• 한국주거학회논문집
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• 제28권1호
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• pp.55-62
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• 2017

As fast-speed of aging in modern society has led to increased concern for aging and health improvement of senior citizens, desire about having healthy living-environment has also increased. Living space for senior citizens has to play role of healing for their body feature as well as decrease in mental and psychological function. Color, as important factor that supplements degenerated sense and coping ability caused by aging, it has been revealed through modern medical science that color is effective for making nervous or calming down when it is delivered to one's nerve through sight. The purpose of this study is to suggest basic resource for color arrangement palette of living space and application method by color therapy to improve seniors' mental health by considering psychological and physical features caused by aging. First, consider psychological and physical feature of seniors and color therapy effect through previous research. Second, extract RGB value after selecting color that is helpful for their mental health by using palette from 'Korea Agency for Technology and Standards'. Third, extract other 3 colors that are similar with extracted color from 'NCS 1950 Color System'. Fourth, deduct palette of 3 color arrangement by using 'NCS Navigator' program. Lastly, extract arrangement palette for them by considering difference in visual features, and then suggest arrangement application for each palette through Computer Simulation.

• Journal of Yeungnam Medical Science
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• 제30권1호
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• pp.62-65
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• 2013

Gastric bezoars are concretion of undigested material in the gastrointestinal tract. In the past, gastric bezoars were generally treated with surgical management. Recently, the efficacy of oral intake or endoscopic injection therapy with Coca-Cola has been reported. We report a case of a 47-year-old-man with huge gastric bezoar ($4{\times}2.5$ cm) that was successfully removed by endoscopic fragmentation with Coca-Cola injection. Compared with a single endoscopic fragmentation therapy, the combination therapy with Coca-Cola injection shortened the procedure time and reduced the complication associated with fragmented bezoar.

• Physical Therapy Rehabilitation Science
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• 제9권3호
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• pp.171-177
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• 2020

Objective: This study aimed to investigate the upper limb strength, active joint range of motion (AROM), and upper limb function in persons with chronic stroke using virtual reality training in combination with upper limb sensory stimulation. Design: Two-group pretest-posttest design. Methods: 20 subjects were divided into two groups of 10, the sensory motor stimulation and virtual reality training (SMVR) and virtual reality training (VR) groups. The training was conducted for 30 minutes per session, three times a week for 8 weeks.The participants' upper limb strength was measured via the hand-held dynamometer, joint angle AROM was measured via dual inclinometer, function was measured using the Jebson-Taylor hand function test and the manual function test. Results: Significant differences were observed in all groups before and after the training for upper extremity strength, AROM, and function (p<0.05). Between the two groups, the SMVR group showed significant improvement in muscle strength, AROM, and Jebsen-Taylor hand function test scores compared with the VR groups (p<0.05). Conclusions: In this study, we confirmed that sensory stimulation and VR had positive effects on upper extremity strength, AROM, and function of persons with chronic stroke. The results suggest that in the future, VR in combination with sensory stimulation of the upper limb is likely to become an effective method (a rehabilitation training program) to improve the upper limb function of persons with chronic stroke.

• 척추신경추나의학회지
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• 제14권1호
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• pp.61-76
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• 2019

Objectives : The purpose of this study was to report the clinical results of various medical methods (including Chuna joint mobilization) used to treat a single patient with polyneuritis. Methods : We treated a 46 year-old female patient diagnosed with polyneuritis using various methods, including acupuncture, moxibustion, infrared therapy, herbal medication, Western medication, Chuna manual therapy, and physical therapy. We evaluated the results using the numeric rating scale (NRS), manual muscle test (MMT), active range of motion (ROM), modified barthel index (MBI). Other evaluation scale included Deep tendon reflex and thickness of muscle especially forearm and lower leg. Results : Following treatment using a combination of the above methods, the general overall condition of the patients was significantly improved. Furthermore, the NRS, MMT, MBI, and the active ROM scores were numerically improved. Conclusions : In this case, a single patient with polyneuritis was treated using a combination of Korean and Western medical methods. Although this study provides useful insight into treatment methods, further studies are required to determine the treatment effects of Korean medicine, specifically Chuna manual therapy, in patients with polyneuritis.

