• Journal of Korean Neurosurgical Society
• /
• 제61권3호
• /
• pp.363-375
• /
• 2018

Intraoperative monitoring (IOM) utilizes electrophysiological techniques as a surrogate test and evaluation of nervous function while a patient is under general anesthesia. They are increasingly used for procedures, both surgical and endovascular, to avoid injury during an operation, examine neurological tissue to guide the surgery, or to test electrophysiological function to allow for more complete resection or corrections. The application of IOM during pediatric brain tumor resections encompasses a unique set of technical issues. First, obtaining stable and reliable responses in children of different ages requires detailed understanding of normal age-adjusted brain-spine development. Neurophysiology, anatomy, and anthropometry of children are different from those of adults. Second, monitoring of the brain may include risk to eloquent functions and cranial nerve functions that are difficult with the usual neurophysiological techniques. Third, interpretation of signal change requires unique sets of normative values specific for children of that age. Fourth, tumor resection involves multiple considerations including defining tumor type, size, location, pathophysiology that might require maximal removal of lesion or minimal intervention. IOM techniques can be divided into monitoring and mapping. Mapping involves identification of specific neural structures to avoid or minimize injury. Monitoring is continuous acquisition of neural signals to determine the integrity of the full longitudinal path of the neural system of interest. Motor evoked potentials and somatosensory evoked potentials are representative methodologies for monitoring. Free-running electromyography is also used to monitor irritation or damage to the motor nerves in the lower motor neuron level : cranial nerves, roots, and peripheral nerves. For the surgery of infratentorial tumors, in addition to free-running electromyography of the bulbar muscles, brainstem auditory evoked potentials or corticobulbar motor evoked potentials could be combined to prevent injury of the cranial nerves or nucleus. IOM for cerebral tumors can adopt direct cortical stimulation or direct subcortical stimulation to map the corticospinal pathways in the vicinity of lesion. IOM is a diagnostic as well as interventional tool for neurosurgery. To prove clinical evidence of it is not simple. Randomized controlled prospective studies may not be possible due to ethical reasons. However, prospective longitudinal studies confirming prognostic value of IOM are available. Furthermore, oncological outcome has also been shown to be superior in some brain tumors, with IOM. New methodologies of IOM are being developed and clinically applied. This review establishes a composite view of techniques used today, noting differences between adult and pediatric monitoring.

• 한국경제지리학회지
• /
• 제15권3호
• /
• pp.343-357
• /
• 2012

수도권 지하철 시스템은 지하철 역을 결절점으로 하고 이들을 연결하는 선로를 간선으로 구성한 그래프로 표현할 수 있다. 본 논문에서 서울 수도권 지하철 시스템의 통행흐름을 바탕으로 그래프를 거의 비슷한 그룹들로 분할하여 지하철역들의 분류와 지하철 승객들의 통행 특성을 연구한다. 그래프의 각 간선을 통과하는 승객수를 교통카드 트랜잭션 데이터베이스에서 추출하여 그 간선의 가중치로 둔다. 그래프 분할 문제는 NP-완전 문제에 속하기 때문에, 본 논문에서 지하철 시스템의 그래프를 분할하기위하여 휴리스틱 알고리즘을 제안한다. 그 휴리스틱 알고리즘은 두 개의 선택 가능한 목적함수들 중에서 하나를 사용하는 데, 첫 번째 목적함수는 다른 그룹들에 속한 결절점들을 연결하는 간선들의 가중치의 합을 최소화하는 것이고 두 번째는 전체 지하철 승객들에 대해 승차역과 하차역이 같은 그룹에 속한 승객들의 비율을 최대화하는 것이다. 실험결과에서 각 그룹에 속한 지하철역들과 간선들을 색깔로 구분하여 지도상에 표시하고 그룹별 기종점 행렬로 지하철 승객들의 통행 특성을 분석한다.

