• Journal of Preventive Medicine and Public Health
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• 제53권4호
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• pp.211-219
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• 2020

Objectives: The goal of this study was to identify chronic conditions and multimorbidity patterns in patients with coronavirus disease 2019 (COVID-19) and to examine their associations with pneumonia and death. Methods: This cross-sectional study analyzed the official data of COVID-19 patients in Mexico through May 18, 2020 (released by the Secretaría de Salud de México). Adjusted logistic regression models were applied to assess the associations of comorbidities with pneumonia and death. The marginal effects were estimated, and the probability of pneumonia or death according to the number of comorbidities was graphed for each year of age. Results: Of the 51 053 COVID-19 patients enrolled in the final analysis, 27 667 (54.2%) had no chronic conditions, while 13 652 (26.7%), 6518 (12.8%) and 3216 (6.3%) were reported to have 1, 2, and 3 or more simultaneous conditions, respectively. Overall, a significant incremental gradient was observed for the association between multimorbidity and pneumonia (p<0.001); for 2 chronic conditions, the adjusted odds ratio (aOR) was 2.07 (95% confidence interval [CI], 1.95 to 2.20), and for ≥3 conditions, the aOR was 2.40 (95% CI, 2.22 to 2.60). A significant incremental gradient was also found for the relationship between multimorbidity and death (p<0.001); an aOR of 2.51 (95% CI, 2.30 to 2.73) was found for 2 chronic conditions and an aOR of 3.49 (95% CI, 3.15 to 3.86) for ≥3 conditions. Conclusions: Underlying chronic conditions and multimorbidity are associated with pneumonia and death in Mexican COVID-19 patients. Future investigation is necessary to clarify the pathophysiological processes behind this association, given the high burden of chronic diseases in various countries, including Mexico.

• 한국임상약학회지
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• 제31권3호
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• pp.231-236
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• 2021

Background: Sarcopenia is a skeletal muscle disorder that involves the loss of muscle mass and function. Handgrip strength (HGS) is the most commonly used tool to assess muscle strength to diagnose sarcopenia. HGS is also associated with various diseases and health outcomes. Thus, we aimed this study to examine the HGS status in Korean adults and relevant factors of HGS. Methods: Data was obtained from the 7th Korea National Health and Nutrition Examination Survey (KNHANES), a population-based nationwide survey. The estimated mean value of HGS was calculated in each age group. The mean HGS in men and women aged over 40 was compared according to the household income level, lifestyle factors, and comorbidities. Results: A total of 16,708 participants were included in this study. The mean HGS showed a maximum value in the 30s for both men and women, and then tended to decrease with increasing age. When analyzed for people aged 40 or older, the mean HGS was significantly higher in the current or past smoker, drinker, and aerobic exercise groups in both men and women. The mean HGS was lower in the group with comorbidities such as hypertension, dyslipidemia, type 2 diabetes, and bone diseases. Conclusion: Our study found that the mean HGS was significantly different between those with and without underlying chronic diseases. In groups with relevant comorbidities, close monitoring for the development of sarcopenia and taking preventive measures such as exercise and nutritional support may be recommended.

• 정신신체의학
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• 제26권1호
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• pp.26-34
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• 2018

연구목적 본 연구에서는 조현병 환자의 만성신체질환 유병현황을 확인하고, 총 의료비용에 미치는 영향을 제시하고자 하였다. 방 법 2014~2015년 건강보험심사평가원 자료를 활용하였으며, 자료의 정확성을 높이기 위하여 조현병 및 만성신체질환은 주/부상병으로 동일 상병을 3회이상 진단받은 경우만 해당 질환으로 분류하였다. 총 의료비용은 보건의료체계적 관점으로 보험자의 비용과 함께 본인부담비용을 포함하였다. 결 과 조현병 환자의 24.5%는 1개, 17.3%는 2개, 23.4%는 3개이상의 만성신체질환을 가지고 있는 것으로 나타났으며, 만성신체질환의 1~5순위는 만성위염/위식도역류질환이 27.3%, 알레르기가 19.5%, 고혈압이 13.2%, 만성요통이 11.0%, 당뇨병이 10.6%로 위장간질환 및 알레르기 질환, 대사성 질환뿐만 아니라 근골격계 질환의 유병률도 높게 나타났다. 2014년에 진단받은 조현병 환자의 2015년 총 의료비용은 약 1조 8백억원이었으며, 총 의료비용에 영향을 미치는 요인으로는 성별, 연령, 만성신체질환의 수, 건강보험여부로 나타났다. 결 론 조현병 환자의 만성신체질환의 문제를 해결하기 위한 접근방법은 단순히 개별 질환을 중심으로 치료하기 보다는 조현병 환자의 다양한 신체 질환을 동시에 치료 및 관리할 수 있는 새로운 형태의 진료체계에 대한 모델 개발이 필요할 것이다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제28권2호
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• pp.46-57
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• 2017

Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric disorder that can affect individuals across their lifespan. It is characterized by the core symptoms of inattention, impulsivity and hyperactivity. ADHD develops as a result of the complex interplay between genetic and environmental factors. Children and adults with ADHD usually suffer concomitantly from other psychiatric comorbidities, including both externalizing and internalizing disorders. It is associated with functional impairment and poor long-term outcomes. This review aims to summarize the key findings from recent research into ADHD and its prevalence, core symptoms, cause and comorbidities from childhood to adulthood.

• 성인간호학회지
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• 제27권2호
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• pp.211-222
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• 2015

Purpose: This study was conducted to test the model for sleep in community-dwelling older adults. The hypothetical model based on a senescent sleep model was constructed using the multiple influencing factors of sleep and associated adverse outcomes of changes in sleep in the older adults. Methods: Data were collected from 203 community-dwelling older adults living in Korea, and analyzed using IBM SPSS 21.0 and AMOS 21.0. Results: Increased age and multiple comorbidities were associated with decreased physical activities. Decreased physical activities were associated with smaller social networks, and smaller social networks were associated with higher level of loneliness. Multiple comorbidities, decreased physical activities, larger social networks, and higher level of loneliness were associated with maladaptive sleep hygiene. Decreased physical activities, higher level loneliness, and shorter actual sleep duration were associated with worse sleep quality. Smaller social networks and shorter actual sleep duration were associated with lower cognitive functions. Smaller social networks, higher loneliness, and worse sleep quality were associated with more severe depressive symptoms. Conclusion: These findings suggest that the sleep improvement interventions not only with physical perspectives but psychosocial ones for older adults may improve depressive symptoms as well as sleep quality.

• Tuberculosis and Respiratory Diseases
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• 제81권1호
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• pp.1-5
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• 2018

Asthma, remains symptomatic despite ongoing treatment with high doses of inhaled corticosteroids (ICS) in conjunction with long-acting beta-agonists (LABA), is classified as "severe" asthma. In the course of caring for those patients diagnosed with severe asthma, stepping up from ICS/LABA to more aggressive therapeutic measures would be justified, though several aspects have to be checked in advance (including inhaler technique, adherence to therapy, and possible associated comorbidities). That accomplished, it would be advisable to step up care in accordance with the Global Initiative for Asthma (GINA) recommendations. Possible strategies include the addition of a leukotriene receptor antagonist or tiotropium (to the treatment regimen). The latter has been shown to be effective in the management of several subgroups of asthma. Oral corticosteroids have commonly been used for the treatment of patients with severe asthma in the past; however, the use of oral corticosteroids is commonly associated with corticosteroid-related adverse events and comorbidities. Therefore, according to GINA 2017 these patients should be referred to experts who specialize in the treatment of severe asthma to check further therapeutic options including biologics before starting treatment with oral corticosteroids.

• 대한한의학회지
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• 제39권4호
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• pp.171-176
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• 2018

Background: Small cell lung cancer (SCLC) tends to grow more rapidly and spread much faster than non-small cell lung cancer (NSCLC). A concurrent combination of chemotherapy and thoracic radiotherapy is suggested as the standard conventional treatment, but it is more challenging for elderly patients having pulmonary and cardiovascular comorbidities. Case presentation: Here we present a case of an 80-year-old male, current smoker diagnosed with SCLC in limited stage T3N0M0 (36mm right upper lobe, satellite nodule) in Dec, 2015. The standard concurrent chemoradiotherapy was not available for his comorbidities, which included chronic obstructive pulmonary disease (COPD) and angina pectoris. Furthermore, he and his family refused the recommended chemotherapy or radiotherapy exclusively. Alternatively, he received various non-conventional treatments including local radiofrequency hyperthermia, mistletoe, and Traditional Korean medicine including acupuncture, moxibustion and herbs since Jan. 2016. Despite the progression in primary tumor size, there have been no other distant relapse so far, and the patient has been in stable condition ever since. Conclusion: We suggest that a combination of various alternative treatments could be a candidate for elderly patients intolerable to conventional cytotoxic treatments.

