• BMB Reports
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• v.34 no.3
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• pp.237-243
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• 2001

Taxol, a natural product extracted from the Taxus brevifolia, is known to have significant anti-tumor activities against many common cancers, including ovarian and breast cancers. Despite the pronounced anti-tumor activity of this compound, its poor solubility in aqueous solutions hampers its clinical applications. We studied the anticancer mechanisms of the water-soluble taxol diethylenetriamine pentaacetate (DTPA) used for radiolabeling, and compared it to that of taxol. In vitro cytotoxicities of taxol and taxol-DTPA conjugate were tested in HT29 human colorectal cancer cells by the MTT method. As the result, the $IC_{50}$ value of the taxol-DTPA conjugate was about three fold higher than that of taxol. When analyzed by an agarose gel electrophoresis, the DNA ladders became evident after the incubation of cells with the taxol-DTPA conjugate for 24 h. We also found morphological changes of the cells undergoing apoptosis with electron microscopy Next, we examined the signal pathway of taxol-DTPA conjugate-induced apoptosis in HT29 cells. The activation of extracellular signal-regulated protein kinase (ERK1/2) occurred at 10, 30, 60 and 120 min after 200 nM taxol-DTPA conjugate treatment. The pretreatment of the MEK inhibitor (PD98059) completely blocked the taxol-DTPA conjugate-induced ERK1/2 activation. The activated ERK1/2 translocated into the nucleus at the same time and phosphorylated its transcriptional factor, c-Jun. These results suggest that the taxol-DTPA conjugate has an apoptotic activity in HT29 cells, and that its proapoptic activity might be related with the signal transduction via ERK1/2 and c-Jun similar to that of taxol.

• Journal of the Korean School Mathematics Society
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• v.3 no.1
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• pp.189-200
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• 2000

The purpose of this thesis is that the students understand the sentence stated math problems closely related to the real life and adapted the right solving strategies try to find the solution to a problem. The following research problem were proposed. 1. How repeated thinking lessons develop the understanding of problems and influence the usage of correct problem solving strategies and extensions of problem solving. 2. There are how much differences of achievement for each type of sentence stated problems by using comparative analysis of upper class, intermediate class, and lower class for each level between the experimental and comparative classes. In order to conduct this research the classes were divided into three different level - upper class, intermediate class and lower class. Each level include an experimental class and a comparative class. The two classes (experimental class and comparative class) of the same level were tested on the basis of class division record with the experimental class repeated learning papers for two weeks were used to guide the fixed thinking algorism for each sentence stated math problems. Eight common problems were chosen from a variety of textbooks : number calculation problems, velocity-distance-time problems, the density of a mixture, benefit problems, distribution problems, problems about working, ratio problems, the length of a figure problems. After conducting this research experiment The differences in achievement level between the experimental class and comparative class, were compared and analyzed through achievement tests made from the achievement test papers with seven problems, which were worth seventy points (total score). The conclusions of this thesis are as follows: Firstly, leaning activities through the usage of repeated learning papers for each level class produce an even development of achievement level especially in the case of the upper class learners, they have particular differences (between experimental class and comparative class) compared to the intermediate level and lower classes. Secondly, according to the analysis about achievement development each problems, learners easily accept the strategies of solution through the formula setting up to the problem of velocity -distance-time, and to the density of the mixture they adapted the picture drawing strategies interestingly, However each situation requires a variety of appropriate solution strategies. Teachers will have to employ other interesting solution strategies which relate to real life.

• Korean Journal of Pharmacognosy
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• v.37 no.2 s.145
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• pp.103-109
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• 2006

Advanced glycation end products (AGEs) formation plays an important role in the progression of diabetic complications. To develop effective herbal formulations with suppression of diabetic nephropathy, a common complication in diabetic patients, we evaluated inhibitory activities of KIOM-79, a new herbal prescription, on the formation of AGEs using in vitro and in vivo model systems. Effects of KIOM-79 on the expression of AGEs, RAGEs (receptor for Advanced glycation end products), type IV collagen and renal $TGF-{\beta}1$ mRNA was also examined in streptozotocon (STZ)-induced diabetic rats. STZ-induced diabetic rats were treated orally with KIOM-79 (250 and $500\;kg^{-1}$ once a day for 13 weeks). In vitro system KIOM-79 suppressed the formation of AGEs $(18.12\;{\mu}g/ml)$. In STZ-induced diabetic rats showing accumulation of AGE and RAGE, pathological examination revealed that KIOM-79 prevented AGE and RAGE deposition in the kidney. In STZ induced diabetic rats, the expansion of mesangial matrix and the glomerular tufts seemed to be larger than those in normal rats. Howεver, after administration with KIOM-79, mesangial metrix and glomerular volume were decreased, and overexpression of type IV collagen was also decreased. Overexpression of renal $TGF-{\beta}1$ mRNA was inhibited significantly. These results suggest that the KIOM-79 might be an effective herbal prescription to prevent or alleviate the progression of diabetic nephropathy.

