• 한국임상약학회지
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• 제32권3호
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• pp.185-190
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• 2022

Background: Denosumab (Prolia®) is administered every 6 months for osteoporosis treatment. Co-administration of calcium and vitamin D is required to minimize hypocalcemia risk. We evaluated clinical outcomes based on the administration interval of denosumab and co-prescription with calcium-vitamin D combination products. Methods: A retrospective study was conducted using electronic medical records from 668 patients who started denosumab therapy between January 1 and December 31, 2018, at Seoul National University Bundang Hospital. Clinical outcomes, as measured by changes in T-score, were evaluated by the intervals and concurrent prescriptions with calcium-vitamin D combination products. Results: Of the 668 patients, 333 patients met the eligibility criteria. These patients were divided into two groups based on appropriateness of the administration interval: "Appropriate" (304 patients, 91.3%) and "Inappropriate" (29 patients, 8.3%). T-score changes were significantly higher in the "Appropriate" than in the "Inappropriate" group (0.30±0.44 vs. 0.13±0.37, p=0.048). At the beginning of the treatment, 221 patients (66.4%) were prescribed calcium-vitamin D combination products, but the changes in T-scores were not significantly different by the prescription status of the product (0.29±0.46 vs. 0.28±0.38, p=0.919). Conclusion: T-scores were significantly improved in patients with appropriate administration intervals. No significant changes in T-scores were observed by the prescription status with calcium-vitamin D combination products. For optimal treatment outcomes, prescribers should encourage adherence to the approved prescription information on dosage and administration, and pharmacists should provide medication counseling for patients.

• 무역학회지
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• 제47권4호
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• pp.161-176
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• 2022

Most companies are achieving economic benefits by producing products in the form of bi-national products, but there are also negative consequences such as reduced brand power, so strategic bi-national product planning and branding is essential. In order to actively reflect these practical needs, this study conducted a comprehensive and easy-to-generalize evaluation of Bi-national products that has been somewhat underdeveloped in previous studies. To this end, the selection and evaluation criteria of the products to be investigated were differentiated. This is to classify the products by place of use and the purpose of use so that the majority of bi-national products can be included, and then use the combination to derive the specific products to be evaluated for bi-national products. The evaluation of the product identified the phenomenon of psychological conflict among consumers due to the country of origin discrepancy at the level of decreasing brand authenticity. The above research design is an evaluation method that can encompass bi-national products as a whole, rather than an evaluation of a specific product or product line that is mainly reported in previous studies, and it is also very easy to apply to practice because it allows us to more carefully identify changes in psychological attitudes.

• 한국식품영양과학회지
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• 제31권6호
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• pp.1119-1125
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• 2002

C.perfringens의 성장은 선택되어진 천연산물의 한 종류 및 이들의 조합에 의하여 특징적으로 성장이 저해되었으며, 이것은 항산화력이 강한 천연산물들을 free radical의 제거와 동시 에 C.pefringens의 성장 억제 물질로 사용할 수 있고 이를 이용하여 기능성 항산화 제제의 제조가 가능하리라 사료된다. 한 종류의 천연산물, 백작약, 백출, 음양곽, 석창포, 오미자, 기 및 황련 등에 의하여 성장이 저해되었고, 황기는 40%의 제어율을 보여, 이 세균의 대사를 제어하는 성분이 있거나, 세포막의 수송 환경의 변화에 의한 물질의 전달이 제어되는 것으로 추정된다. 그리고 두 종류 천연산물의 조합인 황금과 감초, 황금과 상백피, 황백과 감초 및 황금과 황기등의 조합에 의해서 저해되었고, 황백과 감초의 조합에서 64%의 제어 효과를 보였다. 세 종류의 천연산물 조합인 황금과 황백 및 구기자, 황금과 황백 및 음양곽의 조합에 의하여 70%의 제어율을 보였고, 황백, 음양곽, 황기 및 감초의 조합등의 4종류의 천연산물 조합에 의해서도 성장이 저해되었으며, 75%의 제어율을 보였다. 4종류의 조합의 항산화력은 황백, 음양곽, 황기 및 감초 조합의 AUC가 581.89로써 대조군보다 4.4배 정도 강하였으며, 항산화력 이 강한 조합에서 제어가 잘되는 것으로 나타났다. Hydroxyl radical의 소거 활성은 황백, 음양곽, 황기 및 감초의 조합이 300배의 희석액에서 93.49%로서 최상의 소거율을 보였고, 방향족의 함량 및 총 phenol할량은 가공된 녹차보다 10배 정도 높은 것으로 나타났다. 이것은 항산화력이 강한 천연산물들을 이용하여 free radical의 제거와 동시에 C. pefringens의 성장 저해 물질로 사용할 수 있으며, 생체의 기능을 향상시킬 수 있는 기능성 제제로의 응용 가능성을 보였다.

