• Fire Science and Engineering
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• v.20 no.3 s.63
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• pp.65-70
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• 2006

From the beginning of the construction stage, the fire protection regulation for the nuclear power plants conforms to the design requirements for the acquisition of the license permit. This regulation is based on the plant status of the normal operation, but it is not enough to be used as an application standard for fire protection at the transient mode of the plant and the outage time for refueling as well as for the plant decommissioning. While the advanced fire protection requirement that has been developed in America recently suggests the performance-based requirement and management rule applicable to the overall life time of the plant, it simply represents the conceptual application. It means that it can not be treated as appropriate standards because it does not deal with the qualitative and quantitative approach in specific ways. By the way, with the use of the performance-based fire risk analysis, the dynamic behavior of the heat and smoke at the fire compartment of the nuclear power plants can be analyzed and the thermal effect to the safety-related equipment and cables can be evaluated as well. At this paper, it suggests the ways to change the applicable fire protection regulations and the required evaluation items for the fire risk resulted from the plant configuration change with an intent to introduce the state-of-the-art quantitative fire risk analysis technology at the domestic nuclear power plants.

• Fire Science and Engineering
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• v.28 no.1
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• pp.37-43
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• 2014

The high predictive performance of fire detector models is essentially needed to assure the reliability of fire and evacuation modeling in the process of Performance-Based fire safety Design (PBD). The main objective of the present study is to measure input information in order to predictive the accurate activation time of fixed temperature heat detectors adopted in Fire Dynamics Simulator (FDS) as a representative fire model. To end this, Fire Detector Evaluator (FDE) which could be measured the device properties of detector was used, and the spot-type fixed temperature heat detectors of two thermistor types and one bimetal type were considered as research objectors. Activation temperature and Response Time Index (RTI) of detectors required for the fire modeling were measured, and then the RTI was measured for ceiling jet flow and vertical jet flow in consideration of the install location of detectors. The results of fire modeling using measured device properties were compared and validated with the experimental results of full-scale compartment fires. It was confirmed that, in result, the numerically predicted activation time of detector showed reasonable agreement with the measured activation time.

• Fire Science and Engineering
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• v.26 no.3
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• pp.106-111
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• 2012

In this study, EIFS (Exterior insulation finish system) of exterior cladding was applied Cone calorimeter test to confirm the effect of flame retardant. As a results, the initial ignition points in accordance with the coated form and concentration of the flame retardant was delayed. But flame resistant treatment of EIFS cladding to control the fire will not affect confirmed that. In addition, EIFS that uses high-density and low-density due to difference in the density of the impact of the fire was no difference. The exterior of the ignition experiment occurred before and after 40 seconds, heat release rate to 100 seconds appears to occur about 90 % compared with the other exterior wall materials, the initial fire spread very fast was confirmed. EIFS cladding in order to prevent the spread of fire in the application of EIFS legally use is limited by the use of the building. And flame spread can be prevented, such as a vertical outer wall compartment measures are urgently needed.

• Korean Journal of Clinical Pharmacy
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• v.9 no.1
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• pp.49-54
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• 1999

This study was carried out to compare the bioavailability of Hanmi clarithromycin (250 mg/tablet) with that of $Klaricid^{(R)}$ The bioavailability was examined on 20 volunteers who received a single dose (500 mg) of each drug in the fasting state in a randomized balanced 2-way crossover design. After dosing, blood samples were collected for a period of 12 hours. Plasma samples were analyzed for clarithromycin and roxithromycin(internal standard) by HPLC/Coulometric BCD. The pharmaco-kinetic parameters ($AUC_{0-l2hr}$, Cmax, Tmax, $AUC_{inf}$, Ka, Kel, $t_{1/2}$, Vd/F and Cl/F) were calculated from the plasma clarithromycin concentration-time data of each volunteer. The computer program 'WinNonlin' was used for compartmental analysis. One compartment model with first-order input, from order output with lag time, weighting factor $l/y^2$ was chosen as the appropriate pharmacokinetic model. The major pharmacokinetic parameters ($AUC_{0-l2hr},\;AUC_{inf}$, Cmax and Tmax) of Hanmi clarithromycin were $10.7\pm0.5\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;12.7\pm0.7\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;1.7\pm0.1\;{\mu}g/ml\;and\;2.0\pm0.2\;hr$, respectively, and those of $Klaricid^{(R)}\;were\;9.8\pm0.5\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;11.7\pm0.6\;{\mu}g{\cdot}hr{\cdot}ml^{-1},\;1.6\pm0.1\;{\mu}g/ml\;and\;2.1\pm0.1\;hr$, respectively. The differences in mean values of $AUC_{0-l2hr},\;AUC_{inf}$ and Cmax between two products were $9.88\%,\;8.94%\;and\;6.59\%$, respectively. The least significant differences at $\alpha=0.05$ for $AUC_{0-l2hr},\;AUC_{inf}$ and Cmax were $16.08\%,\;17.81\%\;and\;18.94\%$, respectively. Though the plasma clarithromycin concentrations of Hanmi clarithromycin were higher than those of $Klaricid^{(R)}$ at all observed times, the bioavailability of Hanmi clarithromycin appeared to be bioequivalent with that of $Klaricid^{(R)}$. The Ka, Kel, $t_{1/2}$, Vd/F and Cl/F of the Hanmi clarithromycin were $2.69\pm0.53\;hr^{-1},\;0.18\pm0.01 hr^{-1},\;3.9\;hr,\;248.8\pm11.4\;L\;and\;43.7\pm2.6\;L/hr$, respectively, and those of $Klaricid^{(R)} were 2.19\pm0.51\;hr^{-1},\;0.18\pm0.02\;hr^{-1},\;3.7\;hr,\;266.7\pm22.4\;L\;and\;45.3\pm2.8L/hr$, respectively. There were no statistically significant differences between two drugs in all pharmacokinetic parameters.