• Title/Summary/Keyword: Combination ratio

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Radio-Sensitization by Piper longumine of Human Breast Adenoma MDA-MB-231 Cells in Vitro

  • Yao, Jian-Xin;Yao, Zhi-Feng;Li, Zhan-Feng;Liu, Yong-Biao
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.7
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    • pp.3211-3217
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    • 2014
  • Background: The current study investigated the effects of Piper longumine on radio-sensitization of human breast cancer MDA-MB-231 cells and underlying mechanisms. Materials and Methods: Human breast cancer MDA-MB-231 cells were cultured in vitro and those in logarithmic growth phase were selected for experiments divided into four groups: control, X-ray exposed, Piper longumine, and Piper longumine combined with X-rays. Conogenic assays were performed to determine the radio-sensitizing effects. Cell survival curves were fitted by single-hit multi-target model and then the survival fraction (SF), average lethal dose ($D_0$), quasi-threshold dose ($D_q$) and sensitive enhancement ratio (SER) were calculated. Cell apoptosis was analyzed by flow cytometry (FCM). Western blot assays were employed for expression of apoptosis-related proteins (Bc1-2 and Bax) after treatment with Piper longumine and/or X-ray radiation. The intracellular reactive oxygen species (ROS) level was detected by FCM with a DCFH-DA probe. Results: The cloning formation capacity was decreased in the group of piperlongumine plus radiation, which displayed the values of SF2, D0, Dq significantly lower than those of radiation alone group and the sensitive enhancement ratio (SER) of D0 was1.22 and 1.29, respectively. The cell apoptosis rate was increased by the combination treatment of Piper longumine and radiation. Piper longumine increased the radiation-induced intracellular levels of ROS. Compared with the control group and individual group, the combination group demonstrated significantly decreased expression of Bcl-2 with increased Bax. Conclusions: Piper longumine at a non-cytotoxic concentration can enhance the radio-sensitivity of MDA-MB-231cells, which may be related to its regulation of apoptosis-related protein expression and the increase of intracellular ROS level, thus increasing radiation-induced apoptosis.

A Study on the Effective Combining Technology and Credit Appraisal Information in the Innovation Financing Market (기술금융시장에서의 신뢰성있는 기술평가 정보와 신용평가 정보의 최적화 결합에 관한 연구)

  • Lee, Jae-Sik;Kim, Jae-jin
    • Journal of Digital Convergence
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    • v.15 no.1
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    • pp.199-208
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    • 2017
  • This study investigates the components and rating system of reliable technology credit information for a technology finance donor who is a consumer of the information and aims to create an effective and optimal technology credit appraisal system to enlarge technology finance supply. Firstly, we calculate the optimal TCAR which becomes the maximum AUROC through the combination of ratio change, verify the substitution possibility between TAR and CR through the existing CR and system gap simulation, and propose a rating system by which financial institutes can utilize the TCAR as a credit rating. As a result, 70% : 30% is the most suitable as the weighted combination ratio of credit rating : technology rating. As a result of this study, we confirmed the possibility that the technical credit rating information could be substituted by the credit rating or the technology appraisal rating. Furthermore, it also suggests that sophisticated risk management is possible through using technology credit rating that are combined with credit and technology appraisal rating.

Evaluation of Compost Maturity during the Active Composting of Cow Manure and Castor Meal (우분과 피마자박을 이용한 퇴비화 과정 중 부숙도 평가)

  • Chang, Ki-Woon;Hong, Joo-Hwa;Lee, Jong-Jin;Han, Ki-Pil;Kim, Nam-Cheon
    • Korean Journal of Agricultural Science
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    • v.35 no.1
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    • pp.25-32
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    • 2008
  • This study was conducted to find an optimal combination rate of castor meal for the good qualitative compost and to estimate the humification grade by physico-chemical characterization and phyto-toxicity test during composting of the mixture with cow manure and castor meal. The material ratios of the compost which was mixed with cow manure(C), castor meal(C), and saw dust(S) were 5 : 1 : 4(CCS-1), 5 : 2.5 : 2.5(CCS-2) and 5 : 4 : 1(CCS-3) by volume to volume, and they were decomposed for 60 days. In the result, the changes of temperature in all treatments during composting radically increased more than $63.6^{\circ}C$ at the incipient stage, and gradually decreased around $42^{\circ}C$. At the 60 days after the treatment, pH was slowly increased from 7.0 to 8.0, and the C/N ratio was 12.3~13.8 at the final composting stage. The low C/N ratio value was caused by the castor meal with high nitrogen level(T-N 5.7%). G.I.(germination index) showed in the range of 77.5 to 82.6 in all treatments. Among all treatments CCS-1 was appeared to be the best condition for composting. Therefore, the combination rate of castor meal which was used for compost humification improvement could be recommended 10% to manufacture the good qualitative cow manure compost.