• 한국산학기술학회논문지
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• 제22권3호
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• pp.323-332
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• 2021

본 연구의 목적은 배뇨장애 치료를 위한 실로도신과 솔리페나신 숙신산염을 함유한 새로운 복합 정제를 개발하는 것이다. 이러한 목표를 달성하기 위하여 실로도신과 솔리페나신 숙신산염의 동시 정량법을 확립하였다. 두 약물은 다양한 완충액에서 1 mg/ml 이상의 수용해도 값을 나타내었으며, 실로도신과 솔리페나신 숙신산염이 함유된 시판제품의 용출은 다양한 용출조건에서 30분 이내에 완료되었다. 시차 주사 열량계를 사용하여 부형제와 약물 간 상호 반응성을 확인하여 선정된, 약물과 반응성이 없는 부형제를 사용하여 습식 과립화 방법을 사용하여 결합제와 붕해제의 사용에 따른 다양한 처방을 제조한 후 용출시험을 진행하였다. 제조한 정제의 처방 중 실로도신, 솔리페나신 숙신산염, 유당, 미결정셀룰로오스 PH101, 소듐라우릴설페이트, 포비돈 K-30, 크로스포비돈 및 스테아린산마그네슘이 8/10/56/112/2/6/6/2(w/w)의 비율로 제조된 정제는 트루패스정(실로도신 시판 제품) 및 베시케어정(솔리페나신 숙신산염 시판 제품)과의 비교용출 시험시 동등성을 나타내는 것을 확인하였다. 따라서, 본 연구를 통해 얻어진 복합 정제는 각 약물의 시판 제품과 동등한 생체이용률을 나타낼 수 있을 것으로 판단되며, 향후 배뇨 장애 치료에 복약순응도가 우수한 의약품으로 활용될 수 있을 것으로 사료된다.

• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 2000년도 THE THIRD INTERNATIONAL CONFERENCE ON AGRICULTURAL MACHINERY ENGINEERING. V.II
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• pp.388-395
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• 2000

This study was performed to examine the effects of infrared (IR)/heated-air combination drying on some quality attributes of Korean white ginsengs. Ginseng roots were dried in a dryer where both the far infrared ray and heated-air are available as drying energy sources. Diametral shrinkage, external color, total saponin content, and ginsenosides and free sugar composition of the IR/heated-air combination dried ginsengs were measured and compared with those of commercial white ginseng products. The external color became lower in lightness and higher in saturation as the IR radiating plate temperature increased. IR/heated-air combination dried white ginsengs at IR plate temperature of 100$^{\circ}C$ was comparable to the commercial white ginseng products in color characteristics. Diametral shrinkage ratios ranged from 20 to 36% and appeared to be independent on the different drying methods. No definite evidence could be found whether the IR/heated-air combination drying and the conventional. hot-air drying practice resulted in white ginsengs having different ginsenoside contents and compositions. No conclusion could be made on whether the various drying treatments used in the study had effects on the free sugar contents and compositions of white ginsengs.

• Journal of Information Technology Applications and Management
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• 제20권4호
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• pp.263-278
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• 2013

SNS users have increased at rapid rate. Many firms are expected to use SNS, especially in marketing area. This study describes a SNS-based new products promotion case study. We aim to identify how differently SNS users respond to different types of SNS media or SNS contents. In this analysis marketing effects are measured in a number of website hits. The study result shows how the number of user's hits differs upon a combination of SNS media and SNS contents.

• 한국기계가공학회지
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• 제14권6호
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• pp.77-83
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• 2015

This paper is a study of the functions required for the system to quantify the closest target weight by combining several random weights such as chips, snacks, fruits, and vegetables. The multi-head weigher is designed for high-performance applications requiring increased production rates and tight accuracy tolerances. This combination system has 12 heads considered in the form of a rectangular array of $2{\times}6$ or $3{\times}4$. Channel combination can usually occur between 1 and n, and the frequency was the highest with two or three combinations. Experimental result of a combination system for a total target weight was measured at the range from 100g to 500g by increments of 50g, and the average success rate was about 70%. The average elapsed time was about 1.7 seconds, which means it can be used for the packaging of agricultural products with a variety of items.

• Journal of the Korean Wood Science and Technology
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• 제42권5호
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• pp.516-522
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• 2014

Old architectural wood materials damaged by a fire were evaluated on the basis of wood species and scanning electron microscopy (SEM) observation of wood tissues in combination with energy dispersive X-ray spectroscopy (EDXS) analysis. Results of SEM observation showed that tracheid wall thickness of burned parts was very thin compared with undamaged and sound wood, and tylosoid in the resin canals disappeared after the exposure to fire. SEM-EDXS analysis indicated that carbon and oxygen peaks occurred in the original energy band, and the carbon peak was higher than that of the oxygen in the burned part. A computerized tomography was also undertaken to investigate the carbonization layer formed by fire and possible internal defects.

• 소성∙가공
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• 제8권5호
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• pp.491-497
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• 1999

The effect of partial squeeze on the quality of casting products in the vacuum die casting was investigated to make defect free casting products with excellent mechanical properties. The partial squeeze and vacuum die casting process was industrially implemented in making reaction shaft support which was made of a hypereutectic Al-15%Si alloy. To combine squeezing and vacuum effects, the plunger injection system was designed and attached on the chill vent type vacuum machinery system. The combination of vacuum effect before injection and partial squeezing effect after injection resulted in defect free die casting products. The uniform distribution of fine eutectic and proeutectic Si obtained from trial process also provided excellent mechanical properties.

• Natural Product Sciences
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• 제24권4호
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• pp.253-258
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• 2018

Two meroterpenoids (1 and 2) along with twelve known compounds (3 - 14) were isolated from the culture broth of a Penicillium sp. fungus collected from Chuja-do, Korea. Based on the results of a combination of spectroscopic analyses, the new compounds, preaustinoids E (1) and F (2), were determined to be epimeric austintype penta-cyclic lactones.