• Nutrition Research and Practice
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• 제15권4호
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• pp.456-467
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• 2021

BACKGROUND/OBJECTIVES: The prevalence of morbid obesity in Korean women has consistently been increasing, while the overall prevalence rate of obesity in Korean women seems to be stable. In addition to bariatric surgery, intragastric balloons (IGBs), as a nonsurgical therapy, have been reported to be effective in weight loss. However, the beneficial effects of IGB in Korean women with obesity have not been fully investigated. The aim of this study was to evaluate the changes in fat mass in Korean women with obesity who had undergone IGB treatment for 6 mon. SUBJECTS/METHODS: Seventy-four women with obesity (body mass index [BMI] ≥ 25.0 kg/m²) were recruited. Clinical data, including general information, comorbidities with obesity, anthropometric data, and changes in the body fat composition before and after IGB treatment, were obtained from the subjects. RESULTS: Most subjects had one or more comorbidities, such as osteoarthropathy and woman's disease, and had poor eating behaviors, including irregular mealtimes, eating quickly, and frequent overeating. Body composition measurements showed that weight, fat mass, and waist-hip circumference ratio decreased significantly at 6 mon after IGB treatment. In particular, women with morbid obesity (BMI ≥ 30 kg/m²) showed 33% excess weight loss. There was no significant difference in skeletal muscle mass and mineral contents after IGB treatment. CONCLUSIONS: This study suggested that 6 mon of IGB treatment can be a beneficial treatment for obesity without muscle mass and bone mineral loss.

• Journal of Gastric Cancer
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• 제23권3호
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• pp.428-450
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• 2023

This meta-analysis examined the surgical management of older patients (>80 years) with gastric cancer, who were often excluded from randomized controlled trials. We analyzed 23 retrospective cohort studies involving 18,372 patients and found that older patients had a higher in-hospital mortality rate (relative risk [RR], 3.23; 95% confidence interval [CI], 1.46-7.17; P<0.01) and more post-operative complications (RR, 1.36; 95% CI, 1.19-1.56; P<0.01) than did younger patients. However, the surgical complications were similar between the two groups. Older patients were more likely to undergo less extensive lymph node dissection and longer hospital stays. Although older patients had statistically significant post-operative medical complications, they were not deprived of surgery for gastric cancer. The comorbidities and potential risks of post-operative complications should be carefully evaluated in older patients, highlighting the importance of careful patient selection. Overall, this meta-analysis provides recommendations for the surgical management of older patients with gastric cancer. Careful patient selection and evaluation of comorbidities should be performed to minimize the risk of post-operative complications in older patients, while recognizing that they should not be deprived of surgery for gastric cancer.

• 한국융합학회논문지
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• 제11권7호
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• pp.97-104
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• 2020

본 연구는 청각저하 노인의 건강관 관련된 삶의 질 영향 요인을 파악하고자 시도되었다. 제 7기 국민건강영양조사 자료를 (KNHANES 2018) 활용하여 청각저하 노인으로 분류하여 최종적으로 528명을 연구대상으로 하였다. 통계분석은 SPSS 25.0을 사용하여 χ²-test, t-test, ANOVA, 상관분석, 다중회귀분석방법으로 분석하였다. 성별, 나이, 교육, 결혼상태, 소득, 직업, 가족구성원의 수, 이명, 동반질환의 수, 흡연, 음주, 주관적 건강상태, 규직적인 운동, 활동 제한여부, 우울, 스트레스 경험에 따라 삶의 질에 유의한 차이가 있었다. 삶의 질은 나이, 체질량지수, 동반질환의 수에 음의 상관관계를 보였다. 또한 청력저하 노인의 삶의 질에 결혼상태, 동반질환의 수, 체질량지수, 주관적 건강상태, 규칙적인 운동, 활동 제한 여부, 스트레스 경험이 유의한 예측요인으로 나타났고, 삶의 질을 37.3% 설명하였다. 청력저하 노인의 삶의 질 향상을 위한 다학제간 노력과 교육 프로그램 개발 적용이 필요하다.