 2003

In order to reduce the specific absorption rate(SAR) in a human head exposed to electromagnetic fields radiated by a cellular phone, we have analyzed an electromagnetic wave absorber attached to the handset. A manufactured electromagnetic wave absorber was composed of Mn - Zn, which had complex relative permittivity of 7.30-j0.05 and permeability of 2.20-i1.55. The SAR value from the electromagnetic wave absorber attachment was calculated by using the nonuniform finite difference time domain(FDTD) algorithm and measured by phantom model at 835 MHz. The SAR reduction due to the electromagnetic wave absorber are about 18 % at 835 MHz. The V.S.W.R and radiation pattern of antenna are good agreement with the normal antenna. The gain reduction due to the electromagnetic wave absorber are only 0.3 dB at 835 MHz. But the sensitivity of cellular phone generally improves about 1 dB.

• Proceedings of the Korean Biophysical Society Conference
• /
• 2003.06a
• /
• pp.47-47
• /
• 2003

The presenilin 1 (PS1) or PS2 is an essential component of the ${\gamma}$-secretase complex, which mediates the intramembrane proteolysis of selected type-I membrane, including the ${\beta}$-amyloid precursor protein (APP) to yield A${\beta}$. Familial Alzheimer's disease (FAD)-associated mutations in presenilins give rise to an increased production of a highly amyloidogenic A${\beta}$42. In addition to their well-documented proteolytic function, the presenilins play a role in calcium signaling. We have previously reported that presenilin FAD mutations cause highly consistent alterations in intracellular calcium signaling pathways, which include deficits in capacitative calcium entry (CCE), the refilling mechanism for depleted internal calcium stores. However, molecular basis for the presenilin-mediated modulation of CCE remains to be elucidated. In the present study, whole-cell patch clamp method was used to identify a specific calcium-permeable ion channel current(s) that is responsible for the CCE deficits associated with FAD-linked PS1 mutants. Unexpectedly, both voltage-activated and conventional store depletion-activated calcium currents I(CRAC), were absent in HEK293 cells, which were stably transfected either with wild-type or FAD mutant (L286V, M146L, and delta E9) forms of PS1. Recently, magnesium-nucleotide-regulated metal cation current, or I(MagNum), has been described and appears to share many common properties with I(CRAC) including calcium permeability and inhibitor sensitivity (e.g. 2-APB). We have detected I(MagNum) in all 293 cells tested. Interestingly, FAD mutant 293 cells developed only about half of currents compared to PS1 wild type cells.

• Journal of the Korean Geotechnical Society
• /
• v.33 no.6
• /
• pp.37-48
• /
• 2017

Soil-water characteristic curve (SWCC) has been widely used to estimate the shear strength and coefficient of permeability for unsaturated soils. In general, it is divided into the drying path in which the water is discharged and the wetting path in which the water is permeated, and it has a hysteresis indicating different suctions at the same volumetric water content. In reality the field behavior of unsaturated soils is much closer to the wetting path during the infiltration. The drying path has been practically used for various analyses because obtaining the wetting path takes longer than the drying path. Although many approaches for estimating wetting path have been studied till now, these are complex and do not fit well. Therefore, a simple method for estimating wetting path based on empirical approach in this study is proposed in unsaturated soils, and a feasibility study is conducted as well.

• Journal of Navigation and Port Research
• /
• v.33 no.3
• /
• pp.193-197
• /
• 2009

In this paper, the EM wave absorber was designed and fabricated for improvement of Wireless LAN environment at 2.4 GHz. We fabricated several samples in different composition ratios of Sendust and CPE(Chlorinated Polyethylene). Absorption abilities were simulated in accordance with different thicknesses of the prepared absorbers and changed complex relative permittivity and permeability due to composition ratio. The mixing ratio of Sendust and CPE was searched as 80: 20 wt.% by experiments and simulation Then the EM wave absorber was fabricated and tested using the simulated data. As a result, the EM wave absorber was fabricated based on simulated data. Simulated and measured results agreed well. As a result, the developed EM wave absorber with thickness of 3.25 mm has absorption ability of 19 dB at 2.4 GHz.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2004.05a
• /
• pp.113-116
• /
• 2004

The materials showing high structure dispersion with functional properties were developed on the quartz base and those were obtained by mechano-chemical reaction technology. Depending on the processing conditions and subsequent applications the materials produced by mechano-chemical reaction show concurrently magnetic, dielectric and electrical properties. The obtained magnetic-electrical powders classified by aggregate complex of their features as segnetomagnetics, containing a dielectric material as a carrying nucleus, particularly the quartz on that surface one or more layers of different compounds were synthesized having thickness up to 10~50 nm showing magnetic, electrical properties and others. The similarity of the structure of surface layers of quartz particles subjected to mechano-chemical processing and nano-structure cluspol (clusters in a polymer matrics) material was also confirmed by the fact that the characteristics of ferromagnetic quartz of insulating nano-composite powder were changed with time, after its preparing process was completed. The magnetic permeability of the sample was decreasing within first two months down by 15~20 %. Then, the magnetic characteristics were almost stabilized steadily and continuously. The observed changes were related with defective structure of the particles, elastic stress relief, and changes of electron density and magnetic moment in deformation zones. This process of stabilization of the investigated properties could be intensified by the thermal annealing heat treatment in short time period of the nano-composite quartz powders at the temperature ranges of 100~15$0^{\circ}C$.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.10 no.2
• /
• pp.67-75
• /
• 2006

