• YAKHAK HOEJI
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• v.29 no.4
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• pp.193-198
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• 1985

In formulation technology, the drugs forming eutectic mixture cause many pharmaceutical problems. In this study, the method to prevent such problems has been investigated. The combined drugs of aspirin and isopropylantipyrine forming eutectic mixtures were granulated by using three kinds of binders (PVP, HPMC, starch) and these granules were made into pellets by compacting them with various compressional forces. It was possible to select optimum conditions in granulating, tableting, etc. Disintegration time and dissolution pattern were investigated about this formulation, too.

• Structural Engineering and Mechanics
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• v.28 no.2
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• pp.167-188
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• 2008

This study is concerned with the establishment of the characteristic equation of a combined system consisting of a cantilever beam with a tip mass and an in-span visco-elastic helical spring-mass, considering the mass of the helical spring. After obtaining the "exact" characteristic equation of the combined system, by making use of a boundary value problem formulation, the characteristic equation is established via a transfer matrix method, as well. Further, the characteristic equation of a reduced system is obtained as a special case. Then, the characteristic equations are numerically solved for various combinations of the physical parameters. Further, comparison of the results with the massless spring case and the case in which the spring mass is partially considered, reveals the fact that neglecting or considering the mass of the spring partially can cause considerable errors for some combinations of the physical parameters of the system.

• Natural Product Sciences
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• v.6 no.4
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• pp.165-169
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• 2000

In vitro cytotoxic activities of cisplatin combined with Chungpesagan-tang or puerarin, which were treated with or without human intestinal bacteria, were measured. When cisplatin was combined with Chungpesagan-tang and its ingredient treated without intestinal bacteria, they did not affect the in vitro cytotoxicity of cisplatin against tumor cell lines. However, when cisplatin was combined with intestinal bacteria-treated Chungpesagan-tang and its ingredients, the cytotoxicities against SNU C4, L1210, A549 and P388 tumor cell lines were synergistically increased. Puerarin, which was isolated from Puerariae Radix, did not show in vitro cytotoxicity. However, its metabolite, daidzein, showed potent cytotoxicity against tumor cell lines and was synergistic by the combined usage of cisplatin. These results suggest that natural glycosides are not only prodrugs which can be transformed to active compounds by intestinal microflora, but the combined usage of cisplatin with natural components, such as daidzein, and herbal medicinal polyprescriptions, such as Chungpesagan-tang, may be a new method for prevention and minimization of the toxicity of cisplatin.

• Computational Structural Engineering
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• v.3 no.3
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• pp.113-123
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• 1990

The paper is concerned with the elasto-plastic and geometrically nonlinear analysis of shell structures using an improved degenerated shell element. In the formulation of the element stiffness, the combined use of three different techniques was made. They are; 1) an enhanced interpolation of transverse shear strains in the natural coordinate system to overcome the shear locking problem ; 2) the reduced integration technique in in-plane strains to avoid the membrane locking behavior ; and 3) selective addition of the nonconforming displacement modes to improve the element performances. This element is free of serious shear/membrane locking problems and undesirable compatible/commutable spurious kinematic deformation modes. In the formulation for plastic deformation, the concept of a layered element model is used and the material is assumed von Mises yield criterion. An incremental total Lagrangian formulation is presented which allows the calculation of arbitrarily large displacements and rotations. The resulting non-linear equilibrium equations are solved by the Netwon-Raphson method combined with load or displacement increment. The versatility and accuracy of this improved degenerated shell element are demonstrated by solving several numerical examples.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.8
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• pp.2005-2015
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• 1994

An analytical method based on the upper bound approach for the cup-bar axisymmetric combined extrusion is presented to determine the deformation zones as well as extrusion load and deformed geometry in the early stage. A new kiematically admissible velocity field is derived by the appropriate transformation of the original velocity field and applying the flow function approach. The derived velocity field is directly related to the boundary function for the plastically deforming zones and the parameter controlling the flow direction to the forward part or backward part. Experiments are carred out with the annealed aluminum 2024 at room temperature for the various area reductions. The workhardening effect is considered in the formulation as a function of the height ratio between the deformed billet and the orighinal billet to calculate the extrusion pressures. The theoretical predictions for the extrusion loads and deformed configuration are in good agreement with the experimental results.

