• 한국임상약학회지
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• 제27권2호
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• pp.63-68
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• 2017

Neonates have large inter-individual variability in pharmacokinetic parameters of many drugs due to developmental differences. The aim of this study was to investigate the factors affecting the pharmacokinetic parameters of drugs, which are commonly used in critically ill neonates. Factors that reflect physiologic maturation such as gestational age, postnatal age, postconceptional age, birth weight, and current body weight were correlated with pharmacokinetic parameters in neonates, especially preterm infants. Comorbidity characteristics affecting pharmacokinetics in critically ill neonates were perinatal asphyxia, hypoxic ischemic encephalopathy, patent ductus arteriosus (PDA), and renal dysfunction. Administration of indomethacin or ibuprofen in neonates with PDA was associated with the reduced clearance of renally excreted drugs such as vancomycin and amikacin. Therapeutic hypothermia and extracoporeal membrane oxygenation were influencing factors on pharmacokinetic parameters in critically ill neonates. Dosing adjustment and careful monitoring according to the factors affecting pharmacokinetic variability is required for safe and effective pharmacotherapy in neonatal intensive care unit.

• 대한간호학회지
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• 제38권1호
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• pp.92-100
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• 2008

Purpose: The aim of this study was to estimate the prevalence of urinary incontinence among nursing home residents and to identify the factors associated with this condition. Method: The data were collected from 618 subjects (146 males and 472 females; mean age $79.9{\pm}8.4$ yr; range 65-102 yr) of 30 nursing homes in Seoul, Gyeonggi-do and Gangwon-do in this cross-sectional study. The data were analyzed by chi-square test, t-test, and multiple logistic regression by using the SPSS/PC ver 12.0 program. Results: The prevalence of UI was 64.7% (64.6% in women; 65.1% in men). After adjustment for each of the variables considered in this study, six potential factors were strongly associated with UI: activities of daily living, comorbidity, age, cognition, specialty of the facility, and a bladder training program. Conclusion: Our finding suggests that it is necessary to develop a program for promotion of activities of daily living and to provide a bladder training program to prevent urinary incontinence among nursing home residents.

• 보건의료산업학회지
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• 제8권4호
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• pp.47-55
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• 2014

The purpose of this study was to analyze the differences in the outcome for CABG according to whether hospitals provided heart related surgeries. The 2011 National Inpatient Sample (NIS) and inpatient quality indicator principles from the Healthcare Research and Quality (AHRQ) were used for analysis. Hospitals were divided into three groups according to the surgeries they provided. The length of stay and in-hospital deaths were adjusted for the differences in risks. ANOVA was performed to examine the differences for the risk-adjusted in-hospital mortality rate and risk-adjusted length of stay among the three groups. The analysis results showed that hospitals providing CABG, PTCA, and PHS had lower risk-adjusted in-hospital mortality rates or similar risk-adjusted lengths of stay compared to those of hospitals providing only CABG. However, the three groups did not have statistically significant differences in outcome indicators. Another study will be needed with a larger sample.

• 보건행정학회지
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• 제17권3호
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• pp.87-105
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• 2007

The purpose of this study was to analyze whether nonemergency, isolated coronary artery bypass graft (CABG) surgery for high- or low-risk patients biases the assessment of the risk-adjusted mortality rates of hospitals. This study used 2002 National Health Insurance claims data for tertiary hospitals in Korea. The study sample consisted of 1,959 patients from 23 tertiary hospitals. The risk-adjustment model used the patients' biological, admission, and comorbidity data identified in the claims. The subjects were classified into high- and low-risk groups based on predicted surgical risk. The crude mortality rates and risk-adjusted mortality rates for low-risk, high-risk, and all patients in a hospital were compared based on the rank and the four intervals defined by quartile. Also, the crude mortality rates of the three groups were compared with their 95% confidence intervals of predicted mortality rates. The C-statistic (0.83) and Hosmer-Lemeshow test ($X^2$=11.47, p=0.18) indicated that the risk-adjustment model performed well. Presenting crude mortality rates with their 95% confidence intervals of predicted rates showed higher agreements among the three groups than using the rank or intervals of mortality rates defined by quartile in the hospital performance assessment. The crude mortality rates for the low-risk patients in 21 of the 23 hospitals were located on the same side of their 95% confidence intervals compared to that for all patients. High-risk patients and all patients differed at only one hospital. In conclusion, the impact of risk selection by hospital on the assessment results was the smallest when comparing the crude inpatient mortality rates of CABG patients with the 95% confidence intervals of predicted mortality rates. Given the increasing importance of quality improvements in Korean health policy, it will be necessary to use the appropriate method of releasing the hospital performance data to the public to minimize any unwanted impact such as risk-based hospital selection.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제13권1호
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• pp.93-103
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• 2002