• 대한간호학회지
• /
• 제21권2호
• /
• pp.129-149
• /
• 1991

Circadian rhythm is entrained in the 24-hour time interval by periodic factors in the environment, known as zeitgeber. But most rotating work schedules are outside the range of the entrainment of the pacemaker timing the human circadian sleep - wake cycle. It has been postulated that physiological and emotional disturbances occur in most human functions when the circadian rhythm is disturbed. So application of circadian principles to the design of shift schedules can aid in maintaining the temporal integrity of the circadian system and thereby minimize for the shift worker any detrimental consequences of circadian disruption. This study was a quasi-experimental study to test the effect of shift intervals for the clinical nurse on the circadian rhythm. Twenty nurses newly employed in general units of two hospitals were selected as an experimental group and twelve college nursing students as a control group. Both groups were selected according to an established criteria using a purposive sampling technique. Ten subjects were assigned to a weekly shift group and another ten to a biweekly shift group engaged in a semi -continuous shift schedule(sunday off) with a backward direction, that is, morning -evening - night shift. The control group worked a morning shift for 42 days. Oral temperature rhythm, waking tim, sleep - wake cycle, fatigue, and mental performance were measured during the experimental period. The data collection period was from April 30, 1990 to June 10, 1990. MANOVA, paired t-test, ANOVA, and Student Newman Keuls method were used for statistical analysis. The results are summarized as follows. 1. Phase delay in the acrophase of temperature rhythm was shown according to the backward rotating shift. A complete adaptation to work on the night shift was achieved between the sixth and ninth day of the night shift. 2. There was no difference in either waking time or sleep- wake cycle according to the duration of the working day for every shift group. Significant difference was found in the waking time and the sleep -wake cycle for subjects on the morning, evening, and night shift in both of the shift groups(weekly shift group : λ＝0.121, p＜0.01, λ＝0.112, p＜0.01, biweekly shift group : λ＝0.116, p＜0.01, λ＝0.084, p＜0.01). 3. There was no difference in fatigue between the first working day and the last working day for the control group and for the biweekly shift group. In the weekly shift group, physical fatigue was significantly different for the first day and the sixth day of the night shift(t＝-2.28, p＜0.05). Physical fatigue and total fatigue on the first day of the night shift showed a significant difference among the control group, the weekly shift group, and the biweekly shift group(F＝5.79, p＜0.01, F＝4.56, p＜0.05). There was a significant difference between the shift groups and the control group(p＜0.05), Physical fatigue, neurosensory fatigue and total fatigue on the last day of the night shift showed a significant difference among the control group, the weekly shift group, and the biweekly shift group(F＝12.65, p＜0.01, F＝7.77, p＜0.01, F＝9.68, p＜0.01). There was a significant difference between the shift groups and the control group(p＜0.05). 4. No difference in mental performance was seen between the first day and the last day of work in each case. An arithmatic test on the first day of the night shift revealed a significant difference among the control group, the weekly shift group, and the biweekly shift group(F＝3.79, p＜0.05). There was a significant difference between the shift groups and the control group(p＜0.05) . The digital symbol substitution test and the arithmetic test on the last day of the night shift showed a significant difference among the control group, the weekly shift group, and the biweekly shift group(F＝3.68, p＜0.05, F＝5.55, p＜0.01), and both showed a significant difference between the shift groups and the control group(p＜0.05). Accordingly, this study showed that during night duty, the waking time, sleep- wake cycle, and fatigue increased and mental performance decreased compared with morning and evening duty. It was also found that the weekly shift group had a higher fatigue score on the sixth day of night duty as compared to the -first day, but the waking time, sleep- wake cycle, and mental performance revealed no difference for the duration of the night duty or between shift groups, and complete adaptation of temperature rhythm was achieved between the sixth and ninth day of night duty. It is possible to conclude from these results that for intermediate circadian type in a healthy young woman, a biweekly shift system is more compatible with the circadian timing system than weekly shift system.

• Asia pacific journal of information systems
• /
• 제24권1호
• /
• pp.31-50
• /
• 2014