• Journal of KSNVE
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• v.8 no.5
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• pp.936-948
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• 1998

A theoretical formulation for the analysis of free vibration of a cylindrical shell with a circular plate attached at an arbitrary axial position of the shell under various kinds of boundary conditions was derived and programed to get the numerical results for natural frequencies and mode shapes of the combined system. The boundary conditions of the shell to be considered here are clamped-free, clamped-simply supported, both ends clamped and both ends simply supported. The frequencies and mode shapes from theoretical calculation were compared with those of commercial finite element code, ANSYS. The results showed good agreement with those of ANSYS in frequencies and mode shapes. The program will contribute to the design optimization of a shell/plate combined system through the analysis of natural frequencies and mode shapes for the system.

• Journal of applied mathematics & informatics
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• v.12 no.1_2
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• pp.219-231
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• 2003

This paper aims to study the problem of combined harvesting of a system involving one predator and two prey species fishery in which the predator feeds more intensively on the more abundant species. Mathematical formulation of the optimal harvest policy is given and its solution is derived in the equiblibrium case by using Pontryagin's Maximum principle. Dynamic optimization of the harvest policy is also discussed by taking E(t), the combined harvest effort, as a dynamic variable. Biological and bioeconomic interpretations of the results associated with the optimal equilibirum solution are explained. The significance of the constraints required for the existence of an optimal singular control are also given.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.6
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• pp.419-425
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• 2001

A dense pellicular solid matrix has been fabricated by coating 4% agarose gel on to dense zironia-silica(ZS) spheres by watr-in-oil emulsification . The agarose evenly laminated the ZS bead to a depth of 30㎛, and the resultin gpellicular assembly was characterised by densities up to 2.39g/mL and a mean particle dimeter of 136 ㎛. In comparative fluidisation tests, the pellicular solid phase exhibited a two-fold greater flow velocity than commercial benchmark ad-sorbents necessary to achieve common values of bed expansion. Furthermore, the perlicular parti-cles were characterised by improved qualities of chromatographic behaviour, particularly with re-spect to a three-fold increase in the apparent effective diffusivity of lysozyme within a pellicular assembly modified with Cibacron Blue 3GA. The properties of rapid protein adsorption/desorp-tion were attributed to the physical design and pellicular deployment of the reactive surface in the solid phase. When combined with enhanced feedstock throughput, such practical advantages recommend the pellicular assembly as a base matrix for the selective recovery of protein products from complex, particulate feedstocks(whole fermentation broths, cell disruptates and biological extracts).

• Structural Engineering and Mechanics
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• v.40 no.2
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• pp.191-213
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• 2011

This paper presents an improved 8-node shell element for the analysis of plates and shells. The finite element, based on a refined first-order shear deformation theory, is further improved by the combined use of assumed natural strain method. We analyze the influence of the shell element with the different patterns of sampling points for interpolating different components of strains. Using the assumed natural strain method with proper interpolation functions, the present shell element generates neither membrane nor shear locking behavior even when full integration is used in the formulation. Further, a refined first-order shear deformation theory, which results in parabolic through-thickness distribution of the transverse shear strains from the formulation based on the third-order shear deformation theory, is proposed. This formulation eliminates the need for shear correction factors in the first-order theory. Numerical examples demonstrate that the present element perform better in comparison with other shell elements.

• Proceedings of the KIEE Conference
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• 1990.11a
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• pp.78-81
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• 1990

The Engquist-Majdas second-order Absorbing Boundary Conditions (ABC) has been combined with the finite element formulation replacing the boundary integral equations in the hybrid finite-boundary element method (HEM). The method is applied to electromagnetic field radiation problems, especially to the microwave launcher, in order to verify the finite element formulation with the ABC's. The results with ABC are in good agreement with those of HEM. In order to see the applicability of the ABC, a simplified microwave oven utilizing ABC and an absorbing material are provided. The EM field distribution of the model is visualized. This method could be a useful analysis and design tool for EM field devices.