Recently sewage facilities mainly consisted of concrete structures are being deteriorated seriously by biodeterioration originated from sulfur-oxidizing bacteria. In this study, to prevent biochemical corrosion of the sewer concrete, antibiotics which prevent growth of sulfur-oxidizing bacteria were developed and antimicrobial performance of it was investigated. After that, to consider applicability of antibiotics to concrete, physical properties of concrete spread with antibiotics were investigated. As a results of the study, it was proved that the antimicrobial performance of antibiotics was available. Also compressive strength and bond strength of concrete didn't closely connected with antibiotics, and resistance to abrasion, water absorption and air permeability of concrete was improved remarkably by spraying with it.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2016.05a
• /
• pp.317-317
• /
• 2016

저영향개발(Low Impact Development, LID) 시설들은 미국 일본 등 선진국을 중심으로 관련법에 따라 개발 및 적용 되어왔으나 국내에서는 최근에서야 LID 시설을 적용할 수 있는 제도적인 틀을 구축하고 있는 실정이며, 국내 여건에 맞는 LID 시설을 개발하여 그 효용성을 검증하기 까지는 상당한 시간이 소요될 것으로 판단된다. 서울시는 2014년 '서울특별시 빗물관리에 관한 조례 전부개정조례'를 발표함으로써 한국형 LID 시설을 대단위로 적용 하고 검증 할 수 있는 발판을 마련하였다. 서울시의 2014년 전부개정조례에 따르면 시장 및 구청장은 저영향개발 계획 수립의 실효성 확보를 위하여 저영항개발 사전협의 제도를 마련하여 시행하여야 하며, 시장은 저영향개발 지구단위계획을 수립하여야 한다. 이에 따라, 본 연구에서는 실제로 적용 가능한 투수포장 주차장을 설계 할 수 있도록 투수 주차장형 LID 시설을 검증할 수 있는 투수효율성 검증실험단지를 설계 및 구축 하였다. 과거 도심의 우수배제는 중앙 집중형 시스템으로 단기간에 우수를 차집하여 배제하는 방식이었으나, 근래에는 집중형 우수배제 시스템의 위험성, 경제성 그리고 용량한계 등 여러 가지 문제점이 부각되면서 분산형 시스템으로의 전환이 이루어지고 있다. 물순환도시 및 지속가능한 도시 등이 분산형 우수배제 시스템의 예이며, 주차장, 도로, 건물 등 불투수 표면으로부터의 우수를 지면으로 침투 및 침루시키는 방법 등을 활용하여 건전한 물순환을 꾀하고 있다. 침투 및 침루 능력은 각각 포장체 및 포장면 하부구조의 재료와 밀접한 관련이 있으며 재료의 선정은 하부구조의 안정성 확보를 고려하여 선택되어야 한다. 또한 우수 배제를 위한 유공관은 접합점에서 강도를 유지하면서 효율적으로 유수를 배제할 수 있어야 하며, 저류조 설치는 강수의 활용목적에 맞게 선정되어야 한다. 이러한 투수 주차장형 LID 시설은 하나의 시스템으로서 포장체의 재료에 따른 공학적 성질, 하부구조 구축방법 및 재료 선정 그리고 유공관 배열 등에 따라 그 시스템의 거동이 변화하므로 기존에 행해왔던 단순 재료실험으로는 투수성 주차장의 우수배제 시스템을 평가할 수 없다. 따라서 본 연구에서는 이를 검증할 수 있는 투수효율성 검증실험단지 설계 및 구축하였다.

• YAKHAK HOEJI
• /
• v.42 no.1
• /
• pp.59-69
• /
• 1998

To increase the solubility of quercetin, which is a practically insoluble flavonoid of Ginkgo biloba leaf, the effects of nonaqueous vehicles. Their cosolvents, water-sol uble polymers and modified cyclodextrins (CDs) were observed. Polyethylene glycols, diethyleneglycol monoethyl ether, and their cosolvents with water showed a good solvency toward quercetin. Also the aqueous solutions of povidone, copolyvidone and Cremophor RH 40 was effective in solubilizing quercetin. Complex formation of quercetin with ${\beta}$-cyclodextrin (${\beta}$-CD), dimethyl-${\beta}$-cyclodextiin (DMCD), 2-hydroxypropyl-${\beta}$-cyclodextrin (HPCD) and ${\beta}$-cyclodextrin sulfobutyl ether (SBCD) in water was investigated by solubility method at $37^{\circ}C$. The addition of CDs in water markedly increased the solubility of quercetin with increasing the concentration. AL type phase solubility diagrams were obtained with CDs studied. Solubilizaton efficiency by CDs was in the order of SBCD >> DMCD > HPCD > ${\beta}$-CD. The dissolution rates of quercetin from solid dispersions with copolyvidone, povidone and HPCD were much faster than those of drug alone and corresponding physical mixtures, and exceeded the equilibrium solubility (3.03${\pm}1.72{\mu}$g/ml). The permeation of quercetin through duodenal mucosa did not occur even in the presence of enhancers such as bile salts, but the permeation was observed when the mucus layer was scraped off. This was due to the fact that quercetin had a strong binding to mucin ($58.5{\mu}$g/mg mucin). However rutin was permeable to the duodenal mucosa. The addition of enhancer significantly increased the permeation of rutin in the order of sodium glycocholate.