The ubiquitous accessibility of information through mobile devices has led to an increased mobility of workers from their fixed workplaces. Market researchers estimate that by 2016, 350 million workers will be using their smartphones for business purposes, and the use of smartphones will offer new business benefits. Enterprises are now adopting mobile technologies for numerous applications to increase their operational efficiency, improve their responsiveness and competitiveness, and cultivate their innovativeness. For these reasons, various organizational aspects concerning "mobile work" have received a great deal of recent attention. Moreover, many CIOs plan to allocate a considerable amount of their budgets mobile work environments. In particular, with the consumerization of information technology, enterprise mobile applications (EMA) have played a significant role in the explosive growth of mobile computing in the workplace, and even in improving sales for firms in this field. EMA can be defined as mobile technologies and role-based applications, as companies design them for specific roles and functions in organizations. Technically, EMA can be defined as business enterprise systems, including critical business functions that enable users to access enterprise systems via wireless mobile devices, such as smartphones or tablets. Specifically, EMA enables employees to have greater access to real-time information, and provides them with simple features and functionalities that are easy for them to complete specific tasks. While the impact of EMA on organizational workers' productivity has been given considerable attention in various literatures, relatively little research effort has been made to examine how EMA actually lead to users' job performance. In particular, we have a limited understanding of what the key antecedents are of such an EMA usage outcome. In this paper, we focus on employees' perceived job performance as the outcome of EMA use, which indicates the successful role of EMA with regard to employees' tasks. Thus, to develop a deeper understanding of the relationship among EMA, its environment, and employees' perceived job performance, we develop a comprehensive model that considers the perceived-fit between EMA and employees' tasks, satisfaction on EMA, and the organizational environment. With this model, we try to examine EMA to explain how job performance through EMA is revealed from both the task-technology fit for EMA and satisfaction on EMA, while also considering the antecedent factors for these constructs. The objectives of this study are to address the following research questions: (1) How can employees successfully manage EMA in order to enhance their perceived job performance? (2) What internal and/or external factors are important antecedents in increasing EMA users' satisfaction on MES and task-technology fit for EMA? (3) What are the impacts of organizational (e.g. organizational agility), and task-related antecedents (e.g., task mobility) on task-technology fit for EMA? (4) What are the impacts of internal (e.g., self-efficacy) and external antecedents (e.g., system reputation) for the habitual use of EMA? Based on a survey from 254 actual employees who use EMA in their workplace across industries, our results indicate that task-technology fit for EMA and satisfaction on EMA are positively associated with job performance. We also identify task mobility, organizational agility, and system accessibility that are found to be positively associated with task-technology fit for EMA. Further, we find that external factor, such as the reputation of EMA, and internal factor, such as self-efficacy for EMA that are found to be positively associated with the satisfaction of EMA. The present findings enable researchers and practitioners to understand the role of EMA, which facilitates organizational workers' efficient work processes, as well as the importance of task-technology fit for EMA. Our model provides a new set of antecedents and consequence variables for a TAM involving mobile applications. The research model also provides empirical evidence that EMA are important mobile services that positively influence individuals' performance. Our findings suggest that perceived organizational agility and task mobility do have a significant influence on task-technology fit for EMA usage through positive beliefs about EMA, that self-efficacy and system reputation can also influence individuals' satisfaction on EMA, and that these factors are important contingent factors for the impact of system satisfaction and perceived job performance. Our findings can help managers gauge the impact of EMA in terms of its contribution to job performance. Our results provide an explanation as to why many firms have recently adopted EMA for efficient business processes and productivity support. Our findings additionally suggest that the cognitive fit between task and technology can be an important requirement for the productivity support of EMA. Further, our study findings can help managers in formulating their strategies and building organizational culture that can affect employees perceived job performance. Managers, thus, can tailor their dependence on EMA as high or low, depending on their task's characteristics, to maximize the job performance in the workplace. Overall, this study strengthens our knowledge regarding the impact of mobile applications in organizational contexts, technology acceptance and the role of task characteristics. To conclude, we hope that our research inspires future studies exploring digital productivity in the workplace and/or taking the role of EMA into account for employee job performance.

• 환경영향평가
• /
• 제32권6호
• /
• pp.533-544
• /
• 2023

농림축산식품부는 농촌 중심지의 기능(문화·복지·경제·교육 등)을 강화하고, 중심지의 서비스가 배후마을로 전달되어 연계시키는 정책을 추진해왔다. 이러한 정책목적을 위해 일반농산어촌개발사업 내 농촌중심지활성화사업, 기초생활거점조성사업을 추진중에 있지만 실제 사업을 추진하는 과정에서 농촌 중심지의 기능 강화에 초점이 맞춰져 배후마을과의 서비스 전달 및 연계 등은 활성화되고 있지 않은 실정이다. 따라서 본 연구에서는 무주군 적상면에서 기 수행했던 사업과 지역현황을 분석하여 배후마을 서비스가 연계 및 활성화되지 못한 이유를 분석하여 앞으로 수행하게될 기초생활거점조성 2단계사업의 추진방향을 제시하고자 하였다. 배후마을 서비스가 활성화되지 못한 원인을 분석한 결과, 농촌의 분산거주 및 지형구조의 한계성으로 나타나는 서비스 접근의 불리함과 배후지역의 수요 발굴을 위한 서비스 전달 체계의 미확보 등이 문제점으로 나타났으며 그에 따른 개선방안을 다음과 같이 도출하였다. 첫 번째로, 지형적 한계를 극복하고자 제안한 디딤거점 조성계획이다. 서비스 중간 터미널 기능을 담당할 디딤거점을 설정하여 효율적인 서비스전달이 이루어지도록 한다. 두 번째로, 합리적 의사결정구조를 위해 중심지 및 배후마을 주민 그리고 다양한 계층이 포함된 주민위원회의 효율적 구성과 함께 다양한 소규모 커뮤니티를 운영하여 지역의 견을 촘촘하게 수렴할 수 있는 소통창구 배치계획을 제안하였다. 세 번째로, 지역주민을 전문강사로 양성하는 선순환 지역인력 양성계획이다. 서비스 전달에서 가장 중요한 서비스 전달자, 즉 활동가를 양성하여 지속 가능한 주민 주도 서비스 공급체계를 완성하고자 한다.

