• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1911-1915
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• 2012

Aim: New technologies for the early detection of pancreatic cancer (PC) are urgently needed. The aim of the present study was to screen for the potential protein biomarkers in serum using proteomic fingerprint technology. Methods: Magnetic beads combined with surface-enhanced laser desorption/ionization (SELDI) TOF MS were used to profile and compare the protein spectra of serum samples from 85 patients with pancreatic cancer, 50 patients with acute-on-chronic pancreatitis and 98 healthy blood donors. Proteomic patterns associated with pancreatic cancer were identified with Biomarker Patterns Software. Results: A total of 37 differential m/z peaks were identified that were related to PC (P < 0.01). A tree model of biomarkers was constructed with the software based on the three biomarkers (7762 Da, 8560 Da, 11654 Da), this showing excellent separation between pancreatic cancer and non-cancer., with a sensitivity of 93.3% and a specificity of 95.6%. Blind test data showed a sensitivity of 88% and a specificity of 91.4%. Conclusions: The results suggested that serum biomarkers for pancreatic cancer can be detected using SELDI-TOF-MS combined with magnetic beads. Application of combined biomarkers may provide a powerful and reliable diagnostic method for pancreatic cancer with a high sensitivity and specificity.

• Journal of Korea Society of Digital Industry and Information Management
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• v.8 no.2
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• pp.145-160
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• 2012

The globe-trotting trend has been converted from tourism for the simple purposes of sightseeing and enjoyment to a form of learning and practicing the more specialized contents by directly participation. Traditional cultural resources have sufficient potential as culture and tourism assets that fit this kind of trend. Therefore, building proper tourist resources for their application has become a very urgent and important matter. To make masterpiece tourism packages through combined services of traditional cultural resources, it is necessary for operators to ponder diverse methods that can be used to develop various experience programs and conserve traditional cultural properties by continuously generating profits. The major results of this research are as follows. Firstly, this study proposes plans for unified tourist information and combined services of traditional cultural resources based on ubiquitous IT. Secondly, it is ascertained that the organization of combined operational consultative groups and the improvement of operator' capability are required to execute combined services of traditional cultural resources. Thirdly, we propose business plans to generate profits in both product aspect and network aspect.

• Journal of Electrical Engineering and Technology
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• v.1 no.4
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• pp.414-422
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• 2006

Deterministic techniques have been applied in power system planning for many years and there is a growing interest in combining these techniques with probabilistic considerations to assess the increased system stress due to the restructured electricity environment. The overall reliability framework proposed in this paper incorporates the deterministic N-1 criterion in a probabilistic framework, and results in the joint inclusion of both adequacy and security considerations in system planning. The combined framework is achieved using system well-being analysis and traditional adequacy assessment. System well-being analysis is used to quantify the degree of N-1 security and N-1 insecurity in terms of probabilities and frequencies. Traditional adequacy assessment is Incorporated to quantify the magnitude of the severity and consequences associated with system failure. The concepts are illustrated by application to two test systems. The results based on the overall reliability analysis framework indicate that adequacy indices are adversely affected by a generation deficient environment and security indices are adversely affected by a transmission deficient environment. The combined adequacy and security framework presented in this paper can assist system planners to realize the overall benefits associated with system modifications based on the degree of adequacy and security, and therefore facilitate the decision making process.

• Journal of the Korean Society of Propulsion Engineers
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• v.10 no.2
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• pp.115-128
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• 2006

A technical analysis of current scramjet and combined-cycle engine is presented. Substantial research has been pursued to characterize the operation mechanism of scramjet propulsion, especially in the areas of flame stabilization and system integration, dramatically over the years in support of both military and space access application. Major technology that had significant impact on the maturation of scramjet propulsion technology are dual combustion ramjet, dual mode ramjet, and combined cycle engine to cover a typical wide rage of flight, up to flight Mach number 10. Notable are the fundamental and practical techniques, for instance, scram propulsion itself, thermal relaxation and protection using endothermic fuel and/or CSiC composit materials, and design/manufacture of movable intake and nozzle, to realize high speed propulsion system in near future.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.53 no.spc
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• pp.65-71
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• 2008