• Cartoon and Animation Studies
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• s.29
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• pp.77-102
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• 2012

Interactive Media Art has been developed a lot in digital age. Especially, the audience try to make interactions by accessing the world of art as one of main interacting figures, while they used to be totally separated from the art in traditional art. Also, it is one of exclusive features distinguished from the other art genres. In this thesis, the intercommunication process of interactive media art is classified and compared with Merleau-Ponty's corporeity phenomenology theories. Merleau-Ponty's corporeity phenomenology insists integrated perception through body against the western intelligence philosophy focusing on binomial reasons. Merleau-Ponty's corporeity phenomenology, which suggested the new perception way towards the art, is analyzed in this thesis by comparing it with detailed factors of Intercommunication process of Interactive Media Art. The Intercommunication process of Media Art is classified into , , , , . Additionally, they are studied and compared with the concept of , , , , out of Ponty's corporeity phenomenology theories. Therefore, it is concluded clearly that corporeity, synesthesia, poly sensation and spaciality drawn from Intercommunication process of Media Art have something in common with Ponty's corporeity phenomenology theories rather than the other art genre or minimalism art styles. Furthermore, a new direction of study upon modern Interactive Media Art is suggested.

• Cartoon and Animation Studies
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• s.12
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• pp.1-12
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• 2007

The long-term stagnation in the country involving missing it is starting from the late 1990s accumulated on the common vision. The government has, since 2002, cartoon comics industry nurture long-term industrial development of five-year plan, 346.7. During that period of unprecedented material support to the government's sweeping received. Upcoming in 2008 is the second long-term development plan will be effective. The temperature inside and outside the government, however, various tax and go to feel quite differently. The first plan is merely a period of enforced projects listed are only fit for Panathinaikos has endorsed this general trend, yirugo diagnosis. But fundamentally, the exact diagnosis is necessary for the long-term stagnation. Children's Learning Results cartoon wepmanhwawa not thrive households. Comics readers about the consumption pattern is changing. Therefore, long-term plan for the development of cartoon industry only a few government budget plan is not the government write 73 gala, companies and the private sector are coming together to plan and worry that the plan should be a comprehensive and bevels. In addition, through the selection and concentration to increase efficiency. You will probably need to strengthen the capabilities of our private organizations, it is a priority. Furthermore, the government's financial and policy support for the lobbying power also lead to an increase in betting. It features a think tank to study the policy framework for the establishment and promotion assume the ultimate proposal includes a cartoon film cozy confines of the legislation that parallels activities in the various proposals.

• The Journal of Engineering Geology
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• v.8 no.2
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• pp.175-188
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• 1998

This paper describes the internal structures and K-Ar ages of fault gouges collected from the Dongnae fault zone. This fault zone is internally zoned and occurs in the multiple fault cores. A fault core consists of thin gouge and narrow cataclastic zones that are bounded by a much thicker damage zone. Intensity of deformation and alteration increases from damage zone through cataclastic zone to gouge zone. It is thought that cataclasis of brittle deformation was the dominant strain-accomodation mechanism in the early stage of deformation to form the gouge zone and that crushed materials in the regions of maximum localization of fault slip subsequently moved by cataclastic flow. Deformation mechanism drastically changed from brittle processes to fluid-assisted flow along the gouge zone as the high porosity and permeability of pulverzied materials during faulting facilitated the influx of the hydrothermal fluids. Subsequently, the fluids reacted with gouge materials to form clay minerals. Fracturing and alteration could have repeatedly taken place in the gouge zone by elevated fluid pressures generated from the reduction of pore volume due to the formation of clay minerals and precipitation of other materials. XRD analysis revealed that the most common clay minerals of the gouge zones are illite and smectite with minor zeolite and kaolinite. Most of illites are composed of 1Md polytype, indicating the products of hydrothermal alteration. The major activities of the Dongnae fault can be divided into two periods based upon K-Ar age data of the fault gouges : 51.4∼57.5Ma and 40.3∼43.6Ma. Judging from the enviromental condition of clay mineral formation, it is inferred that the hydrothermal alteration of older period occured at higher temperature than that of younger period.