저자는 소아정신과 영역에서 흔하게 관찰되는 주의산만과 과잉운동을 주소로 하는 아동들의 진단특성과 이와 관련된 임상변인들을 알아보기 위하여 본 연구를 시행하였다. 대학병원 소아정신과에 내원한 아동들에서 주의력과 과잉운동 문제를 보이는 5세에서 14세 사이 총 71명(남자 63 명, 여자 8명)을 대상으로 하여, KEDI-WISC, KPI-C, ADS를 시행하였고 진단 분류에 따라 1) ADHD만 있는 군 2) 공존 질환이 있는 ADHD군 3) ADHD 이외의 진단군으로 나누어 비교한 결과 아래와 같은 결과를 얻었다. 1) ADHD 단독 진단군이 17명(23.9%), 공존질환이 ADHD는 26명(38.0%)이었으며 공존질환은 틱장애가 가장 많고 발달성 언어장애, 경계성 지능, 적대적 반항/품행장애, 경계성 지적능력, 학습장애의 순서를 보였으며, ADHD 이외의 진단군 27명(38.0%)은 틱장애, 경계성 지능, 우울/불안장애, 적대적 반항/품행장애의 진단 분포를 나타냈다. 2) 지능검사에서 전체지능, 언어성 지능, 동작성 지능 모두 군별 차이를 보였고 ADHD만 있는 군에서 공존질환 ADHD군보다 전체지능과 언어지능이 유의하게 높은 수치를 나타냈다. KPI-C 임상 척도는 군별 차이를 보이지 않았다. ADS 시각자극 검사에서 누락오류(omission)와 민감도(d')가 세 군 사이에 의미있는 차이를 보였고, 공존질환이 있는 ADHD 군이 ADHD이외의 진단군에 비해 유의하게 누락오류가 많고 민감도는 낮았다. 본 연구 결과를 볼때 아동의 주의산만과 과잉운동 증상은 주 진단인 ADHD 이외에도 다양한 정신과 질환으로 진단될 수 있으므로 이에 대한 감별이 필요하며, 또한 공존질환이 있는 ADHD군이 ADHD만 있는 군이나 기타 질환군보다 주의력에 문제가 많고 지능 수치가 상대적으로 낮아 학습 및 학교 생활 적응에 어려움이 더 많을 것이므로 적극적인 치료개입이 필요할 것으로 생각되었다.

• 한국산학기술학회논문지
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• 제14권10호
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• pp.4910-4918
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• 2013

본 연구는 급성심근경색환자의 효율적인 재원일수 관리를 위해 재원일수에 대한 중증도 보정 모형을 개발하고자 하였다. 2004-2009년 퇴원손상심층조사 자료에서 주진단이 I21인 급성심근경색환자 6,074명을 추출하였으며, 모형 개발 시 데이터마이닝 기법(다중회귀분석, 의사결정나무, 신경망 기법)을 적용하였다. 개발된 모형들 중에서 의사결정나무 모형이 가장 우수한 모형으로 판정되어 이를 본 연구의 중증도 보정 모형으로 채택하였다. 급성심근경색 환자의 재원일수의 중증도 보정에 영향을 미치는 주요한 요인은 관상동맥우회술 시행유무, 퇴원 시 사망유무, 동반지수 등 이였으며, 병상규모와 의료기관 소재지 별로 중증도 보정 재원일수와 실제 재원일수에 차이가 있었다. 급성심근경색환자의 재원일수 변이를 줄이고 효율적으로 관리하기 위해서는 개발된 모형에 각 의료기관의 자료를 적용하여 중증도를 보정한 후, 차이가 나는 요인을 규명하여 이를 해결하는 활동이 수행되어야 할 것이다.

• 품질경영학회지
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• 제39권3호
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• pp.391-399
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• 2011

Our study was carried out to analyze the variation factors of severity-adjusted length of stay(LOS) in coronary artery bypass graft(CABG). The subjects were 932 CABG inpatients of the Korean National Hospital Discharge In-depth Injury Survey from 2004 through 2008. The data were analyzed using $x^2$ test and the severity-adjusted model was developed using data mining technique. The results of the study were as follows: male(71.1%), older than 61 years of age(61.6%), more than 500 beds(92.8%) and admitting via ambulatory care(70.0%) appeared to have higher rate than otherwise. In-hospital mortality of CABG inpatients was 2.8%. In addition, 46.4% of the patients received their care in other residence. The angina pectoris(45.6%) was found to be the highest in principle diagnosis, followed by chronic ischemic heart disease(36.9%) and acute myocardial infarction(12.0%). We developed severity-adjusted LOS model using the variables such as gender, age and comorbidity. Comparison of adjusted values in predicted LOS revealed that there were significant variations in LOS by location of hospital, bed size, and whether patients received the care in their residences. The variations of LOS can be explained as the indirect indicator for quality variation of medical process. It is suggested that the severity-adjusted LOS model developed in this study should be utilized as a useful method for benchmarking in hospital and it is necessary that national standard clinical practice guideline should be developed.