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A Study on the Residents' Behaviors in Living Area of Special Nursing Homes for the Elderly (노인전문요양시설 입소노인의 거실이용실태에 관한 조사연구)

  • An, Byeong-Young;Cho, Jun-Young;Yang, Nae-Won
    • Journal of The Korea Institute of Healthcare Architecture
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    • v.14 no.1
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    • pp.31-38
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    • 2008
  • Nursing Homes are different from other medical facilities, because they have a living space. And most of residents in a nursing home have dementia, therefore nursing homes are in control of outdoor activities for resident's safety and most of residents live in the living room at the daytime. The purpose of this study is analysis of spacial behaviors of residents in the living room, and reflection of the analysis into the architectural plan of nursing homes.There are two activities, individual activity and social interchange activity, in a living room and the role of a living room is semi-private space that includes both of them. Most numerous activities are watching TV and take a eat. Activities are different in accordance with the position at the living room. Individual activity and social interchange activity is same ratio in the middle and the ratio of social interchange activities are more than individuals in outside of living room. but alcove use of private.The types of living rooms are distinguished by combination of functions of livingroom, activity-room, and diningroom. The activity of use of residents have been shown different phases following the types of livingroom. The type of combination has been seen high rate of use and private activities and social communications are expressed evenly. The type of mixing has been seen low rae of use, but two activities, the above, are equal. The type of separation has been seen not only low rate of use, but also there has been only private activities.

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Efficient Micropropagation of Pear Germplasm Using Soot Tips and Nodal Explants

  • Yi, JungYoon;Lee, GiAn;Chung, JongWook;Lee, YoungYi;Gwag, JaeGyun;Lee, SeokYoung
    • Korean Journal of Plant Resources
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    • v.28 no.6
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    • pp.690-696
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    • 2015
  • We micropropagated pear (Pyrus species) using shoot tips and nodal explants from three pear genotypes. The ability to establish shoot tip cultures, proliferate shoots, induce rooting, and acclimatize the resulting plantlets are all elements of in vitro micropropagation. Shoots were induced from shoot tips on Murashige and Skoog medium (MS) with five different plant growth regulator combinations. The highest shoot formation rates were achieved for the three genotypes using MS supplemented with 1.0 mg/L N6-benzyladenine (BA) and 0.1 mg/L gibberellic acid (GA3). The maximum shoot number and shoot length for the three cultivars were recorded with 2.0 mg/L BA and 0.2 mg/L indole-3-butyric acid (IBA) in multiplication medium using nodal explants produced from microshoots. Nodal explants with one or two axillary buds cultured for three weeks initiated roots on medium supplemented with various concentrations of 1-naphthaleneacetic acid (NAA) or/and IBA in half-strength MS medium for adventitious rooting. The highest rooting response was with the combination of 0.2 mg/L NAA and 0.2 mg/L IBA. A combination of NAA and IBA resulted in a significant increase in the rooting ratio over NAA or IBA alone. In this medium, the root formation rate according to ranged from 68.9% for the BaeYun No. 3 genotype to 51.8% for the Hwanggeum genotype. We also investigated the influence of the concentration the polyamine phloroglucinol in rooting medium. For all three genotypes, the highest rooting ratio, longest root length, and greatest root number were observed in the treatments with 75-150 mg/L phloroglucinol. Most rooted plants were acclimatized successfully.

A Study on Wall Materials for Flavor Encapsulation (향기 성분의 미세캡슐화를 위한 피복물질에 대한 연구)

  • Cho, Young-Hee;Shin, Dong-Suck;Park, Ji-Yong
    • Korean Journal of Food Science and Technology
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    • v.31 no.6
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    • pp.1563-1569
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    • 1999
  • For the encapsulation of flavor compounds, maltodextrin (MD), gum arabic (GA) alkenylsuccinated modified starch (MS) and gellan gum were chosen for wall materials and their combination was optimized. Five fruit flavor compounds having boiling point of $90{\sim}200^{\circ}C$ were selected as core materials and their mixture was incorporated with rapeseed oil (flavor mixture to oil = 1 : 4). Flavor compound mixture to wall material ratio of 1 : 4 was selected, and the amount of maltodextrin was fixed to 30% of the wall material mixture. Gellan gum was selected as an additional wall material to increase emulsion stability. The optimum combination ratio of the wall material mixture for maximal total oil retention and minimal surface oil content is : 30.0% MD ; 26.4% GA ; 39.6% MS ; 4% gellan gum.

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The Effect of Poverty Reduction by Public Pension: A comparative study of 34 OECD Countries (공적연금의 빈곤 완화 효과: OECD 34개 회원국의 비교연구)

  • Kim, Yun Tae;Suh, Jae Wook;Park, Yeon Jin
    • 한국사회정책
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    • v.25 no.4
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    • pp.301-321
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    • 2018
  • The purpose of this paper is to analyze whether any combination of the quantitative and qualitative aspects of the public pension system is a causal factor for the elderly poverty reduction rate. For this, fuzzy-set qualitative comparison analysis was conducted with the poverty reduction rate as the outcome condition variable, the public pension expenditure ratio, the redistributive index, the first floor public pension weight, the second floor public pension weight and the second floor forced private pension weight did. As a result of the analysis, the combination of high public pension expenditure ratio, low two - tier public pension share and high two - tier compulsory private pension share has become a cause of high poverty reduction rate of the elderly. And more various forms of association were found as the cause of low poverty reduction rate of the elderly. This paper suggests policy proposals based on the above findings.