• 대한간호학회지
• /
• 제9권2호
• /
• pp.49-61
• /
• 1979

A review of this literature and discussions reveal a development of ideas concerning the elements of nursing models. The elements of a nursing model are the nurses view of the human being, nursing's goal, and nursing activities. It has long been recognized that human beings, at one time or another, require nursing care. Varieties of literature were reviewed in regard to the human being as recipient of nursing care through the theory development in nursing. Florence Nightingale initiated the modern era of nursing and described more clearly man as the recipient of nursing care. She looked at man as responding to the laws of nature whether the person was healthy or sick. Henderson added to Nightingale's concept of man , the recipient of nursing care by emphasizing that man is a whole, complete, and independent being. Her view is further specified by her enumeration of the activities the human being must perform. Johnson has developed a very comprehensive view of man as the recipient of nursing care. Man is a behavioral system which has a tendency to achieve and maintain stability in patterns of functioning. Like Nightingale, Johnson sees that similar patterns occur in both health and illness. Johnson postulates that the whole behavioral system of the human is composed of eight sub-systems: affiliative, achievement, aggressive, dependency, eliminative, ingestive, restorative, sexual. Roger's main contribution to the development of nursing models was her emphasis upon unitary man. She pointed out that man is a unified whole, possessing his own integrity and manifesting characteristics that“are more than and different from the sum of his parts.”Rogers focuses on the life processes of the human and points out that these processes have the following characteristics. Wholeness, openness, unidirectionality, pattern and organization, sentence, and thought. According to Roy, man is a biopsychosocial being in constant interaction with a changing environment. To cope with this changing environment, man has certain innate and acquired mechanisms. Man's ability to respond positively or to adapt, depends upon the degree of the change taking place and the state of the person coping with the change. When she analyzes man as an adaptive organism she further describes man as being composed of four adaptive modes: physiological needs, self-concept, role function, and interdependence. Based on the literary review through the theory development in nursing, general approach by a unified nursing model to a view of the recipient of nursing care may be stated as follows: Man is a unified whole composed of subsystems with a flexible and normal line of defense; his internal regulating mechanisms help him to cope with a changing environment; he functions by the principles of homeodynamics.

• 생명과학회지
• /
• 제33권6호
• /
• pp.523-529
• /
• 2023

유비퀴틴-프로테아좀 시스템은 E1-E2-E3 효소의 작용으로 단백질 안정성을 조절하며 이를 통해 진핵 세포 내 광범위한 과정을 조절한다. 특히 DNA 수리, 세포 주기, 전이, 혈관형성 및 사멸과 같은 종양의 생장 과정에서 주요한 역할을 하는데 이 과정에서 유비퀴틴 접합 효소인 UBE2는 활성화된 유비퀴틴을 타깃 단백질에 이동시켜주는 중간 매개체 역할을 한다. UBE2는 인간에게서 40개가 존재하며 이는 촉매 도메인의 확장 유무에 따라 4개의 그룹으로 분류된다. 최근 UBE2의 타깃 단백질의 특정 위치를 인식하는 기질 특이성에 대한 연구가 증가하는 추세이다. 특히 암에서 발현이 높은 UBE2는 암 환자의 나쁜 예후와 상관관계가 있어 종양 형성에서 UBE2의 중요성이 강조되고 있다. 본 총설에서는 암에서 UBE2의 역할에 대한 최신 연구 결과 및 동향에 대해 기술하였다. 또한 UBE2에 관한 기초 지식 및 분자적 메커니즘을 제공함으로써 궁극적으로는 UBE2가 종양 치료의 새로운 타깃이 될 수 있음을 시사한다.