• The Journal of Korean Physical Therapy
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• 제15권3호
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• pp.153-165
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• 2003

This study was carried out to evaluate the body fat breakdown during topical seaweed extract treatment and in combination with the iontophoresis method to enhance skin absorption of lipolytic compounds. Of 14 female obesity subjects, 7 treated a gel types of seaweed extract only(control group) and 7 treated in combination with the iontophoresis(experimental group). Topical treatment of each sample was designed for 2 weeks, treated with 2 times a day about $10m{\ell}$ on the abdomen, triceps and thigh, respectively. Experimental group treat with the iontophoresis during 5 minutes immediately after topical treatment. After one and two weeks of topical treatment, measured body fat, skinfolds thickness, body circumference respectively. Then venous blood samples were taken and analyzed serum lipids. The results were as follows; 1) There were decrement of body weight, $\%$ of body fat, abdomen, triceps and thigh circumference and abdomen, triceps and thigh thickness between pre and post treatment in both group. These decrement were predominant in the iontophoresis treated group. Especially, there were $16\%$ of body fat decrement in the experimental group after two weeks iontophoresis treatment(control group VS experimental group = $33.54{\pm}2.70$ VS $28.37{\pm}3.38$, p<0.01). 2) There were decrement in total CHOL, LDL, TRIG and increment in HDL in both group. These phenomena were predominant in the iontophoresis treated group. CHOL decrement in the experimental group were significant after two weeks iontophoresis treatment(control group VS experimental group = $190.24{\pm}34.36$ VS $157.76{\pm}24.45$, p<0.001). These results suggest that the topical treatment of seaweed extract effective for fat breakdown and maximized in the combination with the topical seaweed extracts treatment and the iontophoresis.

• BMB Reports
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• 제53권10호
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• pp.545-550
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• 2020

Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. However, clinical trials have revealed that the co-administration of CQ and AZM resulted in severe side effects, including cardiac arrhythmia, in patients with COVID-19. To elucidate the cardiotoxicity induced by CQ and AZM, we examined the effects of these drugs based on the electrophysiological properties of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) using multi-electrode arrays. CQ treatment significantly increased the field potential duration, which corresponds to prolongation of the QT interval, and decreased the spike amplitude, spike slope, and conduction velocity of hESC-CMs. AZM had no significant effect on the field potentials of hESC-CMs. However, CQ in combination with AZM greatly increased the field potential duration and decreased the beat period and spike slope of hESC-CMs when compared with CQ monotherapy. In support of the clinical data suggesting the cardiovascular side effects of the combination therapy of CQ and AZM, our results suggest that AZM reinforces the cardiotoxicity induced by CQ in hESC-CMs.

• 한국식품영양학회지
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• 제23권2호
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• pp.141-146
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• 2010

Cisplatin(cis-diamminedichloroplatium) is one of the most effective anti-cancer drugs being clinically used in the treatment of solid tumors. Despite its therapeutic benefits, its use in clinical practice is often limited because of dose related toxicity. It is known that yeast cell wall beta-glucans possess immuno-modulating properties, which allows for their application in antitumor therapy. IS2 is a kind of beta-glucan derived from the cell wall of mutated Saccharomyces cerevisiae, which exhibits anti-cancer activity in vitro and in vivo. The present study explored the possibility of combination therapy of IS2 with cisplatin. In experimental metastasis of colon26-M3.1 cells, prophylactic intravenous administration of IS-2 in combination with cisplatin effectively inhibited tumor metastasis compared with cisplatin alone or IS-2 treatment in vivo. IS-2 effectively enhanced Th1 type cytokines including IFN-$\gamma$, IL-2, IL-12 and GM-CSF. Simultaneously, this combined treatment inhibited production of Th2 type cytokines compared with control. These results suggested that IS-2 can be applied in combination therapy with anti-cancer drugs to minimize their side effects.

