• Title/Summary/Keyword: Comparative

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Development of new agrochemicals by quantitative structure-activity relationship (QSAR) methodology. III. 3D QSAR methodologies and computer-assisted molecular design (CAMD) (정량적인 구조-활성상관 (QSAR) 기법에 의한 새로운 농약의 개발. III. 3D QSAR 기법들과 컴퓨터를 이용한 분자설계(CAMD))

  • Sung, Nack-Do
    • The Korean Journal of Pesticide Science
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    • v.7 no.1
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    • pp.1-11
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    • 2003
  • Acoording to improvement of HTOS (high throughput organic synthesis) and HTS (high throughput screening) technique, the CoMFA (comparative molecular field analysis), CoMSIA (comparative molecular similarity indeces analysis) and molecular HQSAR (hologram quantitative structure-activity relationship) analysis techniques as methodology of computer assisted molecular design (CAMD) were introduced generally and summarized for some application cases.

A Meta-analysis on Comparative Studies of Mathematics Textbooks (수학 교과서 비교 연구 논문에 관한 분석)

  • Hong Mira;Cba Insook
    • The Mathematical Education
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    • v.44 no.2 s.109
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    • pp.201-213
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    • 2005
  • The purpose of this study is to find research areas that were less represented by the researchers of mathematics textbooks and to provide feedback for the research and development of mathematics curriculum and textbooks. In order to complete this study, we analyzed comparative studies of mathematics textbooks published in Korean. This study analyzed 107 comparative studies published until recently based on following aspects: countries studied (North Korea, U.S.A., and Japan), Math curriculum studied (6th and 7th mathematics curriculum), and Math contents studied (probability and statistics) and etc. The result of this study suggests that the content area of creative problem solving was particularly less represented by the studies published and require more concern from the mathematics education researchers

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Molecular Docking, 3D QSAR and Designing of New Quinazolinone Analogues as DHFR Inhibitors

  • Yamini, L.;Kumari, K. Meena;Vijjulatha, M.
    • Bulletin of the Korean Chemical Society
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    • v.32 no.7
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    • pp.2433-2442
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    • 2011
  • The three dimensional quantitative structure activity relationship (3D QSAR) models were developed using Comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA) and docking studies. The fit of Quinazolinone antifolates inside the active site of modeled bovine dihydrofolate reductase (DHFR) was assessed. Both ligand based (LB) and receptor based (RB) QSAR models were generated, these models showed good internal and external statistical reliability that is evident from the $q^2_{loo}$, $r^2_{ncv}$ and $r^2_{pred}$. The identified key features enabled us to design new Quinazolinone analogues as DHFR inhibitors. This study is a building bridge between docking studies of homology modeled bovine DHFR protein as well as ligand and target based 3D QSAR techniques of CoMFA and CoMSIA approaches.

Parsing Korean Comparative Constructions in a Typed-Feature Structure Grammar

  • Kim, Jong-Bok;Yang, Jae-Hyung;Song, Sang-Houn
    • Language and Information
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    • v.14 no.1
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    • pp.1-24
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    • 2010
  • The complexity of comparative constructions in each language has given challenges to both theoretical and computational analyses. This paper first identifies types of comparative constructions in Korean and discusses their main grammatical properties. It then builds a syntactic parser couched upon the typed feature structure grammar, HPSG and proposes a context-dependent interpretation for the comparison. To check the feasibility of the proposed analysis, we have implemented the grammar into the existing Korean Resource Grammar. The results show us that the grammar we have developed here is feasible enough to parse Korean comparative sentences and yield proper semantic representations though further development is needed for a finer model for contextual information.