• Journal of Preventive Medicine and Public Health
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• 제47권4호
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• pp.206-215
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• 2014

Objectives: The hospital standardized mortality ratio (HSMR) has been widely used because it allows for robust risk adjustment using administrative data and is important for improving the quality of patient care. Methods: All inpatients discharged from hospitals with more than 700 beds (66 hospitals) in 2008 were eligible for inclusion. Using the claims data, 29 most responsible diagnosis (MRDx), accounting for 80% of all inpatient deaths among these hospitals, were identified, and inpatients with those MRDx were selected. The final study population included 703 571 inpatients including 27 718 (3.9% of all inpatients) in-hospital deaths. Using logistic regression, risk-adjusted models for predicting in-hospital mortality were created for each MRDx. The HSMR of individual hospitals was calculated for each MRDx using the model coefficients. The models included age, gender, income level, urgency of admission, diagnosis codes, disease-specific risk factors, and comorbidities. The Elixhauser comorbidity index was used to adjust for comorbidities. Results: For 26 out of 29 MRDx, the c-statistics of these mortality prediction models were higher than 0.8 indicating excellent discriminative power. The HSMR greatly varied across hospitals and disease groups. The academic status of the hospital was the only factor significantly associated with the HSMR. Conclusions: We found a large variation in HSMR among hospitals; therefore, efforts to reduce these variations including continuous monitoring and regular disclosure of the HSMR are required.

• 대한예방한의학회지
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• 제16권3호
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• pp.15-26
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• 2012

Objective : Only a few studies have investigated the life expectance and health related quality of life (HRQOL) about stroke patients. The purpose of this study is to analyze the life expectancy, preference based quality of life(QOL) and quality adjusted life years(QALYs) of stroke patients. Methods : We used data of 10,533 adults from 4th Korean national health and nutritional examination survey 2009 for evaluating HRQOL of stroke patients. We also analyzed the life expectancy for stroke patients using life table from national public health data. Finally we calculated the QALYs with and without stroke conditions and assumed the difference of QALYs. Results : The mean age of stroke patients was assumed to be 65. Lower income and less educated groups were prone to be exposed to the stroke conditions. Common comorbidities of stroke patients were ischemic heart attack, hypertension, diabetes and hyperlipidemia. The proportions of participants who reported problems in each of the five EQ-5D dimensions increased significantly at chronic stroke group. Participants with chronic stroke conditions had an almost 6-fold higher risk of impaired health utility(the lowest quartile of EQ-5D utility score) compared with non stroke participants, after adjustment of age, gender, income, education, comorbidity variables. The differences of life expectancy and QALYs between non-stroke and stroke group from the age of 65 till death were assumed to be 0.767 year and 3.103 QALYs. Conclusions : Although the authors analyzed the affecting factors of QOL and assumed the differences of life expectance and QALYs about stroke patients using domestic national data and statistic references, well designed cohort studies should be needed to prove the causal effects of affecting factors and to assume more correct QALY differences.

• 보건행정학회지
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• 제25권3호
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• pp.197-206
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• 2015

Background: The purpose of this study was to propose a method for developing a measure of hospital-wide all-cause risk-standardized readmissions using administrative claims data in Korea and to discuss further considerations in the refinement and implementation of the readmission measure. Methods: By adapting the methodology of the United States Center for Medicare & Medicaid Services for creating a 30-day readmission measure, we developed a 6-step approach for generating a comparable measure using Korean datasets. Using the 2010 Korean National Health Insurance (NHI) claims data as the development dataset, hierarchical regression models were fitted to calculate a hospital-wide all-cause risk-standardized readmission measure. Six regression models were fitted to calculate the readmission rates of six clinical condition groups, respectively and a single, weighted, overall readmission rate was calculated from the readmission rates of these subgroups. Lastly, the case mix differences among hospitals were risk-adjusted using patient-level comorbidity variables. The model was validated using the 2009 NHI claims data as the validation dataset. Results: The unadjusted, hospital-wide all-cause readmission rate was 13.37%, and the adjusted risk-standardized rate was 10.90%, varying by hospital type. The highest risk-standardized readmission rate was in hospitals (11.43%), followed by general hospitals (9.40%) and tertiary hospitals (7.04%). Conclusion: The newly developed, hospital-wide all-cause readmission measure can be used in quality and performance evaluations of hospitals in Korea. Needed are further methodological refinements of the readmission measures and also strategies to implement the measure as a hospital performance indicator.