• 자원환경지질
• /
• 제29권6호
• /
• pp.713-724
• /
• 1996

현장에서의 주요 운송 메카니즘을 연구하기 위하여 시간별 잔존수 농도분포곡선 자료를 이용하였다. 운송개념을 대표하는 모델로서 2개의 상반된 가설에 근기한 모델, 즉 CDE와 CLT모델을 사용하였으며 파라미터 추정을 위하여 깊이별 평균농도자료에 최적화기법을 적용하였으며 잔존수 농도의 도달시간을 나타내는 확율밀도함수를 이용하여 모멘트해석도 시행되었다. 모멘트 해석결과 잔존수농도의 1차 및 2차 시간 모멘트는 침출수농도의 것들보다 크게 나타났다. 또한 시간 모멘트를 이용하여 오염물질 운송시간의 변이도와 확산 파라미터도 도출되었다. 변이도 및 확산계수와 운송거리간의 상관관계는 침출수농도 및 잔존수농도에 대해서 동일하게 나타났다. 이러한 관계를 이용하여 2가지 모델을 검정하였으나 운송거리에 따른 운송파라미터의 불규칙한 변화로 확정적 결론을 얻을 수 없었다. 따라서 첫 번째 깊이에서 얻은 파라미터를 이용하여 다른 깊이에서의 오염물질 운송 방식을 예측하여 실측자료와 비교하여 각 모델을 검정하였다. 그 결과 CLT 모델이 CDE 모델보다 현장실측자료에 근접하였다. 이는 오염물질이 이동함에 따라 완전한 혼합이 발생하는 것이 아니라 상관흐름 즉, "오염물질이 각 층을 통과할 때 빠른 물질은 빠르게 느린 물질은 지속적으로 느리게 움직인다"는 사실을 뒷받침한다고 볼 수 있다. 특히 첨두농도에 대한 CDE 모델의 과대예측은 오염물질 확산의 과소평가에 기인하는 것으로 나타났다.

• 한국재료학회지
• /
• 제9권3호
• /
• pp.288-294
• /
• 1999

솔더 범프를 사용하는 플립 칩 접속기술에서 범프와 칩 사이에 위치하는 금속 충들의 조합을 UBM(Under Bump Metallurgy)라고 부르며 이 UBM을 어떤 조합으로 사용하는 가에 따라 접속의 안정성이 크게 좌우된다. 본 연구에서는 UBM중에서 솔더 접착 층으로 사용되는 구리 층의 두께를 $1\mu\textrm{m}와 5\mu\textrm{m}$로 하는 한편 barrier 층으로 사용되는 금속 층을 Ti, Ni, Pd으로 변화시키면서 이들 UBM과 공정 납-주석 사이의 계면반응을 살펴보았다. 이를 위해 $100\mu\textrm{m}$ 크기의 솔더 범프를 전해도금법을 사용하여 제작하고 리플로 횟수와 시효시간에 따른 각 UBM에서의 금속간 화합물의 성장을 관찰하였다. $Cu_6Sn_5 \eta'$-상 금속간 화합물이 모든 조건에서 형성되었고 Cu층의 두께가 $5\mu\textrm{m}$로 두꺼운 경우에는 $Cu_3Sn \varepsilon$-상도 관찰되었다. Pd을 사용한 UBM 구조에서는 시효 처리시에 $Cu_6Sn_5$ 상 아래쪽에 $PdSn_4$상이 형성되었다. 또한 이들 계면에서의 금속간 화합물의 성장은 솔더 범프의 접속강도 값과 밀접한 관계를 가진다.

• 토지주택연구
• /
• 제12권3호
• /
• pp.67-78
• /
• 2021

모듈러주택은 세계대전 이후 신속하고 효율적인 주택공급을 위해 시도되었다. 국내에서도 30년 이상 품질 및 시공방법 개선을 위한 노력을 했으나 경쟁력있는 주택 상품이 되진 못했다. 모듈러 주택은 라멘구조로 평면구성을 자유롭게 할 수 있지만, 대부분 벽식 구조의 일반적인 아파트 평면을 분절한 형태로 변형하여 시공한다. 모듈러 주택의 생산 및 구조적 측면의 장점을 강화하기 위해서는 평면, 건축 구성재의 부품화 및 표준화, 자재, 제작 및 시공법, 공정관리, 공사비 관리 등 종합적인 측면에서 자동차와 같이 공장생산 시스템에 적합한 모델을 발전시키는 것이 필요하다. 본 연구에서는 생산 및 호환을 위해 MC(Modular Coordination)설계원칙을 적용하여 운반 및 생산 용이한 3m×3m 모듈을 공간의 기본 단위로 설정했다. 빌트인 가구를 포함한 3m×3m공간을 다양한 형태의 제품과 같이 생산하고, 이를 거주자의 기호에 맞게 조합하여 46m² 평면을 완성하는 방법을 제시했다. 생산설비, 운송수단, 시공크레인에 따라 생산 모듈을 다르게 설정할 수 있으며 운반장비가 소형화될수록 생산모듈의 가짓수도 적어질 수 있다. 이와같은 모듈러 주택 생산방식은 거주자의 요구에 맞춰 다양한 평면의 주택을 제공하기에 용이하고, 기술과 시스템의 발전에 따라 시공속도도 가속화할 수 있을 것이다.