The effect of rice bran (RB) applied alone or in combination with chemical fertilizer at different application rate on the phytochemical and antioxidant properties of rice was investigated. The treatments were 3 levels of RB namely: 200% RB (500 kg $10a^{-1}$), 100% RB (250 kg $10a^{-1}$), 50% RB (125 kg $10a^{-1}$), Recommended fertilizer dose (RF: $N-{P_2}{O_5}{K_2}O$, 11-5.5-4.8 kg $10a^{-1}$) combined with each RB, Half-recommended fertilizer dose (HRF: $N-{P_2}{O_5}{K_2}O$, 5.5-2.75-2.4 kg $10a^{-1}$) combined with each RB, RF and HRF applied at 1, 5, 10 days before rice transplanting (DBT). The parameters investigated were antioxidant, phytosterol and fatty acid contents. Results showed that the antioxidant property and phytosterol contents were high at 10 DBT HRF plus RB, 5 DBT RF plus RB, and 1 DBT 100 and 200% RB. However, total polyphenols increased from 10 to 1 DBT. In the case of fatty acids, no general trend was observed between treatments at different application times. Linoleic acid was high at 10 DBT HRF plus RB while linolenic acid was not affected at different application times. Palmitoeic and oleic acids were not also affected at 5 and 10 DBT. Saturated fatty acids were not also affected by any treatment at different application times except for palmitic acid.Most parameters obtained higher values at 100 and 200% RB treatments in 1 DBT.

• Journal of Biosystems Engineering
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• v.35 no.2
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• pp.132-137
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• 2010

Site-specific N application for corn is one of the precision crop management. To implement the site-specific N application, various nitrogen stress sensing methods, including aerial image, tissue analysis, soil sampling analysis, and SPAD meter readings, have been used. Use of side-dressing, an efficient nitrogen application method than a uniform application in either late fall or early spring, relies mainly on the capability of nitrogen deficiency detection. This paper presents map-based variable rate nitrogen application based using a multi-spectral corn nitrogen deficiency(CND) sensor. This sensor assess the nitrogen stress by means of the estimated SPAD reading calculated from the corn leave reflectance. The estimated SPAD value from the CND sensor system and location information form DGPS of each field block was combined into the field map using a ArcView program. Then this map was converted into a raster file for a map-based variable rate application software. The relative SPAD (RSPAD = SPAD over reference SPAD) was investigated 2 weeks after the treatments. The results showed that the map-based variable rate application system was feasible.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.6
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• pp.842-850
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• 2018

Objective: Several studies have reported the development of new molecular methods for the prognosis and diagnosis of male fertility based on biomarkers aimed at overcoming the limitations of conventional male fertility analysis tools. However, further studies are needed for the field application of these methods. Therefore, alternative methods based on existing semen analysis methods are required to improve production efficiency in the animal industry. Methods: we examined the possibility of improving litter size in various pig breeds using combined Hoechst 33258/chlortetracycline fluorescence (H33258/CTC) staining. The correlation between field fertility and capacitation status by combined H33258/CTC staining in different ejaculates spermatozoa (n = 3) from an individual boar (20 Landrace, 20 Yorkshire, and 20 Duroc) was evaluated as well as overall accuracy. Results: The acrosome reacted (AR) pattern after capacitation (%) was positively correlated with the litter size of Landrace, Yorkshire, and Duroc pigs and the overall accuracy was 75%, 75%, and 70% in Landrace, Yorkshire, and Duroc pigs, respectively. The difference (${\Delta}$) in AR pattern before and after capacitation was positively correlated with the litter size of Landrace, Yorkshire, and Duroc pigs and the overall accuracy was 80%, 65%, and 55% in Landrace, Yorkshire, and Duroc pigs, respectively. However, the difference (${\Delta}$) in capacitated (B) pattern before and after capacitation was negatively correlated with the litter size of Landrace pigs and the overall accuracy was 75%. Moreover, average litter size was significantly altered according to different combined H33258/CTC staining parameters. Conclusion: These results show that combined H33258/CTC staining may be used to predict male fertility in various breeds. However, the selection of specific efficiency combined H33258/CTC staining parameters requires further consideration. Taken together, these findings suggest that combined H33258/CTC staining may constitute an alternative method for predicting male fertility until such time as fertility-related biomarkers are further validated.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1649-1654
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• 2013