• Journal of Environmental Impact Assessment
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• v.21 no.5
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• pp.649-664
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• 2012

The grid cell analysis is used to select good sites as habitats at the region. The northern area of Yeongjong Island, Incheon has been disturbing by habitat loss due to human activities such as residential development, deforestation. In order to determine significant places as bird habitats and to select conservation areas at this island, the study area was divided into 70 grid cells($500{\times}500m$ each grid) and then each grid was ranked by spatial analysis using the species diversity index. Fieldwork was carried out in Spring and Autumn of 2010. To examine grid cells which were ranked high in both seasons in common, we used the average ranking value, combined data from two seasons. This area consists of mainly agricultural areas and forests(more than 68%) among eight habitat types: the agricultural land, forest, coast, lake, meadow, stream, city and other things. A total of 110 species was recorded: 4,183 birds of 102 species in Spring and 3,326 birds of 58 species in Autumn. In other words, the number of individuals and species was higher in Spring than in Autumn. Species diversity index presented the highest value at M8 grid cell in Spring(3.380) and at A4 gird cell in Autumn(2.736). In 18 of 22 grid cells where the average ranking value was higher than 3, the forest was distributed and in 4 grid cells, the coast and wetland were widely distributed, in which theses were located apart from human-associated disturbances such as construction works for a leisure complex. Our results present a new estimate method not only to minimize loss of bird habitats but also to conserve important habitats when the large-scale development takes place at particular region.

• The Journal of the Korea Contents Association
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• v.18 no.4
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• pp.268-278
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• 2018

The purpose of this study is to compare and analyze phonetic items such as the phonemic system, phonological rules, and pronunciation descriptions and notations incorporated in the textbooks. Based on our analysis results, we point out the problems related to pronunciation education, and suggest directions for improvement. First, the presentation order of consonants and vowels in the phonological systems sections of each textbook was different. We recommend that a standard for consonant and vowel presentation order should be prepared, but that this standard should take into consideration the specific purpose of the textbook; the learning strategies and goals, as well as the possibility of teaching and learning. Second, similar to phonemic systems, the presentation order of phonological rules was different for each textbook. To create a standard order for phonological rules, we have to standardize the order of presentation of rules and determine which rules should be presented. Furthermore, when describing phonological rules, the content should be described in common and essential terms as much as possible without the use of jargon. Third, in other matters of pronunciation, there were problems such as examples for pronunciation and lack of exercises. Regarding this, we propose to provide sentences or dialogues as examples for pronunciation, and to link these to various activities and other language functions for pronunciation practice.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.4 no.3
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• pp.285-299
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• 2006

At the end of 2005, 443 nuclear reactors were operating in 32 countries worldwide. They had provided about 3,000 TWh, which was just over 16 percent of global electricity supply. With the generating capacity of 368 GWe in 2004, the spent fuel generation rate worldwide, now becomes at about 11,000 tHM/y. Projections indicate that cumulative amounts to be generated by the year 2020, the time when most of the existing NPP will be closed to the end of their licensed lifetime, may be close to 445,000 tHM. In this regard, spent fuel management is a common issue in all countries with nuclear reactors. Whatever their national policy and/or strategy is selected for the backend of the nuclear fuel cycle, the management of spent fuel will contribute an impending and imminent issues to be resolved in the foreseeable future. The 2nd Review Meeting of the Contracting Parties to the Joint Convention was held in Vienna from 15 to 24 May 2006. The meeting gave an opportunity to exchange information on the national policy and strategy of spent fuel management of the Contracting Parties, to discuss their situations, prospects and the major factors influencing the national policies in this field and to identify the most important directions that national efforts and international co-operation in this area should be taken. In this paper, an overview of national and global trends of spent fuel management is discussed. In addition, some directions are identified and recent activities of each Member States in the subject area are summarized.

• The Journal of the Korea Contents Association
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• v.18 no.8
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• pp.658-670
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• 2018

Busan Citizen Park has been taken as the research object in this paper to learn about the categories and types of resting facilities such as seats and Pergolas in the park and analyze the visitors' use patterns of bench and Pergolas. In addition, the analysis of the cultural features and preferences of bench and Pergolas will provide the basic data for the future design of resting facilities. After the research on the categories and types of bench and Pergolas and the evaluation factors through literature surveys, the type, location, and number of resting facilities including bench, Pergolas, sheds, etc. in the entire park have been investigated through field surveys. In addition, the behavioral map analysis has been created through the observation of the use patterns of bench and Pergolas in the morning and afternoon of each month, and the degree of preference and satisfaction of park bench and Pergolas has been grasped through questionnaires. The research results are as follows. Among the ten types of bench and Pergolas, the citizens like the mats and awnings + mats best. The environment is the most important factor for the mats with highest score, followed by the functional and regional factors. In addition, various activities such as eating in mats and sheds that block sunlight are Korean use patterns, which is very common in Korean daily life. These results show that bench and Pergolas in urban parks are not placed arbitrarily and the layout and design of bench and Pergolas should be completed based on behavior and preferences, which are influenced by cultural characteristics.