Therapeutic Duplication as a Medication Error Risk in Fixed-Dose Combination Drugs for Dyslipidemia: A Nationwide Study

  • Wonbin Choi;Hyunji Koo;Kyeong Hye Jeong;Eunyoung Kim;Seung-Hun You;Min-Taek Lee;Sun-Young Jung
    • Korean Journal of Clinical Pharmacy
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    • v.33 no.3
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    • pp.168-177
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    • 2023
  • Background & Objectives: Fixed-dose combinations (FDCs) offer advantages in adherence and cost-effectiveness compared to free combinations (FCs), but they can also complicate the prescribing process, potentially leading to therapeutic duplication (TD). This study aimed to identify the prescribing patterns of FDCs for dyslipidemia and investigate their associated risk of TD. Methods: This was a retrospective cohort study involving drugs that included statins, using Health Insurance Review & Assessment Service-National Patient Sample (HIRA-NPS) data from 2018. The unit of analysis was a prescription claim. The primary outcome was TD. The risk ratio of TD was calculated and adjusted for patient, prescriber, and the number of cardiovascular drugs prescribed using a multivariable Poisson model. Results: Our study included 252,797 FDC prescriptions and 515,666 FC prescriptions. Of the FDC group, 46.52% were male patients and 56.21% were aged 41 to 65. Ezetimibe was included in 71.61% of the FDC group, but only 0.25% of the FC group. TD occurred in 0.18% of the FDC group, and the adjusted risk ratio of TD in FDC prescriptions compared to FC was 6. 44 (95% CI 5. 30-7. 82). Conclusions: Prescribing FDCs for dyslipidemia was associated with a higher risk of TD compared to free combinations. Despite the relatively low absolute prevalence of TD, the findings underline the necessity for strategies to mitigate this risk when prescribing FDCs for dyslipidemia. Our study suggests the potential utility of Clinical Decision Support Systems and standardizing nomenclature in reducing medication errors, providing valuable insights for clinical practice and future research.

Communication performance of selective combining frequency diversity with maximum likelihood estimation in underwater multipath frequency selective channels (수중 다중경로 주파수 선택적 채널에서 최대우도추정을 적용한 선택적합성 주파수 다이버시티의 통신 성능)

  • Lee, Chaehui;Park, Kyu-Chil;Park, Jihyun
    • The Journal of the Acoustical Society of Korea
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    • v.41 no.2
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    • pp.143-149
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    • 2022
  • In this paper, we evaluate the underwater frequency diversity communication performance of Selective Combination (SC) using Maximum Likelihood Estimation (MLE). In an underwater multipath frequency selective channel, destructive interference fading due to delay spread of a received signal affects the increase in error and Signal to Noise Ratio (SNR) variability of an underwater acoustic communication. Selective Combination frequency diversity using a single sensor is applied as a transmission performance improvement technique according to the frequency selectivity of a channel. In the sea experiment applying MLE for SC decision value extraction, we evaluate the performance of SC frequency diversity and MLE-SC frequency diversity. In experiment result, we confirm through experiment that the Bit Error Rate (BER) is relatively lower when the decision value extracted through MLE-SC is applied than when the SC decision value is fixed.

Opitmal Design Technique of Nielsen Arch Bridges by Using Genetic Algorithm (유전자 알고리즘을 이용한 닐센아치교의 최적설계기법)

  • Lee, Kwang Su;Chung, Young Soo
    • Journal of Korean Society of Steel Construction
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    • v.21 no.4
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    • pp.361-373
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    • 2009
  • Using the genetic algorithm, the optimal-design technique of the Nielsen arch bridge was proposed in this paper. The design parameters were the arch-rise ratio and the steel weight ratio of the Nielsen arch bridge, and optimal-design techniques were utilized to analyze the behavior of the bridge. The optimal parameter values were determined for the estimated optimal level. The parameter determination requires the standardization of the safety, utility, and economic concepts as the critical factors of a structure. For this, a genetic algorithm was used, whose global-optimal-solution search ability is superior to the optimization technique, and whose object function in the optimal design is the total weight of the structure. The constraints for the optimization were displacement, internal stress, and time and space. The structural analysis was a combination of the small displacement theory and the genetic algorithm, and the runtime was reduced for parallel processing. The optimal-design technique that was developed in this study was employed and deduced using the optimal arch-rise ratio, steel weight ratio, and optimal-design domain. The optimal-design technique was presented so it could be applied in the industry.