Objective: This work aimed to evaluate the safety and clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with c-arm cone-beam CT guided synchronous radiofrequency ablation (RFA) in treatment of large hepatocellular carcinoma (HCC). Methods: 21 patients with large HCC were studied from January 2010 to March 2012. TACE combined with synchronous C-arm cone-beam CT guided RFA were performed on a total of 25 lesions. Conventional imaging examination (CEUS, enhanced CT or MRI) and AFP detection were regularly conducted to evaluate the technical success rate of combined treatment, complications, treatment response, time without disease recurrence and survival rate. Results: The technical success rate of combined treatment was 100%, without any significant complication. After 1 month, there were 19 cases with complete response and 2 cases with partial response, with an complete response rate of 90.4% (19/21) and a clinical effective rate of 100% (21/21). The complete response rates of single nodular lesions (100%, 17/17) was significantly higher than that of multiple nodular lesions (50%, 2/4) (P<0. 05). During 2 to 28 months of follow-up, in 19 cases with complete response, the average time without disease recurrence was $10.8{\pm}6$ months. The total survival rates of 6, 12 and 18 months in 21 patients were 100%, respectively. Conclusion: TACE combined with synchronous C-arm CT guided RFA is safe and effective for treatment of large HCC. The treatment efficacy for single nodular lesion is better than that for multiple nodular lesions.

• Journal of Biosystems Engineering
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• v.22 no.4
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• pp.439-450
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• 1997

Most of Korean feed mill has a pregrind system which was suitable for the processing of less number of ingredients and finished products, and good for the mash type feed product. But industries has been changed in production volume and cost, and also from mash to further processed products such as pelleted and extruded. Therefore, Korea feed industries now should change the process, especially the grinding system from the current pregrind to other grind system, but this change will cost a lot of investment and also loosing current grinding system, and should have production shut down during the construction period. To solve these problems, combined grinding system based on a new model mill has been developed. The combined grind system is combination of pregrind and postgrind system, which has the advantages of those two grind systems, and also which can allow to utilize existing pregrind system continuously without any production interruption due to new postgrind system construction. This newly developed model has been applied to the feed mill expansion project of `B`feed company in 1994, and it was very successful application and showed excellent results as we intended. The new model mill, combined grind system applied can save fixed asset investment because old pregrind system can be used as is, and also can reduce production cost and improve product quality. And the possibility of critical production shut down can be much lowered. Within this new grinding model development, multi-screen combination system has been developed for the better grinding texture quality and safer operation. This new model mill with combined grind system will be applied by most feed manufacturing plant and may enhance their production competitiveness, and the further study and development should be continued.

• Korean Journal of Environmental Agriculture
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• v.29 no.4
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• pp.354-361
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• 2010

Soil physico-chemical properties and microbial densities are affected by organic sources and soil amendment applied to improve soil environments or quality. Generally organic fertilizer effects on forage crops yield and soil properties are partly due to changes of soil composition. We investigated the effects of swine slurry (SS), swine slurry composting-biofilteration(SCB) and chemical fertilizer(F) with gypsum(G) combinations on soil physico-chemical properties and yields of summer forage crop in the Sukmoon reclaimed tidal land in Korea. The forage crops used in this experiment were corn and sorghum$\times$sudangrass hybrid(hereafter sorghum). Our results showed that the soil physico-chemical properties in the combined (F+G, SS+G, SCB+G) treatments increased contents of organic matter and exchangeable $Ca^{2+}$, but exchangeable $Na^+$, $K^+$ and $Mg^{2+}$ reduced to 1-10% for two forage crops, compared to non-combined (F, SS, SCB) treatment. The density of soil microorganism such as bacteria, actinomycetes and fungi, increased significantly by SS+G and SCB+G treatments. This means that treatment of combined organic fertilizer with G lowered salinity levels and improved with microbial growth. The combined treatments also increased the total yields 2.3-6.2% for corn and 2.0-8.7% for sorghum, compared with non-combined treatment. This experiment suggests the combined treatments could increase the total yields of summer forage crops and change of soil physico-chemical properties in the Sukmoon reclaimed tidal land in Korea.