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Comparative Analysis of Competitiveness in the Steel Distribution Industry between Korea and Japan

  • Lee, Jae-Sung
    • Journal of Distribution Science
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    • v.12 no.3
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    • pp.25-32
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    • 2014
  • Purpose - This study reviews changes in the steel export-import structure between Korea and Japan using a trade related index; it focuses on analyzing comparative advantage based on time-series analysis statistics data using the trade intensity index (TII), revealed comparative advantage index (RCA), and trade specialization index (TSI). Research design, data, and methodology - In terms of their economic phase, Korea and Japan have a mutually complementary character. Therefore, this study aims to understand each country's trade structure to strengthen Korea-Japan economic cooperation, examine trade drawbacks, analyze factors that affect trade, and identify ways to improve and expand trade. Results - The results indicate immense potential for mutual cooperation and complementariness, which will yield guaranteed adequate profits comparable to those of any regional economic integrated community. Conclusion - From our viewpoint, Northeast economic cooperation can facilitate industry technological cooperation with Japanese partners in the prevailing environment that is characterized by increasing competition among industries and the need to secure stable resource supplies as well as the expansion of the export market and diversification, which can have significant positive implications.

Evaluation of Competitiveness in Auto Distribution Industry between Korea and Russia

  • Lee, Jae-Sung
    • Journal of Distribution Science
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    • v.13 no.8
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    • pp.5-14
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    • 2015
  • Purpose - This study undertakes to examine the automotive trade structure between Korea and Russia to accelerate economic cooperation and pinpoint trade discrepancies to increase trade volume through improved policies, eventually finding ways for trade expansion. Research design, data, and methodology - To analyze trade decision factors for both countries, the Index of trade specialization invented by trade specialization theory, is used. Although specific factors should materialize in the trade decision analysis, realistically, concrete explanations are difficult as many unsolved factors are involved as well as their complexities Results - First, to assess comparative market competitiveness, the Index describes A value/B value, representing the Korean versus the Russia market share and the Korean market share versus the world. Second, the index shows that Korea is taking comparative advantage of its export specialization. Third, the RCA indices show considerable improvement compared to 2000. Conclusions - This research used a quantitative approach to examine trade specialization and examined a comparative advantage index of market share to see how inter-trade relations have changed over the past 10 years.

Comparison of QSAR Methods (CoMFA, CoMSIA, HQSAR) of Anticancer 1-N-Substituted Imidazoquinoline-4,9-dione Derivatives

  • Suh, Myung-Eun;Park, So-Young;Lee, Hyun-Jung
    • Bulletin of the Korean Chemical Society
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    • v.23 no.3
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    • pp.417-422
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    • 2002
  • Comparison studies of the Quantitative Structure Activity Relationship (QSAR) methods with new imidazo-quinolinedione derivatives were conducted using Comparative Molecular Field Analysis (CoMFA), Comparative Molecular Similarity Indices Analysis (CoMSIA), and the Hologram Quantitative Structure Activity Relationship (HQSAR). When the CoMFA crossvalidation value, q2, was 0.625, the Pearson correlation coefficient, r2, was 0.973. In CoMSIA, q2 was 0.52 and r2 was 0.979. In the HQSAR, q2 was 0.501 and r2 was 0.924. The best result was obtained using the CoMSIA method according to a comparison of the calculated values with the real in vitro cytotoxic activities against human ovarian cancer cell lines.

Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs

  • Mongillo, Paolo;Bernardini, Marco;Prana, Elisa;Balducci, Federica;Gabai, Gianfranco;Marinelli, Lieta
    • Korean Journal of Veterinary Research
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    • v.57 no.1
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    • pp.47-50
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    • 2017
  • Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.

Human Behavior in Newsvendor Decisions: A Comparative Study with Experimental Results

  • Kwak, Jin Kyung
    • Management Science and Financial Engineering
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    • v.21 no.1
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    • pp.19-24
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    • 2015
  • As decision makers do not make optimal decisions in practice despite the existence of optimal solutions in many models, there has been a rising interest in behavioral operations management recently. In this study, we aim for a comparative study to analyze the inventory decisions in Korea, America, and China, by conducting the same newsvendor experiment in Korea and compare the results with those of previous studies. From the comparative analysis, some national characteristics in decision-making processes have been observed but there is lowly significant difference in order quantities among the three groups. Korean students show lower level of understanding in demand distributions and tendencies of anchoring on the mean demand and being risk-averse. The finding that individuals make their own decisions differently based on their different behaviors suggests that we need to consider individual approach in analyzing human decision-making processes rather than adapting aggregate approach.