• The Journal of Korean Physical Therapy
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• 제16권1호
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• pp.70-84
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• 2004

This study was carried out to evaluate the body fat breakdown during topical seaweed extract treatment and in combination with the iontophoresis, phonophoresis method to enhance skin absorption of lipolytic compounds. Of 24 female obesity subjects, 7 treated a gel types of seaweed extract only(control group) and 10 treated in combination with the iontophoresis(experimental group I) and 7 treated in combination with the phonophoresis(experimental group II). Topical treatment of each sample was designed for 2 weeks, treated with 2 times a day about $10m{\ell}$ on the abdomen, triceps, thigh and superior ilium, respectively. Experimental group treat with the iontophoresis and phonophoresis during 5 minutes immediately after topical treatment. After one and two weeks of topical treatment, measured body weight, body fat, skinfolds thickness respectively. Then venous blood samples were taken and analyzed serum lipids. The results were as follows; 1) There were decrement of body weight, $\%$ of body fat, superior ilium, triceps and thigh thickness between pre and post treatment in all group. Especially, there were more decrement of body weight, $\%$ of body fat in the iontophoresis treated group. 2) There were decrement in total CHOL, LDL, TRIG and increment in HDL in all group. These phenomena were predominant in the iontophoresis treated group. CHOL decrement in the experimental group were significant after two weeks iontophoresis treatment.

• PNF and Movement
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• 제19권1호
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• pp.43-55
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• 2021

Purpose: The purpose of this study was to determine the effects of contract relaxation and a combination of isotonics in proprioceptive neuromucular facilitation (PNF) on hip and lumbopelvic motions of male patients with chronic low back pain. Methods: As the subjects of this study, a total of 45 male patients with chronic low back pain were divided into groups: 15 who underwent contract relaxation (CR) of the PNF of their hip joints, 15 who underwent a combination of isotonics (CI) of the PNF, and 15 who underwent both techniques. A device for analyzing three-dimensional motion was used to measure hip medial rotation angles, lumbopelvic rotation angles, and hip medial rotation angles at the start of lumbopelvic rotation during hip medial rotation. A two-way repeated measures ANOVA was used to compare the average values. Results: There were interactions in the hip medial rotation angles, lumbopelvic rotation angles and hip medial rotation angles at the start of lumbopelvic rotation based on the methods and periods of exercise (p < 0.05). The CR and the CR+CI groups displayed more increased hip medial angles when compared to the CI group. The CR+CI group had more decreased lumbopelvic rotation angles when compared to the CR and the CI groups. The CR+CI group had more increased hip medial rotation angles at the start of lumbopelvic rotation when compared to the CR and the CI groups. Conclusion: It can be concluded that the combination of stretching and stability exercises was effective in male patients with chronic low back pain who showed limited hip medial rotation.

• Medical Lasers
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• 제8권1호
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• pp.13-18
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• 2019

Background and Objectives High-intensity focused ultrasound (HIFU) can produce small zones of thermal damage. A HIFU procedure is non-invasive and it can achieve rejuvenation of facial skin. Fractional CO₂ laser resurfacing delivers thermal damage to the pixilated columnar zone of the skin and so evoke collagen remodeling, the same as HIFU. In many cases, the patients who want rejuvenation with HIFU are also good candidates for cutaneous photorejuvenation such as can be accomplished via fractional CO₂ resurfacing. If patients are treated in a single session by remodeling both the superficial and deep compartments of skin by using both modalities, then improvement in rhytides and tightening of sagging skin will optimize the aesthetic result. Materials and Methods Between May 2014 and January 2018, a total of 44 patients were treated with combination HIFU and fractional CO₂ laser resurfacing according to our protocol. First, the HIFU was applied to the entire face with an average of 300 treatment lines. Immediately after HIFU treatment, the ultrasound gel was washed off and then fractional CO₂ laser resurfacing was performed. We evaluated the patients using 4-point grading scales. The clinician examined the skin for evidence of complications after the completion of treatment. Results All the patients' skin quality showed improvement. Further. the clinical results after duel modality treatment were substantially better than that after the use of either modality alone. The recovery times and the incidence of adverse events when quickly and consecutively performing both treatments were similar as compared to those with employing stepwise treatment. We encountered no complications whatsoever. Conclusion When compared with stepwise therapy, combination therapy with HIFU and fractional CO₂ resurfacing offers better, safer and more effective clinical results. Thus, for targeting multiple layers of aging facial skin, this combination therapy can be safely performed in a single treatment session.